Abstract:
OBJECTIVE:This study sought to determine the correlation between baseline cardiac medications and cardiovascular outcomes in patients with obstructive coronary artery disease (CAD) diagnosed by coronary computed tomographic angiography (CCTA). METHODS:1637 patients (mean age 64.8 ± 10.2 years, 69.6% male) with obstructive CAD from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry were followed over the course of three years. Obstructive CAD was defined as a ≥50% stenosis in an epicardial vessel. Medications analyzed included statins, aspirin, beta-blockers, angiotensin converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs). Using Cox proportional-hazards models, we calculated the hazard ratio (HR) with 95% confidence intervals (95% CIs) for incident major adverse cardiovascular events (MACE), defined as death, acute coronary syndrome, or myocardial infarction. RESULTS:At the time of CCTA, 59%, 54%, 40%, and 46% of patients were using statins, aspirin, beta-blockers, and ACE inhibitors or ARBs, respectively. Statins were associated with a 43% (95% CI = 0.38-0.87, p = 0.008) lower adjusted risk of MACE. Following adjustment, aspirin, beta-blockers, ACE inhibitors and ARBs did not attenuate the risk of MACE. When restricted to patients with multivessel obstructive CAD, only statins were associated with lower risk of MACE. CONCLUSION:In patients with obstructive CAD by CCTA, the baseline use of statins was associated with improved clinical outcomes. Other cardiac medications-including aspirin, beta-blockers, ACE inhibitors, and ARBs-were not associated with reduced risk of MACE.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Schulman-Marcus J,Hartaigh BÓ,Giambrone AE,Gransar H,Valenti V,Berman DS,Budoff MJ,Achenbach S,Al-Mallah M,Andreini D,Cademartiri F,Callister TQ,Chang HJ,Chinnaiyan K,Chow BJ,Cury R,Delago A,Hadamitzky M,Hausleiter Jdoi
10.1016/j.atherosclerosis.2014.11.007subject
Has Abstractpub_date
2015-01-01 00:00:00pages
119-25issue
1eissn
0021-9150issn
1879-1484pii
S0021-9150(14)01570-6journal_volume
238pub_type
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