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Involvement of cholesterol-enriched microdomains in class A scavenger receptor-mediated responses in human macrophages.

Abstract：

OBJECTIVE:Lipid rafts are cholesterol-enriched microdomains on cell membranes. We hypothesized that these microdomains could involve modified low-density lipoprotein (LDL) uptake. METHODS AND RESULTS:Co-localizations of cholesterol-enriched microdomains and CD204 during the uptake of acetyl LDL (AcLDL) and oxidized LDL were observed using Alexa488-labeled polyethylene glycol cholesteryl ester, which is a sensitive probe used to analyze the dynamics of cholesterol-rich lipid microdomains in living cells. The lipid raft disruptors, methyl-β cyclodextrin and filipin, inhibited the uptake of AcLDL. CD204 siRNA treatments significantly reduced AcLDL uptake by 80%. We also demonstrated the presence of CD204 in the detergent-resistant membrane fraction (DRM) by immunoblotting analysis. The ratio of CD204/flotillin-1 in DRM was increased 11.5-fold by modified LDL administration. The PI3 kinase inhibitor LY294002, but not the Src kinase inhibitor PP1 or the Gαi/o inhibitor pertussis toxin, inhibited modified LDL uptake. The production of interleukin (IL)-8, but not CCL2, CXCL2, CXCL3, IL-6 or tumor necrosis factor-α was increased by AcLDL administration. The AcLDL-induced IL-8 production was inhibited by LY294002 and filipin. CONCLUSIONS:These data firstly demonstrated that PI3 kinase-associated cholesterol-enriched microdomains are involved in CD204-mediated modified LDL uptake in human macrophages. Cholesterol-enriched microdomains may play a critical role in inflammatory processes.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Kiyanagi T,Iwabuchi K,Shimada K,Hirose K,Miyazaki T,Sumiyoshi K,Iwahara C,Nakayama H,Masuda H,Mokuno H,Sato S,Daida H

doi

10.1016/j.atherosclerosis.2010.10.019

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

60-9

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(10)00873-7

journal_volume

215

pub_type

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