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Carotid and femoral atherosclerotic plaques show different morphology.

Abstract：

OBJECTIVE:Results of endovascular repair vary according to the arterial bed. We hypothesized that these differences may be related to the plaque features. To explore this hypothesis, we designed a prospective study that compared carotid and femoral atheroma. METHODS AND RESULTS:Patients that underwent femoral or carotid endarterectomy were included in our study. Demographic data and blood sampling were obtained prior to surgery. Plaques were evaluated for AHA grading, calcification and lipid content. Eighty-eight plaques were harvested during this study (45 carotid specimens and 43 femoral specimens). No differences were noted between carotid and femoral groups regarding demographic and biological data. Histological data more frequently showed fibrous cap atheroma in carotid arteries (75%) and fibrocalcific plaques in femoral arteries (93%), p<0.001. Morphological analyses showed a high prevalence of osteoid metaplasia in femoral arteries (63%) compared to carotid arteries (20%, p<0.001). Biochemical analyses were consistent with histological data, showing higher calcium and lesser cholesterol concentrations in femoral than in carotid plaques (p<0.01). CONCLUSIONS:Femoral and carotid plaques showed different morphology in comparable groups of patients.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Herisson F,Heymann MF,Chétiveaux M,Charrier C,Battaglia S,Pilet P,Rouillon T,Krempf M,Lemarchand P,Heymann D,Gouëffic Y

doi

10.1016/j.atherosclerosis.2011.02.004

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

348-54

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(11)00120-1

journal_volume

216

pub_type

杂志文章

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