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Peri-aortic fat, cardiovascular disease risk factors, and aortic calcification: the Framingham Heart Study.

Abstract：

OBJECTIVE:Perivascular fat through the secretion of paracrine and pro-inflammatory mediators may play a role in obesity-mediated vascular disease. We sought to examine associations between adipose tissue depots immediately surrounding the thoracic aorta, metabolic risk factors, and vascular calcification. METHODS:In participants free of cardiovascular disease (CVD) from the Framingham Heart Study Offspring cohort who underwent computed tomography (n=1067, mean age 59 years, 56.1% women), thoracic peri-aortic fat depots were quantified. Visceral abdominal tissue (VAT) and calcification of the thoracic and abdominal aorta were also measured. RESULTS:Peri-aortic fat depots were correlated with body mass index, waist circumference (WC), VAT (all p<0.0001), hypertension (p=0.007), low HDL (p<0.0001), serum triglycerides (p<0.0001), impaired fasting glucose (p=0.005), and diabetes (p=0.02). These associations generally remained significant after adjustment for BMI and WC (all p-values<0.05), but not after VAT adjustment. Thoracic aortic fat was associated with thoracic calcification in models containing VAT (OR 1.31, 95% CI 1.01-1.71, p=0.04), but was not significant after adjustment for CVD risk factors (OR 1.16, 95% CI 0.88-1.51, p=0.30). Thoracic aortic fat, however, was associated with abdominal aortic calcification (OR 1.48, 95% CI 1.11-1.98, p=0.008) and coronary artery calcification (OR 1.47, 95% CI 1.09-1.98, p=0.001) even in models including CVD risk factors and VAT. CONCLUSIONS:Thoracic peri-aortic fat is associated with measures of adiposity, metabolic risk factors, and coronary and abdominal aortic calcification.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Lehman SJ,Massaro JM,Schlett CL,O'Donnell CJ,Hoffmann U,Fox CS

doi

10.1016/j.atherosclerosis.2010.01.007

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

656-61

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(10)00053-5

journal_volume

210

pub_type

杂志文章

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