EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques.

Abstract:

:The recruitment of peripheral monocytes to the sub-endothelial space, their development into macrophages and subsequent proliferation are critical events during atherosclerosis. Receptors for epidermal growth factor (EGF) have been identified on cells of the myeloid lineage, but a role for them in atherogenesis has yet to be described. We have identified functional EGF receptors (EGFR, ErbB1/HER-1) on peripheral blood monocytes and monocyte-derived macrophages. Uniquely, these receptors were found to mediate both chemotaxis in monocytes and macrophages and proliferation in macrophages. EGFR mRNA was detected in atherosclerotic plaques, but not in morphologically normal aortae and EGFR receptor staining co-localised with macrophage staining in these plaques. The identification of receptors for EGF on peripheral blood monocytes, macrophages and atherosclerotic lesions, together with their transduction of two functionally important cellular events, heightens the potential importance of members of the EGF super-family in atherogenesis and other chronic inflammatory processes.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Lamb DJ,Modjtahedi H,Plant NJ,Ferns GA

doi

10.1016/j.atherosclerosis.2004.04.012

keywords:

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

21-6

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(04)00222-9

journal_volume

176

pub_type

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