Abstract:
:Oxidized low-density lipoproteins (LDL) impair endothelium-dependent dilation and constrict arteries. This study examined possible relation of the circulating plasma levels of Ox-LDL to coronary spastic angina (CSA). The plasma levels of Ox-LDL were measured by ELISA in 37 consecutive patients with CSA and normal coronary angiograms and in 79 consecutive control patients. The Ox-LDL levels in patients with CSA were significantly higher than those in controls. In multivariate analysis, higher levels of Ox-LDL were a risk factor for CSA independently of other traditional risk factors. The Ox-LDL levels had a significant and positive correlation with constrictor response of coronary arteries to the intracoronary acetylcholine infusion. Thus, Ox-LDL may play a possible role in pathogenesis of coronary spasm.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Kugiyama K,Sugiyama S,Soejima H,Kawano H,Sakamoto T,Takazoe K,Ogawa H,Doi H,Yasue Hdoi
10.1016/s0021-9150(00)00494-9keywords:
subject
Has Abstractpub_date
2001-02-01 00:00:00pages
463-7issue
2eissn
0021-9150issn
1879-1484pii
S0021-9150(00)00494-9journal_volume
154pub_type
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