Abstract:
OBJECTIVE:We evaluated family history as a predictor of incident and progressive coronary artery calcium (CAC) using data from the Multi-Ethnic Study of Atherosclerosis (MESA). BACKGROUND:MESA is a multi-center prospective study of 6814 asymptomatic individuals. The relationship between family history of coronary heart disease (CHD) and CAC incidence or progression has not been described previously. METHODS:A total of 5099 participants had detailed information about family history of CHD (late versus premature and parental versus sibling history). The mean time between CAC scans was 3.1 ± 1.3 years. The association of late versus premature family history was assessed against CAC change using multivariate regression model adjusted for demographics and cardiac risk factors. RESULTS:A family history of premature CHD was associated with an odds ratio (OR) of 1.55 (p < 0.01) for incident development of CAC after adjusting for risk factors and demographics. A premature family history was associated with 14.4 units (p < 0.01) greater volume scores compared to those with no family history in similarly adjusted models by median regression analysis. A combined parental and sibling family history was associated with the greatest incidence and progression in demographic-adjusted models. Caucasians demonstrated the most consistent predictive relationship between family history of premature CHD and incidence (p < 0.01) and progression (p < 0.05) of CAC, though no significant interaction with ethnicity was noted. CONCLUSIONS:Family history of premature CHD is associated with enhanced development and progression of subclinical disease, independent of other risk factors, in a multiethnic, population-based study.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Pandey AK,Blaha MJ,Sharma K,Rivera J,Budoff MJ,Blankstein R,Al-Mallah M,Wong ND,Shaw L,Carr J,O'Leary D,Lima JA,Szklo M,Blumenthal RS,Nasir Kdoi
10.1016/j.atherosclerosis.2013.11.042subject
Has Abstractpub_date
2014-02-01 00:00:00pages
369-76issue
2eissn
0021-9150issn
1879-1484pii
S0021-9150(13)00693-Xjournal_volume
232pub_type
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