Changes in very low and low density lipoproteins with dietary fat modification.

Abstract:

:Since VLDL and LDL are involved in atherogenesis, their response to dietary modification was studied in 15 normal male prisoners. A 3-month reference diet (P/S ratio 0.3, daily cholesterol intake 370 mg) was compared with a modified fat diet (P/S 1.0, 250 mg) given for further 3 months. The decrement in serum cholesterol by 32 mg/dl reflected a decrease in VLDL and LDL. It was associated with a decrease in serum apolipoprotein B by 16 mg/dl and in serum apolipoprotein E by 1.2 mg/dl. The decrement in VLDL cholesterol was paralleled by a lowered VLDL apolipoprotein E content. Serum and VLDL triglycerides, HDL cholesterol and the serum apolipoproteins A-I and A-II did not change significantly. One beneficial result of a conventional dietary regimen is lowered LDL with unaffected HDL. Another effect is the apparent modification of VLDL with a decrement of cholesterol and apolipoprotein E-enriched particles.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Weisweiler P,Drosner M,Janetschek P,Schwandt P

doi

10.1016/0021-9150(83)90143-0

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

325-32

issue

3

eissn

0021-9150

issn

1879-1484

pii

0021-9150(83)90143-0

journal_volume

49

pub_type

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