Peripheral blood mononuclear cell production of interleukin-8 and IL-8-dependent neutrophil function in hypercholesterolemic patients.

abstract：:The oxidation of low density lipoprotein (LDL) is believed to be an important process in the development and progression of atherosclerosis. In this study, human subjects were supplemented daily with one of: 6 g raw garlic; 2.4 g aged garlic extract (AGE); or 0.8 g DL-alpha-tocopherol acetate for 7 days to determine t...

journal_title：Atherosclerosis

authors： Munday JS,James KA,Fray LM,Kirkwood SW,Thompson KG

更新日期：1999-04-01 00:00:00

abstract：:The effect of methyl prednisolone and colchicine on the development of both the early proliferative and advanced atherosclerotic lesion in swine aorta was studied. In order to accelerate the development of atherosclerosis, the abdominal aortic endothelium was partially denuded by a balloon before the animals were plac...

journal_title：Atherosclerosis

authors： Lee WM,Morrison ES,Scott RF,Lee KT,Kroms M

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Studying atherosclerotic calcification in vivo requires mouse models with genetic modifications. Previous studies showed that injection of recombinant adeno-associated virus vector (AAV) encoding a gain-of-function mutant PCSK9 into mice promotes atherosclerosis. We aimed to study cardiovascular cal...

journal_title：Atherosclerosis

authors： Goettsch C,Hutcheson JD,Hagita S,Rogers MA,Creager MD,Pham T,Choi J,Mlynarchik AK,Pieper B,Kjolby M,Aikawa M,Aikawa E

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Detection of inflamed atherosclerotic plaques is of crucial importance. The carotid artery cuff-model in ApoE(-/-) mice results in shear-stress induced atherosclerosis with inflamed plaques upstream (US) and 'stable' plaques downstream (DS) of the cuff. We evaluated the potential of F-18-FDG PET/CT to differ...

journal_title：Atherosclerosis

authors： Wenning C,Kloth C,Kuhlmann MT,Jacobs AH,Schober O,Hermann S,Schäfers MA

更新日期：2014-06-01 00:00:00

abstract：:Large (Sf greater than 100) and small (Sf 100-20) very low density lipoprotein (VLDL) particles were isolated by density gradient ultracentrifugation and characterized chemically in 8 patients with primary hypertriglyceridemia before and after 6 weeks treatment with 4 grammes daily of nicotinic acid (NA). Concomitant ...

journal_title：Atherosclerosis

authors： Tornvall P,Hamsten A,Johansson J,Carlson LA

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND AND AIMS:The pathological process of atherosclerosis is closely related to lipid accumulation at arterial wall caused by lipoproteins transporting lipids through blood. In this study, we investigate the lipid composition in the plasma of apolipoprotein E deficient (ApoE-/-) mice fed a high-fat diet to reveal...

journal_title：Atherosclerosis

authors： Chen Y,Wen S,Jiang M,Zhu Y,Ding L,Shi H,Dong P,Yang J,Yang Y

更新日期：2017-07-01 00:00:00

abstract：:The change of acid cholesteryl ester hydrolase activity in mononuclear leukocyte following treatment of diabetes mellitus was studied in 21 patients with non-insulin-dependent diabetes mellitus (NIDDM). Enzyme activity before treatment in the patients was significantly lower than that in 14 age-matched healthy subject...

journal_title：Atherosclerosis

authors： Onuma T,Tsutsui M,Boku A,Yanada A,Ochiai S,Takebe K

更新日期：1992-02-01 00:00:00

abstract：:To determine whether a relationship between echographically assessed carotid artery and left ventricular (LV) structures existed in asymptomatic men at risk for cardiovascular disease, we evaluated carotid and LV parameters in 69 subjects (23-62 years) without LV hypertrophy. The right common carotid far wall intima-m...

journal_title：Atherosclerosis

authors： Linhart A,Gariepy J,Giral P,Levenson J,Simon A

更新日期：1996-11-15 00:00:00

abstract：:Monocytes and macrophages synthesize tissue factor (TF) which plays a role in thrombogenicity in coronary artery disease. This study was conducted to investigate the effect of Rho/Rho-kinase inhibition on the synthesis of TF in cultured human monocytes. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibit...

journal_title：Atherosclerosis

authors： Nagata K,Ishibashi T,Sakamoto T,Ohkawara H,Shindo J,Yokoyama K,Sugimoto K,Sakurada S,Takuwa Y,Nakamura S,Teramoto T,Maruyama Y

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Both elevated serum uric acid (SUA) and peripheral endothelial dysfunction (PED) are associated independently with cardiovascular disease (CVD). However, the association between SUA and PED is yet to be established. We hypothesized that high normal range of SUA is associated with PED. METHODS:We pe...

journal_title：Atherosclerosis

authors： Taher R,Sara JD,Prasad M,Kolluri N,Toya T,Lerman LO,Lerman A

更新日期：2019-11-01 00:00:00

abstract：:Gender is a strong predictor of coronary heart disease (CHD) susceptibility and reports indicate that males are more likely to develop CHD compared to age-matched premenopausal females. To test whether similar gender differences exist in hamsters, 16 male and 16 female F1B Golden Syrian hamsters, aged 10 weeks, were f...

journal_title：Atherosclerosis

authors： Wilson TA,Nicolosi RJ,Lawton CW,Babiak J

更新日期：1999-09-01 00:00:00

abstract：:Leukotriene B(4) (LTB(4)) is a pro-inflammatory lipid mediator generated by the enzymes 5-lipoxygenase (5-LO) and LTA(4)-hydrolase. LTB(4) signals primarily through its G protein-coupled receptor BLT1, which is highly expressed on specific leukocyte subsets. Recent genetic studies in humans as well as knockout studies...

journal_title：Atherosclerosis

authors： Kristo F,Hardy GJ,Anderson TJ,Sinha S,Ahluwalia N,Lin AY,Passeri J,Scherrer-Crosbie M,Gerszten RE

更新日期：2010-05-01 00:00:00

abstract：:The effectiveness of a new, almost l-thyroxine free preparation of d-thyroxine (Dynothel) was tested in 15 patients with Type IIa and 4 patients with Type IIb hyperlipoproteinemia. Eleven patients with Type IIa and 3 with Type IIb were responsive to treatment and showed an average 26% decrease in plasma TC. This decre...

journal_title：Atherosclerosis

authors： Rakow AD,Klor HU,Kuter E,Ditschuneit HH,Ditschuneit H

更新日期：1976-09-01 00:00:00

abstract：:Previous studies demonstrated that induction of diabetes with streptozotocin (stz) accelerated atherosclerosis in hyperlipidemic apo E null (-/-) mice. Blockade of the Receptor for Advanced Glycation Endproducts (RAGE) in those animals suppressed acceleration of atherosclerotic lesion area, in a manner independent of ...

journal_title：Atherosclerosis

authors： Wendt T,Harja E,Bucciarelli L,Qu W,Lu Y,Rong LL,Jenkins DG,Stein G,Schmidt AM,Yan SF

更新日期：2006-03-01 00:00:00

abstract：:Rabbit apolipoprotein A-I (apo A-I) of molecular weight 27,612 contained 241 amino acids. In contrast to its human counterpart which has 3 methionine residues, the rabbit protein possesses only one and therefore produces 2 fragments after CNBr cleavage (CNBr I and II, NH2- and COOH-terminal, respectively). From a seri...

journal_title：Atherosclerosis

authors： Leroy A,Vu-Dac N,Theret N,Pio F,Fruchart JC

更新日期：1989-09-01 00:00:00

abstract：:Twelve subjects (6 women, 6 men) were given 120 g fat orally for 2 h to study its effect on serum high density lipoproteins (HDL), HDL subfractions and apoproteins A-I and A-II. In addition, we measured the fasting activity of adipose tissue lipoprotein lipase (LPL). The HDL2 mass concentration increased significantly...

journal_title：Atherosclerosis

authors： Taskinen MR,Kuusi T

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Estrogen therapy that is started at the time of menopause seems to protect against the development of atherosclerosis and cardiovascular diseases, in contrast to the initial increased cardiovascular risk when hormone therapy is initiated in older women. With increased aging and degree of atherosclerosis, the...

journal_title：Atherosclerosis

authors： Naessen T,Rodriguez-Macias K

更新日期：2006-12-01 00:00:00

abstract：:Apolipoprotein F (ApoF) is a sialoglycoprotein that is a component of the HDL and LDL fractions of human serum. We sought to test the hypothesis that ApoF plays an important role in atherosclerosis in mice by modulating lipoprotein function. Atherosclerosis was assessed in male low density lipoprotein receptor knockou...

journal_title：Atherosclerosis

authors： Lagor WR,Fields DW,Bauer RC,Crawford A,Abt MC,Artis D,Wherry EJ,Rader DJ

更新日期：2014-03-01 00:00:00

abstract：:Extracellular-superoxide dismutase (EC-SOD) is the major SOD isozyme in the arterial wall and may be important for antioxidation capability of the vascular wall and normal vascular function. EC-SOD is expressed in various cell types in the vascular wall such as fibroblasts, smooth muscle cells and macrophages, and the...

journal_title：Atherosclerosis

authors： Adachi T,Hara H,Yamada H,Yamazaki N,Yamamoto M,Sugiyama T,Futenma A,Katagiri Y

更新日期：2001-12-01 00:00:00

abstract：:A major gene hypothesis for heparin releasable plasma lipoprotein lipase (PH-LPL) activity was assessed using segregation analyses of data on 495 members in 98 normolipidemic sedentary families of Caucasian descent who participated in the HERITAGE Family Study. Segregation analyses were performed on PH-LPL adjusted fo...

journal_title：Atherosclerosis

authors： Hong Y,Rice T,Després JP,Gagnon J,Nadeau A,Bergeron J,Pérusse L,Bouchard C,Leon AS,Skinner JS,Wilmore JH,Rao DC

更新日期：1999-06-01 00:00:00

abstract：:It is still controversial whether circulating soluble form of receptor for AGE (sRAGE) is associated with atherosclerosis in diabetic patients. In this study, we enrolled 276 Japanese type 2 diabetic subjects without history of cardiovascular disease (CVD), assessed their baseline clinical and biochemical data includi...

journal_title：Atherosclerosis

authors： Fujisawa K,Katakami N,Kaneto H,Naka T,Takahara M,Sakamoto F,Irie Y,Miyashita K,Kubo F,Yasuda T,Matsuoka TA,Shimomura I

更新日期：2013-04-01 00:00:00

abstract：:The interaction of mouse peritoneal and human pericardial macrophages with lipoprotein (LP)-antibody (Ab) immune complex isolated from the serum of ischemic heart disease (IHD) patients has been studied. It is shown that the Ab of the autoimmune complex belongs to IgG class, and the antigen is the LP with d less than ...

journal_title：Atherosclerosis

authors： Klimov AN,Denisenko AD,Vinogradov AG,Nagornev VA,Pivovarova YI,Sitnikova OD,Pleskov VM

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Despite its well-established prognostic value, cardiorespiratory fitness (CRF) is not incorporated routinely in risk assessment tools. Whether low CRF provides additional predictive information in asymptomatic type 2 diabetics beyond conventional risk scores and coronary artery calcification (CAC) is unclear...

journal_title：Atherosclerosis

authors： Zafrir B,Azaiza M,Gaspar T,Dobrecky-Mery I,Azencot M,Lewis BS,Rubinshtein R,Halon DA

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Elevated leukocyte count is a classic marker of systemic inflammation. This study examined whether the leukocyte count is associated with incidence of coronary events (CE) and stroke during a long follow-up period. METHODS:A total of 17,131 men and 2932 women, aged 27-61 years, without history of cardiovascu...

journal_title：Atherosclerosis

authors： Li C,Engström G,Hedblad B

更新日期：2010-04-01 00:00:00

abstract：AIMS:Besides carotid or cardiac embolism, stroke can occur via microangiopathy (small arterial disease [SAD]) and macroangiopathy (intracranial atherosclerotic stroke [ICAS]) of the intracranial vasculature. There have been efforts to identify risk factors specific to microangiopathy and macroangiopathy, including vasc...

journal_title：Atherosclerosis

authors： Bang OY,Chung JW,Ryoo S,Moon GJ,Kim GM,Chung CS,Lee KH

更新日期：2016-03-01 00:00:00

abstract：:This study was aimed to test the hypothesis that noninvasive assessment of carotid plaques can be achieved by high-resolution micro-ultrasound imaging in apolipoprotein-E knockout (apoE-KO) mice. Forty-two male apoE-KO mice were fed a high-fat diet and atherosclerotic lesions in the left common carotid artery were ind...

journal_title：Atherosclerosis

authors： Ni M,Zhang M,Ding SF,Chen WQ,Zhang Y

更新日期：2008-03-01 00:00:00

abstract：:There is clear evidence of lipoprotein oxidation in atherosclerotic lesions. Animal studies and observational prospective human cohort studies have been interpreted as supporting a role for antioxidants in the prevention of coronary heart disease (CHD). However, firm recommendations to take antioxidant supplements to ...

journal_title：Atherosclerosis

authors： Kritharides L,Stocker R

更新日期：2002-10-01 00:00:00

abstract：:Two preparations active in reducing hepatic cholesterolgenesis in vitro were demonstrated in human milk. These appear to affect the cholesterol synthetic pathway at different loci. One inhibits the synthesis before the formation of mevalonic acid and has been isolated and subsequently identified as uric acid. The othe...

journal_title：Atherosclerosis

authors： Ward PC,McCarthy RD,Kilara A

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND AND AIMS:The association between cholesterol and stroke has been inconsistent. This study aimed to examine the association between total cholesterol (TC) and mortality from total stroke and stroke subtypes. METHODS:503,340 Korean adults aged 40-80 years without a history of heart disease or stroke participa...

journal_title：Atherosclerosis

authors： Yi SW,Shin DH,Kim H,Yi JJ,Ohrr H

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:To analyze the relationship between office and ambulatory heart rate, and its variability, and arterial stiffness in patients with primary arterial hypertension. METHODS:A cross-sectional study was conducted in a primary care setting, with the inclusion of 356 hypertensive patients aged 30-80 years. Office ...

journal_title：Atherosclerosis

authors： García-Ortiz L,García-García A,Ramos-Delgado E,Patino-Alonso MC,Recio-Rodríguez JI,Rodríguez-Sánchez E,Gómez-Marcos MA

更新日期：2011-08-01 00:00:00