当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > LDL triglycerides, hepatic lipase activity, and coronary artery disease: An epidemiologic and Mendelian randomization study.

LDL triglycerides, hepatic lipase activity, and coronary artery disease: An epidemiologic and Mendelian randomization study.

Abstract：

BACKGROUND AND AIMS:High concentrations of low density lipoprotein (LDL) triglycerides have been associated with prevalent angiographic coronary artery disease. The present analysis was designed to investigate the association of LDL triglycerides with cardiovascular mortality and to explore possible mechanisms that may link LDL triglycerides to cardiovascular risk. METHODS:LDL triglycerides were measured in 3140 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. They were prospectively followed for cardiovascular mortality (median duration 9.9 years). Genome wide association data for LDL triglycerides were available for 2900 LURIC participants. Genetic data and measurements of hepatic lipase activity were available for 478 participants of the HERITAGE Family study. Genome wide association data for cardiovascular disease were available for 184,305 participants of the CARDIoGRAMplusC4D consortium. RESULTS:There was a continuous positive association between LDL triglycerides and cardiovascular mortality (hazard ratio for 5th vs. 1st quintile = 2.53, p < 0.001) and this association was similar in males and females. Genome wide association analysis in LURIC revealed that LDL triglycerides were strongly associated with variation in the hepatic lipase region (p < 10-15 for rs1800588 and rs10468017). The LDL triglyceride raising alleles in rs1800588 and rs10468017 were associated with low hepatic lipase activity in HERITAGE and increased cardiovascular risk in CARDIoGRAMplusC4D. Two-sample Mendelian randomization analysis (HERITAGE and CARDIoGRAMplusC4D) using rs1800588 and rs10468017 as instrumental variable suggested that low hepatic lipase activity may cause increased cardiovascular risk (p = 0.013). CONCLUSIONS:Low hepatic lipase activity may link high LDL triglycerides to increased cardiovascular risk.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Silbernagel G,Scharnagl H,Kleber ME,Delgado G,Stojakovic T,Laaksonen R,Erdmann J,Rankinen T,Bouchard C,Landmesser U,Schunkert H,März W,Grammer TB

doi

10.1016/j.atherosclerosis.2018.12.024

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

37-44

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(18)31555-7

journal_volume

282

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • Effect of a short-term diet and exercise intervention in youth on atherosclerotic risk factors.

    abstract：:Early stages of atherosclerosis are commonly noted in youth. The present study was designed to examine the effects of lifestyle modification in 19 overweight children (age 8-17) who were placed on a high-fiber, low-fat diet in a 2-week residential program where food was provided ad libitum and daily exercise (2-2.5h) ...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.atherosclerosis.2006.09.011

    authors： Roberts CK,Chen AK,Barnard RJ

    更新日期：2007-03-01 00:00:00

  • Coronary artery disease in heterozygous familial hypercholesterolemia.

    abstract：:Serum lipids, lipoproteins and Achilles tendon thickness in 52 patients with heterozygous familial hypercholesterolemia (FH) were investigated in order to clarify what are the important factors for the development of coronary artery disease (CAD) in heterozygous FH patients. There were no significant differences in th...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(82)90114-9

    authors： Hirobe K,Matsuzawa Y,Ishikawa K,Tarui S,Yamamoto A,Nambu S,Fujimoto K

    更新日期：1982-08-01 00:00:00

  • Atherosclerotic dyslipidemia revealed by plasma lipidomics on ApoE-/- mice fed a high-fat diet.

    abstract：BACKGROUND AND AIMS:The pathological process of atherosclerosis is closely related to lipid accumulation at arterial wall caused by lipoproteins transporting lipids through blood. In this study, we investigate the lipid composition in the plasma of apolipoprotein E deficient (ApoE-/-) mice fed a high-fat diet to reveal...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2017.05.010

    authors： Chen Y,Wen S,Jiang M,Zhu Y,Ding L,Shi H,Dong P,Yang J,Yang Y

    更新日期：2017-07-01 00:00:00

  • Cardiovascular implications of HIV-induced dyslipidemia.

    abstract：:Cardiovascular disease (CVD) is currently the second most frequent cause of death (after cancer) among HIV-positive subjects. The clinical use of highly active antiretroviral therapy (HAART) has dramatically reduced mortality and morbidity in HIV-positive population, leading to prolonged and improved quality of life. ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2011.06.003

    authors： Giannarelli C,Klein RS,Badimon JJ

    更新日期：2011-12-01 00:00:00

  • Wall shear stress is lower in the carotid artery responsible for a unilateral ischemic stroke.

    abstract：:According to the focal nature of atherosclerosis, ischemic stroke is frequently unilateral. Atherosclerotic plaques are favoured by local hemodynamic factors as low wall shear stress and/or elevated circumferential wall tension. Aim of the present study was to investigate the possible association between hemodynamic f...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.05.019

    authors： Carallo C,Lucca LF,Ciamei M,Tucci S,de Franceschi MS

    更新日期：2006-03-01 00:00:00

  • Resting heart rate and the incidence and progression of valvular calcium: The Multi-Ethnic Study of Atherosclerosis (MESA).

    abstract：BACKGROUND AND AIMS:Left-sided valvular calcification is associated with cardiovascular disease (CVD) morbidity and mortality. Resting heart rate (RHR) may influence valvular calcium progression through shear stress. Whether RHR, an established CVD risk factor, is associated with valvular calcium progression is unknown...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2018.04.004

    authors： Amoakwa K,Fashanu OE,Tibuakuu M,Zhao D,Guallar E,Whelton SP,O'Neal WT,Post WS,Budoff MJ,Michos ED

    更新日期：2018-06-01 00:00:00

  • Expression of long pentraxin PTX3 in human adipose tissue and its relation with cardiovascular risk factors.

    abstract：UNLABELLED:Pentraxin 3 (PTX3) is an acute phase protein strongly expressed by advanced atherosclerotic lesions. We investigated (a) PTX3 expression and secretion in subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (VAT) obtained from 21 obese (37.4+/-8.15 yr) and 10 normal weight subjects (43.7+/-1...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.05.015

    authors： Alberti L,Gilardini L,Zulian A,Micheletto G,Peri G,Doni A,Mantovani A,Invitti C

    更新日期：2009-02-01 00:00:00

  • Prevalence Of familial hypercholeSTerolaemia (FH) in Italian Patients with coronary artERy disease: The POSTER study.

    abstract：BACKGROUND AND AIMS:Familial hypercholesterolaemia (FH) is a powerful risk factor for cardiovascular (CV) events. High levels of low-density lipoprotein cholesterol (LDL-C) since birth are linked to the early onset of atherosclerotic disease. A genetic mutation determining FH is present in about one subject out of 250;...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2020.07.007

    authors： Gulizia MM,Maggioni AP,Abrignani MG,Bilato C,Mangiacapra F,Sanchez FA,Piovaccari G,Montagna L,Marini M,De Biasio M,Averna M,Casula M,Colivicchi F,Fabbri G,Lucci D,Zampoleri V,Catapano AL,POSTER Investigators.

    更新日期：2020-09-01 00:00:00

  • Effect of treatment with human apolipoprotein A-I on atherosclerosis in uremic apolipoprotein-E deficient mice.

    abstract：OBJECTIVE:Uremia markedly increases the risk of atherosclerosis. Thus, effective anti-atherogenic treatments are needed for uremic patients. This study examined effects of non-lipidated recombinant human apoA-I (h-apoA-I) and a recombinant trimeric apoA-I molecule (TripA-I) on lipid metabolism and atherosclerosis in ur...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.04.041

    authors： Pedersen TX,Bro S,Andersen MH,Etzerodt M,Jauhiainen M,Moestrup S,Nielsen LB

    更新日期：2009-02-01 00:00:00

  • Depression symptoms and the progression of carotid intima-media thickness: a 5-year follow-up study.

    abstract：OBJECTIVE:Only a few studies have investigated the changes in carotid intima-media thickness (IMT) over time, and uncertainties remain on the underlying mechanisms linking depression and subclinical atherosclerosis. We carried out a prospective cohort study to evaluate whether depression is associated with changes in c...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.01.012

    authors： Pizzi C,Costa GM,Santarella L,Flacco ME,Capasso L,Bert F,Manzoli L

    更新日期：2014-04-01 00:00:00

  • Combination of n-3 polyunsaturated fatty acids reduces atherogenesis in apolipoprotein E-deficient mice by inhibiting macrophage activation.

    abstract：BACKGROUND AND AIMS:Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are major components of n-3 polyunsaturated fatty acids (n-3 PUFAs) which inhibit atherogenesis, although few studies have examined the effects of the combination of EPA and DHA on atherogenesis. The aim of this study was to investigate whet...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.10.002

    authors： Takashima A,Fukuda D,Tanaka K,Higashikuni Y,Hirata Y,Nishimoto S,Yagi S,Yamada H,Soeki T,Wakatsuki T,Taketani Y,Shimabukuro M,Sata M

    更新日期：2016-11-01 00:00:00

  • Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr-/- mice.

    abstract：BACKGROUND AND AIMS:Atherosclerosis is a chronic inflammatory disease of medium and large vessels and is typically characterized by the predominant accumulation of low-density lipoprotein (LDL)-cholesterol inside macrophages that reside in the vessel walls. Previous studies clearly demonstrated an association specifica...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.10.038

    authors： Jeurissen MLJ,Walenbergh SMA,Houben T,Gijbels MJJ,Li J,Hendrikx T,Oligschlaeger Y,van Gorp PJ,Binder CJ,Donners MMPC,Shiri-Sverdlov R

    更新日期：2016-12-01 00:00:00

  • Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells.

    abstract：:The vascular endothelial cell (EC) plays an essential role in the pathogenesis of inflammation, transplant rejection and tumour metastasis. Most research on vascular ECs uses human umbilical vein endothelial cells (HUVECs). However, HUVECs are derived from immune-naive foetal tissue, and show significant functional di...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2003.12.011

    authors： Tan PH,Chan C,Xue SA,Dong R,Ananthesayanan B,Manunta M,Kerouedan C,Cheshire NJ,Wolfe JH,Haskard DO,Taylor KM,George AJ

    更新日期：2004-04-01 00:00:00

  • pH Heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque.

    abstract：BACKGROUND:Atherosclerotic plaques are heterogeneous with respect to inflammation, calcification, vascularity, oxygen, and temperature. We hypothesized that they also vary in pH and measured pH in living human carotid endarterectomized atherosclerotic plaques (CEA), Watanabe heritable hyperlipidemic (WHHL) rabbit aorta...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(02)00018-7

    authors： Naghavi M,John R,Naguib S,Siadaty MS,Grasu R,Kurian KC,van Winkle WB,Soller B,Litovsky S,Madjid M,Willerson JT,Casscells W

    更新日期：2002-09-01 00:00:00

  • Lipoprotein(a) serum levels in patients affected by chronic obstructive pulmonary disease.

    abstract：:A recent study has suggested that symptoms of chronic bronchitis predict the risk of coronary disease independently of the known major cardiovascular risk factors. High serum levels of lipoprotein(a) (Lp(a)) have also been considered as an independent risk factor for coronary heart disease. Therefore, the aim of the p...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0021-9150(99)00192-6

    authors： Basili S,Ferroni P,Vieri M,Cardelli P,Ceci F,Paradiso M,Labbadia G,Gazzaniga PP,Cordova C,Alessandri C

    更新日期：1999-12-01 00:00:00

  • Failure of exogenous apoprotein E-3 to enhance cholesterol egress from J-774 murine macrophages in culture.

    abstract：:HDL has been shown to enhance the removal of cholesterol from cultured fibroblasts, smooth muscle cells and macrophages, but fails to stimulate cholesterol removal from J-774 macrophages. Since J-774 macrophages do not synthesize or secrete apolipoprotein E, the effect of exogenous apolipoprotein E on HDL-mediated cel...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)05475-x

    authors： Granot E,Eisenberg S

    更新日期：1995-04-07 00:00:00

  • Effect of risk factors and antirheumatic drugs on the proliferation of aortic wall cells.

    abstract：:The proliferation of aortic smooth muscle cells (ASMC) of Wistar rats, impaired by risk factors such as arterial hypertension, diabetes mellitus, atherogenic diet and staphylolysin injections and of normal Wistar rats treated with antirheumatic drugs such as prednisolone and acetylsalicylic acid was investigated. The ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(79)90135-7

    authors： Hauss WH,Mey J,Schulte H

    更新日期：1979-10-01 00:00:00

  • Alcohol consumption and its relation to lipid-based cardiovascular risk factors among middle-aged women: the role of HDL(3) cholesterol.

    abstract：:To study the association of alcohol consumption and lipid-based cardiovascular risk factors among middle-age women, cross-sectional analysis among 274 middle-aged healthy women with different drinking habits and a follow-up analysis of alcoholic women during abstinence was performed. Serum total cholesterol, low and h...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(00)00369-5

    authors： Sillanaukee P,Koivula T,Jokela H,Pitkäjärvi T,Seppä K

    更新日期：2000-10-01 00:00:00

  • Evidence concerning resistance to atheroma by media-like islands in the intima of coronary arteries.

    abstract：:Coronary arteries with and without atheroma are compared histologically to ask what kind of artery encourages atheroma. When atheroma obliterates the structures that preceded and invited its intrusion, the sites remaining for observation form a censored data set. How to assess media-like island effects using the censo...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.08.011

    authors： Tracy RE

    更新日期：2005-01-01 00:00:00

  • High-sensitivity cardiac troponin T in patients with intermittent claudication and its relation with cardiovascular events and all-cause mortality--the CAVASIC Study.

    abstract：BACKGROUND:Serum concentrations of high-sensitivity cardiac troponin T (hs-cTnT) are elevated in various diseases. The role of this marker in peripheral arterial disease (PAD) has not been fully investigated. METHODS:Hs-cTnT was measured in the CAVASIC Study, a male cohort of 235 patients diagnosed with intermittent c...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.10.097

    authors： Pohlhammer J,Kronenberg F,Rantner B,Stadler M,Peric S,Hammerer-Lercher A,Klein-Weigel P,Fraedrich G,Kollerits B

    更新日期：2014-12-01 00:00:00

  • Risks for cardiovascular disease, stroke, ischaemic heart disease, and diabetes mellitus associated with the metabolic syndrome using the new harmonised definition: findings from nationally representative longitudinal data from an Asian population.

    abstract：OBJECTIVE:We examined the risk of cardiovascular disease, stroke, ischaemic heart disease, and diabetes with the metabolic syndrome according to the new harmonised definition and its components using a national longitudinal data set from an Asian population. METHODS:Data of 9791 men and women aged 20+ from 1998 and 20...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.09.009

    authors： Khang YH,Cho SI,Kim HR

    更新日期：2010-12-01 00:00:00

  • EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques.

    abstract：:The recruitment of peripheral monocytes to the sub-endothelial space, their development into macrophages and subsequent proliferation are critical events during atherosclerosis. Receptors for epidermal growth factor (EGF) have been identified on cells of the myeloid lineage, but a role for them in atherogenesis has ye...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.04.012

    authors： Lamb DJ,Modjtahedi H,Plant NJ,Ferns GA

    更新日期：2004-09-01 00:00:00

  • LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion.

    abstract：:We previously reported linkage for plasma levels of high-density lipoprotein cholesterol (HDL-C) on 15q21 in Caucasian families from the National Heart, Lung, and Blood Institute Family Heart Study (NHLBI FHS). Hepatic lipase gene (LIPC), which has a major role in lipoprotein metabolism, resides within the linkage reg...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2008.09.007

    authors： Feitosa MF,Myers RH,Pankow JS,Province MA,Borecki IB

    更新日期：2009-05-01 00:00:00

  • A concise review of non-alcoholic fatty liver disease.

    abstract：:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and the incidence of which is rising rapidly due to the increasing epidemic of obesity in both adults and children. The initial accumulation of fat followed by subsequent inflammation is central to the development of liver...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2015.01.001

    authors： Than NN,Newsome PN

    更新日期：2015-03-01 00:00:00

  • Evaluation of coronary features of HIV patients presenting with ACS: The CUORE, a multicenter study.

    abstract：BACKGROUND AND AIMS:The risk of recurrence of myocardial infarction (MI) in HIV patients presenting with acute coronary syndrome (ACS) is well known, but there is limited evidence about potential differences in coronary plaques compared to non-HIV patients. METHODS:In this multicenter case-control study, HIV patients ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2018.05.001

    authors： Peyracchia M,De Lio G,Montrucchio C,Omedè P,d'Ettore G,Calcagno A,Vullo V,Cerrato E,Pennacchi M,Sardella G,Manga P,GrossoMarra W,Vullo F,Fedele F,Biondi-Zoccai G,Moretti C,Vachiat A,Bonora S,Rinaldi M,Mancone M,D'

    更新日期：2018-07-01 00:00:00

  • Lack of effect of probucol on atheroma formation in cholesterol-fed rabbits kept at comparable plasma cholesterol levels.

    abstract：:Rabbits were fed cholesterol for 14 weeks to study the effect of probucol on atheroma formation. Three groups of animals were investigated: group CHOL was fed 1% cholesterol and served as control for group P + CHOL. fed 1% cholesterol and 1% probucol from the onset till the end of the experiment: group CHOL + P receiv...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(89)90171-8

    authors： Stein Y,Stein O,Delplanque B,Fesmire JD,Lee DM,Alaupovic P

    更新日期：1989-02-01 00:00:00

  • A high CHA(2)DS(2)-VASc score is associated with a high risk for critical limb ischemia in peripheral arterial occlusive disease patients.

    abstract：BACKGROUND:The CHA(2)DS(2)-VASc (congestive heart failure, hypertension, age ≥ 75 years (doubled), type 2 diabetes, previous stroke, transient ischemic attack, or thromboembolism (doubled), vascular disease, age 65-75 years, and sex category) score was published as a predictive scoring model for stroke in atrial fibril...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.10.025

    authors： Gary T,Belaj K,Hafner F,Hackl G,Froehlich H,Pilger E,Brodmann M

    更新日期：2012-12-01 00:00:00

  • The effect of hypercholesterolemia on aortic endothelium studied en face.

    abstract：:The aortic endothelium of rabbits fed a stock diet containing 1 or 2% cholesterol for intervals of 1 day to 21 weeks was compared with that of normal rabbits on a stock diet without cholesterol. The endothelium was examined en face using the Häutchen technique. The aortic endothelium of the experimental animals reveal...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(75)90015-5

    authors： Silkworth JB,McLean B,Stehbens WE

    更新日期：1975-11-01 00:00:00

  • Kinetics of triglyceride rich lipoproteins: chylomicrons and very low density lipoproteins.

    abstract：:Lipoprotein dynamics are complex during the postprandial state. A significant rise in chylomicron concentration is associated with increased competition for LPL with VLDL particles. This results in an increased concentration of large VLDL. The concentration of small VLDL is reduced as a result of diminished conversion...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/s0021-9150(98)00215-9

    authors： Hugh P,Barrett R

    更新日期：1998-12-01 00:00:00

  • Effect of KC-9432, a new hypolipidemic compound, on high density lipoprotein cholesterol in rats.

    abstract：:KC-9432 (a new hypolipidemic compound, alpha-[p-(p-chlorobenzoyl) phenoxy-alpha-cyclohexyl acetic acid ethyl ester) was studied in rats for its effect on plasma lipid and lipoprotein levels. KC-9432 was particularly effective in hyperlipidemia in rats fed with a diet containing 2% cholesterol and 1% sodium cholate. Th...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(80)90097-0

    authors： Seri K,Sato R,Hamazaki Y,Yamamoto T,Ishiyama N

    更新日期：1980-09-01 00:00:00