Abstract:
:The recruitment of peripheral monocytes to the sub-endothelial space, their development into macrophages and subsequent proliferation are critical events during atherosclerosis. Receptors for epidermal growth factor (EGF) have been identified on cells of the myeloid lineage, but a role for them in atherogenesis has yet to be described. We have identified functional EGF receptors (EGFR, ErbB1/HER-1) on peripheral blood monocytes and monocyte-derived macrophages. Uniquely, these receptors were found to mediate both chemotaxis in monocytes and macrophages and proliferation in macrophages. EGFR mRNA was detected in atherosclerotic plaques, but not in morphologically normal aortae and EGFR receptor staining co-localised with macrophage staining in these plaques. The identification of receptors for EGF on peripheral blood monocytes, macrophages and atherosclerotic lesions, together with their transduction of two functionally important cellular events, heightens the potential importance of members of the EGF super-family in atherogenesis and other chronic inflammatory processes.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Lamb DJ,Modjtahedi H,Plant NJ,Ferns GAdoi
10.1016/j.atherosclerosis.2004.04.012keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
21-6issue
1eissn
0021-9150issn
1879-1484pii
S0021-9150(04)00222-9journal_volume
176pub_type
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