Abstract：
BACKGROUND:Astaxanthin has been reported to improve dyslipidemia and metabolic syndrome in animals, but such effects in humans are not well known. METHODS:Placebo-controlled astaxanthin administration at doses of 0, 6, 12, 18 mg/day for 12 weeks was randomly allocated to 61 non-obese subjects with fasting serum triglyceride of 120-200mg/dl and without diabetes and hypertension, aged 25-60 years. RESULTS:In before and after tests, body mass index (BMI) and LDL-cholesterol were unaffected at all doses, however, triglyceride decreased, while HDL-cholesterol increased significantly. Multiple comparison tests showed that 12 and 18 mg/day doses significantly reduced triglyceride, and 6 and 12 mg doses significantly increased HDL-cholesterol. Serum adiponectin was increased by astaxanthin (12 and 18 mg/day), and changes of adiponectin correlated positively with HDL-cholesterol changes independent of age and BMI. CONCLUSIONS:This first-ever randomized, placebo-controlled human study suggests that astaxanthin consumption ameliorates triglyceride and HDL-cholesterol in correlation with increased adiponectin in humans.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Yoshida H,Yanai H,Ito K,Tomono Y,Koikeda T,Tsukahara H,Tada Ndoi
10.1016/j.atherosclerosis.2009.10.012subject
Has Abstractpub_date
2010-04-01 00:00:00pages
520-3issue
2eissn
0021-9150issn
1879-1484pii
S0021-9150(09)00843-0journal_volume
209pub_type
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