5'-nitro-indirubinoxime inhibits inflammatory response in TNF-alpha stimulated human umbilical vein endothelial cells.

abstract：:Arterial specimens were obtained from 12 patients during arterial repair surgery and 3 patients during nephrectomy following a bolus injection of autologous radio-iodinated very low density lipoprotein (VLDL) up to 30 h before surgery. Radioactivity in apoprotein B (apo B) was determined in lipoprotein fractions isola...

journal_title：Atherosclerosis

authors： Nicoll A,Duffield R,Lewis B

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND AND AIMS:The TNF-superfamily member sTWEAK and its scavenger receptor sCD163 are potentially involved in pathophysiological processes of atherosclerosis. In patients with peripheral arterial disease, previous research has shown that sTWEAK and the sCD163/sTWEAK ratio were independently associated with long t...

journal_title：Atherosclerosis

authors： Mrak D,Zierfuss B,Höbaus C,Herz CT,Pesau G,Schernthaner GH

更新日期：2021-01-01 00:00:00

abstract：:The lecithin:cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma and plays a critical role in high density lipoprotein (HDL) metabolism. Genetic LCAT deficiency is a rare metabolic disorder characterized by low HDL cholesterol levels. This paper reviews the ...

journal_title：Atherosclerosis

authors： Calabresi L,Simonelli S,Gomaraschi M,Franceschini G

更新日期：2012-06-01 00:00:00

abstract：:The differences in the fatty acid spectra of serum samples obtained from vegetarians (62 females, 40 males) and non-vegetarians (70 females, 38 males) were evaluated in a matched-pair study design. This study population made it possible to examine 48 female and 31 male pairs whose age difference did not exceed 3 years...

journal_title：Atherosclerosis

authors： Melchert HU,Limsathayourat N,Mihajlović H,Eichberg J,Thefeld W,Rottka H

更新日期：1987-05-01 00:00:00

abstract：:Elevated serum ferritin concentrations between 200 and 500 microg/l have been found to be a strong risk factor for acute myocardial infarction in Finnish men, but the reason for this association is still uncertain. In the Finnish population ferritin concentrations correlated with factors of insulin resistance syndrome...

journal_title：Atherosclerosis

authors： Halle M,König D,Berg A,Keul J,Baumstark MW

更新日期：1997-02-10 00:00:00

abstract：:Oxidative stress is associated with many chronic diseases. In this review, we look at the role that oxidative stress may play in diabetes and related cardiovascular disease (CVD) and how oxidative damage may be measured in the plasma. Increased production of reactive oxygen species (ROS) has been implicated in the ini...

journal_title：Atherosclerosis

authors： Stephens JW,Khanolkar MP,Bain SC

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To investigate the hypothesis that COMP can influence the morphology, stability and size of murine atherosclerotic lesions. METHODS:ApoE- and ApoE/COMP-knockout mice were fed a high-fat diet to develop atherosclerotic plaques at lesion sites of three different types; inflammatory and fibrous plaques induced ...

journal_title：Atherosclerosis

authors： Bond AR,Hultgårdh-Nilsson A,Knutsson A,Jackson CL,Rauch U

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND AND AIMS:High concentrations of low density lipoprotein (LDL) triglycerides have been associated with prevalent angiographic coronary artery disease. The present analysis was designed to investigate the association of LDL triglycerides with cardiovascular mortality and to explore possible mechanisms that may...

journal_title：Atherosclerosis

authors： Silbernagel G,Scharnagl H,Kleber ME,Delgado G,Stojakovic T,Laaksonen R,Erdmann J,Rankinen T,Bouchard C,Landmesser U,Schunkert H,März W,Grammer TB

更新日期：2019-03-01 00:00:00

abstract：:Several reports have suggested an association between lipid peroxidation and human carotid atherosclerosis, but few reports have demonstrated a link between lipid peroxidation and carotid plaques in humans. In this study, we investigated the relationship between clinical features, histopathological characteristics and...

journal_title：Atherosclerosis

authors： Nishi K,Uno M,Fukuzawa K,Horiguchi H,Shinno K,Nagahiro S

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Peripheral artery disease (PAD) is associated with poor mobility and fatigue, but the relationship between preclinical ankle-brachial index (ABI) and early markers of fatigue and functional decline has not been defined. METHODS:570 adults, 50 and older, from the Baltimore Longitudinal Study of Agin...

journal_title：Atherosclerosis

authors： Martinez-Amezcua P,Matsushita K,Simonsick EM,Ferrucci L,Schrack JA

更新日期：2018-05-01 00:00:00

abstract：:Atherosclerotic lesion progression is associated with intimal calcification. The earliest lesion that shows calcification is pathologic intimal thickening in which calcifications appear as microcalcifications that vary in size from <0.5 to 15 μm. The calcifications become larger as plaques progress, becoming punctate ...

journal_title：Atherosclerosis

authors： Jinnouchi H,Sato Y,Sakamoto A,Cornelissen A,Mori M,Kawakami R,Gadhoke NV,Kolodgie FD,Virmani R,Finn AV

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Increased arterial stiffness is associated with greater risk of cardiovascular events and mortality. However, in patients with peripheral arterial disease (PAD) who have severe atherosclerotic disorder or risk clustering, the major determinants of increased stiffness have been not clarified. METHODS:This st...

journal_title：Atherosclerosis

authors： Makita S,Matsui H,Naganuma Y,Abiko A,Tamada M,Nakamura M

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Given the role of estrogen in the regulation of lipid metabolism, we screened for functional polymorphisms in the estrogen receptor alpha (ER*), and examined for their influence on serum cholesterol. METHODS AND RESULTS:We identified a novel C>T polymorphism (ERNE-145), with a minor allele frequency of 41%. ...

journal_title：Atherosclerosis

authors： Figtree GA,Grieve SM,Speller B,Geiger MJ,Robinson BG,Channon KM,Ragoussis J,Collins P,Watkins H

更新日期：2008-08-01 00:00:00

abstract：:The pyridine derivative cerivastatin is a new entirely synthetic and enantiomerically pure inhibitor of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. As a sodium salt cerivastatin is present in the active, open ring form. Cerivastatin inhibited the membrane-bound (non-solubilized) HMG-CoA reductase of the native...

journal_title：Atherosclerosis

authors： Bischoff H,Angerbauer R,Bender J,Bischoff E,Faggiotto A,Petzinna D,Pfitzner J,Porter MC,Schmidt D,Thomas G

更新日期：1997-11-01 00:00:00

abstract：:Low density lipoproteins (LDL) isolated by ultracentrifugation induce cytotoxic changes in cultured human endothelial cells (EC) and fibroblasts if the ratio between LDL cholesterol and the final protein concentration of the culture medium exceeds 0.10-0.12 mmol/g protein. In order to investigate if reactive oxygen sp...

journal_title：Atherosclerosis

authors： Evensen SA,Galdal KS,Nilsen E

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVE:In this study, we compared the changes in arterial stiffness in chronic hemodialysis patients treated with 8-h vs. 4-h thrice weekly in-center hemodialysis. METHODS:Sixty prevalent chronic hemodialysis patients assigned to 8-h nocturnal in-center thrice weekly HD (NHD) and 60 control cases assigned to 4-h th...

journal_title：Atherosclerosis

authors： Demirci MS,Celik G,Ozkahya M,Tumuklu M,Toz H,Asci G,Duman S,Basci A,Kircelli F,Ozdogan O,Demirci C,Can L,Isik IO,Ok E,Long Dialysis Group.

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Epicardial adipose tissue (EAT) mass correlates with metabolic syndrome and coronary artery disease (CAD). However, little is known about the expression of genes involved in triglyceride (TG) storage and mobilization in EAT. We therefore analyzed the expression of genes involved in fat mobilization in EAT in...

journal_title：Atherosclerosis

authors： Jaffer I,Riederer M,Shah P,Peters P,Quehenberger F,Wood A,Scharnagl H,März W,Kostner KM,Kostner GM

更新日期：2012-01-01 00:00:00

abstract：:Cholesteryl esters (CE) exchange between lipoproteins through the action of cholesteryl ester transfer protein (CETP). Situations at high risk for atherosclerosis are often accompanied by an accelerated net mass CE transfer (CET) from high density lipoproteins (HDL) to very low (VLDL) and low density lipoproteins (LDL...

journal_title：Atherosclerosis

authors： Elchebly M,Porokhov B,Pulcini T,Berthezène F,Ponsin G

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Bisphenol A (BPA) levels have previously been associated with coronary heart disease (CHD). Since CHD is an atherosclerotic disease, we investigated if circulating levels of BPA and phthalate metabolites are related to atherosclerosis in a cross-sectional study. METHODS:In the population-based...

journal_title：Atherosclerosis

authors： Lind PM,Lind L

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Atherogenic dyslipidemia (AD), characterized by high plasma triglycerides and low HDL particles, is considered one of the main effectors of vascular damage associated with obesity, metabolic syndrome (MS) and type 2 diabetes. Adipocyte fatty acid-binding protein (FABP4) plasma concentrations have been linked ...

journal_title：Atherosclerosis

authors： Cabré A,Babio N,Lázaro I,Bulló M,Garcia-Arellano A,Masana L,Salas-Salvadó J

更新日期：2012-05-01 00:00:00

abstract：:The relationship of ischaemic heart disease (IHD) to seasonal and latitude variation has prompted speculation that exposure to the ultraviolet component of solar radiation may reduce IHD risk. This hypothesis was partially tested by exposing 14 post-myocardial infarction patients to a 6 week course of artificial whole...

journal_title：Atherosclerosis

authors： Clark P,Cockburn F,Cowan RA,Czapla K,Dunnigan MG,Farish E,Hughes E

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Familial dysbetalipoproteinemia (FD), also known as type III hyperlipoproteinemia, is a genetic dyslipidemia characterized by elevated very low density lipoprotein (VLDL) and chylomicron remnant particles that confers increased risk of cardiovascular disease (CVD). The objective of this study was to evaluate...

journal_title：Atherosclerosis

authors： Koopal C,Retterstøl K,Sjouke B,Hovingh GK,Ros E,de Graaf J,Dullaart RP,Bertolini S,Visseren FL

更新日期：2015-05-01 00:00:00

abstract：:The ontogenic development of lipoprotein lipase and liver triglyceride hydrolase was studied in the rat. The enzyme activity measured in extrahepatic tissues fulfilled the criteria of lipoprotein lipase from the onset of measurable activity, i.e. it was inhibited by protamine and 1 M NaCl and showed requirement for se...

journal_title：Atherosclerosis

authors： Chajek T,Stein O,Stein Y

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:Various infectious agents are associated with atherosclerosis. This analysis was performed to investigate relation between seropositivity for anti-Borrelia IgG and carotid atherosclerosis. METHODS:The cross-sectional Study of Health in Pomerania was conducted in a general community living in a region with e...

journal_title：Atherosclerosis

authors： Völzke H,Wolff B,Lüdemann J,Guertler L,Kramer A,John U,Felix SB

更新日期：2006-01-01 00:00:00

abstract：:Collagenous components were extracted from bovine aorta by pepsin digestion. Differential salt precipitations separated the interstitial from the basement membrane (BM) collagens, and the latter were subsequently separated into three distinct types. Ion exchange chromatography, SDS-slab gel electrophoresis, cyanogen b...

journal_title：Atherosclerosis

authors： Leushner JR,Haust MD

更新日期：1984-01-01 00:00:00

abstract：:Low-density lipoprotein (LDL) concentration in plasma is an important predictor for atherosclerosis, and desialylated LDL has been proposed to be particularly atherogenic. Atherosclerosis is also associated with vascular endothelial dysfunction. We therefore wished to test the hypothesis that removal of sialic acid re...

journal_title：Atherosclerosis

authors： Stratton PD,Lumb PJ,Paganga G,Crook MA,Ferro A

更新日期：2001-02-01 00:00:00

abstract：:Atherosclerosis is an inflammatory disease characterised by increased expression of adhesion molecules for leukocytes on both the surface of dysfunctional endothelium and on smooth muscle cells (SMC) within the lesion. It is also characterised by altered SMC phenotypic expression, indicated by a decreased volume fract...

journal_title：Atherosclerosis

authors： Rolfe BE,Muddiman JD,Smith NJ,Campbell GR,Campbell JH

更新日期：2000-03-01 00:00:00

abstract：:We studied the functional role of N-linked sugar chains of apolipoprotein (apo) B-100 of low density lipoprotein (LDL) in cholesterol metabolism. The N-linked sugar chains of apo B-100 of LDL obtained from four homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits were liberated by hydrazinolysis, followed by Na...

journal_title：Atherosclerosis

authors： Fujioka Y,Taniguchi T,Ishikawa Y,Shiomi M,Yokoyama M

更新日期：1994-07-01 00:00:00

abstract：:Factor XIII is a transglutaminase that crosslinks fibrin in the last steps of the coagulation process. A few polymorphic sites have been identified in this gene, one of them being a point mutation (FXIII Val34Leu), leading to an amino acid change of valine to leucine. Recently, in British patients, FXIII 34Leu allele ...

journal_title：Atherosclerosis

authors： Wartiovaara U,Perola M,Mikkola H,Tötterman K,Savolainen V,Penttilä A,Grant PJ,Tikkanen MJ,Vartiainen E,Karhunen PJ,Peltonen L,Palotie A

更新日期：1999-02-01 00:00:00

abstract：:Polar coordinate mapping was used to determine the rate of growth of individual sudanophilic lesions on the aortic wall around several major branches of the aortae of cholesterol fed rabbits. Four groups, with 6 8-month old male albino white rabbits in each, were used in the study. One group served as a control and th...

journal_title：Atherosclerosis

authors： Roach MR,Fletcher J,Cornhill JF

更新日期：1976-10-01 00:00:00