当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Carbon monoxide-induced arterial wall hypoxia and atherosclerosis.

Carbon monoxide-induced arterial wall hypoxia and atherosclerosis.

Abstract：

:The elevated carbon monoxide level found in tobacco smokers has been suggested as one etiologic factor linking it with atherosclerosis. Unquestionably carbon monoxide does induce some arterial wall hypoxia, which has been established as an atherogenic factor, but without knowing the extent and location of this hypoxia the importance of this mechanism could not previously be assessed. Carbon monoxide acts both by inducing hypoxemia and shifting the oxyhemoglobin equilibrium curve, with these effects acting on the oxygen transport system from both the luminal blood and the vasa vasorum. We have studied this system using a computer simulation of the human arterial wall and found significant, mid-medial hypoxia with blood carbon monoxide levels routinely found in smokers. Because these levels fluctuate, the hypoxia they induce would be expected to be uncompensated by increased vascularization and therefore potentially represent a much more significant factor in atherogenesis than chronic hypoxia alone.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Schneiderman G,Goldstick TK

doi

10.1016/0021-9150(78)90148-x

subject

Has Abstract

pub_date

1978-05-01 00:00:00

pages

1-15

issue

1

eissn

0021-9150

issn

1879-1484

pii

0021-9150(78)90148-X

journal_volume

30

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • The lipoprotein lipase (LPL) S447X gain of function variant involves increased mRNA translation.

    abstract：OBJECTIVE:A common gain-of-function LPL variant, LPLS447X, has favorable clinical features and involves a C→G base change at nucleotide 1595 of the LPL cDNA, along with a haplotype, which includes other non-coding SNPs. The mechanism for the LPL gain-in-function is not clear. LPL translation is regulated by epinephrine...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.12.028

    authors： Ranganathan G,Unal R,Pokrovskaya ID,Tripathi P,Rotter JI,Goodarzi MO,Kern PA

    更新日期：2012-03-01 00:00:00

  • Evidence for a reversal with age in the pattern of near-wall blood flow around aortic branches.

    abstract：:The changes that occur with age in the distribution of atherosclerotic lesions around arterial branch points challenge accepted theories relating disease to haemodynamic stresses. We investigated whether flow near branch points changes with age in a way that can account for the different lesion distributions. Flow aro...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2003.09.028

    authors： Al-Musawi SL,Bishton J,Dean J,Williams S,Cremers SG,Weinberg PD

    更新日期：2004-01-01 00:00:00

  • Effects of estrogens on lipoprotein metabolism and cardiovascular disease in women.

    abstract：:Estrogen use is associated with protection from cardiovascular disease in postmenopausal women. This benefit appears to be magnified among women with pre-existing heart disease. The possible bias of intrinsically better health in women using estrogen has not been ruled out in observational studies. Therefore, two doub...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/0021-9150(94)05379-w

    authors： Knopp RH,Zhu X,Bonet B

    更新日期：1994-10-01 00:00:00

  • Clinicopathological significance of lipid peroxidation in carotid plaques.

    abstract：:Several reports have suggested an association between lipid peroxidation and human carotid atherosclerosis, but few reports have demonstrated a link between lipid peroxidation and carotid plaques in humans. In this study, we investigated the relationship between clinical features, histopathological characteristics and...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(01)00583-4

    authors： Nishi K,Uno M,Fukuzawa K,Horiguchi H,Shinno K,Nagahiro S

    更新日期：2002-02-01 00:00:00

  • Eosinophils count in peripheral circulation is associated with coronary artery disease.

    abstract：BACKGROUND AND AIMS:Allergic asthma can accelerate atherosclerosis, a disease in which plaque is deposited onto arterial walls and that may lead to coronary artery disease (CAD). Eosinophils are the most important effector cells in allergic asthma and are likely to become novel biomarkers for risk stratification of pat...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2019.05.027

    authors： Gao S,Deng Y,Wu J,Zhang L,Deng F,Zhou J,Yuan Z,Wang L

    更新日期：2019-07-01 00:00:00

  • Oxidisability of low density lipoproteins in patients with carotid or femoral artery atherosclerosis.

    abstract：:Oxidation of low density lipoprotein (LDL) is implicated in the pathogenesis of atherosclerosis. In this study the susceptibility to oxidation of LDL (from patients with atherosclerosis) is related to the progression of the disease. LDL were isolated from 37 patients with demonstrable atherosclerotic plaques. The susc...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)05401-4

    authors： Andrews B,Burnand K,Paganga G,Browse N,Rice-Evans C,Sommerville K,Leake D,Taub N

    更新日期：1995-01-06 00:00:00

  • Focal differences in bioenergetic metabolism of atherosclerosis-susceptible and -resistant pigeon aortas.

    abstract：:To test the hypothesis of altered energy production in aortic sites predisposed to lesion formation, both coupled oxidative phosphorylation (evaluated from P/O ratios) and control of the energy-linked (ATP) NADH transhydrogenase were examined in muscular cushions at the celiac artery bifurcation. Comparisons were made...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(80)90230-0

    authors： Hajjar DP,Smith SC

    更新日期：1980-06-01 00:00:00

  • Low dose apolipoprotein A-I rescues carotid arteries from inflammation in vivo.

    abstract：:This study investigates the ability of a single, low dose of apolipoprotein (apo) A-I, the main lipoprotein of high density lipoproteins (HDL), to inhibit acute vascular inflammation in normocholesterolemic New Zealand White rabbits. Acute vascular inflammation was induced in the animals by placing a non-occlusive, si...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.05.008

    authors： Puranik R,Bao S,Nobecourt E,Nicholls SJ,Dusting GJ,Barter PJ,Celermajer DS,Rye KA

    更新日期：2008-01-01 00:00:00

  • Inhibition of human neutrophil reactive oxygen species production and p67phox translocation by cigarette smoke extract.

    abstract：:The association between cigarette smoking and atherogenesis is well established. Inflammatory cells may participate in atherogenesis via activation of the NADPH oxidase and the subsequent production of reactive oxygen species (ROS), which exacerbates endothelial injury. However, little is known about the ability of ci...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.11.011

    authors： Dunn JS,Freed BM,Gustafson DL,Stringer KA

    更新日期：2005-04-01 00:00:00

  • Predictive factors for all-cause mortality in the hospitalized elderly subject: the importance of arrhythmia.

    abstract：BACKGROUND:In elderly patients traditional cardiovascular (CV) risk factors are poorly correlated with mortality and few data are available on determinants and consequences of supra-ventricular arrhythmia. In a cohort of 331 hospitalized elderly patients (mean age+/-SD=85+/-7 years), we assessed which CV characteristic...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2009.04.035

    authors： Vesin C,Protogerou AD,Lieber A,Safar H,Iaria P,Ducimetière P,Safar ME,Blacher J

    更新日期：2009-12-01 00:00:00

  • Management of non-high-density lipoprotein abnormalities.

    abstract：:Epidemiological evidence supports the use of non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B-100 (apoB), and low-density lipoprotein particles as markers of atherogenic risk. Treatment guidelines also identify these as additional targets of lipid-modifying intervention in patients with elevated ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2009.05.020

    authors： Rosenson RS

    更新日期：2009-12-01 00:00:00

  • The biological relevance and measurement of plasma markers of oxidative stress in diabetes and cardiovascular disease.

    abstract：:Oxidative stress is associated with many chronic diseases. In this review, we look at the role that oxidative stress may play in diabetes and related cardiovascular disease (CVD) and how oxidative damage may be measured in the plasma. Increased production of reactive oxygen species (ROS) has been implicated in the ini...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2008.06.006

    authors： Stephens JW,Khanolkar MP,Bain SC

    更新日期：2009-02-01 00:00:00

  • Clinical aspects of PCSK9.

    abstract：:Proprotein convertase subtilisin kexin type 9 (PCSK9) is a circulating protein that impairs LDL clearance by promoting the LDL receptor (LDLR) degradation. PCSK9 has emerged as a new pharmacological target for hypercholesterolemia, and different PCSK9 inhibitors are now evaluated in clinical trials. Here, we propose a...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2011.04.018

    authors： Cariou B,Le May C,Costet P

    更新日期：2011-06-01 00:00:00

  • Effects of pravastatin on serum adiponectin levels in female patients with type 2 diabetes mellitus.

    abstract：OBJECTIVE:Pravastatin has been reported to elevate circulating adiponectin levels in patients with various insulin resistant state, hypertension, coronary artery disease, and hypercholesterolemia. This study aimed to evaluate whether pravastatin increase serum total and high molecular weight adiponectin levels and impr...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.atherosclerosis.2013.01.045

    authors： Kim JH,Lee MR,Shin JA,Lee SS,Lee JM,You SJ,Yoon KH,Chang SA

    更新日期：2013-04-01 00:00:00

  • PPARα activation differently affects microparticle content in atherosclerotic lesions and liver of a mouse model of atherosclerosis and NASH.

    abstract：BACKGROUND:Atherosclerosis and non-alcoholic fatty liver disease (NAFLD) are complex pathologies characterized by lipid accumulation, chronic inflammation and extensive tissue remodelling. Microparticles (MPs), small membrane vesicles produced by activated and apoptotic cells, might not only be biomarkers, but also fun...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.03.009

    authors： Baron M,Leroyer AS,Majd Z,Lalloyer F,Vallez E,Bantubungi K,Chinetti-Gbaguidi G,Delerive P,Boulanger CM,Staels B,Tailleux A

    更新日期：2011-09-01 00:00:00

  • Clinical study of niceritrol on serum lipids in the treatment of hyperlipidemia.

    abstract：:The effects of niceritrol, a nicotinic acid derivative, on the levels of HDL-cholesterol (HDL-Ch) and a mixture of VLDL- and LDL-Ch (VLDL- + LDL-Ch) were studied in hyperlipidemic patients. Serum total cholesterol (sTC) and serum triglyceride (sTG) were significantly reduced during niceritrol administration. Lipoprote...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(80)90137-9

    authors： Kibata M,Ishida M,Asano K,Uehara H,Saito K,Fuchimoto T,Ugaki K,Murakami H,Matoba K,Kotakemori Y,Shirai K,Yoshioka H,Nanba M,Yasuda M,Ishizaki M,Kitagawa N,Ikejiri K,Inohara R,Lee BJ,Saino S,Sakado J,Matuzaka H,

    更新日期：1980-11-01 00:00:00

  • Serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 as potential markers of carotid atherosclerosis in infraclinical hyperlipidemia.

    abstract：:The proteolytic activity of proinflammatory matrix metalloproteinases (MMPs) is elevated in lipid-rich atherosclerotic plaques, thereby contributing to plaque fragility and rupture. We hypothesized that changes in circulating levels of MMPs and their specific inhibitors (TIMPs) could reflect the atherosclerotic proces...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(03)00149-7

    authors： Beaudeux JL,Giral P,Bruckert E,Bernard M,Foglietti MJ,Chapman MJ

    更新日期：2003-07-01 00:00:00

  • Low density lipoprotein metabolism by cultured skin fibroblasts from atherosclerotic patients.

    abstract：:The aim of this study was to determine whether an abnormality in low density lipoprotein (LDL) metabolism could be demonstrated in fibroblasts cultured from normolipidaemic subjects with atherosclerosis. Seventeen male subjects aged 30-55 years with normal plasma lipid concentrations were divided into 2 groups on the ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(82)90148-4

    authors： Behrman RG,Wynn V

    更新日期：1982-04-01 00:00:00

  • Aging, smooth muscle cells and vascular pathobiology: implications for atherosclerosis.

    abstract：:Epidemiological and autopsy studies suggest a close link between aging and the clinical manifestation of atherosclerosis. Several experiments show increased arterial susceptibility to atherogenetic stimuli in aged subjects. All together, these findings support the concept that aging represents an independent atherogen...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2006.01.018

    authors： Orlandi A,Bochaton-Piallat ML,Gabbiani G,Spagnoli LG

    更新日期：2006-10-01 00:00:00

  • Small dense low-density lipoprotein cholesterol concentration and carotid atherosclerosis.

    abstract：:Low-density lipoprotein cholesterol (LDL-C) and the small dense LDL (SdLDL) phenotype are both predictors for ischemic heart disease. We examined whether cholesterol of SdLDL (SdLDL-C) is more closely associated with carotid artery intima-media thickness (CA-IMT), a surrogate measure of atherosclerosis, than LDL-C and...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.04.042

    authors： Shoji T,Hatsuda S,Tsuchikura S,Shinohara K,Kimoto E,Koyama H,Emoto M,Nishizawa Y

    更新日期：2009-02-01 00:00:00

  • Effect of estrogen on vascular smooth muscle cells is dependent upon cellular phenotype.

    abstract：:To investigate the growth-regulating action of estrogen on vascular smooth muscle cells (SMC), effects of beta-17-estradiol (beta-E2) on phenotypic modulation and proliferation of rabbit aortic SMC were observed in vitro. At 10(-8)M, beta-E2 significantly slowed the decrease in volume fraction of myofilaments (Vv myo)...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(98)00122-1

    authors： Song J,Wan Y,Rolfe BE,Campbell JH,Campbell GR

    更新日期：1998-09-01 00:00:00

  • Cholesteryl ester cycle in cultured hepatoma cells.

    abstract：:The existence of a cholesteryl ester cycle in cultured Fu5AH hepatoma cells was documented and factors affecting the rate of turnover of the cholesteryl ester cycle in this cell line were explored. The influence of the physical state of the lipid inclusion in which the cholesteryl esters are stored could be addressed ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(87)90250-4

    authors： Glick JM,Adelman SJ,Rothblat GH

    更新日期：1987-04-01 00:00:00

  • Experimental atherosclerosis of the heart valves in rats following a long-term atherogenic regimen.

    abstract：:Male and female rats kept on a long-term atherogenic regimen for periods up to 15 months developed marked atherosclerotic changes of cardiac valves in 100% of cases. The degree and the topography of valvular atherosclerotic plaques corresponded widely to that seen in human atherosclerotic valvular disease. The regular...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(77)90023-5

    authors： Záhor Z,Czabanová V

    更新日期：1977-05-01 00:00:00

  • Relationship between brachial flow-mediated dilation and carotid intima-media thickness in an elderly cohort: the Cardiovascular Health Study.

    abstract：OBJECTIVE:The aim of this study was to determine the relationship between brachial flow-mediated dilation (FMD) and carotid intima-media thickness (IMT) in a large multi-ethnic elderly cohort. BACKGROUND:Brachial flow-mediated dilation (FMD) is a physiologic measure and carotid IMT is an anatomic structural measure of...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2007.07.032

    authors： Yeboah J,Burke GL,Crouse JR,Herrington DM

    更新日期：2008-04-01 00:00:00

  • The association of coronary artery calcium score and mortality risk among smokers: The coronary artery calcium consortium.

    abstract：BACKGROUND AND AIMS:Cardiovascular disease (CVD) and cancer are the two leading causes of death in smokers. Lung cancer screening is recommended in a large proportion of smokers. We examined the implication of coronary artery calcium (CAC) score (quantitative and qualitative) for cardiovascular disease (CVD), coronary ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2019.12.014

    authors： Mirbolouk M,Kianoush S,Dardari Z,Miedema MD,Shaw LJ,Rumberger JA,Berman DS,Budoff MJ,Rozanski A,Al-Mallah MH,McEvoy JW,Nasir K,Blaha MJ

    更新日期：2020-02-01 00:00:00

  • Interrelationships between plasma levels of plasminogen activator inhibitor, tissue plasminogen activator, lipoprotein (a), and established cardiovascular risk factors in a north Swedish population.

    abstract：:Serum lipids, lipoprotein (a), plasminogen activator inhibitor and tissue plasminogen activator levels were measured in 260 subjects, constituting a cross-section sample of 30-60-year-old men and women. For Lp(a), there were positive correlations with age and cholesterol, but not with any of other measured parameters....

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(89)90062-2

    authors： Sundell IB,Nilsson TK,Hallmans G,Hellsten G,Dahlén GH

    更新日期：1989-11-01 00:00:00

  • Lysosomal acid lipase deficiency--an under-recognized cause of dyslipidaemia and liver dysfunction.

    abstract：:Lysosomal acid lipase deficiency (LAL-D) is a rare autosomal recessive lysosomal storage disease caused by deleterious mutations in the LIPA gene. The age at onset and rate of progression vary greatly and this may relate to the nature of the underlying mutations. Patients presenting in infancy have the most rapidly pr...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2014.04.003

    authors： Reiner Ž,Guardamagna O,Nair D,Soran H,Hovingh K,Bertolini S,Jones S,Ćorić M,Calandra S,Hamilton J,Eagleton T,Ros E

    更新日期：2014-07-01 00:00:00

  • Effect of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, on hepatic cholesterol 7 alpha-hydroxylase, acyl-coenzyme A: cholesterol acyltransferase, and bile lipid secretion in the hamster with intact enterohepatic circulation.

    abstract：:The effects of administration of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on hepatic cholesterol 7 alpha-hydroxylase and acyl-coenzyme A: cholesterol acyltransferase (ACAT) activities and bile lipid secretion were investigated in Syrian golden hamsters. Continuous administrat...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)90092-2

    authors： Hayashi K,Noshiro M,Kurushima H,Kuga Y,Nomura S,Ohkura Y,Ohtani H,Kurokawa J,Tanaka K,Yasunobu Y

    更新日期：1994-12-01 00:00:00

  • Deficiency of receptor-associated protein attenuates angiotensin II-induced atherosclerosis in hypercholesterolemic mice without influencing abdominal aortic aneurysms.

    abstract：OBJECTIVE:Receptor-associated protein (RAP) was initially described as a regulator of low density lipoprotein receptor-related protein 1 (LRP1), but is now known to regulate many proteins. Since the direct effects of RAP on vascular pathologies have not been studied, this study determined whether RAP deficiency influen...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.11.013

    authors： Wang S,Subramanian V,Lu H,Howatt DA,Moorleghen JJ,Charnigo R,Cassis LA,Daugherty A

    更新日期：2012-02-01 00:00:00

  • Glycated hemoglobin and long-term prognosis in patients with suspected stable angina pectoris without diabetes mellitus: a prospective cohort study.

    abstract：OBJECTIVE:Associations of glycated hemoglobin A1c (HbA1c) levels to incident coronary and cardiovascular events among non-diabetic patients with coronary artery disease are unclear. We investigated relations of HbA1c to long-term prognosis in such patients. METHODS:A prospective cohort of 2519 patients undergoing elec...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.02.053

    authors： Rebnord EW,Pedersen ER,Strand E,Svingen GF,Meyer K,Schartum-Hansen H,Løland KH,Seifert R,Ueland PM,Nilsen DW,Nordrehaug JE,Nygård O

    更新日期：2015-05-01 00:00:00