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Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular risk.

Abstract：

:The search for markers to improve risk prediction for individuals at risk of developing serious cardiovascular events is ongoing. New markers of coronary artery disease progression have been identified in recent years, among which, circulating levels of pregnancy-associated plasma protein-A (PAPP-A) offer an interesting profile. PAPP-A may play a role in the development of atherosclerotic lesions and represent also a marker of atheromatous plaque instability and extent of cardiovascular disease. PAPP-A has been shown to be a marker of adverse outcome in both acute coronary syndrome and stable coronary disease patients. The present article reviews currently available evidence supporting a role for PAPP-A as a marker of cardiovascular risk and discusses some of the pitfalls that may limit its use in clinical practice.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Consuegra-Sanchez L,Fredericks S,Kaski JC

doi

10.1016/j.atherosclerosis.2008.07.042

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

346-52

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(08)00540-6

journal_volume

203

pub_type

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