Oxidisability of low density lipoproteins in patients with carotid or femoral artery atherosclerosis.

abstract：BACKGROUND:Eosinophils have been involved in a wide spectrum of pro-inflammatory and pro-thrombotic conditions, with the development of cardiovascular complications in a significant proportion of hypereosinophilic patients. However, no study has so far evaluated the impact of eosinophils levels on periprocedural myocar...

journal_title：Atherosclerosis

authors： Verdoia M,Schaffer A,Barbieri L,Sinigaglia F,Marino P,Suryapranata H,De Luca G,Novara Atherosclerosis Study Group (NAS).

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Limited evidence suggests NT-proBNP improves prediction of coronary heart disease (CHD) events but further data are needed, especially in people without pre-existing CHD and in women. METHODS:We measured NT-proBNP in serum from 162 women with incident CHD events and 1226 controls (60-79 years) in a case-cont...

journal_title：Atherosclerosis

authors： Sattar N,Welsh P,Sarwar N,Danesh J,Di Angelantonio E,Gudnason V,Davey Smith G,Ebrahim S,Lawlor DA

更新日期：2010-03-01 00:00:00

abstract：:The recruitment of peripheral monocytes to the sub-endothelial space, their development into macrophages and subsequent proliferation are critical events during atherosclerosis. Receptors for epidermal growth factor (EGF) have been identified on cells of the myeloid lineage, but a role for them in atherogenesis has ye...

journal_title：Atherosclerosis

authors： Lamb DJ,Modjtahedi H,Plant NJ,Ferns GA

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Long non-coding RNAs (lncRNAs) have proven to be involved in the progression of atherosclerosis and dyslipidemia. In addition, vascular smooth muscle cells (VSMCs) phenotype switching, including VSMCs-derived foam cells formation, plays a key role in the pathogenesis of atherosclerosis. LncRNA ENST0...

journal_title：Atherosclerosis

authors： Cai C,Zhu H,Ning X,Li L,Yang B,Chen S,Wang L,Lu X,Gu D

更新日期：2019-06-01 00:00:00

abstract：:We studied the aortic histology of 28 Macaca nigra males and females, from 6 to more than 20 years old, normal and manifesting various degrees of spontaneous diabetes. Correlations of several metabolic and hormonal indicators of diabetes severity with gross and microscopic findings in the aortas demonstrated direct as...

journal_title：Atherosclerosis

authors： Howard CF Jr,Vesselinovitch D,Wissler RW

更新日期：1984-07-01 00:00:00

abstract：:The effect of the apolipoprotein C-II/C-III1 ratio on the capacity of purified bovine milk lipoprotein lipase to hydrolyse triglycerides was measured in a controlled model of pyrene-labeled nonanoyltriglycerides (1-2 ditetradecyl 3-pyrene nonanoyl glyceride) monolayer vesicles. Monolayer was composed of triglycerides,...

journal_title：Atherosclerosis

authors： Lambert DA,Catapano AL,Smith LC,Sparrow JT,Gotto AM Jr

更新日期：1996-12-20 00:00:00

abstract：OBJECTIVE:To investigate associations between blood low-density lipoprotein cholesterol (LDL-C) levels and the prevalence of acquired color vision impairment (ACVI) in middle-aged Japanese men. METHODS:Participants in this cross-sectional study underwent color vision testing, ophthalmic examination, a standardized int...

journal_title：Atherosclerosis

authors： Shoji T,Sakurai Y,Sato H,Chihara E,Ishida M,Omae K

更新日期：2010-06-01 00:00:00

abstract：:We determined the effects of different dialysis conditions on the antioxidant content, duration of the lag phase and oxidation rate of LDL. Dialysis for 22 h resulted in a 56%--66% reduction in the concentrations of beta-carotene, lycopene and alpha-tocopherol. The lag phase of copper-induced oxidation of freshly isol...

journal_title：Atherosclerosis

authors： Scheek LM,Wiseman SA,Tijburg LB,van Tol A

更新日期：1995-09-01 00:00:00

abstract：:It has been reported that total cholesterol (Chol) response to probucol is greater in familial hypercholesterolemic (FH) patients with apo E4 than in those without apo E4. We further examined the effect of probucol on plasma triglyceride (TG) and lipoprotein-Chol levels as well as total Chol levels in heterozygous FH ...

journal_title：Atherosclerosis

authors： Eto M,Sato T,Watanabe K,Iwashima Y,Makino I

更新日期：1990-09-01 00:00:00

abstract：:We studied the cytotoxic effect of copper-oxidized LDL in human primary human umbilical vein endothelial cells (HUVEC) and the immortalized EA.hy 926 cell line. Copper oxidized LDL (50-200 microg apoB/ml) induced concentration-dependent apoptotic cell death in HUVEC but did not induce apoptosis in EA.hy 926 cells. Onl...

journal_title：Atherosclerosis

authors： Claise C,Edeas M,Chaouchi N,Chalas J,Capel L,Kalimouttou S,Vazquez A,Lindenbaum A

更新日期：1999-11-01 00:00:00

abstract：:The aim of this study is to assess the relationship of epicardial adipose tissue (EAT) and plaque vulnerability. We consecutively enrolled 82 patients with coronary artery disease (CAD). A symptom-related vessel was imaged by virtual histology intravascular ultrasound (VH-IVUS). In 60 out of 82 patients, all three ves...

journal_title：Atherosclerosis

authors： Park JS,Choi SY,Zheng M,Yang HM,Lim HS,Choi BJ,Yoon MH,Hwang GS,Tahk SJ,Shin JH

更新日期：2013-01-01 00:00:00

abstract：:Cholesteryl ester transfer from solid-phase bound HDL to endogenous plasma HDL or VLDL/LDL was determined in 50 patients with primary disorders of lipid metabolism and 27 normolipidemic subjects. Transfer to the plasma HDL pool was significantly reduced in familial hypercholesterolemia, familial combined hyperlipidemi...

journal_title：Atherosclerosis

authors： Sparks DL,Frohlich J,Lacko AG,Pritchard PH

更新日期：1989-06-01 00:00:00

abstract：:HMG-CoA reductase inhibitor drugs or 'statins' have been shown to effectively reduce plasma total cholesterol (CHOL), CHOL associated with low-density-lipoprotein (LDL), and triglycerides (TG). In addition, slight elevations in HDL-CHOL are also typically observed. Poloxamer 407 (P-407), a nonionic surfactant, effecti...

journal_title：Atherosclerosis

authors： Johnston TP,Baker JC,Hall D,Jamal S,Palmer WK,Emeson EE

更新日期：2000-04-01 00:00:00

abstract：:Despite numerous studies, the precise role of dietary n-6 polyunsaturated fatty acids in the pathogenesis of atherosclerosis remains controversial. It has been shown that feeding an n-6-enriched diet resulted in decreased atherosclerosis in African green monkeys and was associated with a reduction in LDL levels. Howev...

journal_title：Atherosclerosis

authors： George J,Mulkins M,Casey S,Schatzman R,Sigal E,Harats D

更新日期：2000-06-01 00:00:00

abstract：:External jugular veins that had been subjected to the hemodynamic stresses produced by experimental arteriovenous anastomosis developed 2% increased total protein contents and 17% increased collagen contents. When the stressed veins were homogenized and extracted with saline solutions, statistically significant increa...

journal_title：Atherosclerosis

authors： Smith RA,Stehbens WE,Weber P

更新日期：1976-05-01 00:00:00

abstract：:Chronic renal failure markedly accelerates atherogenesis in apolipoprotein E-deficient (apoE(-/-)) mice. To study the putative role of receptor for advanced glycation end products (RAGE) in development of uremic atherosclerosis, apoE(-/-) mice received intraperitoneal injections thrice weekly of a neutralizing murine ...

journal_title：Atherosclerosis

authors： Bro S,Flyvbjerg A,Binder CJ,Bang CA,Denner L,Olgaard K,Nielsen LB

更新日期：2008-12-01 00:00:00

abstract：:This study was aimed to test the hypothesis that noninvasive assessment of carotid plaques can be achieved by high-resolution micro-ultrasound imaging in apolipoprotein-E knockout (apoE-KO) mice. Forty-two male apoE-KO mice were fed a high-fat diet and atherosclerotic lesions in the left common carotid artery were ind...

journal_title：Atherosclerosis

authors： Ni M,Zhang M,Ding SF,Chen WQ,Zhang Y

更新日期：2008-03-01 00:00:00

abstract：:The hydrolysis of lipoprotein triglycerides is catalyzed by lipoprotein lipase (LPL), an enzyme found in many tissues. We have examined tissue LPL activity (LPLA) in rats with experimentally-induced hyperthyroidism. In younger, lighter rats, hyperthyroidism was accompanied by a decrease in LPL in adipose tissue wherea...

journal_title：Atherosclerosis

authors： Wilson DE,Jubiz W,Flowers CM,Carlile SI,Adolf AM

更新日期：1977-03-01 00:00:00

abstract：:The ontogenic development of lipoprotein lipase and liver triglyceride hydrolase was studied in the rat. The enzyme activity measured in extrahepatic tissues fulfilled the criteria of lipoprotein lipase from the onset of measurable activity, i.e. it was inhibited by protamine and 1 M NaCl and showed requirement for se...

journal_title：Atherosclerosis

authors： Chajek T,Stein O,Stein Y

更新日期：1977-04-01 00:00:00

abstract：AIMS:This study was set up to compare the accuracy, sensitivity and specificity of gene expression results between the Illumina HumanHT-12 v3 Expression BeadChip (GWE) and the TaqMan qRT-PCR low-density array (LDA) in atherosclerotic plaques. METHODS:Gene expression levels of 196 genes were determined from 22 atherosc...

journal_title：Atherosclerosis

authors： Raitoharju E,Seppälä I,Lyytikäinen LP,Levula M,Oksala N,Klopp N,Illig T,Laaksonen R,Kähönen M,Lehtimäki T

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:The benefits of fish oil fatty acids eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) on plasma lipid profiles have been inconsistent but may partially depend on individual Apolipoprotein E (APOE) genotypes. We aimed to determine whether APOE genotype modifies the association of lipid profile characteri...

journal_title：Atherosclerosis

authors： Liang S,Steffen LM,Steffen BT,Guan W,Weir NL,Rich SS,Manichaikul A,Vargas JD,Tsai MY

更新日期：2013-05-01 00:00:00

abstract：:The effect of renal hypertension on dry defatted tissue mass and lipid accumulation in different segments of the aortic intima was studied in both normally-fed and cholesterol-fed rabbits. In normally-fed rabbits hypertension caused an increase in intimal dry weight in the aorta. The increase was greatest in the lower...

journal_title：Atherosclerosis

authors： Bretherton KN,Day AJ,Skinner SL

更新日期：1975-11-01 00:00:00

abstract：:In the French Canadian population six mutations appear to be responsible for about 85% of FH cases. Two of these mutations are large deletions. The most prevalent deletion is a >15 kb deletion of the promoter and first exon; the second, a 5 kb deletion that removes exons 2 and 3. The high frequency of these deletions ...

journal_title：Atherosclerosis

authors： Bernier L,Boulet L,Roy M,Dufour R,Larivière F,Davignon J

更新日期：2008-03-01 00:00:00

abstract：:Seasonal variation in the plasma lipids and lipoproteins is reported in the literature. Whether this variation is the result of changes in diet or other factors has not been adequately addressed. We investigated the effects of a controlled diet on the seasonal variation in the levels of plasma lipids and apolipoprotei...

journal_title：Atherosclerosis

authors： Mustad V,Derr J,Reddy CC,Pearson TA,Kris-Etherton PM

更新日期：1996-09-27 00:00:00

abstract：:In the rabbit, dietary cholesterol downregulates the hepatic LDL receptor and concomitant treatment with 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors partly restores its expression. The aim of this study was to determine whether the LDL receptor activity of circulating mononuclear cells would r...

journal_title：Atherosclerosis

authors： Roach PD,Kerry NL,Whiting MJ,Nestel PJ

更新日期：1993-07-01 00:00:00

abstract：:Reactive oxygen species (ROS) contribute to neointimal smooth muscle proliferation by yet to be defined mechanisms. We examined the effects of a novel isoflavone 3,7-dihydroxy-isoflav-3-ene (DHIF) on development of neointimal lesions in relation to ROS elevations and cell signaling in injured arteries. Carotid arterie...

journal_title：Atherosclerosis

authors： Kanellakis P,Pomilio G,Walker C,Husband A,Huang JL,Nestel P,Agrotis A,Bobik A

更新日期：2009-05-01 00:00:00

abstract：:Colesevelam hydrochloride is a novel, potent, non-absorbed lipid-lowering agent previously shown to reduce low density lipoprotein (LDL) cholesterol. To examine the efficacy and safety of coadministration of colesevelam and atorvastatin, administration of these agents alone or in combination was examined in a double-b...

journal_title：Atherosclerosis

authors： Hunninghake D,Insull W Jr,Toth P,Davidson D,Donovan JM,Burke SK

更新日期：2001-10-01 00:00:00

abstract：:Recent evidence suggests that sterol 27-hydroxylase may play a role in cholesterol homeostasis and affect atherogenesis. The major objective of the study was to map and characterize the sterol 27-hydroxylase (CYP27) promoter region. Here we show that CYP27 gene has a TATA-less promoter and transcription initiates at a...

journal_title：Atherosclerosis

authors： Segev H,Honigman A,Rosen H,Leitersdorf E

更新日期：2001-06-01 00:00:00

abstract：:Monocytes and macrophages synthesize tissue factor (TF) which plays a role in thrombogenicity in coronary artery disease. This study was conducted to investigate the effect of Rho/Rho-kinase inhibition on the synthesis of TF in cultured human monocytes. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibit...

journal_title：Atherosclerosis

authors： Nagata K,Ishibashi T,Sakamoto T,Ohkawara H,Shindo J,Yokoyama K,Sugimoto K,Sakurada S,Takuwa Y,Nakamura S,Teramoto T,Maruyama Y

更新日期：2002-07-01 00:00:00

abstract：:Microsomal triglyceride transfer protein (MTP) is a lipid transfer protein that is required for the assembly and secretion of very low density lipoproteins (VLDL) by the liver and chylomicrons by the intestine. The common G-493T polymorphism of the MTP promoter has been shown to be associated with decreased plasma LDL...

journal_title：Atherosclerosis

authors： Couture P,Otvos JD,Cupples LA,Wilson PW,Schaefer EJ,Ordovas JM

更新日期：2000-02-01 00:00:00