Abstract：
:Forty patients with NIDDM and hyperlipoproteinemia were selected for a 12-week double-blind placebo-controlled trial to study the effects of metformin on lipoprotein concentration and composition. A significant decrease occurred in VLDL-apo B and all lipid components of VLDL, indicating a decreased number of circulating VLDL, while LDL-apo B was unchanged. Moreover in VLDL the relative TG content increased, the cholesterol content decreased, while in LDL the TG content decreased and the cholesterol content increased, indicating a change in the particle distribution over the spectrum VLDL-IDL-LDL. The initially enhanced TG-content in HDL was reduced. While a reduction in VLDL is observed together with improving glucose control irrespective of the applied method, the observed compositional changes in VLDL and LDL have not been described before and seem to be metformin-specific.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Schneider J,Erren T,Zöfel P,Kaffarnik Hdoi
10.1016/0021-9150(90)90148-csubject
Has Abstractpub_date
1990-05-01 00:00:00pages
97-103issue
1-2eissn
0021-9150issn
1879-1484pii
0021-9150(90)90148-Cjournal_volume
82pub_type
临床试验,杂志文章,随机对照试验相关文献
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journal_title：Atherosclerosis
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journal_title：Atherosclerosis
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journal_title：Atherosclerosis
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pub_type： 杂志文章,多中心研究,随机对照试验
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