SR-PSOX at sites predisposed to atherosclerotic lesion formation mediates monocyte-endothelial cell adhesion.

abstract：BACKGROUND:CVD risk increases in women after menopause. Recent data suggest higher levels of complement protein C3 and cardiovascular fat (CF) in postmenopausal women. Whether complement proteins are associated with early markers of atherosclerosis in healthy midlife women has never been evaluated. Additionally, the po...

journal_title：Atherosclerosis

authors： Nagaraj N,Matthews KA,Shields KJ,Barinas-Mitchell E,Budoff MJ,El Khoudary SR

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the relationship between brachial flow-mediated dilation (FMD) and carotid intima-media thickness (IMT) in a large multi-ethnic elderly cohort. BACKGROUND:Brachial flow-mediated dilation (FMD) is a physiologic measure and carotid IMT is an anatomic structural measure of...

journal_title：Atherosclerosis

authors： Yeboah J,Burke GL,Crouse JR,Herrington DM

更新日期：2008-04-01 00:00:00

abstract：:Men with ankylosing spondylitis (AS) and females with systemic lupus erythematosus (SLE) were found to have low total serum lipid concentrations similar to results previously obtained in patients with rheumatoid arthritis (RA). In AS men total serum TG was about 50% of control values and in AS men and SLE women total ...

journal_title：Atherosclerosis

authors： Rössner S

更新日期：1978-09-01 00:00:00

abstract：:Statins are widely used for treatment of hypercholesterolemia. Recent experimental studies revealed that these drugs also exert anti-inflammatory effects. The aim of this study was to assess immunomodulatory effects of statins in humans in vivo. Twenty-seven healthy volunteers were analyzed for serum cytokines and acu...

journal_title：Atherosclerosis

authors： Fehr T,Kahlert C,Fierz W,Joller-Jemelka HI,Riesen WF,Rickli H,Wüthrich RP,Ammann P

更新日期：2004-07-01 00:00:00

abstract：:To test the hypothesis of altered energy production in aortic sites predisposed to lesion formation, both coupled oxidative phosphorylation (evaluated from P/O ratios) and control of the energy-linked (ATP) NADH transhydrogenase were examined in muscular cushions at the celiac artery bifurcation. Comparisons were made...

journal_title：Atherosclerosis

authors： Hajjar DP,Smith SC

更新日期：1980-06-01 00:00:00

abstract：:beta-very low-density lipoprotein (beta-VLDL), a collective term for VLDL and chylomicron remnants, has recently shown to potently promote the development of atherosclerosis. However, the effects of beta-VLDL on the accumulation of nitric oxide (NO) and the expression of inducible NO synthase (iNOS) in vascular smooth...

journal_title：Atherosclerosis

authors： Takahashi M,Takahashi S,Shimpo M,Naito A,Ogata Y,Kobayashi E,Ikeda U,Shimada K

更新日期：2002-06-01 00:00:00

abstract：:Genome-wide association studies (GWASs) have identified several risk loci for coronary artery calcification. Four single-nucleotide polymorphisms (SNPs, rs1537370, rs1333049, rs2026458 and rs9349379) were associated with coronary artery calcification with P values less than 5 × 10(-8) in GWASs. It is unclear if these ...

journal_title：Atherosclerosis

authors： Zhang Y,Wang L,Zhang Z,Zhang Z,Zhou S,Cao L,Cai B,Liu K,Bai W,Xie X,Fan W,Liu X,Lu G,Xu G

更新日期：2015-08-01 00:00:00

abstract：:The metabolism in vitro of exogenous and endogenous arachidonic acid was studied in circulating blood monocytes obtained from control (control group) and cholesterol (0.5%)-fed (cholesterol group) rabbits. The production of superoxide anion (O2-), tissue plasminogen activator (t-PA) and adherence of monocytes were ass...

journal_title：Atherosclerosis

authors： Saito H,Salmon JA,Moncada S

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Ticagrelor reduces cardiovascular events in patients with acute coronary syndrome (ACS). Recent studies demonstrated the expression of P2Y12 on vascular cells including endothelial cells, as well as platelets, and suggested its contribution to atherogenesis. We investigated whether ticagrelor attenu...

journal_title：Atherosclerosis

authors： Ganbaatar B,Fukuda D,Salim HM,Nishimoto S,Tanaka K,Higashikuni Y,Hirata Y,Yagi S,Soeki T,Sata M

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Studying atherosclerotic calcification in vivo requires mouse models with genetic modifications. Previous studies showed that injection of recombinant adeno-associated virus vector (AAV) encoding a gain-of-function mutant PCSK9 into mice promotes atherosclerosis. We aimed to study cardiovascular cal...

journal_title：Atherosclerosis

authors： Goettsch C,Hutcheson JD,Hagita S,Rogers MA,Creager MD,Pham T,Choi J,Mlynarchik AK,Pieper B,Kjolby M,Aikawa M,Aikawa E

更新日期：2016-08-01 00:00:00

abstract：:The effect of a fish lipid concentrate rich in eicosapentaenoic acid was studied in 107 subjects for periods up to 2 years. Ninety-two had heart disease or hyper-lipidaemia and 15 had no history of heart disease. Serum triglyceride levels were rapidly reduced, cholesterol fell more slowly but high density lipoprotein ...

journal_title：Atherosclerosis

authors： Saynor R,Verel D,Gillott T

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:PPARgamma (PPARg) is a nuclear transcription factor involved in the control of lipid and glucose homeostasis. Two PPARg common polymorphisms, Pro12Ala and 161C>T, have been found to be associated with cardiovascular disease. In this study, in addition to PPARg coding region, we looked for genetic variations ...

journal_title：Atherosclerosis

authors： Evangelisti L,Attanasio M,Lucarini L,Sofi F,Marcucci R,Giglioli C,Valente S,Gensini G,Abbate R,Pepe G

更新日期：2009-07-01 00:00:00

abstract：:The ultrastructural effects of a single brief intra-arterial infusion of palmitic, linoleic and acetoacetic acid on the arterial endothelium of the rat were investigated, and the following results obtained: (1) Palmitic acid, infused at a concentration of 4 mM/l, damaged the arterial lining by producing large cytoplas...

journal_title：Atherosclerosis

authors： Constantinides P,Kiser M

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND AND AIMS:The pathogenesis of abdominal aortic aneurysm (AAA) shares several common pathways with atherosclerosis. Prospective clinical plasma biomarker studies in AAA have been hampered by the need for very large cohorts and long follow-up time. METHODS:We analyzed a prospective longitudinal cohort of middl...

journal_title：Atherosclerosis

authors： Acosta S,Taimour S,Gottsäter A,Persson M,Engström G,Melander O,Zarrouk M,Nilsson PM,Smith JG

更新日期：2017-07-01 00:00:00

abstract：:Human serum paraoxonase (PON1) is an HDL-associated enzyme involved in the protection of lipoproteins from oxidation. A polymorphism at position 192 (Gln/Arg) influences its activity in a substrate-dependent manner. The aim of the present study was to evaluate, in vivo, the contribution of the PON1-192 polymorphism to...

journal_title：Atherosclerosis

authors： Gnasso A,Motti C,Irace C,Di Gennaro I,Pujia A,Leto E,Ciamei M,Crivaro A,Bernardini S,Federici G,Cortese C

更新日期：2002-10-01 00:00:00

abstract：:High serum concentrations of soluble adhesion molecules are present in diabetics, but whether similar levels are present in patients with impaired glucose tolerance (IGT) is unclear. We measured serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), an...

journal_title：Atherosclerosis

authors： Matsumoto K,Miyake S,Yano M,Ueki Y,Tominaga Y

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:How 9p21 variation affects risk of cardiovascular disease is unclear, so we assessed whether 9p21 variants are associated with arterial elasticity or retinal microvascular findings. METHODS:In the prospective Multi-Ethnic Study of Atherosclerosis (MESA) we assessed 378 SNPs in the 9p21 locus. Within four eth...

journal_title：Atherosclerosis

authors： Folsom AR,Pankow JS,Li X,Duprez DA,Jacobs DR Jr,Klein R,Klein B,Tang W,Wong TY,Cotch MF,Taylor KD,Rich SS,Hall JL,Post WS,Rotter JI

更新日期：2013-10-01 00:00:00

abstract：:It is still controversial whether circulating soluble form of receptor for AGE (sRAGE) is associated with atherosclerosis in diabetic patients. In this study, we enrolled 276 Japanese type 2 diabetic subjects without history of cardiovascular disease (CVD), assessed their baseline clinical and biochemical data includi...

journal_title：Atherosclerosis

authors： Fujisawa K,Katakami N,Kaneto H,Naka T,Takahara M,Sakamoto F,Irie Y,Miyashita K,Kubo F,Yasuda T,Matsuoka TA,Shimomura I

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Fenofibrate, a PPAR-α agonist and rosiglitazone, a PPAR-γ agonist, reduce triglycerides and fatty acids in humans and in animal disease models. The efficacy of PPAR-α agonists in mouse model of human atherosclerosis disease has shown mixed results, and efficacy of PPAR-γ and liver X receptor (LXR) agonists h...

journal_title：Atherosclerosis

authors： Srivastava RA

更新日期：2011-01-01 00:00:00

abstract：:The purpose of this study was to determine the extent and sources of oxidative stress within skeletal muscle following an acute bout of contractile claudication. Twenty-four hours after unilateral ligation of the femoral artery, rat hind limbs were stimulated in vivo for 30 min, and force production measured. One-hour...

journal_title：Atherosclerosis

authors： Judge AR,Dodd SL

更新日期：2003-12-01 00:00:00

abstract：:Oxidized LDL (OxLDL) is a proatherogenic lipoprotein, accumulating in the vascular wall and contributing to the pathogenesis of vascular dysfunction early in the development of atherosclerosis. Enhanced serum levels of OxLDL, as well as antibodies against its epitopes, are predictive for endothelial dysfunction and co...

journal_title：Atherosclerosis

authors： Galle J,Hansen-Hagge T,Wanner C,Seibold S

更新日期：2006-04-01 00:00:00

abstract：:This paper reports the results of the largest autopsy-based comparative study of atherosclerotic lesions between young Japanese and Americans, aged 15-34 years and autopsied between 1987 and 1995, by analyzing the data from the Japanese second nation-wide study of atherosclerosis and Pathobiological Determinants of At...

journal_title：Atherosclerosis

authors： Takei H,Strong JP,Yutani C,Malcom GT

更新日期：2005-05-01 00:00:00

abstract：:The effect of cage population density on plasma lipids and the development of atherosclerosis was examined in female C57BL/6 mice. Mice were housed at a density of one, two or five animals per cage and fed an atherogenic diet for 28 weeks. Subsequently, the animals were bled, sacrificed, the hearts removed and the ext...

journal_title：Atherosclerosis

authors： Lin AH,Castle CK,Melchior GW,Marotti KR

更新日期：1995-05-01 00:00:00

abstract：:Using a simple, standardized denaturing gradient gel electrophoresis (DGGE) based mutation screening technique, a novel G-to-A mutation in the last base of the intron 12 splice acceptor site of the LDL receptor gene was found in 2 Danish families with familial hypercholesterolemia (FH). The mutation is shown to result...

journal_title：Atherosclerosis

authors： Nissen H,Hansen AB,Guldberg P,Petersen NE,Hansen TS,Hørder M

更新日期：1997-01-03 00:00:00

abstract：INTRODUCTION:Cardio- and/or cerebro-vascular risk are associated with high lipoprotein (a) [Lp(a)] levels and low-molecular-weight (LMW) apo(a) isoforms. Aims of this study were to evaluate the deposition of apo(a) isoforms and apoprotein B (apo B) in atherosclerotic plaque from patients (males and females) who had car...

journal_title：Atherosclerosis

authors： Baldo G,Giunco S,Kontothanassis D,Baiocchi MR,Valerio A,Frego M

更新日期：2007-07-01 00:00:00

abstract：:High density lipoprotein cholesterol (HDL-C) is a primary risk factor for cardiovascular disease. Apolipoprotein A-1 (apoA1) is the major HDL-associated apolipoprotein. The -75G/A single nucleotide polymorphism (SNP) in the apolipoprotein A1 gene (APOA1) promoter has been reported to be associated with HDL-C concentra...

journal_title：Atherosclerosis

authors： Ruaño G,Seip RL,Windemuth A,Zöllner S,Tsongalis GJ,Ordovas J,Otvos J,Bilbie C,Miles M,Zoeller R,Visich P,Gordon P,Angelopoulos TJ,Pescatello L,Moyna N,Thompson PD

更新日期：2006-03-01 00:00:00

abstract：:Pressure recordings in 120 patients, aged 0-35 years, undergoing operation for coarctation of the aorta, show a slow but steady rise in both systolic and diastolic peak pressures, the highest peak registered being in patients aged 16-18 years. The finding of significant morphological changes in the aorta in this age g...

journal_title：Atherosclerosis

authors： Anyanwu E,Dittrich H,Jelesijević V,Drüen B,Krefting ER,Höhling H

更新日期：1981-06-01 00:00:00

abstract：OBJECTIVE:Peritoneal macrophages are used in many studies related to atherosclerosis. In situ, they are non-adherent and upon culturing, they adhere and function as scavengers of modified lipoproteins and dead apoptotic cells. They also produce growth factors, suggesting that they may provide life-supporting function a...

journal_title：Atherosclerosis

authors： Selvarajan K,Moldovan L,Chandrakala AN,Litvinov D,Parthasarathy S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND AIMS:We aimed to evaluate a possible atheroprotective effect of saffron aqueous extract (SFE), and its potential anti-inflammatory mechanisms, in apoE knockout (ApoE-/-) mice. METHODS:Fifty male, ApoE-/- mice, fed a high-fat diet (HFD) for 12 weeks, were randomized into 5 groups: (1) baseline group, eut...

journal_title：Atherosclerosis

authors： Christodoulou E,Kadoglou NPE,Stasinopoulou M,Konstandi OA,Kenoutis C,Kakazanis ZI,Rizakou A,Kostomitsopoulos N,Valsami G

更新日期：2018-01-01 00:00:00

abstract：AIMS:Besides carotid or cardiac embolism, stroke can occur via microangiopathy (small arterial disease [SAD]) and macroangiopathy (intracranial atherosclerotic stroke [ICAS]) of the intracranial vasculature. There have been efforts to identify risk factors specific to microangiopathy and macroangiopathy, including vasc...

journal_title：Atherosclerosis

authors： Bang OY,Chung JW,Ryoo S,Moon GJ,Kim GM,Chung CS,Lee KH

更新日期：2016-03-01 00:00:00