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The fractional catabolic rate of low density lipoprotein in normal individuals is influenced by variation in the apolipoprotein B gene: a preliminary study.

Abstract：

:In a random sample of 22 normolipidaemic male Caucasian individuals, 35-49 years old, homozygosity for the X2 allele (cutting site) of the XbaI RFLP of the apo B gene was associated with higher mean total cholesterol and LDL-cholesterol concentration. These individuals also had significantly lower LDL fractional catabolic rate (P less than 0.03) and a lower degradation of LDL by mononuclear cells in vitro. We propose that the XbaI polymorphism is associated with amino acid changes in the apo B protein which influences LDL binding to the LDL-receptor. This modulates catabolism of this lipoprotein and so contributes to variability of plasma cholesterol levels.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Houlston RS,Turner PR,Revill J,Lewis B,Humphries SE

doi

10.1016/0021-9150(88)90305-x

subject

Has Abstract

pub_date

1988-05-01 00:00:00

pages

81-5

issue

1

eissn

0021-9150

issn

1879-1484

pii

0021-9150(88)90305-X

journal_volume

71

pub_type

杂志文章

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