Abstract:
:The relationships between the particle size of low density lipoproteins (LDL) and various lipid parameters, including apolipoprotein (apo) E concentration and apo E phenotype, were analyzed in plasma samples obtained from 196 apparently healthy 35-year-old males. The LDL particle size was determined by gradient gel electrophoresis. Using stepwise multiple regression analysis it was found that LDL particle size correlated negatively to the plasma concentrations of triglyceride (r = -0.497, P < 0.001), apo E (r = -0.415, P < 0.001), apo B (r = 0.395, P < 0.001) and cholesterol (r = -0.235, P < 0.001) and correlated positively to the plasma concentrations of apo A-I (r = 0.297, P < 0.001) and apo A-II (r = 0.145, P < 0.05). However, the LDL particle size did not differ significantly among the different apo E phenotypes. Indeed, when entered as a variable in the multiple regression analysis, the apo E phenotype was not correlated to the LDL particle size. It is concluded that the LDL particle size is related to the plasma concentrations of triglyceride, apo E, apo B, apo A-I, apo A-II and cholesterol and is not affected by the apo E phenotype in healthy 35-year-old males.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Zhao SP,Verhoeven MH,Vink J,Hollaar L,van der Laarse A,de Knijff P,van 't Hooft FMdoi
10.1016/0021-9150(93)90156-osubject
Has Abstractpub_date
1993-09-01 00:00:00pages
147-54issue
2eissn
0021-9150issn
1879-1484pii
0021-9150(93)90156-Ojournal_volume
102pub_type
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