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Heparin-stimulated expression of extracellular-superoxide dismutase in human fibroblasts.

Abstract：

:Extracellular-superoxide dismutase (EC-SOD) is the major SOD isozyme in the arterial wall and may be important for antioxidation capability of the vascular wall and normal vascular function. EC-SOD is expressed in various cell types in the vascular wall such as fibroblasts, smooth muscle cells and macrophages, and the synthesis of EC-SOD by human fibroblasts is known to be highly responsive to various inflammatory cytokines, although there is no response to oxidative stress. Heparin is a highly sulfated glycosaminoglycan with many functions such as antithrombotic, antilipemic and antiatherosclerotic effects. Another less well-known function of heparin is regulation of protein synthesis. In this study, we measured the induction of EC-SOD after treatment with heparin to understand the role of heparin in the antiatherosclerotic response of fibroblasts. Heparin induced EC-SOD expression at both the mRNA and protein levels. Heparin showed the greatest stimulatory effect and heparan sulfate showed moderate effects. The effect of chondroitin sulfate A was not clear. In contrast, desulfated heparin and chondroitin sulfate C did not increase EC-SOD expression. The stimulatory effect seemed to increase roughly with the degree of glycosaminoglycan sulfation. The enhanced expression of EC-SOD by heparin must contribute to the antiatherosclerotic effect of heparin.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Adachi T,Hara H,Yamada H,Yamazaki N,Yamamoto M,Sugiyama T,Futenma A,Katagiri Y

doi

10.1016/s0021-9150(01)00512-3

keywords:

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

307-12

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(01)00512-3

journal_volume

159

pub_type

杂志文章

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