On the mechanism for PPAR agonists to enhance ABCA1 gene expression.

abstract：OBJECTIVE:We evaluated family history as a predictor of incident and progressive coronary artery calcium (CAC) using data from the Multi-Ethnic Study of Atherosclerosis (MESA). BACKGROUND:MESA is a multi-center prospective study of 6814 asymptomatic individuals. The relationship between family history of coronary hear...

journal_title：Atherosclerosis

authors： Pandey AK,Blaha MJ,Sharma K,Rivera J,Budoff MJ,Blankstein R,Al-Mallah M,Wong ND,Shaw L,Carr J,O'Leary D,Lima JA,Szklo M,Blumenthal RS,Nasir K

更新日期：2014-02-01 00:00:00

abstract：:A total of 1200 patients with angina were cardiac catheterized establishing that 63% had 70-100% stenosis, 12% had 10-69% stenosis of one or more of their coronary arteries and 25% had microvascular angina listed as 0% stenosis. Prior to catheterization 10 ml of blood was drawn and the plasma subjected to analysis for...

journal_title：Atherosclerosis

authors： Kummerow FA,Olinescu RM,Fleischer L,Handler B,Shinkareva SV

更新日期：2000-03-01 00:00:00

abstract：:Smooth muscle cell (SMC) proliferation is a prominent feature of intimal hyperplasia after percutaneous coronary interventions. p27 is a critical regulator of cell proliferation. Our aims were to analyze the time course of p27 expression, Ki67 proliferative index, and apoptosis after angioplasty in the porcine coronar...

journal_title：Atherosclerosis

authors： Roque M,Cordon-Cardo C,Fuster V,Reis ED,Drobnjak M,Badimon JJ

更新日期：2000-12-01 00:00:00

abstract：:Inflammatory response genes may influence life span or quality at advanced ages. Using data from the population-based cardiovascular health study (CHS) cohort, we examined the associations between promoter polymorphisms of several inflammation and thrombosis genes with longevity. We ascertained genotypes for interleuk...

journal_title：Atherosclerosis

authors： Reiner AP,Diehr P,Browner WS,Humphries SE,Jenny NS,Cushman M,Tracy RP,Walston J,Lumley T,Newman AB,Kuller LH,Psaty BM

更新日期：2005-07-01 00:00:00

abstract：AIMS:To assess efficacy and safety of HMG-CoA reductase inhibitor (statin) treatment in children and adolescents with heterozygous familial hypercholesterolaemia. METHODS:MEDLINE, EMBASE, COCHRANE and Current Controlled Trials databases were searched. Study design, efficacy, and safety outcome-measures were extracted....

journal_title：Atherosclerosis

authors： Arambepola C,Farmer AJ,Perera R,Neil HA

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:Postprandial lipemia influences the development of atherosclerosis. Age has been defined as a regulating factor of the extent of postprandial lipemia, but its independence of other age-associated phenotypic features, such as metabolic syndrome, has not been fully elucidated. METHODS:To investigate if age is ...

journal_title：Atherosclerosis

authors： Perez-Caballero AI,Alcala-Diaz JF,Perez-Martinez P,Garcia-Rios A,Delgado-Casado N,Marin C,Yubero-Serrano E,Camargo A,Caballero J,Malagon MM,Tinahones FJ,Perez-Jimenez F,Lopez-Miranda J,Delgado-Lista J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND AIMS:We aimed at developing a novel risk prediction model for death from cardiovascular disease (CVD) for Chinese individuals, based upon a large cohort from Taiwan. METHODS:This Chinese cohort came from Taiwan, with 381,963 individuals free from CVD, recruited from a private health surveillance program...

journal_title：Atherosclerosis

authors： Hu WS,Lee JH,Tsai MK,Wen CP

更新日期：2017-09-01 00:00:00

abstract：:The changes that occur with age in the distribution of atherosclerotic lesions around arterial branch points challenge accepted theories relating disease to haemodynamic stresses. We investigated whether flow near branch points changes with age in a way that can account for the different lesion distributions. Flow aro...

journal_title：Atherosclerosis

authors： Al-Musawi SL,Bishton J,Dean J,Williams S,Cremers SG,Weinberg PD

更新日期：2004-01-01 00:00:00

abstract：:The serum concentrations of testosterone, androstenedione, oestradiol and total low polar oestrogens, mainly oestradiol and oestrone, were measured in 26 healthy male subjects. The subjects were divided into two groups each of them with low (less than 1.04 mmol/l) and high (greater than 1.56 mmol/l) levels of serum HD...

journal_title：Atherosclerosis

authors： Nordøy A,Aakvaag A,Thelle D

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Using a nationwide epidemiological database, we aimed to clarify the association of fasting plasma glucose (FPG) with subsequent cardiovascular disease (CVD) risk among young adults. METHODS AND RESULTS:Medical records of 1,180,062 young adults (20-49 years old) without a prior history of CVD and w...

journal_title：Atherosclerosis

authors： Kaneko H,Itoh H,Kiriyama H,Kamon T,Fujiu K,Morita K,Michihata N,Jo T,Takeda N,Morita H,Yasunaga H,Komuro I

更新日期：2021-01-16 00:00:00

abstract：OBJECTIVES:To analyze the relationship between office and ambulatory heart rate, and its variability, and arterial stiffness in patients with primary arterial hypertension. METHODS:A cross-sectional study was conducted in a primary care setting, with the inclusion of 356 hypertensive patients aged 30-80 years. Office ...

journal_title：Atherosclerosis

authors： García-Ortiz L,García-García A,Ramos-Delgado E,Patino-Alonso MC,Recio-Rodríguez JI,Rodríguez-Sánchez E,Gómez-Marcos MA

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Metabolic syndrome (MS) is associated with dyslipidemia, and insulin resistance (IR) may be a main determinant of this dyslipidemia. OBJECTIVE:To determine how lipoprotein particle concentration and size are related to MS and IR in a population-based sample of Alaska Eskimos. DESIGN:Participants underwent ...

journal_title：Atherosclerosis

authors： Rivellese AA,Patti L,Kaufman D,Zhu J,Annuzzi G,Vaccaro O,Ebbesson SO,Howard WJ,Riccardi G,Howard BV

更新日期：2008-10-01 00:00:00

abstract：:Atherosclerotic plaque rupture and erosions precipitate thrombus formation and may lead to an acute ischemic syndrome. Lipids and lipoproteins modulate the expression and/or function of thrombotic, fibrinolytic and rheologic factors, and thereby influence hemostasis and potential tissue damage resulting from vascular ...

journal_title：Atherosclerosis

authors： Rosenson RS,Lowe GD

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Clinical interventions targeting nonlipid risk factors are needed given the high residual risk of atherothrombotic events despite effective control of dyslipidemia. Dickkopf-1 (DKK1) plays a lipid-independent role in vascular pathophysiology but its involvement in atherosclerosis development and its...

journal_title：Atherosclerosis

authors： Rakipovski G,Rolin B,Barascuk N,Lund HE,Bjørn Bonde MF,Djordjevic D,Wulff-Larsen PG,Petersen M,Kirk RK,Hultman K,Manfe V,Blume N,Zahn S,Lengquist M,Maegdefessel L,Hovingh GK,Conde-Knape K,Hedin U,Matic L,Nyberg M

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND AIMS:The pathological process of atherosclerosis is closely related to lipid accumulation at arterial wall caused by lipoproteins transporting lipids through blood. In this study, we investigate the lipid composition in the plasma of apolipoprotein E deficient (ApoE-/-) mice fed a high-fat diet to reveal...

journal_title：Atherosclerosis

authors： Chen Y,Wen S,Jiang M,Zhu Y,Ding L,Shi H,Dong P,Yang J,Yang Y

更新日期：2017-07-01 00:00:00

abstract：:We studied the effect of lysolecithin on the clearing of plasma cholesterol. The immediate and maximal conversion of plasma lecithin to lysolecithin was produced in rats by intravenous injection of phospholipase A. The changes which took place in the converted lysolecithin and of cholesterol were followed in rats whic...

journal_title：Atherosclerosis

authors： Dobiásová M,Faltová E,Marek J,Obenberger J

更新日期：1975-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Bone marrow (BM)-derived progenitor cells are functionally impaired in patients with ischemic heart disease (IHD), thereby hampering the outcome of autologous stem cell therapy. In search for underlying mechanisms for this BM dysfunction, accelerated cellular senescence was explored. METHODS:We ana...

journal_title：Atherosclerosis

authors： Nollet E,Hoymans VY,Rodrigus IR,De Bock D,Dom M,Van Hoof VOM,Vrints CJ,Van Craenenbroeck EM

更新日期：2017-05-01 00:00:00

abstract：:Tissue plasminogen activator (tPA) is emerging as an important risk factor for coronary heart disease, but the association between tPA concentration and mortality in acute myocardial infarction (AMI) remains uncertain. We studied the relationship between tPA antigen level on admission and 30-day mortality in 226 conse...

journal_title：Atherosclerosis

authors： Lee CW,Ahn JM,Park DW,Kim YH,Hong MK,Song JK,Kim JJ,Park SW,Chi HS,Park SJ

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND AIMS:This study evaluated the effects of resveratrol on arterial aging and the renin-angiotensin system (RAS) in mice and vascular smooth muscle cells (VSMCs). METHODS:Aging mice were divided into control and resveratrol groups. Histological changes, inflammation, oxidative stress, RAS components, and t...

journal_title：Atherosclerosis

authors： Kim EN,Kim MY,Lim JH,Kim Y,Shin SJ,Park CW,Kim YS,Chang YS,Yoon HE,Choi BS

更新日期：2018-03-01 00:00:00

abstract：:Secretory non-pancreatic (group II) phospholipase A2 (sPLA2) releases precursors of important mediators of inflammation from phospholipids. Based on the inflammatory character of atherosclerosis we previously described the identification of sPLA2 in human atherosclerotic plaques. In vitro studies on lipoproteins have ...

journal_title：Atherosclerosis

authors： Schiering A,Menschikowski M,Mueller E,Jaross W

更新日期：1999-05-01 00:00:00

abstract：:High-density lipoproteins (HDL) have several antiatherogenic actions, including the ability to sequester cellular cholesterol, to protect low-density lipoproteins from oxidation and to inhibit platelet aggregation. An early event in atherogenesis is the adhesion and recruitment of blood monocytes, a process mediated b...

journal_title：Atherosclerosis

authors： Stannard AK,Khan S,Graham A,Owen JS,Allen SP

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Perivascular fat through the secretion of paracrine and pro-inflammatory mediators may play a role in obesity-mediated vascular disease. We sought to examine associations between adipose tissue depots immediately surrounding the thoracic aorta, metabolic risk factors, and vascular calcification. METHODS:In p...

journal_title：Atherosclerosis

authors： Lehman SJ,Massaro JM,Schlett CL,O'Donnell CJ,Hoffmann U,Fox CS

更新日期：2010-06-01 00:00:00

abstract：:The new millennium has brought intense focus of interest on the risk of cardiovascular disease in women. The polycystic ovary syndrome (PCOS) is a common endocrine disorder in women characterised by hyperandrogenism and oligomenorrhoea. Most women with PCOS also exhibit features of the metabolic syndrome, including in...

journal_title：Atherosclerosis

authors： Cussons AJ,Stuckey BG,Watts GF

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Nonalcoholic fatty liver disease (NAFLD) may be associated with a wide spectrum of cardiac abnormalities, which share many metabolic risk factors. This study aimed to evaluate whether NAFLD is associated with left ventricular (LV) diastolic dysfunction independent of other classical risk factors. M...

journal_title：Atherosclerosis

authors： Chung GE,Lee JH,Lee H,Kim MK,Yim JY,Choi SY,Kim YJ,Yoon JH,Kim D

更新日期：2018-05-01 00:00:00

abstract：:Intimal proliferation and functional changes involving vascular smooth muscle cells are key events in the development of atherosclerosis, including restenosis after percutaneous transluminal angioplasty. Nonmuscle myosin (NMM) is required for cytokinesis and has been shown in cultures of vascular smooth muscle cells t...

journal_title：Atherosclerosis

authors： Nikol S,Murakami N,Pickering JG,Kearney M,Leclerc G,Höfling B,Isner JM,Weir L

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:Recent reports have suggested that dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonists are associated with adverse cardiovascular events. This study aimed to investigate the actions of the non-thiazolidinedione PPARalpha/gamma agonist, compound 3q, on plaque development in the apolipop...

journal_title：Atherosclerosis

authors： Calkin AC,Allen TJ,Lassila M,Tikellis C,Jandeleit-Dahm KA,Thomas MC

更新日期：2007-11-01 00:00:00

abstract：:The interaction of mouse peritoneal and human pericardial macrophages with lipoprotein (LP)-antibody (Ab) immune complex isolated from the serum of ischemic heart disease (IHD) patients has been studied. It is shown that the Ab of the autoimmune complex belongs to IgG class, and the antigen is the LP with d less than ...

journal_title：Atherosclerosis

authors： Klimov AN,Denisenko AD,Vinogradov AG,Nagornev VA,Pivovarova YI,Sitnikova OD,Pleskov VM

更新日期：1988-11-01 00:00:00

abstract：:Tendon xanthoma are a hallmark of familial hypercholesterolemia and are among its earliest clinical manifestations. Achilles tendon size, advanced to a generally accepted marker, is virtually specific for the disease and easily accessible for measurement. Hypercholesterolemic patients with coronary heart disease have ...

journal_title：Atherosclerosis

authors： Steinmetz A,Schmitt W,Schuler P,Kleinsorge F,Schneider J,Kaffarnik H

更新日期：1988-12-01 00:00:00

abstract：:To test if the prevalence of genetic risk factors for coronary heart disease (CHD) is low in individuals who have reached an extremely old age, the allele frequencies of apolipoprotein E (apo E) and B (apo B) polymorphisms and plasma lipoprotein(a) levels were investigated in nonagenarians and in younger control group...

journal_title：Atherosclerosis

authors： Kervinen K,Savolainen MJ,Salokannel J,Hynninen A,Heikkinen J,Ehnholm C,Koistinen MJ,Kesäniemi YA

更新日期：1994-01-01 00:00:00

abstract：:Atherosclerotic lesion progression is associated with intimal calcification. The earliest lesion that shows calcification is pathologic intimal thickening in which calcifications appear as microcalcifications that vary in size from <0.5 to 15 μm. The calcifications become larger as plaques progress, becoming punctate ...

journal_title：Atherosclerosis

authors： Jinnouchi H,Sato Y,Sakamoto A,Cornelissen A,Mori M,Kawakami R,Gadhoke NV,Kolodgie FD,Virmani R,Finn AV

更新日期：2020-08-01 00:00:00