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No association of 9p21 with arterial elasticity and retinal microvascular findings.

Abstract：

OBJECTIVE:How 9p21 variation affects risk of cardiovascular disease is unclear, so we assessed whether 9p21 variants are associated with arterial elasticity or retinal microvascular findings. METHODS:In the prospective Multi-Ethnic Study of Atherosclerosis (MESA) we assessed 378 SNPs in the 9p21 locus. Within four ethnic groups, we used an additive genetic model to relate the 9p21 SNPs to five vascular phenotypes: small and large elasticity derived from radial diastolic pulse contour analysis; Young's elastic modulus from carotid artery ultrasound measurements; and the diameter of the central retinal arteries and veins. RESULTS:In neither ethnic-specific nor pooled data was there any statistically significant association between any of the 9p21 SNPs and any of the five vascular phenotypes. CONCLUSION:Our study does not support an association of 9p21 variation with arterial elasticity or retinal microvascular abnormalities.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Folsom AR,Pankow JS,Li X,Duprez DA,Jacobs DR Jr,Klein R,Klein B,Tang W,Wong TY,Cotch MF,Taylor KD,Rich SS,Hall JL,Post WS,Rotter JI

doi

10.1016/j.atherosclerosis.2013.07.049

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

301-3

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(13)00454-1

journal_volume

230

pub_type

杂志文章

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