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A novel oxidized low-density lipoprotein marker, serum amyloid A-LDL, is associated with obesity and the metabolic syndrome.

Abstract：

BACKGROUND:The putative association between the novel oxidized low-density lipoprotein markers, serum amyloid A-LDL (SAA-LDL) and alpha1-antitrypsin-LDL (AT-LDL), and obesity and the metabolic syndrome (MetS) has not been previously studied. In the present report, we investigated the levels of SAA-LDL and AT-LDL in relation to the components of the MetS. We also assessed the effect of weight reduction therapy on serum SAA-LDL and AT-LDL levels among obese subjects. METHODS:The study population included 421 obese Japanese outpatients (185 men and 236 women, mean age: 51.1 years) enrolled in the multicenter Japan Obesity and Metabolic Syndrome Study (JOMS). The novel oxidized low-density lipoprotein markers, serum SAA-LDL and AT-LDL, were measured in all participants. RESULTS:Circulating SAA-LDL levels were independently associated with the presence and the number of components of the MetS. SAA-LDL levels were also significantly and independently correlated with high-sensitivity C-reactive protein. Notably, successful weight reduction resulted in a significant decrease in circulating SAA-LDL concentrations. Levels of AT-LDL were not associated with the MetS. CONCLUSIONS:We documented, for the first time, that serum SAA-LDL levels correlate positively with the number of components of the MetS and weight reduction. Whether SAA-LDL may be involved in the pathophysiology of MetS and atherosclerosis deserves further investigation.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Kotani K,Satoh N,Kato Y,Araki R,Koyama K,Okajima T,Tanabe M,Oishi M,Yamakage H,Yamada K,Hattori M,Shimatsu A,Japan Obesity and Metabolic Syndrome Study Group.

doi

10.1016/j.atherosclerosis.2008.09.017

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

526-31

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(08)00673-4

journal_volume

204

pub_type

杂志文章,多中心研究

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