The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease.

Abstract:

:Increased oxidative stress (SOX), inflammation and prevalence of cardiovascular disease (CVD) have been reported in end-stage renal disease (ESRD), but their associations with kynurenine (KYN) pathway activation remain unknown. We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HKYN); two distinct SOX markers: Cu/Zn superoxide dismutase (Cu/Zn SOD) and total peroxide; and high sensitivity C-reactive protein (hs CRP) as a indicator of inflammation in 146 ESRD patients and healthy controls. Analysis of TRP degradation through the KYN pathway demonstrated that in uremia the concentrations of this aminoacid were decreased by 40-60% in comparison with controls. In contrast, the plasma levels of KYN and 3-HKYN in ESRD patients were increased by 32-96% and 184-306%, respectively. These changes were accompanied by significant increase in the kyn/trp ratios by 140-240%, and 3-hkyn/kyn ratios by 40-154% in uremics compared to controls. ESRD patients showed a significant increase in Cu/Zn SOD, total peroxide and hs CRP levels between controls and all patients group. KYN and 3-HKYN were positively associated with inflammation and SOX markers in uremics. Logistic regression analysis showed that age, gender, presence of DM (all p<0.001), elevated hs CRP (p<0.01) and 3-HKYN levels (p<0.05) were independently associated with the presence of CVD in this population. These results suggest a relationship between KYN pathway activation and increased SOX, inflammation and CVD prevalence in ESRD patients.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Pawlak K,Domaniewski T,Mysliwiec M,Pawlak D

doi

10.1016/j.atherosclerosis.2008.08.014

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

309-14

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(08)00591-1

journal_volume

204

pub_type

杂志文章
  • "Low dose" colestipol in children, adolescents and young adults with familial hypercholesterolemia.

    abstract::The effect of colestipol on plasma lipids and lipoproteins was studied in children, adolescents and young adults with familial hypercholesterolemia. O.125 g or 0.25 g/kg body weight were given in randomized sequence for period of 4 weeks. Total cholesterol was lowered by 13 and 18% with the smaller and larger dose , r...

    journal_title:Atherosclerosis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0021-9150(82)90077-6

    authors: Schlierf G,Mrozik K,Heuck CC,Middelhoff G,Oster P,Riesen W,Schellenberg B

    更新日期:1982-01-01 00:00:00

  • Left ventricular hypertrophy assessed by electrocardiogram is associated with more severe stroke and with higher in-hospital mortality in patients with acute ischemic stroke.

    abstract:BACKGROUND AND AIMS:Left ventricular hypertrophy (LVH), assessed by electrocardiogram (ECG), is associated with increased risk for stroke. However, few studies that evaluated whether ECG-detected LVH predicts ischemic stroke severity and outcome. We aimed to evaluate these associations. METHODS:We prospectively studie...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2018.05.030

    authors: Tziomalos K,Sofogianni A,Angelopoulou SM,Christou K,Kostaki S,Papagianni M,Satsoglou S,Spanou M,Savopoulos C,Hatzitolios AI

    更新日期:2018-07-01 00:00:00

  • von Willebrand factor and soluble E-selectin in the prediction of cardiovascular disease progression in hyperlipidaemia.

    abstract::Two specific endothelial cell products, von Willebrand factor and soluble E-selectin, were measured together with serum lipids, lipoprotein(a), systolic and diastolic blood pressure (SHP, DBP) in a follow up study of 162 patients attending a dedicated lipid clinic. Patients were further classified by the presence or a...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(97)00081-6

    authors: Blann AD,Miller JP,McCollum CN

    更新日期:1997-07-25 00:00:00

  • Cigarette smoke is an endothelial stressor and leads to cell cycle arrest.

    abstract::The molecular mechanisms underlying the atherogenic activity of cigarette smoke have yet to be fully elucidated. In the present study, genome-wide microarray analysis was performed on endothelial cells exposed to an aqueous cigarette smoke extract (CSE) for 3, 7, and 24 h, to obtain a better insight into how smoking m...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2008.02.022

    authors: Henderson B,Csordas A,Backovic A,Kind M,Bernhard D,Wick G

    更新日期:2008-12-01 00:00:00

  • Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study.

    abstract:BACKGROUND AND PURPOSE:It has not been fully determined whether non-high-density lipoprotein cholesterol (non-HDLC) levels are involved in vascular events, especially stroke, in general Asian populations. We evaluated the association between non-HDLC levels and the risk of type-specific cardiovascular disease in a pros...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2014.01.005

    authors: Imamura T,Doi Y,Ninomiya T,Hata J,Nagata M,Ikeda F,Mukai N,Hirakawa Y,Yoshida D,Fukuhara M,Kitazono T,Kiyohara Y

    更新日期:2014-04-01 00:00:00

  • Flux of plasma lipoproteins into human arterial intima. Comparison between grossly normal and atheromatous intima.

    abstract::Arterial specimens were obtained from 12 patients during arterial repair surgery and 3 patients during nephrectomy following a bolus injection of autologous radio-iodinated very low density lipoprotein (VLDL) up to 30 h before surgery. Radioactivity in apoprotein B (apo B) was determined in lipoprotein fractions isola...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(81)90073-3

    authors: Nicoll A,Duffield R,Lewis B

    更新日期:1981-05-01 00:00:00

  • Thoracic aortic atherosclerosis in patients with aortic regurgitation.

    abstract:OBJECTIVE:Hemodynamic forces are potential determinants of aortic atherosclerosis. Aortic regurgitation (AR) alters the flow pattern in the aorta. However, the association between AR and aortic atherosclerosis is not well known. METHODS:We assessed the presence, extent and distribution of atherosclerotic lesions in th...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2011.05.026

    authors: Shimoni S,Zilberman L,Edri O,Bar I,Goland S,Gendelman G,Swissa M,Livshitz S,Paz O,Ayzenberg O,George J

    更新日期:2011-09-01 00:00:00

  • Low-density lipoprotein oxidized to various degrees activates ERK1/2 through Lox-1.

    abstract::Although the standard procedure for preparing extensively oxidized low-density lipoprotein (Ox-LDL) is to incubate it with 10muM CuSO(4) at 37 degrees C for 24h, it is not well known how important the degree of oxidation of LDL is for inducing cell signaling. Since Lox-1 (an Ox-LDL receptor) contributes to cell prolif...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2005.10.046

    authors: Tanigawa H,Miura S,Zhang B,Uehara Y,Matsuo Y,Fujino M,Sawamura T,Saku K

    更新日期:2006-10-01 00:00:00

  • Ideal cardiovascular health associated with fatty liver: Results from a multi-ethnic survey.

    abstract:BACKGROUND AND AIMS:Little is known about the role of liver enzymes as predictors of non-liver-related morbidity and mortality. The ideal cardiovascular health (CVH) score proposed by the American Heart Association (AHA) can be used to predict mortality and morbidity. We investigated the association of the CVH score wi...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2018.11.012

    authors: Mazidi M,Katsiki N,Mikhailidis DP,Banach M

    更新日期:2019-05-01 00:00:00

  • Chronic inflammation, albuminuria, and functional disability in older adults with cardiovascular disease: the National Health and Nutrition Examination Survey, 1999-2008.

    abstract:OBJECTIVE:Although C-reactive protein (CRP) and albuminuria are well-documented cardiovascular risk markers, the functional implications of these biomarkers and their combination on functional disability and metabolic risks in patients with cardiovascular disease (CVD) are unknown. METHODS:Data were from 1403 adults (...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2012.03.004

    authors: Kuo HK,Al Snih S,Kuo YF,Raji MA

    更新日期:2012-06-01 00:00:00

  • Glimepiride induces nitric oxide production in human coronary artery endothelial cells via a PI3-kinase-Akt dependent pathway.

    abstract::Diabetes mellitus is one of the major risk factors for coronary artery disease (CAD). A recent study reported that glimepiride, a new third-generation sulfonylurea, inhibited the formation of atheromatous plaques in high-cholesterol fed rabbits. However, the mechanism by which glimepiride induces atheroprotection rema...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2005.01.055

    authors: Ueba H,Kuroki M,Hashimoto S,Umemoto T,Yasu T,Ishikawa SE,Saito M,Kawakami M

    更新日期:2005-11-01 00:00:00

  • Nuclear magnetic resonance-determined lipoprotein subclasses and carotid intima-media thickness in type 1 diabetes.

    abstract:BACKGROUND:Dyslipidemia has been linked to vascular complications of Type 1 diabetes (T1DM). We investigated the prospective associations of nuclear magnetic resonance-determined lipoprotein subclass profiles (NMR-LSP) and conventional lipid profiles with carotid intima-media thickness (IMT) in T1DM. METHODS:NMR-LSP a...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2015.10.106

    authors: Basu A,Jenkins AJ,Zhang Y,Stoner JA,Klein RL,Lopes-Virella MF,Garvey WT,Lyons TJ,DCCT\/EDIC Research Group.

    更新日期:2016-01-01 00:00:00

  • Effects of peripheral blood monocytes on human vascular cell proliferation.

    abstract::Incubated human peripheral blood monocytes release a factor(s) which specifically stimulates homologous vascular smooth muscle (SMC) but not endothelial cells (EC) to proliferate in vitro. Conditioned medium from activated monocytes significantly (P less than 0.001) stimulated proliferation of SMC within 6 days of cul...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(81)90056-3

    authors: Ziats NP,Robertson AL Jr

    更新日期:1981-02-01 00:00:00

  • Soluble intercellular adhesion molecule-1 and interleukin-6 levels reflect endothelial dysfunction in patients with primary hypercholesterolaemia treated with atorvastatin.

    abstract::Adhesion molecules and cytokines are involved in the pathogenesis of intimal injury in atherosclerosis but their relationship with endothelial function remains unclear. The objectives of this study were to examine the effects of atorvastatin on soluble adhesion molecules, interleukin-6 (IL-6) and brachial artery endot...

    journal_title:Atherosclerosis

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0021-9150(03)00193-x

    authors: Nawawi H,Osman NS,Annuar R,Khalid BA,Yusoff K

    更新日期:2003-08-01 00:00:00

  • Differential suppression of lymphocyte cholesterol synthesis by low density lipoprotein and erythrocyte insulin receptors in normolipidemic subjects.

    abstract::The rates of cholesterol synthesis from acetate were studied in freshly isolated peripheral blood lymphocytes in 41 age- and sex-matched subjects with essentially normal serum lipid profiles. Insulin binding to erythrocytes obtained from the same blood samples was also studied simultaneously. From the data on lymphocy...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(83)90141-7

    authors: Sanghvi A,Virji MA,Warty V,Dimasi MJ

    更新日期:1983-12-01 00:00:00

  • Serum lipoprotein abnormalities in renal allograft recipients.

    abstract::Detailed lipid composition of serum and isolated lipoprotein fractions in male and female transplant recipients has been determined. Results have been compared with appropriate controls and a number of abnormalities have become apparent: (i) Serum total cholesterol, triglyceride and phospholipid levels were significan...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(78)90053-9

    authors: Abbott LK,Elliot C,Aitken JM,Somer JB

    更新日期:1978-06-01 00:00:00

  • Aortic glutathione metabolic status: time-dependent alterations in fat-fed rabbits.

    abstract::Little is known about the vascular metabolic status of glutathione (GSH), which is crucial in cell antioxidant protection, in experimental conditions like high-fat diet-induced atherosclerosis. This issue was, therefore, investigated in two groups of seven rabbits fed a 0.5% cholesterol-, 5% lard- and 5% peanut oil-en...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2003.11.014

    authors: Lapenna D,Pierdomenico SD,Ciofani G,Giamberardino MA,Cuccurullo F

    更新日期:2004-03-01 00:00:00

  • Fenofibrate induces plaque regression in hypercholesterolemic atherosclerotic rabbits: in vivo demonstration by high-resolution MRI.

    abstract:INTRODUCTION:Fenofibrate has shown to reduce major cardiovascular events and slow angiographic progression of coronary atherosclerosis. The postulated mechanism of action is via the activation of peroxisomal proliferator-activated receptor-alpha (PPAR-alpha), a nuclear transcription factor that controls a variety of ce...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2006.02.036

    authors: Corti R,Osende J,Hutter R,Viles-Gonzalez JF,Zafar U,Valdivieso C,Mizsei G,Fallon JT,Fuster V,Badimon JJ

    更新日期:2007-01-01 00:00:00

  • Postprandial lipoproteins and progression of coronary atherosclerosis.

    abstract::The relations between triglyceride-rich lipoproteins, alimentary lipaemia and coronary heart disease (CHD) have remained obscure and much debated. We studied the basal and postprandial plasma levels of chylomicron remnants and very low density lipoproteins (VLDL) of varying particle size in 32 male postinfarction pati...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(94)90085-x

    authors: Karpe F,Steiner G,Uffelman K,Olivecrona T,Hamsten A

    更新日期:1994-03-01 00:00:00

  • Characterization of LncRNA expression profile and identification of novel LncRNA biomarkers to diagnose coronary artery disease.

    abstract:BACKGROUND AND AIMS:Dysregulation of long non-coding RNAs (lncRNAs) has been proven to be involved in the pathogenesis of coronary artery disease (CAD). However, it remains to be extensively explored. Thus, the present study aims to study expression patterns, biological functions, and diagnostic value of lncRNAs in CAD...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2018.06.866

    authors: Li L,Wang L,Li H,Han X,Chen S,Yang B,Hu Z,Zhu H,Cai C,Chen J,Li X,Huang J,Gu D

    更新日期:2018-08-01 00:00:00

  • Pioglitazone inhibits connective tissue growth factor expression in advanced atherosclerotic plaques in low-density lipoprotein receptor-deficient mice.

    abstract::Connective tissue growth factor (CTGF) is expressed in atherosclerotic plaques. It is generally recognized that CTGF contributes to atherosclerosis by stimulating vascular smooth muscle cell (VSMC) proliferation and extracellular matrix production during the development of atherosclerosis. Recent studies indicate that...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2006.06.025

    authors: Game BA,He L,Jarido V,Nareika A,Jaffa AA,Lopes-Virella MF,Huang Y

    更新日期:2007-05-01 00:00:00

  • 360His polymorphism of the apolipoproteinA-IV gene and plasma lipid response to energy restricted diets in overweight subjects.

    abstract::Obesity is commonly associated with high rates of cardiovascular disease (CVD). Weight loss in obese subjects reduces risk factors for CVD but this response is not uniform. Genetic factors could be involved in this variability. The 360His polymorphism of apolipoproteinA-IV (apoA-IV) influences the lipid response to fa...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(99)00367-6

    authors: Heilbronn LK,Noakes M,Morris AM,Kind KL,Clifton PM

    更新日期:2000-05-01 00:00:00

  • Mitral annulus calcification--a window to diffuse atherosclerosis of the vascular system.

    abstract::Mitral annulus calcification (MAC) is a chronic, non-inflammatory, degenerative process of the fibrous support structure of the mitral valve. It occurs more often in women and the elderly. MAC is associated with known atherosclerotic risk factors such as diabetes mellitus, hypertension and hypercholesterolemia. It is ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,评审

    doi:10.1016/s0021-9150(00)00737-1

    authors: Adler Y,Fink N,Spector D,Wiser I,Sagie A

    更新日期:2001-03-01 00:00:00

  • Involvement of MAP kinases in the control of cPLA(2) and arachidonic acid release in endothelial cells.

    abstract::Cytosolic Phospholipase A(2) (cPLA(2)) has been implicated in receptor-mediated release of arachidonic acid from membrane phospholipids, the limiting step in prostacyclin and other eicosanoid production. Its activity is controlled by Ca(++) levels and enzymatically regulated phosphorylation. The purpose of this study ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(00)00631-6

    authors: Gudmundsdóttir IJ,Halldórsson H,Magnúsdóttir K,Thorgeirsson G

    更新日期:2001-05-01 00:00:00

  • Advanced glycation end-product Nε-carboxymethyl-Lysine accelerates progression of atherosclerotic calcification in diabetes.

    abstract:OBJECTIVE:Vascular calcification is an active deposition process of calcium phosphate which resembles bone formation and is highly regulated by osteoblast-like cells. Existing studies demonstrate that advanced glycation end-products (AGEs) may play a pathogenic role in the vascular calcification process. However, their...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2012.01.019

    authors: Wang Z,Jiang Y,Liu N,Ren L,Zhu Y,An Y,Chen D

    更新日期:2012-04-01 00:00:00

  • The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells.

    abstract:OBJECTIVE:Obesity and cardiovascular disease recognize a common metabolic soil and may therefore share part of their genetic background. Genome-wide association studies have identified variability at the SH2B1 locus as a predictor of obesity. We investigated whether SNP rs4788102, which captures the entire SH2B1 variab...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.atherosclerosis.2011.08.019

    authors: Prudente S,Morini E,Larmon J,Andreozzi F,Di Pietro N,Nigro A,Gervino EV,Mannino GC,Bacci S,Hauser TH,Bellacchio E,Formoso G,Pellegrini F,Proto V,Menzaghi C,Frittitta L,Pandolfi A,Sesti G,Doria A,Trischitta V

    更新日期:2011-12-01 00:00:00

  • Diminished baroreceptor sensitivity in elderly hypertensives. Possible role of atherosclerosis.

    abstract::Baroreceptor sensitivity was studied in twelve young normotensive subjects and forty hypertensive patients, separated into two groups according to their age, severity of hypertension and signs of severe atherosclerotic vascular disease. Under stabilized circulatory conditions, the changes of pulse rate in response to ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(76)90079-4

    authors: Vlachakis ND,Mendlowitz M,DGuia D,DGusman D

    更新日期:1976-07-01 00:00:00

  • Endothelium-dependent and -independent functions are impaired in patients with coronary heart disease.

    abstract::Endothelium plays a pivotal role in the development of atherosclerosis. Endothelial dysfunction participates in the course of acute coronary event. Using high-resolution ultrasound technique, endothelial dysfunction has been demonstrated in patients with atherosclerosis and risk factors for coronary disease, such as h...

    journal_title:Atherosclerosis

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0021-9150(99)00288-9

    authors: Zhang X,Zhao SP,Li XP,Gao M,Zhou QC

    更新日期:2000-03-01 00:00:00

  • Inflammatory and metabolic mechanisms underlying the calcific aortic valve disease.

    abstract::Although calcific aortic stenosis is a very common disease with major adverse cardiovascular events and healthcare costs, there are no effective medical interventions to delay or halt its progression. Cardiometabolic risk factors, including smoking and male sex, are linked to aortic stenosis. Emerging studies have ide...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,评审

    doi:10.1016/j.atherosclerosis.2018.08.029

    authors: Cho KI,Sakuma I,Sohn IS,Jo SH,Koh KK

    更新日期:2018-10-01 00:00:00

  • Dietary linoleate increases fluidity and influences chemical composition of plasma low density lipoprotein in adult men.

    abstract::Dietary linoleate was effective to increase LDL fluidity in adult men but did not significantly influence VLDL or HDL fluidities. Lipoproteins were isolated ultracentrifugally from plasma of sixteen healthy, free living male volunteers consuming controlled diets formulated from typical U.S.A. foods to have 35 energy %...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(87)90065-7

    authors: Berlin E,Judd JT,Marshall MW,Kliman PG

    更新日期:1987-08-01 00:00:00