Arachidonic acid of platelet phospholipids is decreased after extracorporeal removal of plasma low density lipoproteins in patients with familial hypercholesterolemia.

Abstract:

:Platelet phospholipid composition was analyzed before and after extracorporeal removal of low density lipoproteins (LDL) by LDL apheresis in six patients with familial hypercholesterolemia. Elevated levels of total plasma cholesterol and the portion of plasma cholesterol carried by LDL were reduced by 56 and 66% after LDL apheresis. Platelet cholesterol contents remained unaffected. While the phosphatidylcholine (PC):sphingomyelin (SM) ratio in plasma lipoproteins was increased by 22% following apheresis, the same parameter was lowered by 14% in platelets. LDL apheresis induced decreases in the percentages of distinct molecular species containing arachidonic acid in platelet diacyl subgroups of PC, phosphatidylinositol (PI) and phosphatidylserine (PS) as well as in alkenylacyl (plasmalogen) phosphatidylethanolamine (PE). Directly after apheresis, the percentages of molecular species with arachidonic acid of diacyl PC, diacyl PI and alkenylacyl PE were reduced by 20, 23 and 8%, respectively. Two days after the procedure, total arachidonic acid of diacyl PC, diacyl PS and alkenylacyl PE was lowered by 11, 20 and 8%. Overall, the amount of phospholipid bound arachidonic acid was reduced by 16% after apheresis (from 79.1 to 66.4 nmol/10(8) platelets). The results are thus in agreement with previous data indicating decreased phospholipid bound arachidonic acid in red blood cells after apheresis (Engelman B. Bräutigam C, Kulschar R et al. Biochim Biophys Acta 1994:1196:154). Urinary 2,3-dinor thromboxane B2, an estimate of platelet thromboxane A2 (TXA2) production, tended to be decreased following the procedure. The percentage change in the TXA2 metabolite was positively related to the magnitude of change induced by apheresis in phospholipid bound arachidonic acid. In summary, the results suggest that in patients with hypercholesterolemia, the level of plasma LDL is an important determinant of the arachidonic acid content of several platelet phospholipids.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Bräutigam R,Bräutigam C,Lorenz R,Richter WO,Engelmann B

doi

10.1016/s0021-9150(97)06087-5

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

97-106

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(97)06087-5

journal_volume

131

pub_type

杂志文章
  • Metabolic products of the intestinal microbiome and extremes of atherosclerosis.

    abstract:BACKGROUND AND AIMS:There is increasing awareness that the intestinal microbiome plays an important role in human health. We investigated its role in the burden of carotid atherosclerosis, measured by ultrasound as total plaque area. METHODS:Multiple regression with traditional risk factors was used to identify three ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2018.04.015

    authors: Bogiatzi C,Gloor G,Allen-Vercoe E,Reid G,Wong RG,Urquhart BL,Dinculescu V,Ruetz KN,Velenosi TJ,Pignanelli M,Spence JD

    更新日期:2018-06-01 00:00:00

  • The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells.

    abstract:OBJECTIVE:Obesity and cardiovascular disease recognize a common metabolic soil and may therefore share part of their genetic background. Genome-wide association studies have identified variability at the SH2B1 locus as a predictor of obesity. We investigated whether SNP rs4788102, which captures the entire SH2B1 variab...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.atherosclerosis.2011.08.019

    authors: Prudente S,Morini E,Larmon J,Andreozzi F,Di Pietro N,Nigro A,Gervino EV,Mannino GC,Bacci S,Hauser TH,Bellacchio E,Formoso G,Pellegrini F,Proto V,Menzaghi C,Frittitta L,Pandolfi A,Sesti G,Doria A,Trischitta V

    更新日期:2011-12-01 00:00:00

  • Natural resistance to atherosclerosis exhibited by the first centimeter of left and right coronary arteries.

    abstract::A combined gross and histologic study carried out on 270 selected male subjects with the common type of distribution of the coronary arteries revealed a natural resistance to intimal thickening and plaque development exhibited by the left main coronary artery and by the first centimeter of the right coronary artery. T...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(84)90020-0

    authors: Velican C,Velican D

    更新日期:1984-02-01 00:00:00

  • Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice.

    abstract:BACKGROUND:Acrolein is a dietary aldehyde that is present in high concentrations in alcoholic beverages and foods including cheese, donuts and coffee. It is also abundant in tobacco smoke, automobile exhaust and industrial waste and is generated in vivo during inflammation and oxidative stress. OBJECTIVES:The goal of ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2011.01.001

    authors: Srivastava S,Sithu SD,Vladykovskaya E,Haberzettl P,Hoetker DJ,Siddiqui MA,Conklin DJ,D'Souza SE,Bhatnagar A

    更新日期:2011-04-01 00:00:00

  • The effect of sex hormones on glycosaminoglycan content of canine aorta and coronary arteries.

    abstract::Hyaluronate (HA), heparan sulfate (HS), dermatan sulfate (DS) and isomeric chondroitin sulfates (CS) were measured in vascular walls of 9-10 months old normal and hypophysectomized female beagles treated with sex hormones. Following hypophysectomy the animals were maintained for 8 weeks without any hormonal replacemen...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(77)90060-0

    authors: Sirek OV,Sirek A,Fikar K

    更新日期:1977-06-01 00:00:00

  • The fatty acid pattern of triglycerides and FFA in serum of spontaneously hypertensive rats (SHR).

    abstract::The fatty acid patterns of serum triglycerides and FFA in SHR and in normotensive controls aged 4, 8 and 26 weeks were estimated by gas-liquid chromatography. In serum triglycerides of SHR, the percentage of linoleic acid (C18:2) was lower and the content of arachidonic acid (C20:4) higher than in age-matched control ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(79)90119-9

    authors: Singer P,Voigt S,Moritz V,Baumann R

    更新日期:1979-06-01 00:00:00

  • Profound resolution of early atherosclerosis with conjugated linoleic acid.

    abstract::Conjugated linoleic acid (CLA) refers to a group of positional and geometric isomers of linoleic acid and has been shown to suppress the development of atherosclerosis in experimental models. However, the mechanism involved is unclear although it is believed it may act as a cyclooxygenase inhibitor or as an agonist of...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2005.08.024

    authors: Toomey S,Harhen B,Roche HM,Fitzgerald D,Belton O

    更新日期:2006-07-01 00:00:00

  • Triglycerides and HDL-cholesterol as risk factors for ischemic heart disease. Results from the Québec cardiovascular study.

    abstract::The relative importance of reduced plasma high density lipoprotein-cholesterol (HDL-C) levels and elevated plasma triglyceride (TG) concentrations as risk factors for ischemic heart disease (IHD) was examined in a sample of 2177 men from the Québec City suburbs. The sample included 202 men with known IHD. The relation...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(95)05653-x

    authors: Lamarche B,Després JP,Moorjani S,Cantin B,Dagenais GR,Lupien PJ

    更新日期:1996-01-26 00:00:00

  • Simvastatin potenciates PGI(2) release induced by HDL in human VSMC: effect on Cox-2 up-regulation and MAPK signalling pathways activated by HDL.

    abstract::High density lipoproteins (HDL) induce prostacyclin (PGI(2)) release in vascular smooth muscle cells (VSMC) by up-regulation of cyclooxygenase-2 (Cox-2). Our goal was to analyse the mechanisms underlying this effect, and its potential modulation by HMG-CoA reductase inhibition in human VSMC. The contribution of mitoge...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2004.01.037

    authors: Martínez-González J,Escudero I,Badimon L

    更新日期:2004-06-01 00:00:00

  • Validation of the european SCORE risk chart in the healthy middle-aged Japanese.

    abstract:BACKGROUND AND AIMS:The European Society of Cardiology developed prediction models (SCORE) for low- and high-risk populations in the European countries. However, whether or not these models are valid in different ethnicities is unknown. We aimed to evaluate the performance of the low-risk SCORE model in the general Jap...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2016.07.926

    authors: Sawano M,Kohsaka S,Okamura T,Inohara T,Sugiyama D,Watanabe M,Nakamura Y,Higashiyama A,Kadota A,Okud N,Murakami Y,Ohkubo T,Fujiyoshi A,Miura K,Okayama A,Ueshima H,National Integrated Project for Prospective Observation of

    更新日期:2016-09-01 00:00:00

  • Activity and concentration of lipoprotein lipase in post-heparin plasma and the extent of coronary artery disease.

    abstract::Numerous studies have found polymorphisms in the lipoprotein lipase (LPL) gene to be associated with the risk of coronary artery disease (CAD), implicating LPL in the development of atherothrombotic disease. It remains controversial, however, whether LPL acts in a pro- or anti-atherogenic fashion. We quantitated activ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(01)00752-3

    authors: Dugi KA,Schmidt N,Brandauer K,Ramacher D,Fiehn W,Kreuzer J

    更新日期:2002-07-01 00:00:00

  • A sensitive RNase protection assay for the quantitation of the mRNAs for the LDL receptor and HMG-CoA reductase in human total RNA. Effects of treatments on cells in culture designed to up- and down-regulate expression of the LDL receptor.

    abstract::Regulation of expression of the genes for the low density lipoprotein receptor (LDLR) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) is of central importance in the control of cholesterol metabolism and thus in influencing the concentration of low density lipoprotein in the plasma. This can be studied by i...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(91)90246-y

    authors: Le Cras TD,Gherardi E,Bowyer DE

    更新日期:1991-09-01 00:00:00

  • Effect of ursodeoxycholic acid on hepatic LDL binding and uptake in dietary hypercholesterolemic hamsters.

    abstract::Administration of ursodeoxycholic acid (UDCA) has been shown to decrease serum total and low density lipoprotein (LDL) cholesterol in hypercholesterolemic patients with primary biliary cirrhosis. Results of previous studies prompted us to postulate that the cholesterol-lowering effect of UDCA may be due, at least in p...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(00)00396-8

    authors: Ceryak S,Bouscarel B,Malavolti M,Robins SJ,Caslow KL,Fromm H

    更新日期:2000-11-01 00:00:00

  • Assessment of carotid plaque echolucency in addition to plaque size increases the predictive value of carotid ultrasound for coronary events in patients with coronary artery disease and mild carotid atherosclerosis.

    abstract:OBJECTIVES:This study examined whether combined ultrasound assessment of plaque size and echolucency in the carotid artery had an additive effect for predicting coronary events in patients with coronary artery disease (CAD). Ultrasound assessment of either plaque size or echolucency of carotid artery provides prognosti...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2010.03.003

    authors: Hirano M,Nakamura T,Kitta Y,Sano K,Kodama Y,Kobayashi T,Fujioka D,Saito Y,Yano T,Watanabe K,Watanabe Y,Kawabata K,Obata JE,Kugiyama K

    更新日期:2010-08-01 00:00:00

  • Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia.

    abstract:OBJECTIVE:To investigate the lipotropic action of betaine on plasma lipoproteins and tissue lipids. METHODS AND RESULTS:Adult mice, wild type (+/+) or heterozygous (+/-) for a disruption of the methylenetetrahydrofolate reductase (Mthfr) gene, were supplemented with betaine for 1 year and compared with mice on control...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2007.06.030

    authors: Schwahn BC,Wang XL,Mikael LG,Wu Q,Cohn J,Jiang H,Maclean KN,Rozen R

    更新日期:2007-12-01 00:00:00

  • Fibrinogen and C-reactive protein on admission as markers of final infarct size after primary angioplasty for acute myocardial infarction.

    abstract:BACKGROUND:In acute myocardial infarction (AMI) treated conservatively or with thrombolysis, marked increases of C-reactive protein (CRP) and fibrinogen have been observed. No data are however available concerning a possible relation between CRP and fibrinogen levels on admission and markers of infarct size after obtai...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(00)00703-6

    authors: De Sutter J,De Buyzere M,Gheeraert P,Van de Wiele C,Voet J,De Pauw M,Dierckx R,De Backer G,Taeymans Y

    更新日期:2001-07-01 00:00:00

  • Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids.

    abstract::Endothelial dysfunction is pivotal in atherosclerosis. Endothelial progenitor cells (EPC) predict cardiovascular events and could serve as a cellular biomarker of endothelial function. Epidemiological studies suggest the benefits of omega 3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahexaenoic acid (DHA) and ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2013.02.036

    authors: Devaraj S,Chien A,Rao B,Chen X,Jialal I

    更新日期:2013-05-01 00:00:00

  • Myeloid atg5 deletion impairs n-3 PUFA-mediated atheroprotection.

    abstract:BACKGROUND AND AIMS:Dietary long-chain (≥20 carbons) n-3 polyunsaturated fatty acids (PUFAs) reduce atherosclerosis and enhance macrophage autophagy activation. How macrophage autophagy impacts atherosclerotic progression, particularly when comparing dietary n-3 PUFA supplementation vs. saturated fat feeding, is unknow...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2020.01.004

    authors: Wang Z,Sequeira RC,Zabalawi M,Madenspacher J,Boudyguina E,Ou T,Nelson JM,Nie Y,Zhao Q,Fessler MB,Zhu X

    更新日期:2020-02-01 00:00:00

  • Effect of risk factors and antirheumatic drugs on the proliferation of aortic wall cells.

    abstract::The proliferation of aortic smooth muscle cells (ASMC) of Wistar rats, impaired by risk factors such as arterial hypertension, diabetes mellitus, atherogenic diet and staphylolysin injections and of normal Wistar rats treated with antirheumatic drugs such as prednisolone and acetylsalicylic acid was investigated. The ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(79)90135-7

    authors: Hauss WH,Mey J,Schulte H

    更新日期:1979-10-01 00:00:00

  • The role of Fas/APO 1 and apoptosis in the development of human atherosclerotic lesions.

    abstract::The possibility that Fas/APO 1 is involved in the apoptosis of advanced human coronary atherosclerosis was examined in the present study. Coronary arteries with atherosclerosis were obtained from human hearts with chronic ischemic heart disease at cardiac transplantation. Normal vessels were used as controls. Fas/APO ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(97)06099-1

    authors: Cai W,Devaux B,Schaper W,Schaper J

    更新日期:1997-06-01 00:00:00

  • Effects of thrice weekly nocturnal hemodialysis on arterial stiffness.

    abstract:OBJECTIVE:In this study, we compared the changes in arterial stiffness in chronic hemodialysis patients treated with 8-h vs. 4-h thrice weekly in-center hemodialysis. METHODS:Sixty prevalent chronic hemodialysis patients assigned to 8-h nocturnal in-center thrice weekly HD (NHD) and 60 control cases assigned to 4-h th...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.atherosclerosis.2011.11.015

    authors: Demirci MS,Celik G,Ozkahya M,Tumuklu M,Toz H,Asci G,Duman S,Basci A,Kircelli F,Ozdogan O,Demirci C,Can L,Isik IO,Ok E,Long Dialysis Group.

    更新日期:2012-02-01 00:00:00

  • ACAT inhibitor pactimibe sulfate (CS-505) reduces and stabilizes atherosclerotic lesions by cholesterol-lowering and direct effects in apolipoprotein E-deficient mice.

    abstract::The objective of the present study was to determine whether a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, pactimibe sulfate (CS-505), could reduce atherosclerotic lesions beyond and independent of the reduction achieved by cholesterol lowering alone from two different types of lesions. (1) Early lesio...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2006.03.007

    authors: Terasaka N,Miyazaki A,Kasanuki N,Ito K,Ubukata N,Koieyama T,Kitayama K,Tanimoto T,Maeda N,Inaba T

    更新日期:2007-02-01 00:00:00

  • VEGF-A-induced chemotaxis of CD16+ monocytes is decreased secondary to lower VEGFR-1 expression.

    abstract:BACKGROUND:Monocyte recruitment into the vessel wall is a crucial initial step in vascular repair, arteriogenesis and atherogenesis. Two distinct human monocyte subpopulations can be classified according to their CD14/16 surface expression, namely CD14++CD16-monocytes (CD16-mo) and CD14+CD16+ monocytes (CD16+mo). We in...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2011.01.004

    authors: Czepluch FS,Olieslagers S,van Hulten R,Vöö SA,Waltenberger J

    更新日期:2011-04-01 00:00:00

  • Effects of stimulation of nitric oxide synthesis on large artery stiffness in patients with peripheral arterial disease.

    abstract::The role of endothelium-derived nitric oxide (NO) in modulation of large artery stiffness in patients with peripheral arterial disease (PAD) is unexplored. The aim of this study was to evaluate, using pulse wave analysis (PWA), changes in aortic and systemic arterial stiffness following administration of nitroglycerin...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2005.06.014

    authors: Kals J,Kampus P,Kals M,Pulges A,Teesalu R,Zilmer M

    更新日期:2006-04-01 00:00:00

  • P-selectin and subclinical and clinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA).

    abstract:OBJECTIVE:P-selectin is a cellular adhesion molecule that has been shown to be crucial in development of coronary heart disease (CHD). We sought to determine the role of P-selectin on the risk of atherosclerosis in a large multi-ethnic population. METHODS:Data from the Multi-Ethnic Study of Atherosclerosis (MESA), inc...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.atherosclerosis.2015.02.036

    authors: Bielinski SJ,Berardi C,Decker PA,Kirsch PS,Larson NB,Pankow JS,Sale M,de Andrade M,Sicotte H,Tang W,Hanson NQ,Wassel CL,Polak JF,Tsai MY

    更新日期:2015-05-01 00:00:00

  • Clinical aspects of PCSK9.

    abstract::Proprotein convertase subtilisin kexin type 9 (PCSK9) is a circulating protein that impairs LDL clearance by promoting the LDL receptor (LDLR) degradation. PCSK9 has emerged as a new pharmacological target for hypercholesterolemia, and different PCSK9 inhibitors are now evaluated in clinical trials. Here, we propose a...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,评审

    doi:10.1016/j.atherosclerosis.2011.04.018

    authors: Cariou B,Le May C,Costet P

    更新日期:2011-06-01 00:00:00

  • Association of plasma intermediate density lipoproteins with atherogenic intimal proliferative activity in abdominal aortas of hyperlipidemic swine.

    abstract::In an earlier study of swine fed hyperlipidemic (HL) diets containing either butter or corn oil we found wide differences in atherogenic intimal proliferative responses among the swine, especially in the corn oil group, that could not be entirely accounted for by differences in serum cholesterol levels. We hypothesize...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(85)90068-1

    authors: Kim DN,Geourzoung SM,Schmee J,Lee KT,Thomas WA

    更新日期:1985-12-01 00:00:00

  • Baseline and on-statin treatment lipoprotein(a) levels for predicting cardiovascular events in patients with familial hypercholesterolemia.

    abstract:BACKGROUND AND AIMS:Lipoprotein(a) [Lp(a)] has been considered as a causal risk factor for cardiovascular disease (CVD) in the general population and levels vary in different ethnicities. However, no systemic analysis is currently available regarding the relation of plasma Lp(a) levels to cardiovascular events (CVEs) i...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2019.10.010

    authors: Cao YX,Jin JL,Guo YL,Sun D,Liu HH,Wu NQ,Xu RX,Zhu CG,Liu G,Dong Q,Sun J,Li JJ

    更新日期:2019-12-01 00:00:00

  • Homocysteine-related hTERT DNA demethylation contributes to shortened leukocyte telomere length in atherosclerosis.

    abstract:AIMS:Leukocyte telomere length (LTL) is shortened in patients with clinical atherosclerosis (AS). Here we aimed to explore the contribution of elevated homocysteine (Hcy) level to LTL shortening in AS patients and the underlying mechanism. METHODS:Circulating leukocytes were collected from 197 patients with AS and 165...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2013.08.029

    authors: Zhang D,Wen X,Wu W,Xu E,Zhang Y,Cui W

    更新日期:2013-11-01 00:00:00

  • Pathophysiological implication of the structural domains of lipoprotein(a).

    abstract::Numerous epidemiological studies have shown that lipoprotein(a) (Lp(a)) is an independent risk factor for the premature development of cardiovascular disease. In spite of such evidence, the structural and functional features of this atherogenic, cholesterol-rich particle are not clearly understood. We have demonstrate...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,评审

    doi:10.1016/s0021-9150(97)00111-1

    authors: Huby T,Chapman J,Thillet J

    更新日期:1997-08-01 00:00:00