Plasma proprotein convertase subtilisin-kexin type 9 does not change during 24h insulin infusion in healthy subjects and type 2 diabetic patients.

abstract：:We studied the effect of gemfibrozil on the compositions of VLDL, LDL and distribution of LDL subspecies in type II hyperlipidemic patients. Gemfibrozil significantly lowered serum triglyceride levels in this group of patients who had normal to moderately elevated triglyceride prior to therapy. Gemfibrozil also change...

journal_title：Atherosclerosis

authors： Tsai MY,Yuan J,Hunninghake DB

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Mutations in the 5'-nucleotidase ecto (NT5E) gene that encodes CD73, a nucleotidase that converts AMP to adenosine, are linked to arterial calcification. However, the role of purinergic receptor signaling in the pathology of intimal calcification is not well understood. In this study, we examined wh...

journal_title：Atherosclerosis

authors： Qian S,Regan JN,Shelton MT,Hoggatt A,Mohammad KS,Herring PB,Seye CI

更新日期：2017-02-01 00:00:00

abstract：:Homozygotes (TT genotype) for the C677T mutation in the gene of methylenetetrahydrofolate reductase (C677T/MTHFR mutation) constitute about 12% of the Caucasian population. They have mild hyperhomocysteinemia which is an established risk factor for cardiovascular disease. If the mutation is associated with premature d...

journal_title：Atherosclerosis

authors： Brattström L,Zhang Y,Hurtig M,Refsum H,Ostensson S,Fransson L,Jonés K,Landgren F,Brudin L,Ueland PM

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND AND AIMS:We aimed to evaluate a possible atheroprotective effect of saffron aqueous extract (SFE), and its potential anti-inflammatory mechanisms, in apoE knockout (ApoE-/-) mice. METHODS:Fifty male, ApoE-/- mice, fed a high-fat diet (HFD) for 12 weeks, were randomized into 5 groups: (1) baseline group, eut...

journal_title：Atherosclerosis

authors： Christodoulou E,Kadoglou NPE,Stasinopoulou M,Konstandi OA,Kenoutis C,Kakazanis ZI,Rizakou A,Kostomitsopoulos N,Valsami G

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Significant sex differences exist in cardiovascular diseases. Although an impact of gonadal hormones is presumed, it is largely unknown whether sexually dimorphic gene expression also plays a role and whether cells themselves show intrinsic sex differences. METHODS:We performed whole genome expression analys...

journal_title：Atherosclerosis

authors： Lorenz M,Koschate J,Kaufmann K,Kreye C,Mertens M,Kuebler WM,Baumann G,Gossing G,Marki A,Zakrzewicz A,Miéville C,Benn A,Horbelt D,Wratil PR,Stangl K,Stangl V

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:Microvascular mechanisms are increasingly recognized as being involved in a significant proportion of coronary artery disease (CAD) cases, but their exact contribution or role is unclear. We aimed to define the association between retinal microvascular signs and both CAD extent and severity. METHODS:1120 par...

journal_title：Atherosclerosis

authors： Gopinath B,Chiha J,Plant AJ,Thiagalingam A,Burlutsky G,Kovoor P,Liew G,Mitchell P

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The association between cholesterol and stroke has been inconsistent. This study aimed to examine the association between total cholesterol (TC) and mortality from total stroke and stroke subtypes. METHODS:503,340 Korean adults aged 40-80 years without a history of heart disease or stroke participa...

journal_title：Atherosclerosis

authors： Yi SW,Shin DH,Kim H,Yi JJ,Ohrr H

更新日期：2018-03-01 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1) recruits monocytes into atherosclerotic plaques. A single nucleotide polymorphism in the MCP-1 gene promoter (-2578A>G) results in greater production of MCP-1 protein. We examined the association of this polymorphism with occult coronary artery disease (CAD) and its interacti...

journal_title：Atherosclerosis

authors： Kim MP,Wahl LM,Yanek LR,Becker DM,Becker LC

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:The objective of the present study was to investigate the effects of one-year treatment with exenatide or Insulin Glargine, followed by a 5-week off-drug period, on postprandial lipidaemia, glycaemia and measures of oxidative stress. METHODS:Sixty-nine metformin-treated patients with type 2 diabetes were ran...

journal_title：Atherosclerosis

authors： Bunck MC,Cornér A,Eliasson B,Heine RJ,Shaginian RM,Wu Y,Yan P,Smith U,Yki-Järvinen H,Diamant M,Taskinen MR

更新日期：2010-09-01 00:00:00

abstract：:This study investigates the ability of a single, low dose of apolipoprotein (apo) A-I, the main lipoprotein of high density lipoproteins (HDL), to inhibit acute vascular inflammation in normocholesterolemic New Zealand White rabbits. Acute vascular inflammation was induced in the animals by placing a non-occlusive, si...

journal_title：Atherosclerosis

authors： Puranik R,Bao S,Nobecourt E,Nicholls SJ,Dusting GJ,Barter PJ,Celermajer DS,Rye KA

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Carotid intima-media thickness (cIMT) is associated with CV events in adults. Thicker cIMT is found in youth with CV risk factors including obesity. Which risk factors have the most effect upon cIMT in youth and whether obesity has direct or indirect effects is not known. We used structural equation modeling...

journal_title：Atherosclerosis

authors： Gao Z,Khoury PR,McCoy CE,Shah AS,Kimball TR,Dolan LM,Urbina EM

更新日期：2016-03-01 00:00:00

abstract：:Elevated serum cholesterol is a risk factor in the development of coronary artery disease. Magnesium has been reported to decrease total serum cholesterol, low density lipoprotein, and very low density lipoprotein, and increase high density lipoprotein. A randomized, double-blind, placebo-controlled, crossover study w...

journal_title：Atherosclerosis

authors： Marken PA,Weart CW,Carson DS,Gums JG,Lopes-Virella MF

更新日期：1989-05-01 00:00:00

abstract：:Serum total and HDL cholesterol concentrations were measured in schoolboy populations from 16 countries. Total and HDL cholesterol concentrations were determined in one laboratory to reduce methodological variability as much as possible. A standardized protocol was used for the drawing of blood, preparation, storage a...

journal_title：Atherosclerosis

authors： Knuiman JT,Hermus RJ,Hautvast JG

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:CVD risk increases in women after menopause. Recent data suggest higher levels of complement protein C3 and cardiovascular fat (CF) in postmenopausal women. Whether complement proteins are associated with early markers of atherosclerosis in healthy midlife women has never been evaluated. Additionally, the po...

journal_title：Atherosclerosis

authors： Nagaraj N,Matthews KA,Shields KJ,Barinas-Mitchell E,Budoff MJ,El Khoudary SR

更新日期：2015-12-01 00:00:00

abstract：:Hypercholesterolemia impairs endothelial function. However, the production/release of nitric oxide from the hypercholesterolemic aorta is reported to be enhanced rather than impaired in animal studies. L-arginine improves endothelial function in hypercholesterolemic subjects. The goal of the present study was to inves...

journal_title：Atherosclerosis

authors： Kawano H,Motoyama T,Hirai N,Kugiyama K,Yasue H,Ogawa H

更新日期：2002-04-01 00:00:00

abstract：:Cholesteryl esters (CE) exchange between lipoproteins through the action of cholesteryl ester transfer protein (CETP). Situations at high risk for atherosclerosis are often accompanied by an accelerated net mass CE transfer (CET) from high density lipoproteins (HDL) to very low (VLDL) and low density lipoproteins (LDL...

journal_title：Atherosclerosis

authors： Elchebly M,Porokhov B,Pulcini T,Berthezène F,Ponsin G

更新日期：1996-06-01 00:00:00

abstract：:Inflammatory cytokine synthesis by monocyte-macrophages in the developing plaque represents an important amplification point in atherosclerotic disease progression. Here we have investigated whether the state of monocyte-macrophage differentiation can influence TNF alpha synthesis in response to scavenged modified low...

journal_title：Atherosclerosis

authors： Smythe CD,Skinner VO,Bruckdorfer KR,Haskard DO,Landis RC

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Increased arterial stiffness is associated with greater risk of cardiovascular events and mortality. However, in patients with peripheral arterial disease (PAD) who have severe atherosclerotic disorder or risk clustering, the major determinants of increased stiffness have been not clarified. METHODS:This st...

journal_title：Atherosclerosis

authors： Makita S,Matsui H,Naganuma Y,Abiko A,Tamada M,Nakamura M

更新日期：2010-01-01 00:00:00

abstract：:Several studies indicate that the inter-individual variation in plasma concentrations of lipoprotein(a) (Lp(a)) is mainly under genetic control. To define the effect of three DNA polymorphisms on apolipoprotein(a) (apo(a)) expression, we have determined plasma Lp(a) concentrations, apo(a) isoform size, KpnI allele siz...

journal_title：Atherosclerosis

authors： Valenti K,Aveynier E,Leauté S,Laporte F,Hadjian AJ

更新日期：1999-11-01 00:00:00

abstract：:The hydrolysis of lipoprotein triglycerides is catalyzed by lipoprotein lipase (LPL), an enzyme found in many tissues. We have examined tissue LPL activity (LPLA) in rats with experimentally-induced hyperthyroidism. In younger, lighter rats, hyperthyroidism was accompanied by a decrease in LPL in adipose tissue wherea...

journal_title：Atherosclerosis

authors： Wilson DE,Jubiz W,Flowers CM,Carlile SI,Adolf AM

更新日期：1977-03-01 00:00:00

abstract：:Methodological differences and variations in health care regulations among countries often preclude direct comparisons of cost-effectiveness studies. A projected risk model was applied, designed to determine the economic value in the United States of pravastatin in the secondary prevention of coronary heart disease (C...

journal_title：Atherosclerosis

authors： Muls E,Van Ganse E,Closon MC

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:The goal of the study was to examine possible sex-related differences in the clinical characteristics and risk factors in Japanese patients with peripheral arterial disease (PAD). METHODS:Sex-related differences in clinical profiles, risk factors and treatments were examined in 730 consecutive patients with ...

journal_title：Atherosclerosis

authors： Kumakura H,Kanai H,Araki Y,Kasama S,Sumino H,Ito T,Iwasaki T,Takayama Y,Ichikawa S,Fujita K,Nakashima K,Minami K

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Molecular imaging with 18Fluorodeoxyglucose (FDG) and 18F-sodium-fluoride (NaF) captures arterial inflammation and micro-calcification and can reveal potentially unstable atherosclerotic plaques. METHODS:We performed FDG and NaF PET/CT imaging in two clinically similar cohorts of patients living wi...

journal_title：Atherosclerosis

authors： Guaraldi G,Milic J,Prandini N,Ligabue G,Esposito F,Ciusa G,Malagoli A,Scaglioni R,Besutti G,Beghetto B,Nardini G,Roncaglia E,Mussini C,Raggi P

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Few studies have evaluated the associations of plasma homocysteine concentration, the methylenetetrahydrofolate reductase (MTHFR) C677T genotype and B vitamin concentration with intima media thickness (IMT) in multiethnic populations. METHODS:In the Study of Health Assessment and Risk in Ethnic groups (SHAR...

journal_title：Atherosclerosis

authors： Kelemen LE,Anand SS,Hegele RA,Stampfer MJ,Rosner B,Willett WC,Montague PA,Lonn E,Vuksan V,Teo KK,Devanesen S,Yusuf S

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:Obesity and cardiovascular disease recognize a common metabolic soil and may therefore share part of their genetic background. Genome-wide association studies have identified variability at the SH2B1 locus as a predictor of obesity. We investigated whether SNP rs4788102, which captures the entire SH2B1 variab...

journal_title：Atherosclerosis

authors： Prudente S,Morini E,Larmon J,Andreozzi F,Di Pietro N,Nigro A,Gervino EV,Mannino GC,Bacci S,Hauser TH,Bellacchio E,Formoso G,Pellegrini F,Proto V,Menzaghi C,Frittitta L,Pandolfi A,Sesti G,Doria A,Trischitta V

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) was rarely diagnosed in Latvia before 2015, when the Latvian Registry of FH (LRFH) was established. Here, we report the first experience of the LRFH over three years (2015-2017). METHODS:The LRFH is an ongoing nationwide, dynamic, long-term prospective cohort. The...

journal_title：Atherosclerosis

authors： Latkovskis G,Saripo V,Gilis D,Nesterovics G,Upena-Roze A,Erglis A

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:The association between cholesterol and endothelial dysfunction remains controversial. We tested the hypothesis that lipoprotein subclasses are associated with coronary endothelial dysfunction. METHODS AND RESULTS:Coronary endothelial function was assessed in 490 patients between November 1993 and February 2...

journal_title：Atherosclerosis

authors： Ford MA,McConnell JP,Lavi S,Rihal CS,Prasad A,Sandhu GS,Hartman SJ,Lerman LO,Lerman A

更新日期：2009-11-01 00:00:00

abstract：:The effect of chlorthalidone treatment on serum lipids and lipoproteins was investigated in 21 hypertensive patients. Chlorthalidone caused an increase in total serum and low density lipoprotein (LDL) cholesterol, but not in high density lipoprotein (HDL) cholesterol. Serum and lipoprotein triglycerides also increased...

journal_title：Atherosclerosis

authors： Rosenthal T,Holtzman E,Segal P

更新日期：1980-05-01 00:00:00

abstract：:A single centre randomised placebo-controlled trial was performed to assess the 2-year effects of hormone replacement therapy compared to placebo on mechanical arterial properties in 99 perimenopausal women recruited from the general population. The trial was double-blind with respect to a sequential combined regimen ...

journal_title：Atherosclerosis

authors： Westendorp IC,de Kleijn MJ,Bots ML,Bak AA,Planellas J,Coelingh Bennink HJ,Hofman A,Grobbee DE,Witteman JC

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:It is uncertain whether the novel single nucleotide polymorphisms (SNPs) that have recently been associated with coronary artery disease (CAD) in genome-wide studies also influence carotid atheroma and stroke risk. The mechanisms of their association with CAD are unknown; relationships to other cardiovascula...

journal_title：Atherosclerosis

authors： Cunnington MS,Mayosi BM,Hall DH,Avery PJ,Farrall M,Vickers MA,Watkins H,Keavney B

更新日期：2009-03-01 00:00:00