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Inverse association between serum concentrations of neopterin and antioxidants in patients with and without angiographic coronary artery disease.

Abstract：

:Neopterin is released from human monocyte-derived macrophages upon stimulation with interferon-gamma and is a sensitive indicator for cellular immune activation. Furthermore, reactive oxygen species (ROS) are produced in case of immune activation and inflammation. In a cross-sectional approach, plasma concentrations of neopterin and of antioxidant compounds and vitamins were compared in 1463 patients investigated by coronary angiography, which were recruited within the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study. Serum neopterin concentrations were higher in patients with coronary artery disease (CAD; mean+/-S.D.: 8.7+/-7.3 nmol/L) compared to controls (7.4+/-5.0 nmol/L; Welch's t-test: p<0.001). Mean concentrations of ascorbic acid (p<0.0001), gamma-tocopherol (p<0.05), lycopene (p<0.001), lutein+zeaxanthin (p<0.05), alpha-carotene (p<0.05) and beta-carotene (p<0.05) were lower in CAD than in controls. Neopterin concentrations correlated with CAD-score (r(s)=0.156; p<0.0001) and inversely with antioxidants lycopene (r(s)=-0.277; p<0.0001) and lutein+zeaxanthin (r(s)=-0.175; p<0.0001) levels and with vitamins ascorbic acid (r(s)=-0.207; p<0.0001) and alpha-tocopherol (r(s)=-0.105; p<0.0001). The study demonstrates that higher neopterin production is associated with lower concentrations of antioxidant compounds in patients at risk for atherosclerosis. Results suggest that lower concentrations of antioxidant compounds may relate to higher grade of chronic immune activation in patients.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Murr C,Winklhofer-Roob BM,Schroecksnadel K,Maritschnegg M,Mangge H,Böhm BO,Winkelmann BR,März W,Fuchs D

doi

10.1016/j.atherosclerosis.2008.04.047

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

543-9

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(08)00330-4

journal_volume

202

pub_type

杂志文章

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