Abstract:
BACKGROUND AND AIMS:The risk of recurrence of myocardial infarction (MI) in HIV patients presenting with acute coronary syndrome (ACS) is well known, but there is limited evidence about potential differences in coronary plaques compared to non-HIV patients. METHODS:In this multicenter case-control study, HIV patients presenting with ACS, with intravascular-ultrasound (IVUS) data, enrolled between February 2015 and June 2017, and undergoing highly active antiretroviral therapy (HAART), were retrospectively compared to non-HIV patients presenting with ACS, before and after propensity score with matching, randomly selected from included centers. Primary end-point was the prevalence of multivessel disease. Secondary end-points were the prevalence of abnormal features at IVUS, the incidence of major-acute-cardiovascular-events (MACE), a composite end point of cardiovascular death, MI, target lesion revascularization (TLR), stent thrombosis (ST), non-cardiac death and target vessel revascularization (TVR). For each end-point, a subgroup analysis was conducted in HIV patients with CD4 cell count <200/mm3. RESULTS:Before propensity score, 66 HIV patients and 120 non-HIV patients were selected, resulting in 20 and 40 after propensity score. Patients with multivessel disease were 11 and 17, respectively (p = 0.56). IVUS showed a lower plaque burden (71% vs. 75%, p < 0.001) and a higher prevalence of hyperechoic non-calcified plaques (100% vs. 35%, p < 0.05) in HIV patients; a higher prevalence of hypoechoic plaques (7% vs. 0%, p < 0.05), a higher incidence of MACE (17.4% vs. 9.1% vs. l'8.0%, p < 0.05), MI recurrence (17.2% vs. 0.0% vs. 2.3%, p < 0.05), and ST (6.7% vs. 0.3% vs. 03%, p < 0.05) in HIV patients with CD4 < 200/mm3. CONCLUSIONS:Our study may provide a part of the pathophysiological basis of the differences in coronary arteries between HIV-positive and HIV-negative patients, suggesting that the former present with peculiar morphological features at IVUS, even after adjustment for clinical variables. Furthermore, we confirmed that an advanced HIV infection is associated with a high risk of non-calcific plaques and with a worse prognosis, including cardiovascular events and ACS recurrence.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Peyracchia M,De Lio G,Montrucchio C,Omedè P,d'Ettore G,Calcagno A,Vullo V,Cerrato E,Pennacchi M,Sardella G,Manga P,GrossoMarra W,Vullo F,Fedele F,Biondi-Zoccai G,Moretti C,Vachiat A,Bonora S,Rinaldi M,Mancone M,D'doi
10.1016/j.atherosclerosis.2018.05.001subject
Has Abstractpub_date
2018-07-01 00:00:00pages
218-226eissn
0021-9150issn
1879-1484pii
S0021-9150(18)30228-4journal_volume
274pub_type
杂志文章,多中心研究相关文献
ATHEROSCLEROSIS文献大全abstract:OBJECTIVE:Sarcopenia of legs is an important cause of physical dysfunctions, frailty and dependence. Many predisposing and underlying mechanisms of sarcopenia, including age, sedentary life style, oxidative stress, insulin resistance, and low testosterone levels, are also known to be related to atherosclerosis, which i...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2010.05.026
更新日期:2010-09-01 00:00:00
abstract::Reactive oxygen species (ROS) contribute to neointimal smooth muscle proliferation by yet to be defined mechanisms. We examined the effects of a novel isoflavone 3,7-dihydroxy-isoflav-3-ene (DHIF) on development of neointimal lesions in relation to ROS elevations and cell signaling in injured arteries. Carotid arterie...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2008.09.005
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:Low levels of high density lipoprotein-cholesterol (HDL-C) are highly prevalent in subjects presenting premature atherosclerosis. It is indeterminate as to whether high cardiovascular risk in low HDL-C subjects occurs concomitantly with elevated oxidative stress and/or with biologically dysfunctional HDL part...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2005.03.001
更新日期:2005-10-01 00:00:00
abstract::This paper reports the results of the largest autopsy-based comparative study of atherosclerotic lesions between young Japanese and Americans, aged 15-34 years and autopsied between 1987 and 1995, by analyzing the data from the Japanese second nation-wide study of atherosclerosis and Pathobiological Determinants of At...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2004.11.014
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To compare lipid-lowering efficacy of adding alirocumab to rosuvastatin versus other treatment strategies (NCT01730053). METHODS:Patients receiving baseline rosuvastatin regimens (10 or 20 mg) were randomized to: add-on alirocumab 75 mg every-2-weeks (Q2W) (1-mL subcutaneous injection via pre-filled pen); ad...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.atherosclerosis.2015.11.010
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Previous epidemiological studies have shown positive associations between serum calcium concentration and risk of cardiovascular disease (CVD), but results differ by definition of CVD. We examined the association of circulating calcium with incident and fatal CVD, myocardial infarction (MI), and str...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2016.06.004
更新日期:2016-08-01 00:00:00
abstract::The metabolism of homocysteine requires contributions of several enzymes and vitamin cofactors. Earlier studies identified a common polymorphism of methylenetetrahydrofolate reductase that was associated with mild hyperhomocysteinemia. Common variants of two other enzymes involved in homocysteine metabolism, methionin...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(02)00204-6
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:The objective of this article is to review the current literature on Wnt5a and its signaling mechanism, along with its role in atherosclerosis. In addition, the significance of Wnt5a as a diagnostic marker and a potential therapeutic target is reviewed. Wnt5a, a secreted glycoprotein, belongs to a family of h...
journal_title:Atherosclerosis
pub_type: 杂志文章,评审
doi:10.1016/j.atherosclerosis.2014.08.027
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:Associations of glycated hemoglobin A1c (HbA1c) levels to incident coronary and cardiovascular events among non-diabetic patients with coronary artery disease are unclear. We investigated relations of HbA1c to long-term prognosis in such patients. METHODS:A prospective cohort of 2519 patients undergoing elec...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2015.02.053
更新日期:2015-05-01 00:00:00
abstract::Thiobarbituric acid reactive substances (TBARS) in 38 low density lipoprotein (LDL) samples from 21 healthy male non-smokers and 17 smokers (greater than 20 cigarettes per day) were measured before and after oxidation. TBARS in the freshly isolated LDL from non-smokers and smokers were similar, however, oxidized LDL s...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(90)90048-n
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Lipoprotein Lp(a) has been shown to be an independent risk factor for coronary artery disease (CAD). However, its association with CAD burden in patients with ACS is largely unknown, as well as the association of Lp(a) with lipid rich plaques prone to rupture. AIM:We aim at assessing CAD burden by coronary ...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究
doi:10.1016/j.atherosclerosis.2016.01.020
更新日期:2016-03-01 00:00:00
abstract::The PERTINENT study measured biomarkers of atherosclerosis and thrombosis in a stable coronary artery disease population from EUROPA receiving ACE inhibition with perindopril 8 mg/day or placebo. Biomarkers of inflammation, C-reactive protein (CRP), fibrinogen, and tumor necrosis factor-alpha (TNF-alpha), and a biomar...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.atherosclerosis.2008.08.042
更新日期:2009-05-01 00:00:00
abstract::The aortic endothelium of rabbits fed a stock diet containing 1 or 2% cholesterol for intervals of 1 day to 21 weeks was compared with that of normal rabbits on a stock diet without cholesterol. The endothelium was examined en face using the Häutchen technique. The aortic endothelium of the experimental animals reveal...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(75)90015-5
更新日期:1975-11-01 00:00:00
abstract::We have previously reported that plasma levels of remnant-like lipoprotein particles (RLP) significantly increased in sudden cardiac death cases with and without coronary atherosclerosis. In this study we have elucidated the major subset of proatherogenic RLP, containing both apoB-48 and apoB-100-carrying remnants, in...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2006.08.057
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:Deletion of inducible nitric oxide synthase (iNOS) in apolipoprotein E knockout mice was shown to mitigate the extent of arteriosclerosis. Oxidized low density lipoprotein (oxLDL) inhibits macrophage migration and traps foam cells, possibly through a mechanism involving oxidative stress. Here, we addressed wh...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2014.04.020
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:We examined the use of lipid lowering medications and control of dyslipidemia among US adults in 1999-2006. METHODS:Data were extracted from the National Health and Nutrition Examination Survey 1999-2006. RESULTS:The mean low-density lipoprotein-cholesterol (LDL-C) level significantly decreased from 3.25+/-...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2009.08.001
更新日期:2010-02-01 00:00:00
abstract::The ontogenic development of lipoprotein lipase and liver triglyceride hydrolase was studied in the rat. The enzyme activity measured in extrahepatic tissues fulfilled the criteria of lipoprotein lipase from the onset of measurable activity, i.e. it was inhibited by protamine and 1 M NaCl and showed requirement for se...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(77)90122-8
更新日期:1977-04-01 00:00:00
abstract::Free radical mediated oxidation of apoB lipoproteins in the arterial intima appears to contribute to atherogenicity of the entrapped particles. A plausible pathogenic mechanism for oxidation is the one induced by heme leaking from erythrocytes that is then carried into the arterial wall by its high affinity for lipopr...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(01)00422-1
更新日期:2001-09-01 00:00:00
abstract::An attempt was made to explore the reasons why men develop coronary heart disease (CHD) despite being at low risk on the basis of established risk factors. A case control study was designed to take place after the end of a longitudinal study in which both low- and high-risk men who had developed CHD over the course of...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(83)90196-x
更新日期:1983-11-01 00:00:00
abstract::The pyridine derivative cerivastatin is a new entirely synthetic and enantiomerically pure inhibitor of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. As a sodium salt cerivastatin is present in the active, open ring form. Cerivastatin inhibited the membrane-bound (non-solubilized) HMG-CoA reductase of the native...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(97)00188-3
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:Type 2 diabetes (DM2) and impaired glucose metabolism (IGM) are associated with an increased cardiovascular disease risk. Impaired endothelial synthesis of nitric oxide (NO) is an important feature of atherothrombosis and can be estimated from endothelium-dependent flow-mediated dilation (FMD). It is controv...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2004.01.002
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:We aimed to determine, whether the amount of local pericoronary fat volume is associated with the presence of plaque burden in the underlying coronary artery segment. METHODS:We assessed 311 coronary segments from ECG-gated contrast-enhanced dual-source computed tomography for presence of plaque as well as s...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2010.02.013
更新日期:2010-07-01 00:00:00
abstract::Reconstituted high-density lipoprotein (rHDL) has been shown to produce a rapid regression of atherosclerosis in animal models and humans. Sphingosine-1-phosphate (S1P), which is a bioactive lipid in HDL, plays a role in mitogenesis, endothelial cell motility, and cell survival, as well as organization and differentia...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2006.10.020
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND AND AIMS:An environment-wide association study (EWAS) may be useful to comprehensively test and validate associations between environmental factors and peripheral arterial disease (PAD) in an unbiased manner. METHODS:Data from cross-sectional cohorts from the US National Health and Nutrition Examination Sur...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2018.01.006
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Recent failures of clinical trials promoting HDL-elevating therapies have prompted research groups to focus on its functional activity in disease. Endothelial effects of HDL can be measured with in vitro cell assays. The reproducibility and biological relevance of these assays have not been explored both in ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2015.06.005
更新日期:2015-08-01 00:00:00
abstract::Coronary arteries with and without atheroma are compared histologically to ask what kind of artery encourages atheroma. When atheroma obliterates the structures that preceded and invited its intrusion, the sites remaining for observation form a censored data set. How to assess media-like island effects using the censo...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2004.08.011
更新日期:2005-01-01 00:00:00
abstract::Lack of physical activity appears to have deleterious effects on serum lipoproteins. Twenty-three patients who were completely immobilised by traumatic fracture of the spine had significantly lower (P < 0.001) plasma high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I levels than normally mobile paired...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(80)90151-3
更新日期:1980-11-01 00:00:00
abstract:OBJECTIVE:Lipid rafts are cholesterol-enriched microdomains on cell membranes. We hypothesized that these microdomains could involve modified low-density lipoprotein (LDL) uptake. METHODS AND RESULTS:Co-localizations of cholesterol-enriched microdomains and CD204 during the uptake of acetyl LDL (AcLDL) and oxidized LD...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2010.10.019
更新日期:2011-03-01 00:00:00
abstract::An inverse relationship between moderate alcohol consumption and coronary artery disease (CAD) has been observed in several epidemiologic studies. Whether improvement of endothelial function is involved in this beneficial effect is unknown. We investigated endothelial function of the brachial artery in 108 men with CA...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(02)00193-4
更新日期:2002-11-01 00:00:00
abstract::Whole blood and plasma viscosity, red cell aggregability and deformability, and plasma fibrinogen have been compared between 20 patients with heterozygous familial hypercholesterolaemia (FH), without clinical arterial disease, and 20 age- and sex-matched controls. Plasma fibrinogen was elevated in FH, associated with ...
journal_title:Atherosclerosis
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/0021-9150(90)90117-2
更新日期:1990-12-01 00:00:00