当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Epicardial adipose tissue thickness is a predictor for plaque vulnerability in patients with significant coronary artery disease.

Epicardial adipose tissue thickness is a predictor for plaque vulnerability in patients with significant coronary artery disease.

Abstract：

:The aim of this study is to assess the relationship of epicardial adipose tissue (EAT) and plaque vulnerability. We consecutively enrolled 82 patients with coronary artery disease (CAD). A symptom-related vessel was imaged by virtual histology intravascular ultrasound (VH-IVUS). In 60 out of 82 patients, all three vessels were studied by VH-IVUS. EAT thickness was measured by echocardiography. All patients were divided into thick (≥3.5 mm) and thin EAT groups (<3.5 mm). VH-IVUS parameters were compared according to the EAT group. To evaluate the independent effect of EAT thickness on plaque vulnerability, a set of well-known CAD risk factors and EAT thickness were included in multiple linear regression models of VH-IVUS parameters which denotes plaque vulnerability. In a symptom-related vessel analysis, the thick EAT group had significantly more thin-cap fibroatheromas (TCFAs). In a symptom-related vessel analysis among 62 patients with unstable angina out of 82 patients, the thick EAT group had significantly more thin-cap fibroatheromas (TCFAs). In all three vessels analysis, the thick EAT group was associated with significantly larger total plaque volume, higher total plaque volume index, higher mean plaque burden, higher plaque volume indexes of the necrotic core (NC), and more total number of TCFAs than the thin EAT group. By multivariate analysis, total TCFAs of a symptom-related vessel, both in total population and in patients with unstable angina, and plaque volume index of the NC of all three vessels were independent factors associated with thick EAT. In multiple linear regression models of VH-IVUS parameters which means plaque vulnerability, EAT thickness was one of the independent factors. In the present study, the VH-IVUS parameters indicating vulnerable plaque were significantly related with the thickness of EAT.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Park JS,Choi SY,Zheng M,Yang HM,Lim HS,Choi BJ,Yoon MH,Hwang GS,Tahk SJ,Shin JH

doi

10.1016/j.atherosclerosis.2012.11.001

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

134-9

issue

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(12)00796-4

journal_volume

226

pub_type

杂志文章

在线工具

Epicardial adipose tissue thickness is a predictor for plaque vulnerability in patients with significant coronary artery disease.