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Characterization of atherosclerosis in a patient with familial high-density lipoprotein deficiency.

Abstract：

:We describe the cardiovascular state of a 60-year-old homozygous patient with familial HDL deficiency (Tangier disease). The patient was examined by coronary angiography and intravascular ultrasound because of chest pain at rest and on exertion. We found a normal left ventricular function, moderately diffuse coronary sclerosis without stenosis and no critical stenosis of peripheral arteries. Intravascular ultrasound revealed the three layer appearance of arterial intima, media and adventitia with normal thickness. No calcified plaques or intimal hyperplasia could be detected apart from a single, discrete atherosclerotic lesion in one iliac artery segment. Concentric non-occlusive atherosclerotic lesions which are readily detectable with intravascular ultrasound were not found. The lack of severe atherosclerosis was remarkable insofar as massive foam cell formation and the virtually complete absence of circulating HDL is characteristic of Tangier disease and has been previously demonstrated in this patient. Our findings suggest that HDL deficiency and foam cell formation in Tangier disease are not necessarily associated with accelerated development of atherosclerosis.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Walter M,Kerber S,Fechtrup C,Seedorf U,Breithardt G,Assmann G

doi

10.1016/0021-9150(94)90205-4

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

203-8

issue

2

eissn

0021-9150

issn

1879-1484

pii

0021-9150(94)90205-4

journal_volume

110

pub_type

杂志文章

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