Differential distribution of vasa vasorum in different vascular beds in humans.

abstract：:Chylomicron catabolism in the bloodstream consists of lipolysis by lipoprotein lipase and uptake of remnants by the liver. In rats, triglyceride-rich emulsions can mimic chylomicron metabolism. To further validate this model in man, the emulsion was injected intravenously into fasting and into subjects previously fed ...

journal_title：Atherosclerosis

authors： Maranhão RC,Feres MC,Martins MT,Mesquita CH,Toffoletto O,Vinagre CG,Gianinni SD,Pileggi F

更新日期：1996-09-27 00:00:00

abstract：:The possible mechanisms of action of probucol on the metabolism of low density lipoprotein and of high density lipoprotein were studied in 5 hyperlipidaemic subjects. The kinetics of LDL-B protein and of HDL-AI protein were determined by 2-pool analysis of specific radioactivity-time curves after reinjection of 131I-l...

journal_title：Atherosclerosis

authors： Nestel PJ,Billington T

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:A direct correlation between blood glucose levels and the microvascular complications of diabetes is well established. However, the effects of hyperglycaemia on the vasa vasorum, a microvascular network which surrounds and supplies the walls of large arteries, is not known. The objective of this study is to i...

journal_title：Atherosclerosis

authors： Veerman KJ,Venegas-Pino DE,Shi Y,Khan MI,Gerstein HC,Werstuck GH

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Mitochondrial damage and augmented production of reactive oxygen species (ROS) may represent an intermediate step by which hypercholesterolemia exacerbates atherosclerotic lesion formation. METHODS:To test this hypothesis, in mice with severe but genetically reversible hypercholesterolemia (i.e. th...

journal_title：Atherosclerosis

authors： Vilne B,Skogsberg J,Foroughi Asl H,Talukdar HA,Kessler T,Björkegren JLM,Schunkert H

更新日期：2017-12-01 00:00:00

abstract：:Rats were fed for 24 days a liquid diet with ethanol as 36% of calories to produce hyperlipemia and hepatic steatosis. The catabolism of chylomicrons doubly-labeled in the triacylglycerol and cholesteryl ester moieties was studied in conscious rats after ingestion of their usual liquid diets with or without ethanol. A...

journal_title：Atherosclerosis

authors： Redgrave TG,Martin G

更新日期：1977-09-01 00:00:00

abstract：AIM:The present clinical study tested the hypothesis that oil-rich fish consumption improves CHD risk factors. METHODS:Forty-eight (16 men) non-obese, healthy adults aged 20-55, consumed 125 g/day of salmon for a 4-week period followed by a 4-week period with no-fish (41 completers). Subjects were instructed to mainta...

journal_title：Atherosclerosis

authors： Lara JJ,Economou M,Wallace AM,Rumley A,Lowe G,Slater C,Caslake M,Sattar N,Lean ME

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:The association of high-density lipoprotein particle (HDL-P) with atherosclerosis may be stronger than that of HDL-cholesterol (HDL-C) and independent of conventional cardiovascular risk factors. Whether associations persist in populations at low risk of coronary heart disease (CHD) remains unclear. This stud...

journal_title：Atherosclerosis

authors： Zaid M,Fujiyoshi A,Miura K,Abbott RD,Okamura T,Takashima N,Torii S,Saito Y,Hisamatsu T,Miyagawa N,Ohkubo T,Kadota A,Sekikawa A,Maegawa H,Nakamura Y,Mitsunami K,Ueshima H,SESSA Research group.

更新日期：2015-04-01 00:00:00

abstract：:The ultrastructure of the aortic intima and serum lipid levels in Fischer 344 rats were examined at the ages of 12, 18 and 24 months after feeding the animals an atherogenic diet (2% cholesterol, 0.25% sodium cholate, 5% beef fat) for 6 months. Structural changes in the intima were noticeable only at the age of 24 mon...

journal_title：Atherosclerosis

authors： Nakamura H,Izumiyama N,Nakamura K,Ohtsubo K

更新日期：1989-10-01 00:00:00

abstract：:A marked reduction of serum cholesterol was obtained by treatment with probucol in heterozygous as well as in homozygous cases of familial hypercholesterolemia. A strict dietary regimen (low-fat, low-calories) intensified the hypocholesterolemic effect of the drug. The drug was also useful in diminishing the rebound o...

journal_title：Atherosclerosis

authors： Yamamoto A,Matsuzawa Y,Kishino B,Hayashi R,Hirobe K,Kikkawa T

更新日期：1983-08-01 00:00:00

abstract：:The presence of Chlamydia pneumoniae in the human arterial system has mainly been determined in atherosclerotic plaque, whereas the adventitia has remained relatively unexplored. We assessed the presence of C. pneumoniae in all three vessel wall layers of coronary (n=72) and brachial (n=48) arteries in relation to loc...

journal_title：Atherosclerosis

authors： Vink A,Pasterkamp G,Poppen M,Schoneveld AH,de Kleijn DP,Roholl PJ,Fontijn J,Plomp S,Borst C

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Treatment of severe peripheral arterial occlusive disease requires percutaneous revascularization. However, little is known about risk factors or predictors for reocclusion/restenosis. Cysteinyl leukotrienes are highly bioactive lipid mediators of inflammation. Their intravascular production may tak...

journal_title：Atherosclerosis

authors： Maga P,Sanak M,Rewerska B,Maga M,Jawien J,Wachsmann A,Rewerski P,Szczeklik W,Celejewska-Wójcik N

更新日期：2016-06-01 00:00:00

abstract：:High circulating levels of carotenoids have been thought to exhibit a protective function in the development of atherosclerosis. We investigated whether aortic atherosclerosis was associated with lower levels of the major serum carotenoids in alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein, lycopene, and zea...

journal_title：Atherosclerosis

authors： Klipstein-Grobusch K,Launer LJ,Geleijnse JM,Boeing H,Hofman A,Witteman JC

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:Bone marrow cell therapy contributes to collateral formation through the secretion of angiogenic factors by progenitor cells and muscle cells per se, thereby presenting a novel option for patients with critical limb ischemia. However, some cases are refractory to this therapy due to graft failure. Therefore, ...

journal_title：Atherosclerosis

authors： Ishii M,Numaguchi Y,Okumura K,Kubota R,Ma X,Murakami R,Naruse K,Murohara T

更新日期：2009-09-01 00:00:00

abstract：INTRODUCTION:Cardio- and/or cerebro-vascular risk are associated with high lipoprotein (a) [Lp(a)] levels and low-molecular-weight (LMW) apo(a) isoforms. Aims of this study were to evaluate the deposition of apo(a) isoforms and apoprotein B (apo B) in atherosclerotic plaque from patients (males and females) who had car...

journal_title：Atherosclerosis

authors： Baldo G,Giunco S,Kontothanassis D,Baiocchi MR,Valerio A,Frego M

更新日期：2007-07-01 00:00:00

abstract：:Paraoxanase (PON 1), a high-density lipoprotein-associated enzyme, exerts an antiatherogenic effect by protecting low-density lipoproteins (LDL) against oxidation. A common polymorphism at codon 192(Q/R) of the PON 1 gene has been shown to be associated with an adverse lipoprotein profile and increased coronary artery...

journal_title：Atherosclerosis

authors： Srinivasan SR,Li S,Chen W,Tang R,Bond MG,Boerwinkle E,Berenson GS

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND AIMS:The mechanisms that drive atherosclerotic plaque progression and destabilization in humans remain largely unknown. Laboratory models are needed to study these mechanisms under controlled conditions. The aim of this study was to establish a new ex vivo model of human atherosclerotic plaques that pres...

journal_title：Atherosclerosis

authors： Lebedeva A,Vorobyeva D,Vagida M,Ivanova O,Felker E,Fitzgerald W,Danilova N,Gontarenko V,Shpektor A,Vasilieva E,Margolis L

更新日期：2017-12-01 00:00:00

abstract：:Recent evidence suggests that sterol 27-hydroxylase may play a role in cholesterol homeostasis and affect atherogenesis. The major objective of the study was to map and characterize the sterol 27-hydroxylase (CYP27) promoter region. Here we show that CYP27 gene has a TATA-less promoter and transcription initiates at a...

journal_title：Atherosclerosis

authors： Segev H,Honigman A,Rosen H,Leitersdorf E

更新日期：2001-06-01 00:00:00

abstract：:The relationships between the particle size of low density lipoproteins (LDL) and various lipid parameters, including apolipoprotein (apo) E concentration and apo E phenotype, were analyzed in plasma samples obtained from 196 apparently healthy 35-year-old males. The LDL particle size was determined by gradient gel el...

journal_title：Atherosclerosis

authors： Zhao SP,Verhoeven MH,Vink J,Hollaar L,van der Laarse A,de Knijff P,van 't Hooft FM

更新日期：1993-09-01 00:00:00

abstract：AIMS:Apolipoprotein C-III (apoC-III) has been recognized as a useful marker of triglyceride-rich lipoproteins (TRLs) metabolism and proposed as an indicator of prognosis for coronary risk in healthy subjects. We studied cross-sectionally in a population having low cholesterol levels, but a high prevalence of the metabo...

journal_title：Atherosclerosis

authors： Onat A,Hergenç G,Sansoy V,Fobker M,Ceyhan K,Toprak S,Assmann G

更新日期：2003-05-01 00:00:00

abstract：AIMS:This study was set up to compare the accuracy, sensitivity and specificity of gene expression results between the Illumina HumanHT-12 v3 Expression BeadChip (GWE) and the TaqMan qRT-PCR low-density array (LDA) in atherosclerotic plaques. METHODS:Gene expression levels of 196 genes were determined from 22 atherosc...

journal_title：Atherosclerosis

authors： Raitoharju E,Seppälä I,Lyytikäinen LP,Levula M,Oksala N,Klopp N,Illig T,Laaksonen R,Kähönen M,Lehtimäki T

更新日期：2013-01-01 00:00:00

abstract：:To investigate the growth-regulating action of estrogen on vascular smooth muscle cells (SMC), effects of beta-17-estradiol (beta-E2) on phenotypic modulation and proliferation of rabbit aortic SMC were observed in vitro. At 10(-8)M, beta-E2 significantly slowed the decrease in volume fraction of myofilaments (Vv myo)...

journal_title：Atherosclerosis

authors： Song J,Wan Y,Rolfe BE,Campbell JH,Campbell GR

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Peripheral artery disease (PAD) is associated with poor mobility and fatigue, but the relationship between preclinical ankle-brachial index (ABI) and early markers of fatigue and functional decline has not been defined. METHODS:570 adults, 50 and older, from the Baltimore Longitudinal Study of Agin...

journal_title：Atherosclerosis

authors： Martinez-Amezcua P,Matsushita K,Simonsick EM,Ferrucci L,Schrack JA

更新日期：2018-05-01 00:00:00

abstract：:The ability of triglyceride (TG)-rich lipoproteins from apolipoprotein (apo) E2 heterozygote, apo E3/2 which is relatively common, to stimulate cholesteryl ester synthesis in human monocyte-derived macrophages was studied to clarify the atherogenicity of apo E3/2. Twenty-three subjects were randomly sampled from our h...

journal_title：Atherosclerosis

authors： Saito M,Eto M,Makino I

更新日期：1997-02-28 00:00:00

abstract：:According to the focal nature of atherosclerosis, ischemic stroke is frequently unilateral. Atherosclerotic plaques are favoured by local hemodynamic factors as low wall shear stress and/or elevated circumferential wall tension. Aim of the present study was to investigate the possible association between hemodynamic f...

journal_title：Atherosclerosis

authors： Carallo C,Lucca LF,Ciamei M,Tucci S,de Franceschi MS

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND AND AIMS:South Asians are at increased risk for cardiovascular disease (CVD). Aortic valve calcium (AVC) is associated with CVD risk and aortic stenosis. Elevated Lp(a) is a heritable risk factor for CVD and AVC. AVC prevalence and its association with Lp(a) have not been studied in South Asians. METHODS:Am...

journal_title：Atherosclerosis

authors： Makshood M,Joshi PH,Kanaya AM,Ayers C,Budoff M,Tsai MY,Blaha M,Michos ED,Post WS

更新日期：2020-11-01 00:00:00

abstract：:A study conducted in 1953 by one of the authors (H.S.M. Uhl) reported that orally administered ethylenediamine tetraacetic acid (EDTA) both prevented the accumulation of cholesterol in the liver of cholesterol-fed rabbits and caused the removal of accumulated cholesterol from the liver. These observations were made in...

journal_title：Atherosclerosis

authors： Uhl HS,Dysko RC,St Clair RW

更新日期：1992-10-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea results in nocturnal intermittent hypoxia (IH) as a main trigger for cardiovascular morbidity, including atherosclerosis. IH induces hemodynamic, hormono-metabolic and also immuno-inflammatory alterations that could differentially contribute to atherosclerosis. Our study aimed at exami...

journal_title：Atherosclerosis

authors： Arnaud C,Poulain L,Lévy P,Dematteis M

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes (DM2) and impaired glucose metabolism (IGM) are associated with an increased cardiovascular disease risk. Impaired endothelial synthesis of nitric oxide (NO) is an important feature of atherothrombosis and can be estimated from endothelium-dependent flow-mediated dilation (FMD). It is controv...

journal_title：Atherosclerosis

authors： Henry RM,Ferreira I,Kostense PJ,Dekker JM,Nijpels G,Heine RJ,Kamp O,Bouter LM,Stehouwer CD

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:Recent studies have revealed that sequence variation on chromosome 9p21 is a major genetic determinant for coronary heart disease and stroke, however, the underlying mechanism remains unknown. This genomic region contains the gene encoding cyclin-dependent kinase 2A, a regulator of proliferation and different...

journal_title：Atherosclerosis

authors： Ye S,Willeit J,Xiao Q,Motterle A,Laxton RC,Oberhollenzer F,Kiechl S,Xu Q

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Dietary long-chain (≥20 carbons) n-3 polyunsaturated fatty acids (PUFAs) reduce atherosclerosis and enhance macrophage autophagy activation. How macrophage autophagy impacts atherosclerotic progression, particularly when comparing dietary n-3 PUFA supplementation vs. saturated fat feeding, is unknow...

journal_title：Atherosclerosis

authors： Wang Z,Sequeira RC,Zabalawi M,Madenspacher J,Boudyguina E,Ou T,Nelson JM,Nie Y,Zhao Q,Fessler MB,Zhu X

更新日期：2020-02-01 00:00:00