Cardiorespiratory fitness and coronary artery calcification in young adults: The CARDIA Study.

abstract：:Lipoprotein dynamics are complex during the postprandial state. A significant rise in chylomicron concentration is associated with increased competition for LPL with VLDL particles. This results in an increased concentration of large VLDL. The concentration of small VLDL is reduced as a result of diminished conversion...

journal_title：Atherosclerosis

authors： Hugh P,Barrett R

更新日期：1998-12-01 00:00:00

abstract：:To assess the risk for homocyst(e)ine-associated vascular disease, overt hyperhomocyst(e)inemia should be demonstrated. In nonhomocystinuric subjects, clinical vascular disease must have developed after 40 or more years of persistent hyperhomocyst(e)inemia which may not be present without a genetic defect(s). Nongenet...

journal_title：Atherosclerosis

authors： Kang SS,Wong PW

更新日期：1996-01-26 00:00:00

abstract：:The postheparin plasma lipoprotein lipase (LPL) activity and plasma HDL and LDL cholesterol concentrations, decreases significantly during probucol treatment of the rat. The reduction of the LPL activity obviously took place in adipose tissue. The activity of hepatic lipase and the in vitro synthesis of cholesterol in...

journal_title：Atherosclerosis

authors： Strandberg T,Kuusi T,Tilvis R,Miettinen TA

更新日期：1981-11-01 00:00:00

abstract：BACKGROUND:The identification of mutations in PCSK9 (proprotein convertase subtilisin kexin9) in autosomal dominant hypercholesterolemia (ADH), has revealed the existence of a new player in cholesterol homeostasis. PCSK9 has been shown to enhance the degradation of the LDL receptor (LDLR) at the cell surface. Gain-of-f...

journal_title：Atherosclerosis

authors： Abifadel M,Guerin M,Benjannet S,Rabès JP,Le Goff W,Julia Z,Hamelin J,Carreau V,Varret M,Bruckert E,Tosolini L,Meilhac O,Couvert P,Bonnefont-Rousselot D,Chapman J,Carrié A,Michel JB,Prat A,Seidah NG,Boileau C

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:Plaque with dense inflammatory cells, including macrophages, thin fibrous cap and superficial necrotic/lipid core is thought to be prone-to-rupture. We report a time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) technique for detection of such markers of plaque vulnerability in human plaques. ME...

journal_title：Atherosclerosis

authors： Marcu L,Jo JA,Fang Q,Papaioannou T,Reil T,Qiao JH,Baker JD,Freischlag JA,Fishbein MC

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Tissue proportions of long chain n-6 [especially arachidonic acid (AA)] and n-3 fatty acids [FA; eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) acids], or some ratio of these may be markers of risk for coronary heart disease (CHD). The purpose of this paper is to evaluate the published associatio...

journal_title：Atherosclerosis

authors： Harris WS,Poston WC,Haddock CK

更新日期：2007-07-01 00:00:00

abstract：:Rabbits were fed cholesterol for 14 weeks to study the effect of probucol on atheroma formation. Three groups of animals were investigated: group CHOL was fed 1% cholesterol and served as control for group P + CHOL. fed 1% cholesterol and 1% probucol from the onset till the end of the experiment: group CHOL + P receiv...

journal_title：Atherosclerosis

authors： Stein Y,Stein O,Delplanque B,Fesmire JD,Lee DM,Alaupovic P

更新日期：1989-02-01 00:00:00

abstract：OBJECTIVE:Recent reports of animal models have shown that growth factors have stimulating effect on brain perfusion via the development of blood vessels. However, studies on the effect of growth factors on brain perfusion in humans are lacking. The aim of our study was to prospectively investigate in humans the relatio...

journal_title：Atherosclerosis

authors： van Laar PJ,van Raamt AF,van der Grond J,Mali WPTM,van der Graaf Y,Hendrikse J,SMART Study Group.

更新日期：2008-01-01 00:00:00

abstract：:Methionine is converted by the transmethylation/transsulfuration pathway to homocysteine which may exert atherogenic effects by several mechanisms, including lipid peroxidation. Therefore, the excessive dietary methionine may induce the development of atherosclerosis. To test this hypothesis, plasma and aortic thiobar...

journal_title：Atherosclerosis

authors： Toborek M,Kopieczna-Grzebieniak E,Drózdz M,Wieczorek M

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:Being the earliest step on the way to atherosclerosis, endothelial dysfunction is particularly escalated in diabetes. This study aimed at assessing endothelial dysfunction and blood pressure disturbances in young patients with type 1 diabetes mellitus (T1DM) and defining their interrelations. METHODS:The stu...

journal_title：Atherosclerosis

authors： Machnica L,Deja G,Polanska J,Czupryniak L,Szymanska-Garbacz E,Loba J,Jarosz-Chobot P

更新日期：2014-11-01 00:00:00

abstract：:We have examined the prevalence of clinically significant atherosclerosis in 78 patients with type III hyperlipoproteinemia (HLP) and homozygosity for apolipoprotein (apo) E2. Forty-six of these individuals (59%) had no atherosclerosis, 32 patients (41%) had atherosclerosis, i.e., atherosclerosis of the extracranial c...

journal_title：Atherosclerosis

authors： Dobmeyer J,Lohrmann J,Feussner G

更新日期：1996-01-05 00:00:00

abstract：:The arterial endothelial intercellular cleft (AEC) and its associated junctional complex (JC) are the determinants of permeability to macromolecules. This study analyzed frequencies of AEC and JC profile types in the rat thoracic aorta at 1 and 12 months after feeding the animals with a normal or a high-cholesterol di...

journal_title：Atherosclerosis

authors： Lee WC,Chao WT,Yang VC

更新日期：2001-04-01 00:00:00

abstract：:The proteolytic activity of proinflammatory matrix metalloproteinases (MMPs) is elevated in lipid-rich atherosclerotic plaques, thereby contributing to plaque fragility and rupture. We hypothesized that changes in circulating levels of MMPs and their specific inhibitors (TIMPs) could reflect the atherosclerotic proces...

journal_title：Atherosclerosis

authors： Beaudeux JL,Giral P,Bruckert E,Bernard M,Foglietti MJ,Chapman MJ

更新日期：2003-07-01 00:00:00

abstract：:The effect of immunological injury upon the early in vivo changes in aortic connective tissue metabolism was studied. It was found that a single antigen (bovine serum albumin), when administered in multiple doses, activated collagen synthesis and increased the rate of lgycosaminoglycan synthesis in the arterial wall. ...

journal_title：Atherosclerosis

authors： Rokosova B,Bentley JP

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Carotid artery plaque is an established marker of subclinical atherosclerosis and common patho-mechanisms with coronary artery disease (CAD) are hypothesized. We aimed to identify genetic variants associated with carotid plaque and to examine the potential shared genetic basis with CAD. METHODS:Aft...

journal_title：Atherosclerosis

authors： Pott J,Burkhardt R,Beutner F,Horn K,Teren A,Kirsten H,Holdt LM,Schuler G,Teupser D,Loeffler M,Thiery J,Scholz M

更新日期：2017-04-01 00:00:00

abstract：:The involvement of endothelium-derived hyperpolarizing factor (EDHF) in the protective effect of 17beta-estradiol was investigated on the phenylephrine-precontracted carotid artery from cholesterol fed rabbits. Animals were fed for 8 weeks as follows: control group, standard chow; (control+estradiol) group, standard c...

journal_title：Atherosclerosis

authors： Ghanam K,Ea-Kim L,Javellaud J,Oudart N

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Familial dysbetalipoproteinemia (FD), also known as type III hyperlipoproteinemia, is a genetic dyslipidemia characterized by elevated very low density lipoprotein (VLDL) and chylomicron remnant particles that confers increased risk of cardiovascular disease (CVD). The objective of this study was to evaluate...

journal_title：Atherosclerosis

authors： Koopal C,Retterstøl K,Sjouke B,Hovingh GK,Ros E,de Graaf J,Dullaart RP,Bertolini S,Visseren FL

更新日期：2015-05-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) is expressed in atherosclerotic plaques. It is generally recognized that CTGF contributes to atherosclerosis by stimulating vascular smooth muscle cell (VSMC) proliferation and extracellular matrix production during the development of atherosclerosis. Recent studies indicate that...

journal_title：Atherosclerosis

authors： Game BA,He L,Jarido V,Nareika A,Jaffa AA,Lopes-Virella MF,Huang Y

更新日期：2007-05-01 00:00:00

abstract：:beta-Oxidation of long-chain fatty acids increases many-fold in atherosclerotic aortas; this may be due to an increase in the activity of the mitochondrial enzyme hexadecanoyl-CoA: carnitine O-hexadecanoyltransferase EC 2.3.1.23 (trivial name: carnitine palmitoyltransferase, CPT). To investigate this possibility, an a...

journal_title：Atherosclerosis

authors： Gillies PJ,Bell FP

更新日期：1979-09-01 00:00:00

abstract：:We examined cross-sectional associations between sex hormones and carotid artery intimal-medial thickness (cIMT) and coronary artery calcium in women in the Multi-Ethnic Study of Atherosclerosis. Serum testosterone, estradiol, sex hormone binding globulin (SHBG), and dehydroepiandrosterone levels were measured in 1947...

journal_title：Atherosclerosis

authors： Ouyang P,Vaidya D,Dobs A,Golden SH,Szklo M,Heckbert SR,Kopp P,Gapstur SM

更新日期：2009-05-01 00:00:00

abstract：:The hydrolysis of lipoprotein triglycerides is catalyzed by lipoprotein lipase (LPL), an enzyme found in many tissues. We have examined tissue LPL activity (LPLA) in rats with experimentally-induced hyperthyroidism. In younger, lighter rats, hyperthyroidism was accompanied by a decrease in LPL in adipose tissue wherea...

journal_title：Atherosclerosis

authors： Wilson DE,Jubiz W,Flowers CM,Carlile SI,Adolf AM

更新日期：1977-03-01 00:00:00

abstract：:Cardiovascular risk is increased in patients with diabetic nephropathy. The aim of this study was to examine the relative impacts of albuminuria and renal failure, the two important features of diabetic nephropathy, on potentially atherogenic lipoprotein changes in this condition. The subjects were 160 non-diabetic he...

journal_title：Atherosclerosis

authors： Shoji T,Emoto M,Kawagishi T,Kimoto E,Yamada A,Tabata T,Ishimura E,Inaba M,Okuno Y,Nishizawa Y

更新日期：2001-06-01 00:00:00

abstract：:Oxidant signalling and lipoprotein oxidation may play important roles in atherosclerotic lesion development. Given coincident localization of 15-lipoxygenase (15-LO), stereospecific products of 15-LO and epitopes of modified LDL in atherosclerotic lesions, we hypothesized that inhibition of 15-LO by PD146176, an inhib...

journal_title：Atherosclerosis

authors： Bocan TM,Rosebury WS,Mueller SB,Kuchera S,Welch K,Daugherty A,Cornicelli JA

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:Adiponectin is one of several important, metabolically active cytokines secreted from adipose tissue. Epidemiologic studies have associated low circulating levels of this adipokine with multiple metabolic disorders including obesity, insulin resistance, type II diabetes, and cardiovascular disease. To investi...

journal_title：Atherosclerosis

authors： Luo N,Chung BH,Wang X,Klein RL,Tang CK,Garvey WT,Fu Y

更新日期：2013-05-01 00:00:00

abstract：:Inflammation has been demonstrated to be an important risk factor for the development of cardiovascular events. Patients with elevated white blood cell counts have been shown to be in a higher risk of developing acute myocardial infarction and acute coronary and vascular events. We review the clinical data of high whi...

journal_title：Atherosclerosis

authors： Hoffman M,Blum A,Baruch R,Kaplan E,Benjamin M

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:Markers of non-specific inflammation, such as C-reactive protein (CRP) or leukocyte count are increased in end-stage renal disease patients. Recent studies have shown positive associations between inflammatory markers and cardiovascular mortality in kidney transplant recipients, but these analyses had been l...

journal_title：Atherosclerosis

authors： Krüger B,Walberer A,Debler J,Böger CA,Farkas S,Reinhold SW,Obed A,Schlitt HJ,Fischereder M,Banas B,Krämer BK

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:The influence of hepatitis C virus (HCV) infection on atherosclerosis risk in HIV-infected patients has not been adequately evaluated in real-life situations. OBJECTIVES AND METHODS:We compared indexes of early atherosclerosis evaluated by echo-Doppler ultrasound (presence of plaque in carotid or femoral ar...

journal_title：Atherosclerosis

authors： Sosner P,Wangermez M,Chagneau-Derrode C,Le Moal G,Silvain C

更新日期：2012-05-01 00:00:00

abstract：:HMG-CoA reductase inhibitor drugs or 'statins' have been shown to effectively reduce plasma total cholesterol (CHOL), CHOL associated with low-density-lipoprotein (LDL), and triglycerides (TG). In addition, slight elevations in HDL-CHOL are also typically observed. Poloxamer 407 (P-407), a nonionic surfactant, effecti...

journal_title：Atherosclerosis

authors： Johnston TP,Baker JC,Hall D,Jamal S,Palmer WK,Emeson EE

更新日期：2000-04-01 00:00:00

abstract：:Although it has been widely acknowledged that endothelial injury is an important contributing factor to the pathogenesis of atherosclerosis, and may even represent an initiating event, morphologic documentation of its occurrence both in humans and animals has been difficult to obtain. However, electrical stimulation o...

journal_title：Atherosclerosis

authors： Gutstein WH

更新日期：1988-03-01 00:00:00

abstract：:There are no definitive explanations as to why individuals with hypercholesterolemia, a major cardiovascular risk factor, respond differently to dietary change. Fifty five free-living individuals completed a double crossover trial with two dietary regimens, a high saturated fat diet (providing 21% energy from saturate...

journal_title：Atherosclerosis

authors： Wallace AJ,Mann JI,Sutherland WH,Williams S,Chisholm A,Skeaff CM,Gudnason V,Talmud PJ,Humphries SE

更新日期：2000-10-01 00:00:00