当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Macrophage migration inhibitory factor induces MMP-9 expression: implications for destabilization of human atherosclerotic plaques.

Macrophage migration inhibitory factor induces MMP-9 expression: implications for destabilization of human atherosclerotic plaques.

Abstract：

:Macrophage migration inhibitory factor (MIF) has been shown to participate in both experimental and human atherogenesis. Expression of MMP-9 has been shown to play a role in the instability of atherosclerotic plaque. Thus, we hypothesize that MIF may participate in the destabilization of atherosclerotic plaques by stimulating MMP-9 expression. This hypothesis was investigated by examining the expression of MIF and MMP-9 in human atherosclerotic plaques using two-color immunostaining and by determining the potential role of MIF in the induction of MMP-9 expression in vascular smooth muscle cells (VSMC) and macrophages in vitro. Two-color immunohistochemistry demonstrated that MIF was strongly upregulated by macrophages and VSMCs. This was associated with marked increase in MMP-9 expression in vulnerable atheromatous plaques, but not in the fibrous lesions. Upregulation of MIF and MMP-9 in vulnerable atheromatous plaques was associated with the weakening of fibrous caps. The role of MIF in MMP-9 expression was demonstrated by the ability of MIF to directly induce MMP-9 mRNA and protein expression in macrophages and in VSMCs in a dose and time-dependent manner, which was blocked by a neutralizing MIF antibody. In conclusion, MIF and MMP-9 are markedly upregulated in vulnerable atheromatous plaques. The ability of MIF to induce MMP-9 expression in VSMCs and macrophages suggests that MIF may play a role in the destabilization of human atherosclerotic plaques.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Kong YZ,Yu X,Tang JJ,Ouyang X,Huang XR,Fingerle-Rowson G,Bacher M,Scher LA,Bucala R,Lan HY

doi

10.1016/j.atherosclerosis.2004.08.030

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

207-15

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(04)00457-5

journal_volume

178

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • A major gene influences variation in large HDL particles and their response to diet in baboons.

    abstract：:Some baboons accumulate appreciable amounts of large apoE-rich HDLs (HDL(1)) which are similar to those reported in humans with several different dyslipoproteinemias. We estimated HDL(1) cholesterol concentrations by gradient gel electrophoresis of serum samples obtained from 634 pedigreed baboons fed with three diets...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(02)00015-1

    authors： Rainwater DL,Kammerer CM,Cox LA,Rogers J,Carey KD,Dyke B,Mahaney MC,McGill HC Jr,VandeBerg JL

    更新日期：2002-08-01 00:00:00

  • Tissue n-3 and n-6 fatty acids and risk for coronary heart disease events.

    abstract：BACKGROUND:Tissue proportions of long chain n-6 [especially arachidonic acid (AA)] and n-3 fatty acids [FA; eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) acids], or some ratio of these may be markers of risk for coronary heart disease (CHD). The purpose of this paper is to evaluate the published associatio...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2007.03.018

    authors： Harris WS,Poston WC,Haddock CK

    更新日期：2007-07-01 00:00:00

  • Ex vivo culture of human atherosclerotic plaques: A model to study immune cells in atherogenesis.

    abstract：BACKGROUND AND AIMS:The mechanisms that drive atherosclerotic plaque progression and destabilization in humans remain largely unknown. Laboratory models are needed to study these mechanisms under controlled conditions. The aim of this study was to establish a new ex vivo model of human atherosclerotic plaques that pres...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2017.10.003

    authors： Lebedeva A,Vorobyeva D,Vagida M,Ivanova O,Felker E,Fitzgerald W,Danilova N,Gontarenko V,Shpektor A,Vasilieva E,Margolis L

    更新日期：2017-12-01 00:00:00

  • Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis.

    abstract：:The current epidemic of obesity with the associated increasing incidence of insulin resistance, diabetes mellitus and atherosclerosis affecting a large proportion of the North American and Western populations, has generated a strong interest in the potential role of visceral adipose tissue in the development of athero...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2013.12.023

    authors： Alexopoulos N,Katritsis D,Raggi P

    更新日期：2014-03-01 00:00:00

  • Blood pressure disturbances and endothelial dysfunction markers in children and adolescents with type 1 diabetes.

    abstract：OBJECTIVE:Being the earliest step on the way to atherosclerosis, endothelial dysfunction is particularly escalated in diabetes. This study aimed at assessing endothelial dysfunction and blood pressure disturbances in young patients with type 1 diabetes mellitus (T1DM) and defining their interrelations. METHODS:The stu...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.09.006

    authors： Machnica L,Deja G,Polanska J,Czupryniak L,Szymanska-Garbacz E,Loba J,Jarosz-Chobot P

    更新日期：2014-11-01 00:00:00

  • 7-ketocholesteryl-9-carboxynonanoate enhances ATP binding cassette transporter A1 expression mediated by PPARγ in THP-1 macrophages.

    abstract：BACKGROUND:ATP binding cassette transporter A1 (ABCA1) is a member of the ATP-binding cassette transporter family. It plays an essential role in mediating the efflux of excess cholesterol. It is known that peroxisome proliferator-activated receptor gamma (PPARγ) promoted ABCA1 expression. We previously found 7-ketochol...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.01.052

    authors： Chi Y,Wang L,Liu Y,Ma Y,Wang R,Han X,Qiao H,Lin J,Matsuura E,Liu S,Liu Q

    更新日期：2014-06-01 00:00:00

  • A hypercoagulable and hypofibrinolytic state is detectable by global methods in patients with retinal vein occlusion.

    abstract：:The pathogenesis of retinal vein occlusion (RVO), has not been well understood. Recent data have shown the efficacy of an anticoagulant therapy with LMWHs in the treatment of acute RVO suggesting the presence of a hypercoagulable state in these patients. New global tests for detection of hypercoagulability and hypofib...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.06.053

    authors： Cellai AP,Lami D,Fedi S,Marcucci R,Mannini L,Cenci C,Rogolino A,Sodi A,Menchini U,Abbate R,Prisco D

    更新日期：2012-09-01 00:00:00

  • Genetic variation in paraoxonase-1 and paraoxonase-2 is associated with variation in plasma lipoproteins in Alberta Hutterites.

    abstract：:In a sample taken from the genetically isolated Alberta Hutterites, we previously found that PON1 variation was associated with variation in plasma lipoprotein traits, including LDL and HDL cholesterol. With the recent cloning of the PON1-related gene PON2, we undertook studies of the association between genetic varia...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(98)00071-9

    authors： Boright AP,Connelly PW,Brunt JH,Scherer SW,Tsui LC,Hegele RA

    更新日期：1998-07-01 00:00:00

  • Effects of dietary saturated, monounsaturated and n-3 fatty acids on fasting lipoproteins, LDL size and post-prandial lipid metabolism in healthy subjects.

    abstract：BACKGROUND:The influence of the quality of dietary fat on some aspects of lipid metabolism-i.e. lipoprotein concentrations, post-prandial lipids and LDL size-is not completely understood, especially in healthy individuals. OBJECTIVES:Aim of this study was to evaluate the effects of different types of dietary fat (mono...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0021-9150(02)00424-0

    authors： Rivellese AA,Maffettone A,Vessby B,Uusitupa M,Hermansen K,Berglund L,Louheranta A,Meyer BJ,Riccardi G

    更新日期：2003-03-01 00:00:00

  • Arterial effects of palmitic, linoleic and acetoacetic acid.

    abstract：:The ultrastructural effects of a single brief intra-arterial infusion of palmitic, linoleic and acetoacetic acid on the arterial endothelium of the rat were investigated, and the following results obtained: (1) Palmitic acid, infused at a concentration of 4 mM/l, damaged the arterial lining by producing large cytoplas...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(81)90047-2

    authors： Constantinides P,Kiser M

    更新日期：1981-02-01 00:00:00

  • Serum selenium concentration and risk of ischaemic heart disease in a prospective cohort study of 3000 males.

    abstract：:Whether an association, causative or not, exists between the level of serum selenium and the risk of ischaemic heart disease (IHD) remains unsettled. We investigated the issue in a cohort of 3387 males aged 53-74 years (mean 63). Based on information about health status, life-style and socioeconomic factors given in a...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(92)90035-f

    authors： Suadicani P,Hein HO,Gyntelberg F

    更新日期：1992-09-01 00:00:00

  • Association of blood active matrix metalloproteinase-3 with carotid plaque score from a community population in Taiwan.

    abstract：OBJECTIVE:Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of atherosclerosis. However, the relationship between blood levels of MMPs and the extent of carotid atherosclerosis remains uncertain. We assessed blood levels of active MMPs in relation to the extent of carotid plaque formation and intima-m...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.05.040

    authors： Lien LM,Hsieh YC,Bai CH,Chen WH,Chiu HC,Hsieh FI,Shyu KG,Chiou HY,Hsu CY

    更新日期：2010-10-01 00:00:00

  • Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar.

    abstract：:The effect of guar (15.6 g/day), a dietary fibre, and simultaneous administration of bezafibrate (600 mg/day) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia (corresponding to the HLP type IIa pattern). Either bezafibrate alone...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0021-9150(82)90230-1

    authors： Wirth A,Middelhoff G,Braeuning C,Schlierf G

    更新日期：1982-12-01 00:00:00

  • Comparative effects of cholesteryl ester transfer protein inhibition, statin or ezetimibe on lipid factors: The ACCENTUATE trial.

    abstract：BACKGROUND AND AIMS:The optimal approaches to management of patients treated with moderate statin doses on lipid parameters are unknown. The ACCENTUATE study aimed to compare the effects of adding the cholesteryl ester transfer protein inhibitor (CETP) evacetrapib, ezetimibe or increasing statin dose in atorvastatin-tr...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.atherosclerosis.2017.04.008

    authors： Nicholls SJ,Ray KK,Ballantyne CM,Beacham LA,Miller DL,Ruotolo G,Nissen SE,Riesmeyer JS,ACCENTUATE Investigators.

    更新日期：2017-06-01 00:00:00

  • Artificial ultraviolet whole-body radiation does not modify serum lipoprotein, plasma fibrinogen, plasminogen or antithrombin III concentrations in post-myocardial infarction patients.

    abstract：:The relationship of ischaemic heart disease (IHD) to seasonal and latitude variation has prompted speculation that exposure to the ultraviolet component of solar radiation may reduce IHD risk. This hypothesis was partially tested by exposing 14 post-myocardial infarction patients to a 6 week course of artificial whole...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章

    doi：10.1016/0021-9150(94)90142-2

    authors： Clark P,Cockburn F,Cowan RA,Czapla K,Dunnigan MG,Farish E,Hughes E

    更新日期：1994-05-01 00:00:00

  • Detection of the terminal complement complex in patient plasma following acute myocardial infarction.

    abstract：:The mechanisms of inflammation responsible for the myocardial tissue damage seen after an acute myocardial infarction (AMI) have not been clearly identified. Recent lines of evidence, demonstrating depressed sera levels of individual complement components in patients after myocardial infarction, have suggested involve...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(88)90103-7

    authors： Langlois PF,Gawryl MS

    更新日期：1988-03-01 00:00:00

  • Progesterone abolishes estrogen and/or atorvastatin endothelium dependent vasodilatory effects.

    abstract：UNLABELLED:This double blind randomized placebo controlled study assessed the effects of atorvastatin, estradiol and norethisterone, isolated and in combination, on the lipid profile and on vascular reactivity, in post-menopausal women with hypercholesterolemia and arterial hypertension. Ninety-four women aged 50-65 we...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2004.05.030

    authors： Faludi AA,Aldrighi JM,Bertolami MC,Saleh MH,Silva RA,Nakamura Y,Pereira IR,Abdalla DS,Ramires JA,Sousa JE

    更新日期：2004-11-01 00:00:00

  • Chronic inflammation, albuminuria, and functional disability in older adults with cardiovascular disease: the National Health and Nutrition Examination Survey, 1999-2008.

    abstract：OBJECTIVE:Although C-reactive protein (CRP) and albuminuria are well-documented cardiovascular risk markers, the functional implications of these biomarkers and their combination on functional disability and metabolic risks in patients with cardiovascular disease (CVD) are unknown. METHODS:Data were from 1403 adults (...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.03.004

    authors： Kuo HK,Al Snih S,Kuo YF,Raji MA

    更新日期：2012-06-01 00:00:00

  • Hypocholesterolemic effects of cholestyramine and colestipol in patients with familial defective apolipoprotein B-100.

    abstract：:Familial defective apolipoprotein B-100 (FDB) is a dominantly inherited disorder associated with hypercholesterolemia, in which substitution of the amino acid glutamine for arginine at position 3500 in the apoprotein B molecule results in LDL particles which bind poorly to the LDL receptor. To date, patients with FDB ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(93)90130-m

    authors： Schmidt EB,Illingworth DR,Bacon S,Mahley RW,Weisgraber KH

    更新日期：1993-01-25 00:00:00

  • High-density lipoprotein subclasses distribution and composition in Mexican adolescents with low HDL cholesterol and/or high triglyceride concentrations, and its association with insulin and C-reactive protein.

    abstract：:We tested whether low high-density lipoprotein cholesterol (HDL-C) and/or high triglycerides are associated to abnormal HDL subclasses distribution and composition, and their relationships with fasting insulin and C-reactive protein (CRP). Four groups of adolescents were studied: group 1 (HDL-C< or =35 mg/dl+TG> or =1...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.02.029

    authors： Medina-Urrutia A,Juarez-Rojas JG,Martínez-Alvarado R,Jorge-Galarza E,Posadas-Sánchez R,Cardoso-Saldaña G,Caracas-Portilla N,Mendoza-Perez E,Posadas-Romero C

    更新日期：2008-12-01 00:00:00

  • Genomic variant in CAV1 increases susceptibility to coronary artery disease and myocardial infarction.

    abstract：BACKGROUND:The CAV1 gene encodes caveolin-1 expressed in cell types relevant to atherosclerosis. Cav-1-null mice showed a protective effect on atherosclerosis under the ApoE(-/-) background. However, it is unknown whether CAV1 is linked to CAD and MI in humans. In this study we analyzed a tagSNP for CAV1 in intron 2, r...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.01.008

    authors： Chen S,Wang X,Wang J,Zhao Y,Wang D,Tan C,Fa J,Zhang R,Wang F,Xu C,Huang Y,Li S,Yin D,Xiong X,Li X,Chen Q,Tu X,Yang Y,Xia Y,Xu C,Wang QK

    更新日期：2016-03-01 00:00:00

  • Synergistic effects of the apolipoprotein E epsilon3/epsilon2/epsilon4, the cholesteryl ester transfer protein TaqIB, and the apolipoprotein C3 -482 C>T polymorphisms on their association with coronary artery disease.

    abstract：:The single nucleotide polymorphisms (SNPs) apolipoprotein E (APOE) epsilon3/epsilon2/epsilon4, cholesteryl ester transfer protein (CETP) TaqIB, and apolipoprotein C3 (APOC3) -482 C>T have been associated with an atherogenic lipid profile and, in some studies, with increased cardiovascular risk. However, no data exist ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.10.030

    authors： Muendlein A,Saely CH,Marte T,Schmid F,Koch L,Rein P,Langer P,Aczel S,Drexel H

    更新日期：2008-07-01 00:00:00

  • Effect of low-density lipoprotein receptor mutation on lipoproteins and cardiovascular disease risk: a parent-offspring study.

    abstract：:Studies on the clinical consequences of different low-density lipoprotein (LDL) receptor genotypes in adult patients have yielded conflicting results. We hypothesized that children with familial hypercholesterolemia (FH) provide a better model to perform genotype-phenotype analyses than adults. We tested this hypothes...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.10.042

    authors： Koeijvoets KC,Wiegman A,Rodenburg J,Defesche JC,Kastelein JJ,Sijbrands EJ

    更新日期：2005-05-01 00:00:00

  • Familial hypercholesterolemia in Canada: Initial results from the FH Canada national registry.

    abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) is under-diagnosed and under-treated in most of the world, including Canada. National registries play a key role in identifying patients with FH, understanding gaps in care, and advancing the science of FH to better treat these patients. METHODS:FH Canada has esta...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2018.05.040

    authors： Brunham LR,Ruel I,Khoury E,Hegele RA,Couture P,Bergeron J,Baass A,Dufour R,Francis GA,Cermakova L,Mancini GBJ,Brophy JM,Brisson D,Gaudet D,Genest J

    更新日期：2018-10-01 00:00:00

  • Regulation of MFGE8 by the intergenic coronary artery disease locus on 15q26.1.

    abstract：BACKGROUND AND AIMS:A recently identified locus for coronary artery disease (CAD) tagged by rs8042271 is in a region of tight linkage disequilibrium (LD) between 2 genes (MFGE8, ABHD2) previously linked to atherosclerosis. Here we have explored the regulatory framework of this region to identify its functional relation...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2019.02.012

    authors： Soubeyrand S,Nikpay M,Turner A,Dang AT,Herfkens M,Lau P,McPherson R

    更新日期：2019-05-01 00:00:00

  • VEGF-A-induced chemotaxis of CD16+ monocytes is decreased secondary to lower VEGFR-1 expression.

    abstract：BACKGROUND:Monocyte recruitment into the vessel wall is a crucial initial step in vascular repair, arteriogenesis and atherogenesis. Two distinct human monocyte subpopulations can be classified according to their CD14/16 surface expression, namely CD14++CD16-monocytes (CD16-mo) and CD14+CD16+ monocytes (CD16+mo). We in...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.01.004

    authors： Czepluch FS,Olieslagers S,van Hulten R,Vöö SA,Waltenberger J

    更新日期：2011-04-01 00:00:00

  • Background differences in baseline and stimulated MMP levels influence abdominal aortic aneurysm susceptibility.

    abstract：OBJECTIVE:Evidence has demonstrated profound influence of genetic background on cardiovascular phenotypes. Murine models in Marfan syndrome (MFS) have shown that genetic background-related variations affect thoracic aortic aneurysm formation, rupture, and lifespan of mice. MFS mice with C57Bl/6 genetic background are l...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.10.006

    authors： Dale MA,Suh MK,Zhao S,Meisinger T,Gu L,Swier VJ,Agrawal DK,Greiner TC,Carson JS,Baxter BT,Xiong W

    更新日期：2015-12-01 00:00:00

  • Serum levels of Mac-2 binding protein increase with cardiovascular risk and reflect silent atherosclerosis.

    abstract：BACKGROUND AND AIMS:Mac-2 binding protein (M2BP) was reported to be a useful biomarker for liver fibrosis and malignant tumors. We hypothesized that expression of M2BP might also change in the process of atherosclerosis. METHODS:This study included subjects who visited our hospital for a physical checkup. RESULTS:The...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.06.027

    authors： Sugiura T,Dohi Y,Takase H,Yamashita S,Murai S,Tsuzuki Y,Ogawa S,Tanaka Y,Ohte N

    更新日期：2016-08-01 00:00:00

  • Homocysteine content of lipoproteins in hypercholesterolemia.

    abstract：:In order to study the connection between homocysteine and lipid metabolism in atherosclerosis, homocysteine was determined in lipoprotein fractions from men with hypercholesterolemia. All lipoprotein fractions contain a considerably higher level of homocysteine in hypercholesterolemia, compared to normolipemic men, va...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(91)90257-4

    authors： Olszewski AJ,McCully KS

    更新日期：1991-05-01 00:00:00

  • Erythrocyte membrane n-3 fatty acid levels and carotid atherosclerosis in Chinese men and women.

    abstract：OBJECTIVE:Prospective studies have supported the beneficial effects of n-3 fatty acid consumption on cardiac deaths, but limited data focused on atherosclerosis. We investigated the associations between n-3 fatty acids in erythrocytes and atherosclerosis in middle-aged and older Chinese. METHODS:847 subjects (285 men ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2013.10.028

    authors： Dai XW,Zhang B,Wang P,Chen CG,Chen YM,Su YX

    更新日期：2014-01-01 00:00:00