Modification of the effects of estrogen therapy on HDL cholesterol levels by polymorphisms of the HDL-C receptor, SR-BI: the Rancho Bernardo Study.

abstract：OBJECTIVE:This study sought to determine the correlation between baseline cardiac medications and cardiovascular outcomes in patients with obstructive coronary artery disease (CAD) diagnosed by coronary computed tomographic angiography (CCTA). METHODS:1637 patients (mean age 64.8 ± 10.2 years, 69.6% male) with obstruc...

journal_title：Atherosclerosis

authors： Schulman-Marcus J,Hartaigh BÓ,Giambrone AE,Gransar H,Valenti V,Berman DS,Budoff MJ,Achenbach S,Al-Mallah M,Andreini D,Cademartiri F,Callister TQ,Chang HJ,Chinnaiyan K,Chow BJ,Cury R,Delago A,Hadamitzky M,Hausleiter J

更新日期：2015-01-01 00:00:00

abstract：:Elevated fibrinogen levels after coronary balloon angioplasty have been reported to be useful in predicting restenosis. Therefore, we sought to evaluate the relationship between preprocedural fibrinogen levels and the 6-12-month outcomes of patients undergoing coronary stenting. Plasma levels of fibrinogen were measur...

journal_title：Atherosclerosis

authors： Otsuka M,Hayashi Y,Ueda H,Imazu M,Kohno N

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:The purpose of the study was to examine the prevalence and risk factors for cerebral infarction (CI) and carotid artery stenosis (CAS) in patients with peripheral arterial disease (PAD) compared with normal controls. METHOD:A cross-sectional analysis was performed in 857 subjects (PAD: 543, controls: 314). C...

journal_title：Atherosclerosis

authors： Araki Y,Kumakura H,Kanai H,Kasama S,Sumino H,Ichikawa A,Ito T,Iwasaki T,Takayama Y,Ichikawa S,Fujita K,Nakashima K,Minami K,Kurabayashi M

更新日期：2012-08-01 00:00:00

abstract：:Interferon gamma (IFN-gamma) is an immunomodulatory and anti-microbial cytokine, which has a variety of proatherogenic effects. It has been reported that IFN-gamma can down-regulate ABCA1 expression. However, its mechanism is elusive. In the present study, we have investigated the effect of IFN-gamma on ABCA1 expressi...

journal_title：Atherosclerosis

authors： Hao XR,Cao DL,Hu YW,Li XX,Liu XH,Xiao J,Liao DF,Xiang J,Tang CK

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:P2X(7) receptor (P2X(7)R), upon its stimulation with extracellular ATP, modulates several inflammatory responses in different cell types. No information is available on its presence in human adipocytes and its potential involvement in the chronic inflammation associated with metabolic syndrome (MS). Therefore...

journal_title：Atherosclerosis

authors： Madec S,Rossi C,Chiarugi M,Santini E,Salvati A,Ferrannini E,Solini A

更新日期：2011-12-01 00:00:00

abstract：:Abundant data is present to implicate oxidatively modified low-density lipoprotein (oxLDL) in enhanced atherogenesis. Among the factors involved in LDL oxidation, an important role has been attributed to human 15-lipoxygenase (LO) and its murine analog 12-LO. The expression of these peroxidizing enzymes is under the c...

journal_title：Atherosclerosis

authors： George J,Mulkins M,Shaish A,Casey S,Schatzman R,Sigal E,Harats D

更新日期：2000-12-01 00:00:00

abstract：:Adhesion molecules and cytokines are involved in the pathogenesis of intimal injury in atherosclerosis but their relationship with endothelial function remains unclear. The objectives of this study were to examine the effects of atorvastatin on soluble adhesion molecules, interleukin-6 (IL-6) and brachial artery endot...

journal_title：Atherosclerosis

authors： Nawawi H,Osman NS,Annuar R,Khalid BA,Yusoff K

更新日期：2003-08-01 00:00:00

abstract：:A synergistic interaction between the insertion/deletion (I/D) polymorphism within the angiotensin-converting enzyme (ACE) gene and an A/C transversion at nucleotide position 1166 within the angiotensin II sub-type 1 receptor (AT1R) gene on risk of myocardial infarction has been reported. The risk associated with the ...

journal_title：Atherosclerosis

authors： Steeds RP,Wardle A,Smith PD,Martin D,Channer KS,Samani NJ

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES:An exonic polymorphism (Y402H) in the complement factor H (CFH) gene, which locates within the binding sites for heparin and C-reactive protein, has recently been described and hypothesized to play an important role in atherothrombosis. METHODS:We, therefore, evaluated the CFH genetic variant Y402H amongst ...

journal_title：Atherosclerosis

authors： Zee RY,Diehl KA,Ridker PM

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:The putative association between the novel oxidized low-density lipoprotein markers, serum amyloid A-LDL (SAA-LDL) and alpha1-antitrypsin-LDL (AT-LDL), and obesity and the metabolic syndrome (MetS) has not been previously studied. In the present report, we investigated the levels of SAA-LDL and AT-LDL in rel...

journal_title：Atherosclerosis

authors： Kotani K,Satoh N,Kato Y,Araki R,Koyama K,Okajima T,Tanabe M,Oishi M,Yamakage H,Yamada K,Hattori M,Shimatsu A,Japan Obesity and Metabolic Syndrome Study Group.

更新日期：2009-06-01 00:00:00

abstract：:Inflammatory cytokine synthesis by monocyte-macrophages in the developing plaque represents an important amplification point in atherosclerotic disease progression. Here we have investigated whether the state of monocyte-macrophage differentiation can influence TNF alpha synthesis in response to scavenged modified low...

journal_title：Atherosclerosis

authors： Smythe CD,Skinner VO,Bruckdorfer KR,Haskard DO,Landis RC

更新日期：2003-10-01 00:00:00

abstract：:Lipid and apoprotein composition of four very low density lipoprotein (VLDL) subfractions decreasing in Sf value were evaluated in the fasting state in 12 normolipidemic Pima Indians (6 M, 6 F, age 39 +/- 1.7 yrs) (mean +/- SEM) with non-insulin-dependent diabetes mellitus (NIDDM) in poor glycemic control (HbA1 9.8 +/...

journal_title：Atherosclerosis

authors： Patti L,Swinburn B,Riccardi G,Rivellese AA,Howard BV

更新日期：1991-11-01 00:00:00

abstract：:Sialic acid is a negatively charged sugar associated with the protein and lipid portions of lipoproteins. Sialic acid has been hypothesised to play an anti-atherogenic role in lipoprotein metabolism through the electrostatic inhibition of lipoprotein interactions with chondroitin-6-sulphate-rich arterial proteoglycans...

journal_title：Atherosclerosis

authors： Millar JS,Anber V,Shepherd J,Packard CJ

更新日期：1999-08-01 00:00:00

abstract：AIMS:Leukocyte telomere length (LTL) is shortened in patients with clinical atherosclerosis (AS). Here we aimed to explore the contribution of elevated homocysteine (Hcy) level to LTL shortening in AS patients and the underlying mechanism. METHODS:Circulating leukocytes were collected from 197 patients with AS and 165...

journal_title：Atherosclerosis

authors： Zhang D,Wen X,Wu W,Xu E,Zhang Y,Cui W

更新日期：2013-11-01 00:00:00

abstract：:Macrophage scavenger receptors class A (MSR) are thought to play an important role in atherogenesis by mediating the unrestricted uptake of modified lipoproteins by macrophages in the vessel wall leading to foam cell formation. To investigate the in vivo role of the MSR in this process, a transgenic mouse model expres...

journal_title：Atherosclerosis

authors： de Winther MP,van Dijk KW,van Vlijmen BJ,Gijbels MJ,Heus JJ,Wijers ER,van den Bos AC,Breuer M,Frants RR,Havekes LM,Hofker MH

更新日期：1999-12-01 00:00:00

abstract：:The role of endothelium-derived nitric oxide (NO) in modulation of large artery stiffness in patients with peripheral arterial disease (PAD) is unexplored. The aim of this study was to evaluate, using pulse wave analysis (PWA), changes in aortic and systemic arterial stiffness following administration of nitroglycerin...

journal_title：Atherosclerosis

authors： Kals J,Kampus P,Kals M,Pulges A,Teesalu R,Zilmer M

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:Genetic variation in CC-chemokine receptor-2 (CCR2) and -5 (CCR5), and their common haplotypes, acting through inflammatory responses, may affect atherosclerosis and risk of coronary heart disease (CHD). METHOD AND RESULTS:We examined seven common variants in the CCR2 and CCR5 loci and risk of CHD among wome...

journal_title：Atherosclerosis

authors： Pai JK,Kraft P,Cannuscio CC,Manson JE,Rexrode KM,Albert CM,Hunter D,Rimm EB

更新日期：2006-05-01 00:00:00

abstract：:Serum and aortic tissue cholesterol levels in parallel with aortic relaxation to endothelium-dependent and independent drugs were determined in Watanabe heritable hyperlipidemic (WHHL) rabbits in comparison with New Zealand (N.Z.) normocholesterolemic rabbits, aged 4-14 months. Serum cholesterol was elevated (626 +/- ...

journal_title：Atherosclerosis

authors： Chinellato A,Banchieri N,Pandolfo L,Ragazzi E,Froldi G,Norido F,Caparrotta L,Fassina G

更新日期：1991-08-01 00:00:00

abstract：:The search for markers to improve risk prediction for individuals at risk of developing serious cardiovascular events is ongoing. New markers of coronary artery disease progression have been identified in recent years, among which, circulating levels of pregnancy-associated plasma protein-A (PAPP-A) offer an interesti...

journal_title：Atherosclerosis

authors： Consuegra-Sanchez L,Fredericks S,Kaski JC

更新日期：2009-04-01 00:00:00

abstract：AIMS:This study was set up to compare the accuracy, sensitivity and specificity of gene expression results between the Illumina HumanHT-12 v3 Expression BeadChip (GWE) and the TaqMan qRT-PCR low-density array (LDA) in atherosclerotic plaques. METHODS:Gene expression levels of 196 genes were determined from 22 atherosc...

journal_title：Atherosclerosis

authors： Raitoharju E,Seppälä I,Lyytikäinen LP,Levula M,Oksala N,Klopp N,Illig T,Laaksonen R,Kähönen M,Lehtimäki T

更新日期：2013-01-01 00:00:00

abstract：:The effect of chlorthalidone treatment on serum lipids and lipoproteins was investigated in 21 hypertensive patients. Chlorthalidone caused an increase in total serum and low density lipoprotein (LDL) cholesterol, but not in high density lipoprotein (HDL) cholesterol. Serum and lipoprotein triglycerides also increased...

journal_title：Atherosclerosis

authors： Rosenthal T,Holtzman E,Segal P

更新日期：1980-05-01 00:00:00

abstract：OBJECTIVE:The benefits of fish oil fatty acids eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) on plasma lipid profiles have been inconsistent but may partially depend on individual Apolipoprotein E (APOE) genotypes. We aimed to determine whether APOE genotype modifies the association of lipid profile characteri...

journal_title：Atherosclerosis

authors： Liang S,Steffen LM,Steffen BT,Guan W,Weir NL,Rich SS,Manichaikul A,Vargas JD,Tsai MY

更新日期：2013-05-01 00:00:00

abstract：:Paraoxonase (PON) is an HDL-bound enzyme capable of hydrolyzing lipid peroxides and believed to be in part responsible for the protective effect of HDL against LDL oxidation. Its activity is mainly determined by a gene polymorphism of the PON 1 gene (Glu-Arg 192). Low activity has been related to an elevated incidence...

journal_title：Atherosclerosis

authors： Cao H,Girard-Globa A,Serusclat A,Bernard S,Bondon P,Picard S,Berthezene F,Moulin P

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:Diabetes and atherosclerosis may share common genetic determinants. A prior study in Hispanics found association of haplotypes in the diabetes gene calpain-10 (CAPN10) with carotid artery intima-media thickness (CIMT). This study sought to replicate this association in an independent cohort. METHODS:Four CAP...

journal_title：Atherosclerosis

authors： Goodarzi MO,Taylor KD,Jones MR,Fang B,Guo X,Xiang AH,Buchanan TA,Hodis HN,Raffel LJ,Rotter JI

更新日期：2009-08-01 00:00:00

abstract：:In response to homocysteine induced toxicity in human umbilical vein endothelial cells, minimal changes in the concentration of cellular protein thiols but substantial changes in the concentration of intracellular soluble thiols were observed. The latter correlated closely with changes in cellular glutathione levels. ...

journal_title：Atherosclerosis

authors： Blundell G,Jones BG,Rose FA,Tudball N

更新日期：1996-05-01 00:00:00

abstract：AIM:The present clinical study tested the hypothesis that oil-rich fish consumption improves CHD risk factors. METHODS:Forty-eight (16 men) non-obese, healthy adults aged 20-55, consumed 125 g/day of salmon for a 4-week period followed by a 4-week period with no-fish (41 completers). Subjects were instructed to mainta...

journal_title：Atherosclerosis

authors： Lara JJ,Economou M,Wallace AM,Rumley A,Lowe G,Slater C,Caslake M,Sattar N,Lean ME

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) is the most common and severe autosomal dominant lipid metabolism dysfunction, which causes xanthoma, atherosclerosis and coronary heart disease. Earlier studies showed that mutations in LDLR, APOB and PCSK9 cause FH. Although more than 75% of the population in Eur...

journal_title：Atherosclerosis

authors： Xiang R,Fan LL,Lin MJ,Li JJ,Shi XY,Jin JY,Liu YX,Chen YQ,Xia K,Zhao SP

更新日期：2017-03-01 00:00:00

abstract：:The risk factors for cardiovascular disease are related directly or indirectly in women, as in men, to lipid and lipoprotein levels. But women have the advantage of the beneficial effects of either endogenous or exogenous estrogen on these levels throughout most of their lives. Behaviors such as smoking or diseases su...

journal_title：Atherosclerosis

authors： Miller VT

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:The EPA/AA ratio has emerged as a predictor of mortality endpoints in cardiac disease; however, its prognostic value in peripheral artery disease (PAD) patients is unclear. We assessed the serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio in patients with PAD caused by femoropopliteal artery l...

journal_title：Atherosclerosis

authors： Hishikari K,Kimura S,Yamakami Y,Kojima K,Sagawa Y,Otani H,Sugiyama T,Kuwahara T,Hikita H,Takahashi A,Isobe M

更新日期：2015-04-01 00:00:00

abstract：:Since VLDL and LDL are involved in atherogenesis, their response to dietary modification was studied in 15 normal male prisoners. A 3-month reference diet (P/S ratio 0.3, daily cholesterol intake 370 mg) was compared with a modified fat diet (P/S 1.0, 250 mg) given for further 3 months. The decrement in serum choleste...

journal_title：Atherosclerosis

authors： Weisweiler P,Drosner M,Janetschek P,Schwandt P

更新日期：1983-12-01 00:00:00