当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Circulating malondialdehyde-modified LDL and atherogenic lipoprotein profiles measured by nuclear magnetic resonance spectroscopy in patients with coronary artery disease.

Circulating malondialdehyde-modified LDL and atherogenic lipoprotein profiles measured by nuclear magnetic resonance spectroscopy in patients with coronary artery disease.

Abstract：

OBJECTIVE:Recent studies have suggested that circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) is a useful marker for the identification of patients with coronary artery disease (CAD). However, the role of MDA-LDL in atherogenic mechanisms has not yet been fully determined. METHOD AND RESULTS:We investigated lipoprotein profiles measured by nuclear magnetic resonance (NMR) spectroscopy and circulating MDA-LDL levels measured by ELISA in 25 male patients with CAD and 15 age-matched male controls. We selected subjects who had a serum LDL cholesterol<160 mg/dL. The MDA-LDL levels were significantly higher in the CAD group than in the control group (P=0.01) even though there was no significant difference in the LDL cholesterol levels between the two groups. NMR analysis demonstrated that the MDA-LDL levels were positively correlated with large and intermediate very low-density lipoprotein triglyceride and LDL particle concentrations, and negatively correlated with LDL diameter and large high-density lipoprotein cholesterol. The MDA-LDL levels were negatively correlated with flow-mediated dilatation of the brachial artery. CONCLUSIONS:The high concentrations of circulating MDA-LDL derived from the atherogenic lipoprotein profiles, which induce the exaggerated production of small dense LDL. The circulating MDA-LDL may impair endothelial function and play an important role in the pathogenesis of atherosclerosis.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Miyazaki T,Shimada K,Sato O,Kotani K,Kume A,Sumiyoshi K,Sato Y,Ohmura H,Watanabe Y,Mokuno H,Daida H

doi

10.1016/j.atherosclerosis.2004.09.013

keywords:

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

139-45

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(04)00502-7

journal_volume

179

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • Flordipine, a calcium channel blocker, which does not influence lipidemia or atherosclerosis in cholesterol-fed rabbits.

    abstract：:Data relating to the effects of calcium channel blockers on experimental atherosclerosis in rabbits are inconsistent with most studies finding no effect on either serum lipids or atherosclerosis. We have administered flordipine (5, 15 or 45 mg/kg/day) for 10 weeks to rabbits fed 1% cholesterol and 4% corn oil. At no l...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(88)90292-4

    authors： Kritchevsky D,Tepper SA,Klurfeld DM

    更新日期：1988-01-01 00:00:00

  • Micro-ultrasound imaging assessment of carotid plaque characteristics in apolipoprotein-E knockout mice.

    abstract：:This study was aimed to test the hypothesis that noninvasive assessment of carotid plaques can be achieved by high-resolution micro-ultrasound imaging in apolipoprotein-E knockout (apoE-KO) mice. Forty-two male apoE-KO mice were fed a high-fat diet and atherosclerotic lesions in the left common carotid artery were ind...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.07.039

    authors： Ni M,Zhang M,Ding SF,Chen WQ,Zhang Y

    更新日期：2008-03-01 00:00:00

  • Evidence of a major locus for lipoprotein lipase (LPL) activity in addition to a pleiotropic locus for both LPL and fasting insulin: results from the HERITAGE Family Study.

    abstract：:A major gene hypothesis for heparin releasable plasma lipoprotein lipase (PH-LPL) activity was assessed using segregation analyses of data on 495 members in 98 normolipidemic sedentary families of Caucasian descent who participated in the HERITAGE Family Study. Segregation analyses were performed on PH-LPL adjusted fo...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/s0021-9150(98)00324-4

    authors： Hong Y,Rice T,Després JP,Gagnon J,Nadeau A,Bergeron J,Pérusse L,Bouchard C,Leon AS,Skinner JS,Wilmore JH,Rao DC

    更新日期：1999-06-01 00:00:00

  • Decreased concentration of high density lipoprotein cholesterol in schizophrenic patients treated with phenothiazines.

    abstract：:In chronic schizophrenic patients treated with phenothiazines (Chlorpromazine, Levomepromazine, Perphenazine) for long periods (average = 8 years), high density lipoprotein cholesterol (HDL-C) levels were significantly lower (P less than 0.001) compared with normal controls. The HDL subfractions showed that HDL3-C was...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(84)90164-3

    authors： Sasaki J,Kumagae G,Sata T,Kuramitsu M,Arakawa K

    更新日期：1984-05-01 00:00:00

  • TRPV1 agonism inhibits endothelial cell inflammation via activation of eNOS/NO pathway.

    abstract：BACKGROUND AND AIMS:Transient receptor potential vanilloid type 1 channel (TRPV1) is found to be expressed in endothelial cells (ECs) and activate endothelial nitric oxide synthase (eNOS). Recent studies implicate TRPV1 in attenuating inflammatory responses. However, the mechanisms underlying the beneficial effects rem...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2017.03.016

    authors： Wang Y,Cui L,Xu H,Liu S,Zhu F,Yan F,Shen S,Zhu M

    更新日期：2017-05-01 00:00:00

  • Chronic hyperbaric oxygen treatment elicits an anti-oxidant response and attenuates atherosclerosis in apoE knockout mice.

    abstract：:We previously demonstrated that hyperbaric oxygen (HBO) treatment inhibits diet-induced atherosclerosis in New Zealand White rabbits. In the present study we investigate the mechanisms that might be involved in the athero-protective effect of HBO treatment in a well-accepted model of atherosclerosis, the apoE knockout...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.08.018

    authors： Kudchodkar BJ,Pierce A,Dory L

    更新日期：2007-07-01 00:00:00

  • Differential effect of soluble intercellular adhesion molecule-1 on the progression of atherosclerosis as compared to arterial thrombosis: a prospective analysis of the Women's Health Study.

    abstract：BACKGROUND:Soluble intercellular adhesion molecule-1 (sICAM-1) is a transmembrane protein involved in the migration and adhesion of leukocytes to the vascular endothelium. While some studies indicate that elevated baseline sICAM-1 levels predict cardiovascular events, most of these studies were done in men; moreover, u...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.04.051

    authors： Albert MA,Glynn RJ,Buring JE,Ridker PM

    更新日期：2008-03-01 00:00:00

  • Triiodothyronine stimulates prostacyclin production by rat aortic smooth muscle cells in culture.

    abstract：:The effect of triiodothyronine (T3) on prostacyclin production in rat aortic smooth muscle cells was investigated by using an intact cell assay system. T3 at its physiological concentrations has no significant effect on smooth muscle cell proliferation, but it does significantly stimulate prostacyclin production by th...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(81)90001-0

    authors： Nakao J,Chang WC,Murota S,Orimo H

    更新日期：1981-07-01 00:00:00

  • Excess coronary heart disease in Familial Combined Hyperlipidemia, in relation to genetic factors and central obesity.

    abstract：AIM:To determine the prevalence of non-fatal coronary artery disease (CAD) in kindred with Familial Combined Hyperlipidemia (FCHL) in relation to various cardiovascular risk factors and DNA variation in the apo AI-CIII-AIV gene cluster. METHODS AND RESULTS:Data were collected from 18 Dutch FCHL probands, 202 living fi...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(00)00752-8

    authors： Voors-Pette C,de Bruin TW

    更新日期：2001-08-01 00:00:00

  • Effect of intessive plasmapheresis on the plasma cholesterol concentration with familial hypercholesterolemia.

    abstract：:Plasmapheresis was studied as a means of reducing the serum cholesterol concentration in 3 hypercholesterolemic patients who each underwent courses of intensive plasmapheresis with removal of 250--500 ml of plasma each day for 5--9 days. In one homozygous Type II patient, the serum cholesterol concentration decreased ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(78)90157-0

    authors： Apstein CS,Zilversmit DB,Lees RS,George PK

    更新日期：1978-10-01 00:00:00

  • Vitamin D modulates the association of circulating insulin-like growth factor-1 with carotid artery intima-media thickness.

    abstract：OBJECTIVE:Experimental evidence indicates that circulating insulin-like growth factor-1 (IGF-1) counteracts vascular aging and atherosclerosis, for which increased carotid artery intima-media thickness (IMT) is a marker. Yet, IGF-1 concentrations have been inconsistently associated with carotid IMT in epidemiological s...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.08.022

    authors： Ameri P,Canepa M,Fabbi P,Leoncini G,Milaneschi Y,Mussap M,AlGhatrif M,Balbi M,Viazzi F,Murialdo G,Pontremoli R,Brunelli C,Ferrucci L

    更新日期：2014-10-01 00:00:00

  • Mitral annular calcification predicts mortality and coronary artery disease in end stage renal disease.

    abstract：BACKGROUND:We sought to determine whether mitral annular calcification (MAC) predicts mortality and cardiac disease in a group of renal transplant candidates. METHODS:Hundred and forty patients were prospectively studied. All had echocardiography and coronary angiography. Significant coronary artery disease (CAD) was ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.03.033

    authors： Sharma R,Pellerin D,Gaze DC,Mehta RL,Gregson H,Streather CP,Collinson PO,Brecker SJ

    更新日期：2007-04-01 00:00:00

  • A neutralizing antibody against receptor for advanced glycation end products (RAGE) reduces atherosclerosis in uremic mice.

    abstract：:Chronic renal failure markedly accelerates atherogenesis in apolipoprotein E-deficient (apoE(-/-)) mice. To study the putative role of receptor for advanced glycation end products (RAGE) in development of uremic atherosclerosis, apoE(-/-) mice received intraperitoneal injections thrice weekly of a neutralizing murine ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.01.015

    authors： Bro S,Flyvbjerg A,Binder CJ,Bang CA,Denner L,Olgaard K,Nielsen LB

    更新日期：2008-12-01 00:00:00

  • High-sensitivity cardiac troponin T in patients with intermittent claudication and its relation with cardiovascular events and all-cause mortality--the CAVASIC Study.

    abstract：BACKGROUND:Serum concentrations of high-sensitivity cardiac troponin T (hs-cTnT) are elevated in various diseases. The role of this marker in peripheral arterial disease (PAD) has not been fully investigated. METHODS:Hs-cTnT was measured in the CAVASIC Study, a male cohort of 235 patients diagnosed with intermittent c...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.10.097

    authors： Pohlhammer J,Kronenberg F,Rantner B,Stadler M,Peric S,Hammerer-Lercher A,Klein-Weigel P,Fraedrich G,Kollerits B

    更新日期：2014-12-01 00:00:00

  • Increased atherosclerosis following treatment with a dual PPAR agonist in the ApoE knockout mouse.

    abstract：OBJECTIVE:Recent reports have suggested that dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonists are associated with adverse cardiovascular events. This study aimed to investigate the actions of the non-thiazolidinedione PPARalpha/gamma agonist, compound 3q, on plaque development in the apolipop...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.11.021

    authors： Calkin AC,Allen TJ,Lassila M,Tikellis C,Jandeleit-Dahm KA,Thomas MC

    更新日期：2007-11-01 00:00:00

  • Differential suppression of lymphocyte cholesterol synthesis by low density lipoprotein and erythrocyte insulin receptors in normolipidemic subjects.

    abstract：:The rates of cholesterol synthesis from acetate were studied in freshly isolated peripheral blood lymphocytes in 41 age- and sex-matched subjects with essentially normal serum lipid profiles. Insulin binding to erythrocytes obtained from the same blood samples was also studied simultaneously. From the data on lymphocy...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(83)90141-7

    authors： Sanghvi A,Virji MA,Warty V,Dimasi MJ

    更新日期：1983-12-01 00:00:00

  • Enhanced vasoconstrictor effect of big endothelin-1 in patients with atherosclerosis: relation to conversion to endothelin-1.

    abstract：:The enhanced production of endothelin-1 (ET-1) in atherosclerotic arteries may be related to increased activity of the endothelin converting enzyme (ECE) which converts big ET-1 to ET-1. The purpose of the present study was to investigate whether the vasoconstrictor activity of big ET-1 is altered as a result of incre...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(01)00564-0

    authors： Böhm F,Johansson BL,Hedin U,Alving K,Pernow J

    更新日期：2002-01-01 00:00:00

  • Prediction of cardiovascular events with levels of proprotein convertase subtilisin/kexin type 9: A systematic review and meta-analysis.

    abstract：BACKGROUND AND AIMS:Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces atherogenic lipoproteins and could lead to reduction of cardiovascular (CV) events. However, it is unclear whether blood PCSK9 levels predict future CV events. We performed a meta-analysis of all longitudinal studies to dete...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.atherosclerosis.2016.07.922

    authors： Vlachopoulos C,Terentes-Printzios D,Georgiopoulos G,Skoumas I,Koutagiar I,Ioakeimidis N,Stefanadis C,Tousoulis D

    更新日期：2016-09-01 00:00:00

  • An investigation of the role of lecithin:cholesterol acyltransferase and triglyceride-rich lipoproteins in the metabolism of pre-beta high density lipoproteins.

    abstract：:Small high density lipoproteins (HDL) with pre-beta electrophoretic mobility (pre-beta HDL) have recently been shown to be the primary acceptor of cholesterol from cultured cells. We studied the metabolism of these particles by incubating serum at 37 degrees C in the presence and absence of active lecithin: cholestero...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(91)90005-n

    authors： Neary R,Bhatnagar D,Durrington P,Ishola M,Arrol S,Mackness M

    更新日期：1991-07-01 00:00:00

  • Circulating IGFBP-2 levels are incrementally linked to correlates of the metabolic syndrome and independently associated with VLDL triglycerides.

    abstract：OBJECTIVE:To assess whether plasma IGFBP-2 is independently associated with components of the lipoprotein-lipid profile and to suggest a cutoff value that could identify subjects with the features of the metabolic syndrome. METHODS:In this cross-sectional study, 379 Caucasian men from the general population and coveri...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.09.022

    authors： Carter S,Li Z,Lemieux I,Alméras N,Tremblay A,Bergeron J,Poirier P,Deshaies Y,Després JP,Picard F

    更新日期：2014-12-01 00:00:00

  • Cerivastatin: pharmacology of a novel synthetic and highly active HMG-CoA reductase inhibitor.

    abstract：:The pyridine derivative cerivastatin is a new entirely synthetic and enantiomerically pure inhibitor of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. As a sodium salt cerivastatin is present in the active, open ring form. Cerivastatin inhibited the membrane-bound (non-solubilized) HMG-CoA reductase of the native...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00188-3

    authors： Bischoff H,Angerbauer R,Bender J,Bischoff E,Faggiotto A,Petzinna D,Pfitzner J,Porter MC,Schmidt D,Thomas G

    更新日期：1997-11-01 00:00:00

  • Newly developed reconstituted high-density lipoprotein containing sphingosine-1-phosphate induces endothelial tube formation.

    abstract：:Reconstituted high-density lipoprotein (rHDL) has been shown to produce a rapid regression of atherosclerosis in animal models and humans. Sphingosine-1-phosphate (S1P), which is a bioactive lipid in HDL, plays a role in mitogenesis, endothelial cell motility, and cell survival, as well as organization and differentia...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.10.020

    authors： Matsuo Y,Miura S,Kawamura A,Uehara Y,Rye KA,Saku K

    更新日期：2007-09-01 00:00:00

  • Elevated CETP activity during acute phase of myocardial infarction is independently associated with endothelial dysfunction and adverse clinical outcome.

    abstract：OBJECTIVE:Recent data suggests that cholesteryl ester transfer protein (CETP) activity may interact with acute stress conditions via inflammatory-oxidative response and thrombogenesis. We investigated this assumption in patients with ST-elevation myocardial infarction (STEMI). METHODS:Consecutive patients with STEMI (...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.10.104

    authors： Carvalho LS,Virginio VW,Panzoldo NB,Figueiredo VN,Santos SN,Modolo RG,Andrade JM,Quinaglia E Silva JC,Nadruz-Junior W,de Faria EC,Sposito AC,Brasilia Heart Study Group.

    更新日期：2014-12-01 00:00:00

  • Passive smoking and mortality from aortic dissection or aneurysm.

    abstract：BACKGROUND AND AIMS:Evidence on the association between passive smoking and risk of aortic dissection or aneurysm is limited. This study aimed to investigate whether passive smoking increases risk of mortality from aortic dissection or aneurysm. METHODS:The Japan Collaborative Cohort (JACC) Study is a prospective comm...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2017.06.022

    authors： Kihara T,Yamagishi K,Iso H,Tamakoshi A,JACC Study Group.

    更新日期：2017-08-01 00:00:00

  • Platelet "-omics" in health and cardiovascular disease.

    abstract：:The importance of platelets for cardiovascular disease was established as early as the 19th century. Their therapeutic inhibition stands alongside the biggest achievements in medicine. Still, certain aspects of platelet pathophysiology remain unclear. This includes platelet resistance to antiplatelet therapy and the c...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2020.05.022

    authors： Gutmann C,Joshi A,Mayr M

    更新日期：2020-08-01 00:00:00

  • Extracellular pyrophosphate is reduced in aortic interstitial valve cells acquiring a calcifying profile: implications for aortic valve calcification.

    abstract：OBJECTIVES:Pyrophosphate (PPi) is a potent inhibitor of ectopic mineralization but its role during aortic valve calcification is not known. METHODS:Anti-calcific effect of PPi was investigated by using an in vitro model of serum-driven calcification of collagen sponges and decellularized porcine aortic valve leaflets....

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.10.027

    authors： Rattazzi M,Bertacco E,Iop L,D'Andrea S,Puato M,Buso G,Causin V,Gerosa G,Faggin E,Pauletto P

    更新日期：2014-12-01 00:00:00

  • Human cardiac microvascular and macrovascular endothelial cells respond differently to oxidatively modified LDL.

    abstract：:Oxidation of low density lipoproteins (LDL) is considered a key event in the pathogenesis of atherosclerotic lesions. Disturbed generation of coagulatory and anticoagulatory factors by endothelial cells contributes to thrombosis and the progression of atherosclerosis in coronary arteries. In this study, the effects of...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00258-x

    authors： Gräfe M,Auch-Schwelk W,Hertel H,Terbeek D,Steinheider G,Loebe M,Fleck E

    更新日期：1998-03-01 00:00:00

  • The effect of sex hormones on glycosaminoglycan content of canine aorta and coronary arteries.

    abstract：:Hyaluronate (HA), heparan sulfate (HS), dermatan sulfate (DS) and isomeric chondroitin sulfates (CS) were measured in vascular walls of 9-10 months old normal and hypophysectomized female beagles treated with sex hormones. Following hypophysectomy the animals were maintained for 8 weeks without any hormonal replacemen...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(77)90060-0

    authors： Sirek OV,Sirek A,Fikar K

    更新日期：1977-06-01 00:00:00

  • Statin therapy among chronic kidney disease patients presenting with acute coronary syndrome.

    abstract：BACKGROUND AND AIMS:The beneficial effect of statin therapy has been well established for both primary and secondary prevention of cardiovascular disease. Nevertheless, it remains under-used among patients with chronic kidney disease (CKD). We aimed to investigate the impact of statin therapy across a wide spectrum of ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2019.05.002

    authors： Natanzon SS,Matetzky S,Beigel R,Iakobishvili Z,Goldenberg I,Shechter M,Acute Coronary Syndrome Israel Survey (ACSIS) investigators.

    更新日期：2019-07-01 00:00:00

  • Effects of gender and social behavior on the development of coronary artery atherosclerosis in cynomolgus macaques.

    abstract：:This experiment involved examination of the effects of gender and social status ('competitive dominance') on the coronary artery atherosclerosis of cynomolgus monkeys. Thirty-two adult Macaca fascicularis (16 males, 16 females) were fed a diet containing a moderate amount of cholesterol (0.56 mg/cal) for 16 months. Th...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(83)90040-0

    authors： Hamm TE Jr,Kaplan JR,Clarkson TB,Bullock BC

    更新日期：1983-09-01 00:00:00