PSK protects macrophages from lipoperoxide accumulation and foam cell formation caused by oxidatively modified low-density lipoprotein.

abstract：BACKGROUND AND AIMS:Long non-coding RNAs (lncRNAs) have proven to be involved in the progression of atherosclerosis and dyslipidemia. In addition, vascular smooth muscle cells (VSMCs) phenotype switching, including VSMCs-derived foam cells formation, plays a key role in the pathogenesis of atherosclerosis. LncRNA ENST0...

journal_title：Atherosclerosis

authors： Cai C,Zhu H,Ning X,Li L,Yang B,Chen S,Wang L,Lu X,Gu D

更新日期：2019-06-01 00:00:00

abstract：:VPS10P domain receptors are a unique class of sorting receptors that direct intracellular transport of target proteins in neurons and that play central roles in neurodegenerative processes. Surprisingly, genome-wide association studies now implicate the very same receptors in cardiovascular and metabolic disturbances....

journal_title：Atherosclerosis

authors： Schmidt V,Willnow TE

更新日期：2016-02-01 00:00:00

abstract：AIMS:Apolipoprotein C-III (apoC-III) has been recognized as a useful marker of triglyceride-rich lipoproteins (TRLs) metabolism and proposed as an indicator of prognosis for coronary risk in healthy subjects. We studied cross-sectionally in a population having low cholesterol levels, but a high prevalence of the metabo...

journal_title：Atherosclerosis

authors： Onat A,Hergenç G,Sansoy V,Fobker M,Ceyhan K,Toprak S,Assmann G

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Astaxanthin has been reported to improve dyslipidemia and metabolic syndrome in animals, but such effects in humans are not well known. METHODS:Placebo-controlled astaxanthin administration at doses of 0, 6, 12, 18 mg/day for 12 weeks was randomly allocated to 61 non-obese subjects with fasting serum trigly...

journal_title：Atherosclerosis

authors： Yoshida H,Yanai H,Ito K,Tomono Y,Koikeda T,Tsukahara H,Tada N

更新日期：2010-04-01 00:00:00

abstract：:A soluble form of endoglin (sEng) is known to be an extracellular domain of the full-length membrane endoglin, which is elevated during various pathological conditions related to vascular endothelium. In the current review, we tried to summarize a possible role of soluble endoglin in cardiovascular pathologies, focusi...

journal_title：Atherosclerosis

authors： Rathouska J,Jezkova K,Nemeckova I,Nachtigal P

更新日期：2015-12-01 00:00:00

abstract：:We measured 381 genomewide markers and performed genetic linkage analyses in search of loci influencing coronary artery calcification (CAC), a measure of atherosclerosis determined by electron beam computed tomography, in 948 non-Hispanic white siblings (mean age [+/-standard deviation] = 59.6 +/- 9.9 years; 73.7% hyp...

journal_title：Atherosclerosis

authors： Turner ST,Peyser PA,Kardia SL,Bielak LF,Sheedy PF 3rd,Boerwinkle E,de Andrade M

更新日期：2006-04-01 00:00:00

abstract：:The relationships between the particle size of low density lipoproteins (LDL) and various lipid parameters, including apolipoprotein (apo) E concentration and apo E phenotype, were analyzed in plasma samples obtained from 196 apparently healthy 35-year-old males. The LDL particle size was determined by gradient gel el...

journal_title：Atherosclerosis

authors： Zhao SP,Verhoeven MH,Vink J,Hollaar L,van der Laarse A,de Knijff P,van 't Hooft FM

更新日期：1993-09-01 00:00:00

abstract：:beta-Oxidation of long-chain fatty acids increases many-fold in atherosclerotic aortas; this may be due to an increase in the activity of the mitochondrial enzyme hexadecanoyl-CoA: carnitine O-hexadecanoyltransferase EC 2.3.1.23 (trivial name: carnitine palmitoyltransferase, CPT). To investigate this possibility, an a...

journal_title：Atherosclerosis

authors： Gillies PJ,Bell FP

更新日期：1979-09-01 00:00:00

abstract：:Thirty-nine synthetic (32 Dacron and 7 Teflon) arterial prostheses (from 38 patients with peripheral arterial disease) removed after periods between 2 months and 18 years, were examined by histology and immuno-histology. The grafts were initially permeated by thrombus containing platelet antigens and this became organ...

journal_title：Atherosclerosis

authors： Walton KW,Slaney G,Ashton F

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Genetic and environmental factors are important components of the development of atherosclerosis. Long non-coding RNA (lncRNAs) have emerged as regulators of multiple pathophysiological pathways in the cardiovascular system. Here, we investigated potential associations between lncRNAs and atheroscle...

journal_title：Atherosclerosis

authors： Arslan S,Berkan Ö,Lalem T,Özbilüm N,Göksel S,Korkmaz Ö,Çetin N,Devaux Y,Cardiolinc™ network.

更新日期：2017-11-01 00:00:00

abstract：:Cholesterol lowering in both primary and secondary prevention has been clearly demonstrated to lower coronary morbidity and, in secondary prevention, to lower coronary mortality as well. Putative dangers of cholesterol lowering remain unproven. Population studies linking low cholesterol to noncoronary mortalities do n...

journal_title：Atherosclerosis

authors： LaRosa JC

更新日期：1994-08-01 00:00:00

abstract：:This is a study to define the profile of chemokine receptors expressed on isolated infiltrating lymphocytes in human abdominal aortic aneurysms (AAAs), and to examine their role in lymphoid recruitment. AAA T-lymphocytes were CXCR4-positive, CCR7-negative and partially CXCR3 and CCR5-positive. Functionally, AAA T-cell...

journal_title：Atherosclerosis

authors： Ocaña E,Pérez-Requena J,Bohórquez JC,Brieva JA,Rodríguez C

更新日期：2008-10-01 00:00:00

abstract：:Mild hyperhomocysteinemia is considered an important risk factor for vascular disease. A common polymorphism (677C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with a decreased enzyme activity and consequent higher circulating levels of homocysteine. We hypothesized that the serum levels ...

journal_title：Atherosclerosis

authors： Pisciotta L,Cortese C,Gnasso A,Liberatoscioli L,Pastore A,Mannucci L,Irace C,Federici G,Bertolini S

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:To investigate whether atherosclerosis can be prevented by magnetically labeled endothelial progenitor cells (EPCs) in rabbits. MATERIALS AND METHODS:EPCs derived from rabbit periphery blood were labeled with a superparamagnetic iron oxide (SPIO) agent Fe(2)O(3)-poly-L-lysine (Fe(2)O(3)-PLL). Rabbit atheroscle...

journal_title：Atherosclerosis

authors： Ma ZL,Mai XL,Sun JH,Ju SH,Yang X,Ni Y,Teng GJ

更新日期：2009-07-01 00:00:00

abstract：:An attempt was made to explore the reasons why men develop coronary heart disease (CHD) despite being at low risk on the basis of established risk factors. A case control study was designed to take place after the end of a longitudinal study in which both low- and high-risk men who had developed CHD over the course of...

journal_title：Atherosclerosis

authors： Heller RF,Miller NE,Wheeler MJ,Kind PR

更新日期：1983-11-01 00:00:00

abstract：:MGL-3196 is an oral, liver-targeted selective agonist for the thyroid hormone receptor-β (THR-β) that is being developed for the treatment of dyslipidemia. The safety profile and tolerability of THR-β agonist MGL-3196 was assessed in first-in humans studies, including a single ascending dose study (NCT01367873) in whi...

journal_title：Atherosclerosis

authors： Taub R,Chiang E,Chabot-Blanchet M,Kelly MJ,Reeves RA,Guertin MC,Tardif JC

更新日期：2013-10-01 00:00:00

abstract：:Variations of circulating C-reactive protein (CRP) levels are supposed to reflect chronic inflammatory process of the cardiovascular system. In particular, it has been reported that high-sensitivity CRP (hsCRP) is a promising marker of coronary heart disease. In the present study, we assessed the relationship between ...

journal_title：Atherosclerosis

authors： Saito M,Ishimitsu T,Minami J,Ono H,Ohrui M,Matsuoka H

更新日期：2003-03-01 00:00:00

abstract：:Elevated fibrinogen levels after coronary balloon angioplasty have been reported to be useful in predicting restenosis. Therefore, we sought to evaluate the relationship between preprocedural fibrinogen levels and the 6-12-month outcomes of patients undergoing coronary stenting. Plasma levels of fibrinogen were measur...

journal_title：Atherosclerosis

authors： Otsuka M,Hayashi Y,Ueda H,Imazu M,Kohno N

更新日期：2002-10-01 00:00:00

abstract：:We investigated the association between the multiple metabolic risk factors and cardiovascular and overall mortality among Korean men, a population with a low prevalence of obesity. This prospective cohort study involved 682,597 Korean men, aged 30-69 years at baseline (1992), who were initially without cancer or debi...

journal_title：Atherosclerosis

authors： Park HS,Cho SI,Song YM,Sung J

更新日期：2006-07-01 00:00:00

abstract：:The metabolism of homocysteine requires contributions of several enzymes and vitamin cofactors. Earlier studies identified a common polymorphism of methylenetetrahydrofolate reductase that was associated with mild hyperhomocysteinemia. Common variants of two other enzymes involved in homocysteine metabolism, methionin...

journal_title：Atherosclerosis

authors： Jacques PF,Bostom AG,Selhub J,Rich S,Ellison RC,Eckfeldt JH,Gravel RA,Rozen R,National Heart, Lung and Blood Institute, National Institutes of Health.

更新日期：2003-01-01 00:00:00

abstract：:Apolipoprotein B (apoB) release from activated washed human platelets was measured by enzyme-linked immunosorbent assay (ELISA) using monospecific rabbit antibodies to human low density lipoprotein (LDL). Activation of platelets with thrombin, Ca2+-ionophore A23187 or stable analogue of prostaglandin endoperoxides U46...

journal_title：Atherosclerosis

authors： Preobrazhensky SN,Podrez EA,Tsibulsky VP,Fuki IV,Mazurov AV,Repin VS,Smirnov VN

更新日期：1986-09-01 00:00:00

abstract：:Oxidative stress is associated with atherosclerosis. Familial combined hyperlipidemia (FCH) is considered as a human model of primary dyslipidemia and atherosclerosis frequently associated with insulin resistance (IR), but there are few data on its possible relation to oxidative stress. The objective of this study was...

journal_title：Atherosclerosis

authors： Martinez-Hervas S,Fandos M,Real JT,Espinosa O,Chaves FJ,Saez GT,Salvador A,Cerdá C,Carmena R,Ascaso JF

更新日期：2008-08-01 00:00:00

abstract：:The effect of endothelial cells (EC) on the binding and internalisation of beta-very low density lipoprotein (beta-VLDL) and the subsequent accumulation of lipid was investigated in cultured smooth muscle cells (SMC) of different phenotype. The following combinations were examined: (i) SMC cultured and incubated with ...

journal_title：Atherosclerosis

authors： Horrigan S,Campbell JH,Campbell GR

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Divergent results have emerged in the past when relating single markers of inflammation to measures of vascular reactivity. The aim of the present study is to relate a wide range of inflammatory markers to vasoreactivity in both resistance and conductance arteries. METHODS:In the Prospective Investigation o...

journal_title：Atherosclerosis

authors： Lind L,Siegbahn A,Hulthe J,Elmgren A

更新日期：2008-07-01 00:00:00

abstract：:The importance of platelets for cardiovascular disease was established as early as the 19th century. Their therapeutic inhibition stands alongside the biggest achievements in medicine. Still, certain aspects of platelet pathophysiology remain unclear. This includes platelet resistance to antiplatelet therapy and the c...

journal_title：Atherosclerosis

authors： Gutmann C,Joshi A,Mayr M

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Lipoprotein(a) [Lp(a)] consists of apolipoprotein B-100 (apoB-100) as part of an LDL-like particle and the covalently linked glycoprotein apolipoprotein(a) [apo(a)]. Detailed mechanisms of its biosynthesis, assembly, secretion and catabolism are still poorly understood. To address the Lp(a) assembly mechanism...

journal_title：Atherosclerosis

authors： Frischmann ME,Ikewaki K,Trenkwalder E,Lamina C,Dieplinger B,Soufi M,Schweer H,Schaefer JR,König P,Kronenberg F,Dieplinger H

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION:Cardio- and/or cerebro-vascular risk are associated with high lipoprotein (a) [Lp(a)] levels and low-molecular-weight (LMW) apo(a) isoforms. Aims of this study were to evaluate the deposition of apo(a) isoforms and apoprotein B (apo B) in atherosclerotic plaque from patients (males and females) who had car...

journal_title：Atherosclerosis

authors： Baldo G,Giunco S,Kontothanassis D,Baiocchi MR,Valerio A,Frego M

更新日期：2007-07-01 00:00:00

abstract：:Factor XIII is a transglutaminase that crosslinks fibrin in the last steps of the coagulation process. A few polymorphic sites have been identified in this gene, one of them being a point mutation (FXIII Val34Leu), leading to an amino acid change of valine to leucine. Recently, in British patients, FXIII 34Leu allele ...

journal_title：Atherosclerosis

authors： Wartiovaara U,Perola M,Mikkola H,Tötterman K,Savolainen V,Penttilä A,Grant PJ,Tikkanen MJ,Vartiainen E,Karhunen PJ,Peltonen L,Palotie A

更新日期：1999-02-01 00:00:00

abstract：:The Del allele of the apolipoprotein B (apoB) signal peptide (SP) insertion/deletion (Ins/Del) polymorphism has been shown to be associated with elevated plasma levels of apoB, cholesterol and low density lipoprotein. It was the aim of the present study to analyse the relation of this gene variation to the risk of cor...

journal_title：Atherosclerosis

authors： Gardemann A,Ohly D,Fink M,Katz N,Tillmanns H,Hehrlein FW,Haberbosch W

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:Recent reports have suggested that dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonists are associated with adverse cardiovascular events. This study aimed to investigate the actions of the non-thiazolidinedione PPARalpha/gamma agonist, compound 3q, on plaque development in the apolipop...

journal_title：Atherosclerosis

authors： Calkin AC,Allen TJ,Lassila M,Tikellis C,Jandeleit-Dahm KA,Thomas MC

更新日期：2007-11-01 00:00:00