Tissue-specific expression pattern of human endothelial lipase in transgenic mice.

abstract：:In vitro incubations of human low density lipoproteins (LDL), high density lipoproteins (HDL) and lipoprotein-free plasma at 37 degrees for 6 h revealed no significant net mass transfers of esterified cholesterol from either lipoprotein fraction to the other. Observed transfers of esterified [3H]cholesterol from LDL t...

journal_title：Atherosclerosis

authors： Barter PJ,Jones ME

更新日期：1979-09-01 00:00:00

abstract：:Lipoprotein(a) (Lp(a)) is regarded as an independent risk factor for Atherosclerotic cardiovascular disease. The objectives of this study were: to determine the effects of diet and exercise on Lp(a) and to evaluate the relation of Lp(a) with the lipid profile (total serum cholesterol (TC), triglycerides (TG), low dens...

journal_title：Atherosclerosis

authors： Randall OS,Feseha HB,Illoh K,Xu S,Ketete M,Kwagyan J,Tilghman C,Wrenn M

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Serum γ-glutamyl transferase (GGT) levels are known to be positively associated with obesity. We aimed at verifying an association between baseline GGT levels and the development of obesity in Korean men. PATIENTS AND METHODS:This prospective cohort study was performed on 18,510 initially non-...

journal_title：Atherosclerosis

authors： Suh YJ,Park SK,Choi JM,Ryoo JH

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To assess whether plasma IGFBP-2 is independently associated with components of the lipoprotein-lipid profile and to suggest a cutoff value that could identify subjects with the features of the metabolic syndrome. METHODS:In this cross-sectional study, 379 Caucasian men from the general population and coveri...

journal_title：Atherosclerosis

authors： Carter S,Li Z,Lemieux I,Alméras N,Tremblay A,Bergeron J,Poirier P,Deshaies Y,Després JP,Picard F

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:To compare lipid-lowering efficacy of adding alirocumab to rosuvastatin versus other treatment strategies (NCT01730053). METHODS:Patients receiving baseline rosuvastatin regimens (10 or 20 mg) were randomized to: add-on alirocumab 75 mg every-2-weeks (Q2W) (1-mL subcutaneous injection via pre-filled pen); ad...

journal_title：Atherosclerosis

authors： Farnier M,Jones P,Severance R,Averna M,Steinhagen-Thiessen E,Colhoun HM,Du Y,Hanotin C,Donahue S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The relationship between alcohol consumption and ischemic stroke or aortic atherosclerosis is unclear, but a protective effect of moderate consumption on stroke risk has been suggested. We conducted a cross-sectional analysis in a population-based sample to evaluate the possible association between alcohol c...

journal_title：Atherosclerosis

authors： Kohsaka S,Jin Z,Rundek T,Homma S,Sacco RL,Di Tullio MR

更新日期：2011-12-01 00:00:00

abstract：:Studies were performed to determine if serum bilirubin, when combined with various lipid and lipoprotein risk factors, enhances our ability to predict coronary artery disease (CAD). This hypothesis was tested in a retrospective study of 644 middle-aged males who had undergone coronary angiography. The traditional risk...

journal_title：Atherosclerosis

authors： Schwertner HA,Fischer JR Jr

更新日期：2000-06-01 00:00:00

abstract：:Epidemiological and clinical data demonstrate differences in atherosclerotic coronary heart disease prevalence between age-matched men and premenopausal women. Mechanisms underlying relative athero-susceptibility in men and athero-resistance in premenopausal women remain to be elucidated. Lack of informative animal mo...

journal_title：Atherosclerosis

authors： Herrera VL,Tsikoudakis A,Didishvili T,Ponce LR,Bagamasbad P,Gantz D,Herscovitz H,Van Tol A,Ruiz-Opazo N

更新日期：2004-11-01 00:00:00

abstract：:Whether an association, causative or not, exists between the level of serum selenium and the risk of ischaemic heart disease (IHD) remains unsettled. We investigated the issue in a cohort of 3387 males aged 53-74 years (mean 63). Based on information about health status, life-style and socioeconomic factors given in a...

journal_title：Atherosclerosis

authors： Suadicani P,Hein HO,Gyntelberg F

更新日期：1992-09-01 00:00:00

abstract：:Two groups of patients were administered either 4.5 X 10(6) U or 90 X 10(6) U each of recombinant DNA-derived interferon-beta serine (IFN-beta ser) i.v. daily for 10 days. IFN-beta ser affected lipoprotein lipids of patients in a dose dependent fashion. A decrease in plasma total cholesterol concentration occurred 24 ...

journal_title：Atherosclerosis

authors： Rosenzweig IB,Wiebe DA,Borden EC,Storer B,Shrago ES

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine with chemokine-like functions that plays a role in several inflammatory diseases including atherosclerosis. We recently demonstrated that in addition to macrophages and endothelial cells, platelets are a source of MIF. However, the funct...

journal_title：Atherosclerosis

authors： Wirtz TH,Tillmann S,Strüßmann T,Kraemer S,Heemskerk JW,Grottke O,Gawaz M,von Hundelshausen P,Bernhagen J

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:The scavenger receptor SR-PSOX/CXCL16, which is identical to the chemokine CXCL16, is thought to be involved in atherogenesis. However, the presence and function of SR-PSOX/CXCL16 in the endothelium of atherosclerotic arteries has not been substantiated. METHODS AND RESULTS:In rabbit aorta immunocytochemistr...

journal_title：Atherosclerosis

authors： Hofnagel O,Engel T,Severs NJ,Robenek H,Buers I

更新日期：2011-08-01 00:00:00

abstract：:In 137 living subjects, arteriosclerotic change in the human abdominal aorta was examined in relation to coronary heart disease (CHD) using a new ultrasonic method. The pressure strain elastic modulus (Ep) was calculated as an index of elastic properties from which arteriosclerotic change in the aorta was estimated. T...

journal_title：Atherosclerosis

authors： Imura T,Yamamoto K,Satoh T,Mikami T,Yasuda H

更新日期：1988-10-01 00:00:00

abstract：:Inflammation has been demonstrated to be an important risk factor for the development of cardiovascular events. Patients with elevated white blood cell counts have been shown to be in a higher risk of developing acute myocardial infarction and acute coronary and vascular events. We review the clinical data of high whi...

journal_title：Atherosclerosis

authors： Hoffman M,Blum A,Baruch R,Kaplan E,Benjamin M

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:The utility of lipoprotein particle profiles measured by nuclear magnetic resonance (NMR) spectroscopy beyond standard serum lipids remains inconclusive. Furthermore, few studies have compared NMR measurements with standard lipids in association with coronary artery calcification (CAC) in Japanese, where the ...

journal_title：Atherosclerosis

authors： Hisamatsu T,Fujiyoshi A,Miura K,Ohkubo T,Kadota A,Kadowaki S,Kadowaki T,Yamamoto T,Miyagawa N,Zaid M,Torii S,Takashima N,Murakami Y,Okamura T,Horie M,Ueshima H,SESSA Research Group.

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It has not been fully determined whether non-high-density lipoprotein cholesterol (non-HDLC) levels are involved in vascular events, especially stroke, in general Asian populations. We evaluated the association between non-HDLC levels and the risk of type-specific cardiovascular disease in a pros...

journal_title：Atherosclerosis

authors： Imamura T,Doi Y,Ninomiya T,Hata J,Nagata M,Ikeda F,Mukai N,Hirakawa Y,Yoshida D,Fukuhara M,Kitazono T,Kiyohara Y

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:Peroxisome proliferator-activated receptors alpha (PPARalpha) is a target gene for atherosclerosis and cardiovascular diseases. However, effects of PPARalpha on endothelial nitric oxide synthase (eNOS) remain unknown. We investigated the eNOS regulation by bezafibrate, a ligand of PPARalpha, and involved sign...

journal_title：Atherosclerosis

authors： Wang Y,Wang Y,Yang Q,Yan JT,Zhao C,Cianflone K,Wang DW

更新日期：2006-08-01 00:00:00

abstract：:Sex differences in incidence and prevalence of and morbidity and mortality from cardiovascular disease are well documented. However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent difficulty in studying t...

journal_title：Atherosclerosis

authors： Winham SJ,de Andrade M,Miller VM

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Previous studies have shown increases in ambulatory short-term blood pressure (BP) variability to be related to cardiovascular disease. In this study, we examined whether an angiotensin II type 1 receptor blocker losartan would improve ambulatory short-term BP variability in hypertensive patients on hemodialy...

journal_title：Atherosclerosis

authors： Mitsuhashi H,Tamura K,Yamauchi J,Ozawa M,Yanagi M,Dejima T,Wakui H,Masuda S,Azuma K,Kanaoka T,Ohsawa M,Maeda A,Tsurumi-Ikeya Y,Okano Y,Ishigami T,Toya Y,Tokita Y,Ohnishi T,Umemura S

更新日期：2009-11-01 00:00:00

abstract：:Two specific endothelial cell products, von Willebrand factor and soluble E-selectin, were measured together with serum lipids, lipoprotein(a), systolic and diastolic blood pressure (SHP, DBP) in a follow up study of 162 patients attending a dedicated lipid clinic. Patients were further classified by the presence or a...

journal_title：Atherosclerosis

authors： Blann AD,Miller JP,McCollum CN

更新日期：1997-07-25 00:00:00

abstract：:To investigate the growth-regulating action of estrogen on vascular smooth muscle cells (SMC), effects of beta-17-estradiol (beta-E2) on phenotypic modulation and proliferation of rabbit aortic SMC were observed in vitro. At 10(-8)M, beta-E2 significantly slowed the decrease in volume fraction of myofilaments (Vv myo)...

journal_title：Atherosclerosis

authors： Song J,Wan Y,Rolfe BE,Campbell JH,Campbell GR

更新日期：1998-09-01 00:00:00

abstract：:Recent studies demonstrate important roles for inflammation in development of atherosclerosis with current attention focusing on interactions of inflammation with traditional lipoprotein risk factors. Since the nature of such relationships is largely unknown, we sought to investigate interactions of inflammation with ...

journal_title：Atherosclerosis

authors： Corsetti JP,Zareba W,Moss AJ,Rainwater DL,Sparks CE

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Overt atherosclerotic cardiovascular disease (ASCVD) warrants aggressive lipid lowering. Imaging for ambiguous symptoms suggesting ischemia or for clarification of CV risk in asymptomatic individuals often uncovers previously unknown ASCVD. Guidelines do not provide clear recommendations for aggress...

journal_title：Atherosclerosis

authors： Mancini GBJ,Gupta M,Tsigoulis M,Cannon CP,Genest J,Ray KK,Santos RD,Watts GF,Raggi P

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND AND AIMS:We aimed at developing a novel risk prediction model for death from cardiovascular disease (CVD) for Chinese individuals, based upon a large cohort from Taiwan. METHODS:This Chinese cohort came from Taiwan, with 381,963 individuals free from CVD, recruited from a private health surveillance program...

journal_title：Atherosclerosis

authors： Hu WS,Lee JH,Tsai MK,Wen CP

更新日期：2017-09-01 00:00:00

abstract：:We investigated the association between the multiple metabolic risk factors and cardiovascular and overall mortality among Korean men, a population with a low prevalence of obesity. This prospective cohort study involved 682,597 Korean men, aged 30-69 years at baseline (1992), who were initially without cancer or debi...

journal_title：Atherosclerosis

authors： Park HS,Cho SI,Song YM,Sung J

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Atherosclerosis is characterized by lipid accumulation and chronic inflammation in the arterial wall. Elevated levels of apolipoprotein (apo) B-containing lipoproteins are a risk factor for cardiovascular disease (CVD). By contrast, plasma levels of functional high-density lipoprotein (HDL) and apoA-I are pr...

journal_title：Atherosclerosis

authors： Hennuyer N,Duplan I,Paquet C,Vanhoutte J,Woitrain E,Touche V,Colin S,Vallez E,Lestavel S,Lefebvre P,Staels B

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Nonalcoholic fatty liver disease (NAFLD) may be associated with a wide spectrum of cardiac abnormalities, which share many metabolic risk factors. This study aimed to evaluate whether NAFLD is associated with left ventricular (LV) diastolic dysfunction independent of other classical risk factors. M...

journal_title：Atherosclerosis

authors： Chung GE,Lee JH,Lee H,Kim MK,Yim JY,Choi SY,Kim YJ,Yoon JH,Kim D

更新日期：2018-05-01 00:00:00

abstract：:Recent evidence suggests that sterol 27-hydroxylase may play a role in cholesterol homeostasis and affect atherogenesis. The major objective of the study was to map and characterize the sterol 27-hydroxylase (CYP27) promoter region. Here we show that CYP27 gene has a TATA-less promoter and transcription initiates at a...

journal_title：Atherosclerosis

authors： Segev H,Honigman A,Rosen H,Leitersdorf E

更新日期：2001-06-01 00:00:00

abstract：:The offspring of type 2 diabetic patients are at elevated risk for type 2 diabetes and cardiovascular disease. The aim of our study was to characterize the role of various biomarkers of endothelial activation in a cohort of offspring of type 2 diabetic subjects and to assess the association of adhesion molecules with ...

journal_title：Atherosclerosis

authors： Ruotsalainen E,Vauhkonen I,Salmenniemi U,Pihlajamäki J,Punnonen K,Kainulainen S,Jalkanen S,Salmi M,Laakso M

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:How 9p21 variation affects risk of cardiovascular disease is unclear, so we assessed whether 9p21 variants are associated with arterial elasticity or retinal microvascular findings. METHODS:In the prospective Multi-Ethnic Study of Atherosclerosis (MESA) we assessed 378 SNPs in the 9p21 locus. Within four eth...

journal_title：Atherosclerosis

authors： Folsom AR,Pankow JS,Li X,Duprez DA,Jacobs DR Jr,Klein R,Klein B,Tang W,Wong TY,Cotch MF,Taylor KD,Rich SS,Hall JL,Post WS,Rotter JI

更新日期：2013-10-01 00:00:00