Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries.

abstract：:We describe the cardiovascular state of a 60-year-old homozygous patient with familial HDL deficiency (Tangier disease). The patient was examined by coronary angiography and intravascular ultrasound because of chest pain at rest and on exertion. We found a normal left ventricular function, moderately diffuse coronary ...

journal_title：Atherosclerosis

authors： Walter M,Kerber S,Fechtrup C,Seedorf U,Breithardt G,Assmann G

更新日期：1994-10-01 00:00:00

abstract：:There is clear evidence of lipoprotein oxidation in atherosclerotic lesions. Animal studies and observational prospective human cohort studies have been interpreted as supporting a role for antioxidants in the prevention of coronary heart disease (CHD). However, firm recommendations to take antioxidant supplements to ...

journal_title：Atherosclerosis

authors： Kritharides L,Stocker R

更新日期：2002-10-01 00:00:00

abstract：:Patients with homozygous familial hypercholesterolemia (FH), as a result of the increased levels and prolonged residence time of low density lipoprotein (LDL) in plasma, have a strong tendency toward accumulation of LDL-cholesterol in the arterial wall, causing premature atherosclerosis. This phenomenon may enhance pe...

journal_title：Atherosclerosis

authors： Napoli C,Postiglione A,Triggiani M,Corso G,Palumbo G,Carbone V,Ruocco A,Ambrosio G,Montefusco S,Malorni A,Condorelli M,Chiariello M

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Early detection of atrial fibrillation after stroke is important for secondary prevention in stroke patients without known atrial fibrillation (AF). We aimed to compare the performance of CHADS2, CHA2DS2-VASc and HATCH scores in predicting AF detected after stroke (AFDAS) and to test whether adding ...

journal_title：Atherosclerosis

authors： Hsieh CY,Lee CH,Wu DP,Sung SF

更新日期：2018-05-01 00:00:00

abstract：:This experiment involved examination of the effects of gender and social status ('competitive dominance') on the coronary artery atherosclerosis of cynomolgus monkeys. Thirty-two adult Macaca fascicularis (16 males, 16 females) were fed a diet containing a moderate amount of cholesterol (0.56 mg/cal) for 16 months. Th...

journal_title：Atherosclerosis

authors： Hamm TE Jr,Kaplan JR,Clarkson TB,Bullock BC

更新日期：1983-09-01 00:00:00

abstract：:We previously identified a G>A single nucleotide polymorphism (SNP) between C57BL/6J (B6) and C3H/HeJ (C3H) mouse strains at position 2077 in the coding region of Vcam1 that leads to substitution of an amino acid from aspartic acid (D) to asparagine (N) in the protein product. In the present study, we investigated the...

journal_title：Atherosclerosis

authors： Miyoshi T,Yuan Z,Shi W

更新日期：2008-01-01 00:00:00

abstract：:The intravascular metabolism of sterol labeled [1,2,6,7-3H(N)]cholesteryl oleate and acyl labeled cholesteryl [9,10-3H]oleate and cholesteryl [1-14C]oleate was compared in the rat, an animal species without plasma cholesteryl ester transfer activity (CETA). In a first series of studies, the metabolism of sterol labele...

journal_title：Atherosclerosis

authors： Terpstra AH

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Recent failures of clinical trials promoting HDL-elevating therapies have prompted research groups to focus on its functional activity in disease. Endothelial effects of HDL can be measured with in vitro cell assays. The reproducibility and biological relevance of these assays have not been explored both in ...

journal_title：Atherosclerosis

authors： O'Neill F,McLoughlin E,Riwanto M,Manz J,Adler A,Sutill E,Khan T,Haywood R,Kay CW,D'Aiuto F,Charakida M,Landmesser U,Deanfield J

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND AND AIMS:The optimal approaches to management of patients treated with moderate statin doses on lipid parameters are unknown. The ACCENTUATE study aimed to compare the effects of adding the cholesteryl ester transfer protein inhibitor (CETP) evacetrapib, ezetimibe or increasing statin dose in atorvastatin-tr...

journal_title：Atherosclerosis

authors： Nicholls SJ,Ray KK,Ballantyne CM,Beacham LA,Miller DL,Ruotolo G,Nissen SE,Riesmeyer JS,ACCENTUATE Investigators.

更新日期：2017-06-01 00:00:00

abstract：:Low-density lipoprotein (LDL) concentration in plasma is an important predictor for atherosclerosis, and desialylated LDL has been proposed to be particularly atherogenic. Atherosclerosis is also associated with vascular endothelial dysfunction. We therefore wished to test the hypothesis that removal of sialic acid re...

journal_title：Atherosclerosis

authors： Stratton PD,Lumb PJ,Paganga G,Crook MA,Ferro A

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Atherosclerosis is a chronic lipid-driven inflammatory disease of the arterial wall. Interferon gamma (IFNγ) is an important immunomodulatory cytokine and a known pro-atherosclerotic mediator. However, cell-specific targeting of IFNγ or its signaling in atherosclerosis development has not been studi...

journal_title：Atherosclerosis

authors： Boshuizen MC,Neele AE,Gijbels MJ,van der Velden S,Hoeksema MA,Forman RA,Muller W,Van den Bossche J,de Winther MP

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:α-Linolenic acid (ALA), the vegetable n-3 fatty acid, appears to have antiatherosclerotic properties akin to those of marine n-3 fatty acids. A prior study in a US population with low fish intake showed an inverse association between ALA intake and carotid plaque. We examined the association between the ALA s...

journal_title：Atherosclerosis

authors： Sala-Vila A,Cofán M,Núñez I,Gilabert R,Junyent M,Ros E

更新日期：2011-01-01 00:00:00

abstract：:Exercise affects lipoprotein metabolism and apolipoprotein E (Apo E) genotype may alter changes in lipoprotein subclasses that occur with exercise. The present study examined the effects of Apo E genotype (APOE) on the response of lipoprotein subclass concentrations to long-term exercise. A prospective longitudinal st...

journal_title：Atherosclerosis

authors： Seip RL,Otvos J,Bilbie C,Tsongalis GJ,Miles M,Zoeller R,Visich P,Gordon P,Angelopoulos TJ,Pescatello L,Moyna N,Thompson PD

更新日期：2006-09-01 00:00:00

abstract：:We describe a new method for the rapid fractionation of plasma lipoproteins, which makes use of a new non-ionic, iodinated, density gradient medium, iodixanol, commercially available as Optiprep(TM). The method is simple: plasma or serum is mixed with iodixanol followed by centrifugation in a vertical or near vertical...

journal_title：Atherosclerosis

authors： Graham JM,Higgins JA,Gillott T,Taylor T,Wilkinson J,Ford T,Billington D

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Recent studies indicate that subclavian stenosis (SS), diagnosed by a large systolic blood pressure difference (SBPD) between the right and left brachial arteries, is associated with cardiovascular disease (CVD) risk factors and outcomes. We sought to describe the epidemiology of SS and determine its associa...

journal_title：Atherosclerosis

authors： Aboyans V,Kamineni A,Allison MA,McDermott MM,Crouse JR,Ni H,Szklo M,Criqui MH

更新日期：2010-07-01 00:00:00

abstract：:Incubated human peripheral blood monocytes release a factor(s) which specifically stimulates homologous vascular smooth muscle (SMC) but not endothelial cells (EC) to proliferate in vitro. Conditioned medium from activated monocytes significantly (P less than 0.001) stimulated proliferation of SMC within 6 days of cul...

journal_title：Atherosclerosis

authors： Ziats NP,Robertson AL Jr

更新日期：1981-02-01 00:00:00

abstract：OBJECTIVE:Several studies have shown that periodontitis is a risk factor for cardiovascular diseases. There is an association between inflammation and endothelial dysfunction. The purpose of this study was to evaluate endothelial function in patients with coronary artery disease (CAD) who had periodontitis. METHODS AN...

journal_title：Atherosclerosis

authors： Higashi Y,Goto C,Hidaka T,Soga J,Nakamura S,Fujii Y,Hata T,Idei N,Fujimura N,Chayama K,Kihara Y,Taguchi A

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Statin is not beneficial for dialysis patients but moderate to high intensity statin is beneficial for patients after acute myocardial infarction (MI). The aim of this study was to evaluate the effect of moderate to high intensity statin on mortality, cardiovascular outcomes in dialysis patients aft...

journal_title：Atherosclerosis

authors： Chung CM,Lin MS,Chang CH,Cheng HW,Chang ST,Wang PC,Chang HY,Lin YS

更新日期：2017-12-01 00:00:00

abstract：:An attempt was made to explore the reasons why men develop coronary heart disease (CHD) despite being at low risk on the basis of established risk factors. A case control study was designed to take place after the end of a longitudinal study in which both low- and high-risk men who had developed CHD over the course of...

journal_title：Atherosclerosis

authors： Heller RF,Miller NE,Wheeler MJ,Kind PR

更新日期：1983-11-01 00:00:00

abstract：:The new millennium has brought intense focus of interest on the risk of cardiovascular disease in women. The polycystic ovary syndrome (PCOS) is a common endocrine disorder in women characterised by hyperandrogenism and oligomenorrhoea. Most women with PCOS also exhibit features of the metabolic syndrome, including in...

journal_title：Atherosclerosis

authors： Cussons AJ,Stuckey BG,Watts GF

更新日期：2006-04-01 00:00:00

abstract：:Several studies indicate that the inter-individual variation in plasma concentrations of lipoprotein(a) (Lp(a)) is mainly under genetic control. To define the effect of three DNA polymorphisms on apolipoprotein(a) (apo(a)) expression, we have determined plasma Lp(a) concentrations, apo(a) isoform size, KpnI allele siz...

journal_title：Atherosclerosis

authors： Valenti K,Aveynier E,Leauté S,Laporte F,Hadjian AJ

更新日期：1999-11-01 00:00:00

abstract：:Simvastatin, an inhibitor of HMG CoA reductase, lowers the plasma total cholesterol and LDL-cholesterol concentration in familial hypercholesterolemic patients. The efficacy of the drug shows considerable inter-individual variation, however. In this study we have assessed the influence of certain LDL-receptor gene mut...

journal_title：Atherosclerosis

authors： Jeenah M,September W,Graadt van Roggen F,de Villiers W,Seftel H,Marais D

更新日期：1993-01-04 00:00:00

abstract：:The levels, isoforms and distribution of apolipoprotein A-IV (apo A-IV) were investigated in 127 term human umbilical cord sera. In addition, apo A-IV levels and isoforms were determined on the 3rd (n = 82) and 6th (n = 68) day following parturition and compared to apo A-I concentrations. Levels of apo A-IV were low i...

journal_title：Atherosclerosis

authors： Steinmetz A,Czekelius P,Thiemann E,Motzny S,Kaffarnik H

更新日期：1988-01-01 00:00:00

abstract：:Epidemiological and clinical data demonstrate differences in atherosclerotic coronary heart disease prevalence between age-matched men and premenopausal women. Mechanisms underlying relative athero-susceptibility in men and athero-resistance in premenopausal women remain to be elucidated. Lack of informative animal mo...

journal_title：Atherosclerosis

authors： Herrera VL,Tsikoudakis A,Didishvili T,Ponce LR,Bagamasbad P,Gantz D,Herscovitz H,Van Tol A,Ruiz-Opazo N

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Heterozygous familial hypercholesterolemia (heFH) is a common autosomal dominant hereditary disorder caused by mutations in the LDL-receptor gene that lead to elevated plasma levels of low-density lipoprotein-cholesterol (LDL-c). Robust lowering of LDL-c levels is essential for risk reduction of premature ca...

journal_title：Atherosclerosis

authors： Pijlman AH,Huijgen R,Verhagen SN,Imholz BP,Liem AH,Kastelein JJ,Abbink EJ,Stalenhoef AF,Visseren FL

更新日期：2010-03-01 00:00:00

abstract：:beta-very low-density lipoprotein (beta-VLDL), a collective term for VLDL and chylomicron remnants, has recently shown to potently promote the development of atherosclerosis. However, the effects of beta-VLDL on the accumulation of nitric oxide (NO) and the expression of inducible NO synthase (iNOS) in vascular smooth...

journal_title：Atherosclerosis

authors： Takahashi M,Takahashi S,Shimpo M,Naito A,Ogata Y,Kobayashi E,Ikeda U,Shimada K

更新日期：2002-06-01 00:00:00

abstract：:The risk factors for cardiovascular disease are related directly or indirectly in women, as in men, to lipid and lipoprotein levels. But women have the advantage of the beneficial effects of either endogenous or exogenous estrogen on these levels throughout most of their lives. Behaviors such as smoking or diseases su...

journal_title：Atherosclerosis

authors： Miller VT

更新日期：1994-08-01 00:00:00

abstract：:Low-density lipoprotein cholesterol (LDL-C) and the small dense LDL (SdLDL) phenotype are both predictors for ischemic heart disease. We examined whether cholesterol of SdLDL (SdLDL-C) is more closely associated with carotid artery intima-media thickness (CA-IMT), a surrogate measure of atherosclerosis, than LDL-C and...

journal_title：Atherosclerosis

authors： Shoji T,Hatsuda S,Tsuchikura S,Shinohara K,Kimoto E,Koyama H,Emoto M,Nishizawa Y

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Individuals with type 1 diabetes mellitus are at high risk of developing atherosclerotic cardiovascular disease, but the underlying mechanisms by which type 1 diabetes accelerates atherosclerosis remain unknown. Increased retention of low-density lipoprotein (LDL) in atherosclerosis-prone sites of t...

journal_title：Atherosclerosis

authors： Hagensen MK,Mortensen MB,Kjolby M,Stillits NL,Steffensen LB,Bentzon JF

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The Jewish population of Israel consumes a diet rich in polyunsaturated fatty acids with a relatively low proportion of saturated fat, has a small alcohol intake and a lipid profile characterized by low HDL-cholesterol and high lipoprotein(a) (Lp(a)). It is therefore of interest to compare occurrence rates o...

journal_title：Atherosclerosis

authors： Kark JD,Goldberger N,Fink R,Adler B,Kuulasmaa K,Goldman S

更新日期：2005-01-01 00:00:00