Abstract:
OBJECTIVE:We investigated whether early atherosclerosis before calcified plaque appeared as assessed by carotid intima-media thickness (IMT) was associated with levels of the major carotenoids, and assessed the associations among these serum carotenoids, carotid IMT, and arterial stiffness. METHODS:The case-control study comprised 125 subjects with early atherosclerosis and 107 controls aged 45-68 years. We simultaneously measured common carotid IMT and arterial stiffness by carotid ultrasonography, and serum carotenoids were determined by high-pressure liquid chromatograph (HPLC). RESULTS:In cases of early atherosclerosis, serum level of lutein was significantly lower than that in controls. Serum lutein was inversely associated with carotid IMT. Zeaxanthin and β-carotene were both negatively correlated with right common carotid artery stiffness β, elastic modulus (E(p)), and pulse wave velocity (PWV). After adjusting for age and gender, the associations remain significantly (P<0.05). However, there is no significant difference for zeaxanthin and β-carotene between the cases and controls. CONCLUSION:These findings suggest that lutein may play a protective role in the prevention of early atherosclerosis, and the associations between serum carotenoids and arterial stiffness remained to be investigated.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Zou Z,Xu X,Huang Y,Xiao X,Ma L,Sun T,Dong P,Wang X,Lin Xdoi
10.1016/j.atherosclerosis.2011.08.006subject
Has Abstractpub_date
2011-12-01 00:00:00pages
789-93issue
2eissn
0021-9150issn
1879-1484pii
S0021-9150(11)00755-6journal_volume
219pub_type
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