Pre- and post-natal development of lipoprotein lipase and hepatic triglyceride hydrolase activity in rat tissues.


:The ontogenic development of lipoprotein lipase and liver triglyceride hydrolase was studied in the rat. The enzyme activity measured in extrahepatic tissues fulfilled the criteria of lipoprotein lipase from the onset of measurable activity, i.e. it was inhibited by protamine and 1 M NaCl and showed requirement for serum and heparin for optimal activity. In the liver, measurable amounts of triglyceride hydrolase, active at pH 8.6 were detected 6 days prior to birth. However, till the fourth postnatal day about 50% of this activity was inhibited by NaCl and its sensitivity towards protamine was also higher than that of the enzyme in adult liver. Three patterns of development of enzymic activity were observed in extrahepatic tissues. In the lung, the lipoprotein activity reached the adult values one day prior to birth, while in the kidney only 30% of adult activity were found at birth. A linear increase of enzyme activity was observed in the heart; only 25% of adult activity were detected at birth and 100% were reached only 20 days after birth. The increase in lipoprotein lipase activity in the heart was accompanied by morphological differentiation of cardiocytes and by a progressive development of the capillary bed, which might be related to the pattern of development of enzyme activity in this organ. Adipose tissue lipoprotein lipase activity in inguinal fat fell from values 15 times than adult values between the 4th and 40th postnatal days. The enzyme activity in epididymal fat increased steeply between day 10 and 40, at which time it exceeded the adult values very considerably. These findings indicate that the regulation of the development of lipoprotein lipase activity in extrahepatic tissues is governed by local factors, which can differ even in the same type of tissue, as exemplified by the difference between inguinal and epididymal fat.






Chajek T,Stein O,Stein Y




Has Abstract


1977-04-01 00:00:00














  • Fibrinogenemia, determined immunonephelometrically, as a possible parameter in the evaluation of peripheral arteriosclerotic arteriopathy.

    abstract::The concentration of plasma fibrinogen increases with age and is particularly elevated in subjects with vascular changes due to atherosclerosis. Fibrinogen, which is the meeting point of the "cascade" of the coagulation factors and an important regulating factor of plasma viscosity, occupies a key position in atherosc...


    pub_type: 杂志文章


    authors: Pola P,Savi L

    更新日期:1978-02-01 00:00:00

  • Age and sex mediated changes in epicardial fat adipokines.

    abstract::Aging, which is an independent risk factor for heart disease, alters body fat mass and its function. Epicardial fat plays an important physiological and pathophysiological role on cardiac structure and function. This study investigated if aging altered the abundance of epicardial (EF) and abdominal fat (AF) derived me...


    pub_type: 杂志文章


    authors: Fei J,Cook C,Blough E,Santanam N

    更新日期:2010-10-01 00:00:00

  • Statin treatment for children and adolescents with heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis.

    abstract:AIMS:To assess efficacy and safety of HMG-CoA reductase inhibitor (statin) treatment in children and adolescents with heterozygous familial hypercholesterolaemia. METHODS:MEDLINE, EMBASE, COCHRANE and Current Controlled Trials databases were searched. Study design, efficacy, and safety outcome-measures were extracted....


    pub_type: 杂志文章,meta分析,评审


    authors: Arambepola C,Farmer AJ,Perera R,Neil HA

    更新日期:2007-12-01 00:00:00

  • The biological relevance and measurement of plasma markers of oxidative stress in diabetes and cardiovascular disease.

    abstract::Oxidative stress is associated with many chronic diseases. In this review, we look at the role that oxidative stress may play in diabetes and related cardiovascular disease (CVD) and how oxidative damage may be measured in the plasma. Increased production of reactive oxygen species (ROS) has been implicated in the ini...


    pub_type: 杂志文章,评审


    authors: Stephens JW,Khanolkar MP,Bain SC

    更新日期:2009-02-01 00:00:00

  • Exercise tolerance test for predicting coronary heart disease in asymptomatic individuals: A review.

    abstract::In symptom-free subjects, exercise tolerance testing (ETT) has a doubtful utility for detecting latent coronary heart disease (CHD) because of frequent false positives, but it may be valuable for predicting future CHD. To clarify the latter question, we calculated CHD incidence associated with presence or absence of E...


    pub_type: 杂志文章,评审


    authors: Mégnien JL,Simon A

    更新日期:2009-08-01 00:00:00

  • Oxidized cholesterol in oxidized low density lipoprotein may be responsible for the inhibition of LPS-induced nitric oxide production in macrophages.

    abstract::Previous work has shown that oxidized low density lipoprotein (Ox-LDL) inhibited lipopolysacchride (LPS)-induced nitric oxide (NO) production in macrophages. In this paper, the role of different components of Ox-LDL in the inhibitory effect was studied by measuring nitrite in media. Ox-LDL inhibited LPS-induced NO pro...


    pub_type: 杂志文章


    authors: Liu SX,Chen Y,Zhou M,Wan J

    更新日期:1998-01-01 00:00:00

  • Molecular role of Cx37 in advanced atherosclerosis: a micro-array study.

    abstract::Recently, we showed that connexin37 (Cx37) protects against early atherosclerotic lesion development by regulating monocyte adhesion. The expression of this gap junction protein is altered in mouse and human atherosclerotic lesions; it is increased in macrophages newly recruited to the lesions and disappears from the ...


    pub_type: 杂志文章


    authors: Derouette JP,Wong C,Burnier L,Morel S,Sutter E,Galan K,Brisset AC,Roth I,Chadjichristos CE,Kwak BR

    更新日期:2009-09-01 00:00:00

  • Cultured bovine aortic endothelial cells show increased histamine metabolism when exposed to oscillatory shear stress.

    abstract::Oscillatory shear stress applied to the lining of blood vessels causes endothelial cell injury, one of the essential postulated prerequisites to the development of atherosclerosis. The purpose of this investigation was to study effects of shear stress on bovine aortic endothelial cells (BAEC), in vitro, for varying le...


    pub_type: 杂志文章


    authors: Skarlatos SI,Hollis TM

    更新日期:1987-03-01 00:00:00

  • Lipoprotein lipase gene polymorphism rs1059611 functionally influences serum lipid concentrations.

    abstract:OBJECTIVE:Dozens of single nucleotide polymorphisms (SNPs) in the lipoprotein lipase (LPL) gene have been reported to be associated with lipid concentrations. The aim of this study was to validate the association between rs1059611 in the LPL gene and serum lipid concentrations in the Chinese Han population and explore ...


    pub_type: 杂志文章


    authors: Mo X,Liu X,Wang L,Li H,Lu X,Huang J,Chen J,Cao J,Li J,Chen S,Tang Y,Peng X,Gu D

    更新日期:2013-08-01 00:00:00

  • Thromboxane A(2) promotes soluble CD40 ligand release from human platelets.

    abstract:OBJECTIVE:The plasma level of soluble CD40 ligand (sCD40L), which induces pro-inflammatory and pro-atherogenic responses, is known to be elevated in atherosclerotic patients. In this study, we investigated the mechanism of sCD40L release from human platelets, focusing on the involvement of thromboxane (TX) A(2). METHO...


    pub_type: 杂志文章


    authors: Enomoto Y,Adachi S,Matsushima-Nishiwaki R,Doi T,Niwa M,Akamatsu S,Tokuda H,Ogura S,Yoshimura S,Iwama T,Kozawa O

    更新日期:2010-04-01 00:00:00

  • Localized vessel expression of lipoprotein lipase in rabbits leads to rapid lipid deposition in the balloon-injured arterial wall.

    abstract::Recent studies on mice demonstrated that lipoprotein lipase (LPL) located in the arterial wall might play a pro-atherogenic role. There are major differences between humans and mice in lipoprotein metabolism and in susceptibility to atherosclerosis. We have therefore used rabbits fed normal chow diet as a model to ass...


    pub_type: 杂志文章


    authors: Wu X,Wang J,Fan J,Chen M,Chen L,Huang W,Liu G

    更新日期:2006-07-01 00:00:00

  • Dietary linoleate increases fluidity and influences chemical composition of plasma low density lipoprotein in adult men.

    abstract::Dietary linoleate was effective to increase LDL fluidity in adult men but did not significantly influence VLDL or HDL fluidities. Lipoproteins were isolated ultracentrifugally from plasma of sixteen healthy, free living male volunteers consuming controlled diets formulated from typical U.S.A. foods to have 35 energy %...


    pub_type: 杂志文章


    authors: Berlin E,Judd JT,Marshall MW,Kliman PG

    更新日期:1987-08-01 00:00:00

  • The relation between plasma cysteine, plasma homocysteine and coronary atherosclerosis.

    abstract::Several studies have reported that elevated plasma levels of total homocysteine (tHcy) are related to an increased risk of cardiovascular disease. Only a few studies have looked at the effect of cysteine, another amino thiol, on cardiovascular disease risk. Therefore, in the present case-control study we compared plas...


    pub_type: 杂志文章


    authors: van den Brandhof WE,Haks K,Schouten EG,Verhoef P

    更新日期:2001-08-01 00:00:00

  • Expression of tissue transglutaminase and elafin in human coronary artery: implication for plaque instability.

    abstract:BACKGROUND:the extracellular matrix (ECM) is an important determinant of plaque instability. Since tissue transglutaminase (tTG) and elafin act as stabilizing factors, they might play a crucial role in the pathogenesis of acute coronary syndrome. We examined their expression in human coronary arteries and the regulatio...


    pub_type: 杂志文章


    authors: Sumi Y,Inoue N,Azumi H,Seno T,Okuda M,Hirata K,Kawashima S,Hayashi Y,Itoh H,Yokoyama M

    更新日期:2002-01-01 00:00:00

  • PPARgamma promoter polymorphisms and acute coronary syndrome.

    abstract:BACKGROUND:PPARgamma (PPARg) is a nuclear transcription factor involved in the control of lipid and glucose homeostasis. Two PPARg common polymorphisms, Pro12Ala and 161C>T, have been found to be associated with cardiovascular disease. In this study, in addition to PPARg coding region, we looked for genetic variations ...


    pub_type: 杂志文章


    authors: Evangelisti L,Attanasio M,Lucarini L,Sofi F,Marcucci R,Giglioli C,Valente S,Gensini G,Abbate R,Pepe G

    更新日期:2009-07-01 00:00:00

  • Molecular and clinical characterization of a series of patients with childhood-onset lysosomal acid lipase deficiency. Retrospective investigations, follow-up and detection of two novel LIPA pathogenic variants.

    abstract:BACKGROUND AND AIMS:Childhood/Adult-onset Lysosomal Acid Lipase Deficiency (LAL-D) is a recessive disorder due to loss of function variants of LAL, the enzyme which hydrolyses cholesteryl esters, derived from internalized apoB containing lipoproteins. The disease is characterized by multi-organ involvement including th...


    pub_type: 杂志文章,多中心研究


    authors: Pisciotta L,Tozzi G,Travaglini L,Taurisano R,Lucchi T,Indolfi G,Papadia F,Di Rocco M,D'Antiga L,Crock P,Vora K,Nightingale S,Michelakakis H,Garoufi A,Lykopoulou L,Bertolini S,Calandra S

    更新日期:2017-10-01 00:00:00

  • Vitamin D modulates the association of circulating insulin-like growth factor-1 with carotid artery intima-media thickness.

    abstract:OBJECTIVE:Experimental evidence indicates that circulating insulin-like growth factor-1 (IGF-1) counteracts vascular aging and atherosclerosis, for which increased carotid artery intima-media thickness (IMT) is a marker. Yet, IGF-1 concentrations have been inconsistently associated with carotid IMT in epidemiological s...


    pub_type: 杂志文章


    authors: Ameri P,Canepa M,Fabbi P,Leoncini G,Milaneschi Y,Mussap M,AlGhatrif M,Balbi M,Viazzi F,Murialdo G,Pontremoli R,Brunelli C,Ferrucci L

    更新日期:2014-10-01 00:00:00

  • Arterial connective tissue changes and distribution of 125I-labelled low density lipoprotein in hypertensive pigs.

    abstract::Young pigs with hypertension of 10 weeks duration, resulting from cellophane perinephritis, were injected with 125I-labelled low-density lipoprotein ([125I]LDL) before being killed 24 h or 48 h later. Intimal thickening and increased acid mucopolysaccharide were demonstrated in the aortas and major arteries of the hyp...


    pub_type: 杂志文章


    authors: Sharpe DN,Scott PJ,Flint MH,Donald J

    更新日期:1980-04-01 00:00:00

  • Intramural stress as a causative factor in atherosclerotic lesions of the aortic valve.

    abstract::Topographic distribution of atherosclerotic lesions of the aortic valve was investigated in rabbits on a 2%-cholesterol-enriched diet and related to distribution of intramural stress in the valve. Initially the lesions appeared at the base of the leaflet on the aortic face and with time spread further out into the lea...


    pub_type: 杂志文章


    authors: Thubrikar MJ,Deck JD,Aouad J,Chen JM

    更新日期:1985-06-01 00:00:00

  • Lp(a) levels and antiestrogen antibodies in women with and without thrombosis in the course of oral contraception.

    abstract::Several reports have shown that lipoprotein(a) is associated with ischemic diseases. Two characteristics might explain this association. Firstly, Lp(a) is an LDL-like lipoprotein which may be implicated in the atherosclerotic process and secondly, Lp(a) possesses an additional apolipoprotein(a) whose structure is clos...


    pub_type: 杂志文章


    authors: Delplanque B,Beaumont V,Lemort N,Beaumont JL

    更新日期:1993-05-01 00:00:00

  • One-year community-based education program for hypercholesterolemia in middle-aged Japanese: a long-term outcome at 8-year follow-up.

    abstract::To examine a long-term effect of community-based education program for hypercholesterolemia and an effect modification by apolipoprotein E polymorphism, we conducted a 1-year randomized clinical trial with 8 year-follow-up. One hundred four persons aged 40-64 years who had serum total cholesterol levels between 6.21 a...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Iso H,Imano H,Nakagawa Y,Kiyama M,Kitamura A,Sato S,Naito Y,Shimamoto T,Iida M

    更新日期:2002-09-01 00:00:00

  • Decreased carotid atherosclerotic process by control of daily acute glucose fluctuations in diabetic patients treated by DPP-IV inhibitors.

    abstract:OBJECTIVE:Blood glucose fluctuations have been found to be relevant to the progression of atherosclerosis in patients with type 2 diabetes and to be more detrimental for the development of atherosclerosis than the sustained hyperglycemia. We aim at evaluating the effect of blunted daily acute glucose fluctuations by DP...


    pub_type: 杂志文章,随机对照试验


    authors: Barbieri M,Rizzo MR,Marfella R,Boccardi V,Esposito A,Pansini A,Paolisso G

    更新日期:2013-04-01 00:00:00

  • Effect of bezafibrate during 4.5 years of treatment of hyperlipoproteinaemia.

    abstract::Bezafibrate in a dosage of 200 mg 3 times daily was given to 24 patients with type II A (n = 8), II B (n = 1) and IV (n = 15) hyperlipoproteinaemia for 4.5 years. In type II A the content of total cholesterol and that of low density lipoprotein in serum decreased by 10-23 and 11-34 percent over the years compared to p...


    pub_type: 杂志文章


    authors: Olsson AG,Lang PD,Vollmar J

    更新日期:1985-05-01 00:00:00

  • Impact of low-density lipoprotein receptor mutational class on carotid atherosclerosis in patients with familial hypercholesterolemia.

    abstract:BACKGROUND AND OBJECTIVES:Defects in the low-density lipoprotein receptor (LDLR) gene cause familial hypercholesterolemia (FH), a highly atherogenic condition. The effect of different LDLR mutations on coronary heart disease (CHD) risk is insufficiently defined. We assessed carotid intima-media thickness (IMT), a surro...


    pub_type: 杂志文章


    authors: Junyent M,Gilabert R,Jarauta E,Núñez I,Cofán M,Civeira F,Pocoví M,Mallén M,Zambón D,Almagro F,Vega J,Tejedor D,Ros E

    更新日期:2010-02-01 00:00:00

  • Glycated hemoglobin and long-term prognosis in patients with suspected stable angina pectoris without diabetes mellitus: a prospective cohort study.

    abstract:OBJECTIVE:Associations of glycated hemoglobin A1c (HbA1c) levels to incident coronary and cardiovascular events among non-diabetic patients with coronary artery disease are unclear. We investigated relations of HbA1c to long-term prognosis in such patients. METHODS:A prospective cohort of 2519 patients undergoing elec...


    pub_type: 杂志文章


    authors: Rebnord EW,Pedersen ER,Strand E,Svingen GF,Meyer K,Schartum-Hansen H,Løland KH,Seifert R,Ueland PM,Nilsen DW,Nordrehaug JE,Nygård O

    更新日期:2015-05-01 00:00:00

  • pH Heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque.

    abstract:BACKGROUND:Atherosclerotic plaques are heterogeneous with respect to inflammation, calcification, vascularity, oxygen, and temperature. We hypothesized that they also vary in pH and measured pH in living human carotid endarterectomized atherosclerotic plaques (CEA), Watanabe heritable hyperlipidemic (WHHL) rabbit aorta...


    pub_type: 杂志文章


    authors: Naghavi M,John R,Naguib S,Siadaty MS,Grasu R,Kurian KC,van Winkle WB,Soller B,Litovsky S,Madjid M,Willerson JT,Casscells W

    更新日期:2002-09-01 00:00:00

  • Pulse wave velocity is associated with early clinical outcome after ischemic stroke.

    abstract:BACKGROUND AND PURPOSES:Pulse wave analysis (PWV), a marker of aortic stiffness, has independent predictive value for cardiovascular morbidity and mortality in both healthy and high-risk populations, especially fatal stroke, and for long-term functional stroke prognosis. Whether arterial stiffness and wave reflection a...


    pub_type: 杂志文章


    authors: Gąsecki D,Rojek A,Kwarciany M,Kowalczyk K,Boutouyrie P,Nyka W,Laurent S,Narkiewicz K

    更新日期:2012-12-01 00:00:00

  • Smoking, inflammatory patterns and postprandial hypertriglyceridemia.

    abstract:BACKGROUND:Smoking is associated with increased postprandial hypertriglyceridemia (PPT). Inflammation and insulin resistance are potential "drivers" for this phenomenon. We tested whether inflammatory patterns and/or insulin resistance explain the effect of smoking on PPT. METHODS AND RESULTS:Men and women in the NHLB...


    pub_type: 杂志文章


    authors: Kabagambe EK,Ordovas JM,Tsai MY,Borecki IB,Hopkins PN,Glasser SP,Arnett DK

    更新日期:2009-04-01 00:00:00

  • A commonly occurring polymorphism upstream of the estrogen receptor alpha alters transcription and is associated with increased HDL.

    abstract:OBJECTIVE:Given the role of estrogen in the regulation of lipid metabolism, we screened for functional polymorphisms in the estrogen receptor alpha (ER*), and examined for their influence on serum cholesterol. METHODS AND RESULTS:We identified a novel C>T polymorphism (ERNE-145), with a minor allele frequency of 41%. ...


    pub_type: 杂志文章


    authors: Figtree GA,Grieve SM,Speller B,Geiger MJ,Robinson BG,Channon KM,Ragoussis J,Collins P,Watkins H

    更新日期:2008-08-01 00:00:00

  • Plasma lipoprotein changes in humans induced by beta-interferon.

    abstract::Two groups of patients were administered either 4.5 X 10(6) U or 90 X 10(6) U each of recombinant DNA-derived interferon-beta serine (IFN-beta ser) i.v. daily for 10 days. IFN-beta ser affected lipoprotein lipids of patients in a dose dependent fashion. A decrease in plasma total cholesterol concentration occurred 24 ...


    pub_type: 临床试验,杂志文章


    authors: Rosenzweig IB,Wiebe DA,Borden EC,Storer B,Shrago ES

    更新日期:1987-10-01 00:00:00