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The state of macrophage differentiation determines the TNF alpha response to nitrated lipoprotein uptake.

Abstract：

:Inflammatory cytokine synthesis by monocyte-macrophages in the developing plaque represents an important amplification point in atherosclerotic disease progression. Here we have investigated whether the state of monocyte-macrophage differentiation can influence TNF alpha synthesis in response to scavenged modified low-density lipoprotein (LDL). We show that LDL modified by nitration induces TNF alpha synthesis when added to undifferentiated human monocytes or a mouse cell line (RAW264.7) bearing an incompletely differentiated phenotype. However, significantly reduced levels of TNF alpha were released from in vitro differentiated human macrophages (P=0.006) or a mouse cell line (IC-21) bearing a well-differentiated macrophage phenotype (P<0.001). A possible scavenging insufficiency in macrophagic cell types was ruled out by lipoprotein-uptake studies and competency to synthesise TNF alpha was confirmed using lipopolysaccharide (LPS) as a stimulus. However, LPS-induced TNF alpha secretion in IC-21 cells was partially suppressed by pre-treatment with nitrated LDL (46%, P=0.0076), with no equivalent effect seen in RAW264.7 cells. Based on these data, we hypothesise that the state of differentiation of intimal monocyte-macrophages may play an important role in their inflammatory response to scavenged modified lipoproteins and that the fully differentiated macrophage end-point may be associated with a non-inflammatory and therefore, atheroprotective, phenotype.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Smythe CD,Skinner VO,Bruckdorfer KR,Haskard DO,Landis RC

doi

10.1016/s0021-9150(03)00285-5

keywords:

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

213-21

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(03)00285-5

journal_volume

170

pub_type

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