Enhanced synthesis of collagen and total protein by smooth muscle cells from atherosclerotic rabbit aortas in culture.

abstract：:The detailed distribution of atherosclerotic lesions in the branching region of the left main coronary artery in man was studied. Tissue cubes of the hearts, containing the left coronary arteries, were removed, and 1.5-mm-thick parallel and consecutive slices were cut perpendicular to the main coronary artery. Histolo...

journal_title：Atherosclerosis

authors： Grøttum P,Svindland A,Walløe L

更新日期：1983-04-01 00:00:00

abstract：:We studied the functional role of N-linked sugar chains of apolipoprotein (apo) B-100 of low density lipoprotein (LDL) in cholesterol metabolism. The N-linked sugar chains of apo B-100 of LDL obtained from four homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits were liberated by hydrazinolysis, followed by Na...

journal_title：Atherosclerosis

authors： Fujioka Y,Taniguchi T,Ishikawa Y,Shiomi M,Yokoyama M

更新日期：1994-07-01 00:00:00

abstract：:This study investigates the ability of a single, low dose of apolipoprotein (apo) A-I, the main lipoprotein of high density lipoproteins (HDL), to inhibit acute vascular inflammation in normocholesterolemic New Zealand White rabbits. Acute vascular inflammation was induced in the animals by placing a non-occlusive, si...

journal_title：Atherosclerosis

authors： Puranik R,Bao S,Nobecourt E,Nicholls SJ,Dusting GJ,Barter PJ,Celermajer DS,Rye KA

更新日期：2008-01-01 00:00:00

abstract：:We investigated the relative hypocholesterolemic activity of linoleic acid (LA), conjugated linoleic acid (CLA), alpha-linolenic acid (LN) and conjugated linolenic acid (CLN) in hamsters. Five groups of hamsters (n=10 each) were fed either the control diet or one of the four fatty acids-supplemented diets for 6 weeks....

journal_title：Atherosclerosis

authors： Lam CK,Chen J,Cao Y,Yang L,Wong YM,Yeung SY,Yao X,Huang Y,Chen ZY

更新日期：2008-05-01 00:00:00

abstract：AIMS:The aims of this study are to describe the relationships between IgG antibodies to 17 oral organisms and atherosclerosis as indexed by carotid intima-medial wall thickness (IMT) and to evaluate the role of smoking. METHODS AND RESULTS:Our study is based on a subset of participants in the Atherosclerosis Risk in C...

journal_title：Atherosclerosis

authors： Beck JD,Eke P,Lin D,Madianos P,Couper D,Moss K,Elter J,Heiss G,Offenbacher S

更新日期：2005-12-01 00:00:00

abstract：:Coating a silica surface with the isolated lipoprotein receptor proteoheparan sulfate (HS-PG) from arterial endothelium and vascular matrices and adding both the atherogenic VLDL/IDL/LDL lipid fraction in its native composition and Ca(2+) ions, we could observe in vitro the earliest stages of atherosclerotic plaque de...

journal_title：Atherosclerosis

authors： Rodríguez M,Ringstad L,Schäfer P,Just S,Hofer HW,Malmsten M,Siegel G

更新日期：2007-06-01 00:00:00

abstract：:The aim of this study was to examine whether the well-established effect of the common TaqIB polymorphism in intron 1 of the gene for cholesterol ester transfer protein (CETP) on high density lipoprotein cholesterol (HDL-C) concentration and increased risk of myocardial infarction (MI), could be explained by the recen...

journal_title：Atherosclerosis

authors： Eiriksdottir G,Bolla MK,Thorsson B,Sigurdsson G,Humphries SE,Gudnason V

更新日期：2001-11-01 00:00:00

abstract：:In the abdominal aortas of young mash-fed swine, intimal cell masses (pads, cushions) are located predominantly away from blood vessel orifices. They are found scattered throughout the aorta but nevertheless have a definite pattern of distribution. In the distal one half of the abdominal aorta, they are more frequent ...

journal_title：Atherosclerosis

authors： Scott RF,Thomas WA,Lee WM,Reiner JM,Florentin RA

更新日期：1979-11-01 00:00:00

abstract：BACKGROUND:Autosomal dominant hypercholesterolemia (ADH) is caused by mutations in the low density lipoprotein receptor (LDLR), its ligand apoB (APOB) or proprotein convertase subtilisin/kexin type 9 (PCSK9) genes. Yet DNA sequencing does not identify mutations in these genes in a significant number of cases, suggestin...

journal_title：Atherosclerosis

authors： Awan Z,Choi HY,Stitziel N,Ruel I,Bamimore MA,Husa R,Gagnon MH,Wang RH,Peloso GM,Hegele RA,Seidah NG,Kathiresan S,Genest J

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Moderate red wine has been shown to reduce cardiovascular disease (CVD) risk, however the effects on certain CVD risk factors are unclear. In this study we have investigated the effects of dealcoholised red wine (DRW) and full-complement red wine (RW) on several cardiovascular risk factors in mildly hypercho...

journal_title：Atherosclerosis

authors： Naissides M,Mamo JC,James AP,Pal S

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The role of circular RNAs (circRNAs) in coronary artery disease (CAD) remains elusive. The aim of the present study was to profile circRNAs expression in CAD patients and assess diagnostics biomarkers for CAD. METHODS:The circRNA profiles of 24 CAD patients and 7 controls were assessed by microarra...

journal_title：Atherosclerosis

authors： Wang L,Shen C,Wang Y,Zou T,Zhu H,Lu X,Li L,Yang B,Chen J,Chen S,Lu X,Gu D

更新日期：2019-07-01 00:00:00

abstract：:Accelerated coronary atherosclerosis is a major risk limiting long-term survival after heart transplantation and is commonly associated with dyslipoproteinemia even in subjects who were not dyslipoproteinemic before intervention. The purpose of this study was to analyse the abnormalities in the lipid profiles of 2 dif...

journal_title：Atherosclerosis

authors： Atger V,Cambillau M,Guillemain R,Farge D,Dreyfus G,Hamon S,Girard A,Carpentier A,Moatti N

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:Adherence to a Mediterranean-style diet (MeDi) may protect against clinical vascular events by reducing atherosclerosis, but data is limited. This is the first observational study of the association between MeDi adherence and carotid plaque thickness and area. METHODS:The study included 1374 participants of ...

journal_title：Atherosclerosis

authors： Gardener H,Wright CB,Cabral D,Scarmeas N,Gu Y,Cheung K,Elkind MS,Sacco RL,Rundek T

更新日期：2014-06-01 00:00:00

abstract：:The purpose of the present study was to examine the relationship between the changes in the expressions of several mRNAs and changes in endothelial function in streptozotocin-induced diabetic and chronic short-term insulin-treated rats. Aortas from later-stage (10 week) diabetics, but not those from their insulin-trea...

journal_title：Atherosclerosis

authors： Kobayashi T,Oishi K,Hayashi Y,Matsumoto T,Kamata K

更新日期：2006-03-01 00:00:00

abstract：:Lipoprotein-lipase activity (LPL) was measured in biopsies of adipose tissue and skeletal muscle of normal human subjects, and the results were related to concentrations of cholesterol and triglycerides in plasma lipoproteins. Adipose-tissue LPL activity was significantly higher in females than in males, whereas no se...

journal_title：Atherosclerosis

authors： Nikkilä EA,Taskinen MR,Kekki M

更新日期：1978-04-01 00:00:00

abstract：:Although triglycerides (TG) are a major risk factor for coronary artery disease (CAD), their exact role is still controversial. Recently, a T/C polymorphism in the promoter region of the apoA5 gene at position 1131 has been found that is associated with an increased plasma TG concentration. We investigated the role of...

journal_title：Atherosclerosis

authors： Szalai C,Keszei M,Duba J,Prohászka Z,Kozma GT,Császár A,Balogh S,Almássy Z,Fust G,Czinner A

更新日期：2004-03-01 00:00:00

abstract：:Dietary linoleate was effective to increase LDL fluidity in adult men but did not significantly influence VLDL or HDL fluidities. Lipoproteins were isolated ultracentrifugally from plasma of sixteen healthy, free living male volunteers consuming controlled diets formulated from typical U.S.A. foods to have 35 energy %...

journal_title：Atherosclerosis

authors： Berlin E,Judd JT,Marshall MW,Kliman PG

更新日期：1987-08-01 00:00:00

abstract：AIMS:To examine the association between white blood cell count (WBC) and metabolic syndrome (MS) in an older Chinese population. METHODS:Three thousand and twenty men and 7,256 women aged 50-85 years were recruited and received a medical check-up including measurement of complete blood count, blood pressure, obesity i...

journal_title：Atherosclerosis

authors： Lao XQ,Neil Thomas G,Jiang C,Zhang W,Adab P,Lam TH,Cheng KK

更新日期：2008-12-01 00:00:00

abstract：:Cytosolic Phospholipase A(2) (cPLA(2)) has been implicated in receptor-mediated release of arachidonic acid from membrane phospholipids, the limiting step in prostacyclin and other eicosanoid production. Its activity is controlled by Ca(++) levels and enzymatically regulated phosphorylation. The purpose of this study ...

journal_title：Atherosclerosis

authors： Gudmundsdóttir IJ,Halldórsson H,Magnúsdóttir K,Thorgeirsson G

更新日期：2001-05-01 00:00:00

abstract：:The chemokines are a family of signalling proteins that participate in regulation of the immune system and have been implicated in the pathogenesis of vascular diseases. Deleting the gene encoding the chemokine MCP-1 in mouse models of atherosclerosis reduces lipid lesion formation and circulating chemokines are upreg...

journal_title：Atherosclerosis

authors： Mosedale DE,Smith DJ,Aitken S,Schofield PM,Clarke SC,McNab D,Goddard H,Gale CR,Martyn CN,Bethell HW,Barnard C,Hayns S,Nugent C,Panicker A,Grainger DJ

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:the extracellular matrix (ECM) is an important determinant of plaque instability. Since tissue transglutaminase (tTG) and elafin act as stabilizing factors, they might play a crucial role in the pathogenesis of acute coronary syndrome. We examined their expression in human coronary arteries and the regulatio...

journal_title：Atherosclerosis

authors： Sumi Y,Inoue N,Azumi H,Seno T,Okuda M,Hirata K,Kawashima S,Hayashi Y,Itoh H,Yokoyama M

更新日期：2002-01-01 00:00:00

abstract：:The serum concentrations of testosterone, androstenedione, oestradiol and total low polar oestrogens, mainly oestradiol and oestrone, were measured in 26 healthy male subjects. The subjects were divided into two groups each of them with low (less than 1.04 mmol/l) and high (greater than 1.56 mmol/l) levels of serum HD...

journal_title：Atherosclerosis

authors： Nordøy A,Aakvaag A,Thelle D

更新日期：1979-12-01 00:00:00

abstract：:We determined the effects of different dialysis conditions on the antioxidant content, duration of the lag phase and oxidation rate of LDL. Dialysis for 22 h resulted in a 56%--66% reduction in the concentrations of beta-carotene, lycopene and alpha-tocopherol. The lag phase of copper-induced oxidation of freshly isol...

journal_title：Atherosclerosis

authors： Scheek LM,Wiseman SA,Tijburg LB,van Tol A

更新日期：1995-09-01 00:00:00

abstract：:The insertion/deletion (I/D) polymorphism of the ACE gene may be involved in structural arterial changes. Aim of the present study was to assess the relationship between the ACE I/D gene and vessel wall stiffness among older adults. The study was conducted within the Rotterdam study, a population-based cohort study in...

journal_title：Atherosclerosis

authors： Mattace-Raso FU,van der Cammen TJ,Sayed-Tabatabaei FA,van Popele NM,Asmar R,Schalekamp MA,Hofman A,van Duijn CM,Witteman JC

更新日期：2004-05-01 00:00:00

abstract：:The effects of lovastatin therapy on concentrations and compositions of lipoproteins were examined in 14 patients with heterozygous familial hypercholesterolemia. The drug lowered plasma levels of cholesterol in total plasma, very low density + intermediate density lipoproteins (VLDL + IDL) and low density lipoprotein...

journal_title：Atherosclerosis

authors： Nozaki S,Vega GL,Haddox RJ,Dolan ET,Grundy SM

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:CVD risk increases in women after menopause. Recent data suggest higher levels of complement protein C3 and cardiovascular fat (CF) in postmenopausal women. Whether complement proteins are associated with early markers of atherosclerosis in healthy midlife women has never been evaluated. Additionally, the po...

journal_title：Atherosclerosis

authors： Nagaraj N,Matthews KA,Shields KJ,Barinas-Mitchell E,Budoff MJ,El Khoudary SR

更新日期：2015-12-01 00:00:00

abstract：:Secretory non-pancreatic (group II) phospholipase A2 (sPLA2) releases precursors of important mediators of inflammation from phospholipids. Based on the inflammatory character of atherosclerosis we previously described the identification of sPLA2 in human atherosclerotic plaques. In vitro studies on lipoproteins have ...

journal_title：Atherosclerosis

authors： Schiering A,Menschikowski M,Mueller E,Jaross W

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Thrombocytopenia in scavenger receptor BI (SR-BI) knockout mice is suggested to result from augmented platelet clearance induced by elevated intracellular unesterified cholesterol (UC) levels. We hypothesize that SR-BI deficiency may also influence platelet production at the level of its precursor c...

journal_title：Atherosclerosis

authors： Ouweneel AB,Hoekstra M,van der Wel EJ,Schaftenaar FH,Snip OSC,Hassan J,Korporaal SJA,Van Eck M

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:We examined the associations between HbA1c levels and various atherosclerotic vascular parameters among adults without diabetes from the general population. METHODS:A total of 6500 community-dwelling adults, who were free of type 2 diabetes and ≥50 years of age, were included. High-resolution B-mode ultraso...

journal_title：Atherosclerosis

authors： Lee YH,Shin MH,Choi JS,Rhee JA,Nam HS,Jeong SK,Park KS,Ryu SY,Choi SW,Kim BH,Oh GJ,Kweon SS

更新日期：2016-04-01 00:00:00

abstract：:To test the hypothesis of altered energy production in aortic sites predisposed to lesion formation, both coupled oxidative phosphorylation (evaluated from P/O ratios) and control of the energy-linked (ATP) NADH transhydrogenase were examined in muscular cushions at the celiac artery bifurcation. Comparisons were made...

journal_title：Atherosclerosis

authors： Hajjar DP,Smith SC

更新日期：1980-06-01 00:00:00