Activity and concentration of lipoprotein lipase in post-heparin plasma and the extent of coronary artery disease.


:Numerous studies have found polymorphisms in the lipoprotein lipase (LPL) gene to be associated with the risk of coronary artery disease (CAD), implicating LPL in the development of atherothrombotic disease. It remains controversial, however, whether LPL acts in a pro- or anti-atherogenic fashion. We quantitated activity and concentration of LPL in post-heparin plasma from 194 male patients undergoing coronary angiography. HDL cholesterol was significantly associated with LPL activity quartiles (1.09+/-0.26 the highest vs. 0.96+/-0.25 mmol/l the lowest quartile, P<0.01). There was also a trend towards higher total (5.61+/-1.33 vs. 5.16+/-1.44 mmol/l, P=0.059) and LDL cholesterol (3.92+/-1.39 vs. 3.46+/-1.06 mmol/l, P=0.09) with higher LPL activity. In contrast, measures of CAD extent showed no differences between LPL quartiles (P>0.30 for prior myocardial infarction, number of diseased vessels, Gensini and extent scores). Additionally, there was no difference in LPL activity (CAD: n=158, 168+/-70 nmol/ml/min, no CAD: n=36, 180+/-89 nmol/ml/min, P=0.47) or concentration (280+/-121 ng/ml and 288+/-111 ng/ml, P=0.72) between patients with and without CAD. Our data show that, in spite of an association with lipoprotein parameters, LPL in post-heparin plasma is unrelated to the presence or the extent of CAD. Therefore, lipoprotein lipase determination in plasma does not appear to be a useful marker in the assessment of CAD risk.






Dugi KA,Schmidt N,Brandauer K,Ramacher D,Fiehn W,Kreuzer J





Has Abstract


2002-07-01 00:00:00














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    authors: Sumi Y,Inoue N,Azumi H,Seno T,Okuda M,Hirata K,Kawashima S,Hayashi Y,Itoh H,Yokoyama M

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    pub_type: 杂志文章


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    pub_type: 杂志文章,随机对照试验


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    更新日期:2011-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Carter S,Li Z,Lemieux I,Alméras N,Tremblay A,Bergeron J,Poirier P,Deshaies Y,Després JP,Picard F

    更新日期:2014-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Evensen SA,Galdal KS,Nilsen E

    更新日期:1983-10-01 00:00:00

  • Relation of plasma high-density lipoprotein cholesterol to lipoprotein-lipase activity in adipose tissue and skeletal muscle of man.

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    pub_type: 杂志文章


    authors: Nikkilä EA,Taskinen MR,Kekki M

    更新日期:1978-04-01 00:00:00