Control of the interaction of cholesterol ester-rich lipoproteins with arterial receptors.

abstract：BACKGROUND:Abdominal aortic aneurysm (AAA) is characterized by vascular remodeling with increased infiltration of inflammatory cells and apoptosis/modulation of vascular smooth muscle cells (SMCs). Imatinib is a selective inhibitor of several tyrosine kinases, including PDGF receptors, Abl, and c-kit. The objective of ...

journal_title：Atherosclerosis

authors： Vorkapic E,Dugic E,Vikingsson S,Roy J,Mäyränpää MI,Eriksson P,Wågsäter D

更新日期：2016-06-01 00:00:00

abstract：:A synergistic interaction between the insertion/deletion (I/D) polymorphism within the angiotensin-converting enzyme (ACE) gene and an A/C transversion at nucleotide position 1166 within the angiotensin II sub-type 1 receptor (AT1R) gene on risk of myocardial infarction has been reported. The risk associated with the ...

journal_title：Atherosclerosis

authors： Steeds RP,Wardle A,Smith PD,Martin D,Channer KS,Samani NJ

更新日期：2001-01-01 00:00:00

abstract：:Endothelial cells (EC) were harvested by 0.1% collagenase treatment for adult human thoracic aortas obtained 1-3 h after sudden death. At least 35-70% of EC were removed from the intimal surface of aorta, 90-95% of them being viable. Plating efficiency was 70-80%. Monolayer formation was achieved at a seeding density ...

journal_title：Atherosclerosis

authors： Antonov AS,Nikolaeva MA,Klueva TS,Romanov YuA,Babaev VR,Bystrevskaya VB,Perov NA,Repin VS,Smirnov VN

更新日期：1986-01-01 00:00:00

abstract：:The present study analysed the effects of hydroxytyrosol (HT) on blood lipids, antioxidant status and the progression of aortic lesions in hyperlipemic rabbits. Sixty-four rabbits were distributed into eight groups of animals (n = 8). Animal groups C, A and H were fed for 1-month with a control diet containing sunflow...

journal_title：Atherosclerosis

authors： González-Santiago M,Martín-Bautista E,Carrero JJ,Fonollá J,Baró L,Bartolomé MV,Gil-Loyzaga P,López-Huertas E

更新日期：2006-09-01 00:00:00

abstract：:Increased oxidative stress (SOX), inflammation and prevalence of cardiovascular disease (CVD) have been reported in end-stage renal disease (ESRD), but their associations with kynurenine (KYN) pathway activation remain unknown. We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HK...

journal_title：Atherosclerosis

authors： Pawlak K,Domaniewski T,Mysliwiec M,Pawlak D

更新日期：2009-05-01 00:00:00

abstract：:Epidemiological evidence supports the use of non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B-100 (apoB), and low-density lipoprotein particles as markers of atherogenic risk. Treatment guidelines also identify these as additional targets of lipid-modifying intervention in patients with elevated ...

journal_title：Atherosclerosis

authors： Rosenson RS

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:A direct correlation between blood glucose levels and the microvascular complications of diabetes is well established. However, the effects of hyperglycaemia on the vasa vasorum, a microvascular network which surrounds and supplies the walls of large arteries, is not known. The objective of this study is to i...

journal_title：Atherosclerosis

authors： Veerman KJ,Venegas-Pino DE,Shi Y,Khan MI,Gerstein HC,Werstuck GH

更新日期：2013-04-01 00:00:00

abstract：:The endothelium contributes to the regulation of vascular tone by producing nitric oxide (NO) and the endothelium-derived hyperpolarising factor (EDHF). In hypercholesterolemia, endothelium-dependent relaxation is impaired but can be restored by treatment with lovastatin (LOVAS). We investigated the effects of LOVAS o...

journal_title：Atherosclerosis

authors： Brandes RP,Behra A,Lebherz C,Böger RH,Bode-Böger SM,Mügge A

更新日期：1999-01-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) is expressed in atherosclerotic plaques. It is generally recognized that CTGF contributes to atherosclerosis by stimulating vascular smooth muscle cell (VSMC) proliferation and extracellular matrix production during the development of atherosclerosis. Recent studies indicate that...

journal_title：Atherosclerosis

authors： Game BA,He L,Jarido V,Nareika A,Jaffa AA,Lopes-Virella MF,Huang Y

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Estrogen therapy that is started at the time of menopause seems to protect against the development of atherosclerosis and cardiovascular diseases, in contrast to the initial increased cardiovascular risk when hormone therapy is initiated in older women. With increased aging and degree of atherosclerosis, the...

journal_title：Atherosclerosis

authors： Naessen T,Rodriguez-Macias K

更新日期：2006-12-01 00:00:00

abstract：:Stent implantation causes significant injury to the vascular wall, resulting in inflammatory activation. Although sirolimus-eluting stents (SES) have anti-inflammatory properties, their effect on periprocedural systemic inflammatory response has not been sufficiently investigated. Eighty-one patients with stable coron...

journal_title：Atherosclerosis

authors： Kochiadakis GE,Marketou ME,Arfanakis DA,Sfiridaki K,Skalidis EI,Igoumenidis NE,Hamilos MI,Kolyvaki S,Chlouverakis G,Kantidaki E,Castanas E,Vardas PE

更新日期：2007-10-01 00:00:00

abstract：:Two preparations active in reducing hepatic cholesterolgenesis in vitro were demonstrated in human milk. These appear to affect the cholesterol synthetic pathway at different loci. One inhibits the synthesis before the formation of mevalonic acid and has been isolated and subsequently identified as uric acid. The othe...

journal_title：Atherosclerosis

authors： Ward PC,McCarthy RD,Kilara A

更新日期：1982-02-01 00:00:00

abstract：:Plasma cholesterol was lower in spontaneously hypertensive rats (SHR), while plasma triglyceride and free fatty acid were increased in comparison with control normotensive Wistar-Kyoto (WK) rats. Correspondingly, [1-14C]-acetate incorporation into liver cholesterol was clearly decreased in SHR as compared with WK. As ...

journal_title：Atherosclerosis

authors： Iritani N,Fukuda E,Nara Y,Yamori Y

更新日期：1977-11-01 00:00:00

abstract：:Serum HDL-cholesterol (HDLc) levels were studied on 2399 healthy urban inhabitants, from newborn to 78 years of age, in Shanghai. The results were as follows. (1) Frequency distribution of serum HDLc levels in most groups was approximately normal after age 20. (2) The serum HDLc levels and HDLc/total cholesterol ratio...

journal_title：Atherosclerosis

authors： Chen H,Zhuang H,Han Q

更新日期：1983-07-01 00:00:00

abstract：:The effect of chlorthalidone treatment on serum lipids and lipoproteins was investigated in 21 hypertensive patients. Chlorthalidone caused an increase in total serum and low density lipoprotein (LDL) cholesterol, but not in high density lipoprotein (HDL) cholesterol. Serum and lipoprotein triglycerides also increased...

journal_title：Atherosclerosis

authors： Rosenthal T,Holtzman E,Segal P

更新日期：1980-05-01 00:00:00

abstract：:The relationships between plasma lecithin:cholesterol acyltransferase (LCAT) mass concentrations and lipids, apolipoprotein, and lipoprotein subfraction concentrations were studied in men assigned at random to a one-year exercise program (n = 48) and to a sedentary control condition (n = 31). Exercise training did not...

journal_title：Atherosclerosis

authors： Williams PT,Albers JJ,Krauss RM,Wood PD

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:It is indicated that total/HDL cholesterol and LDL/HDL cholesterol ratios have more predictive power for cardiovascular disease compared to classic lipid parameters. However, there have been few reports about the usefulness of these indices for the assessment of early stage atherosclerosis in Japanese type 2 ...

journal_title：Atherosclerosis

authors： Katakami N,Kaneto H,Osonoi T,Saitou M,Takahara M,Sakamoto F,Yamamoto K,Yasuda T,Matsuoka TA,Matsuhisa M,Yamasaki Y,Shimomura I

更新日期：2011-02-01 00:00:00

abstract：:The purpose of the present study was to examine the relationship between the changes in the expressions of several mRNAs and changes in endothelial function in streptozotocin-induced diabetic and chronic short-term insulin-treated rats. Aortas from later-stage (10 week) diabetics, but not those from their insulin-trea...

journal_title：Atherosclerosis

authors： Kobayashi T,Oishi K,Hayashi Y,Matsumoto T,Kamata K

更新日期：2006-03-01 00:00:00

abstract：:Paraoxonase (PON) is an HDL-bound enzyme capable of hydrolyzing lipid peroxides and believed to be in part responsible for the protective effect of HDL against LDL oxidation. Its activity is mainly determined by a gene polymorphism of the PON 1 gene (Glu-Arg 192). Low activity has been related to an elevated incidence...

journal_title：Atherosclerosis

authors： Cao H,Girard-Globa A,Serusclat A,Bernard S,Bondon P,Picard S,Berthezene F,Moulin P

更新日期：1998-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) can overcome a potential anti-angiogenic effect of TNF-alpha by inhibiting endothelial apoptosis induced by this cytokine. Soluble TNF-alpha receptor I (sTNFRI) is an extracellular domain of TNFRI and antagonizes the activity of TNF-alpha. Here we report that sTNFRI is able to...

journal_title：Atherosclerosis

authors： Sugano M,Tsuchida K,Tomita H,Makino N

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Statin is not beneficial for dialysis patients but moderate to high intensity statin is beneficial for patients after acute myocardial infarction (MI). The aim of this study was to evaluate the effect of moderate to high intensity statin on mortality, cardiovascular outcomes in dialysis patients aft...

journal_title：Atherosclerosis

authors： Chung CM,Lin MS,Chang CH,Cheng HW,Chang ST,Wang PC,Chang HY,Lin YS

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Endostatin is implicated in the atherosclerosis process and serves as a promising cardiovascular biomarker, while its clinical significance in ischemic stroke patients remains unclear. We aimed to examine the association between endostatin and mortality and disability after ischemic stroke. METHODS...

journal_title：Atherosclerosis

authors： Zhang C,Qian S,Zhang R,Guo D,Wang A,Peng Y,Peng H,Li Q,Ju Z,Geng D,Chen J,Zhang Y,He J,Zhong C,Xu T

更新日期：2020-01-01 00:00:00

abstract：:Sex differences in incidence and prevalence of and morbidity and mortality from cardiovascular disease are well documented. However, many studies examining the genetic basis for cardiovascular disease fail to consider sex as a variable in the study design, in part, because there is an inherent difficulty in studying t...

journal_title：Atherosclerosis

authors： Winham SJ,de Andrade M,Miller VM

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) was rarely diagnosed in Latvia before 2015, when the Latvian Registry of FH (LRFH) was established. Here, we report the first experience of the LRFH over three years (2015-2017). METHODS:The LRFH is an ongoing nationwide, dynamic, long-term prospective cohort. The...

journal_title：Atherosclerosis

authors： Latkovskis G,Saripo V,Gilis D,Nesterovics G,Upena-Roze A,Erglis A

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND AIMS:A recently identified locus for coronary artery disease (CAD) tagged by rs8042271 is in a region of tight linkage disequilibrium (LD) between 2 genes (MFGE8, ABHD2) previously linked to atherosclerosis. Here we have explored the regulatory framework of this region to identify its functional relation...

journal_title：Atherosclerosis

authors： Soubeyrand S,Nikpay M,Turner A,Dang AT,Herfkens M,Lau P,McPherson R

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Effective systemic drugs against restenosis upon percutaneous transluminal coronary angioplasty (PTCA) are largely lacking. Polyphenols have been suggested to ameliorate post-angioplasty restenosis. Hawthorn (Crataegus spp.) extracts, which are among the most frequently used herbal medicinal products against ...

journal_title：Atherosclerosis

authors： Fürst R,Zirrgiebel U,Totzke F,Zahler S,Vollmar AM,Koch E

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND AND AIMS:The aim of this study was to investigate the impact of attenuated-signal plaque (ASP) observed by intravascular ultrasound (IVUS) on vessel response after drug-eluting stent implantation. METHODS:Data were derived from the IVUS cohort of the J-DESsERT trial comparing paclitaxel- and sirolimus-eluti...

journal_title：Atherosclerosis

authors： Kitahara H,Waseda K,Sakamoto K,Yamada R,Huang CC,Nakatani D,Sakata K,Kawarada O,Yock PG,Matsuyama Y,Yokoi H,Nakamura M,Muramatsu T,Nanto S,Fitzgerald PJ,Honda Y

更新日期：2017-04-01 00:00:00

abstract：:Whole blood and plasma viscosity, red cell aggregability and deformability, and plasma fibrinogen have been compared between 20 patients with heterozygous familial hypercholesterolaemia (FH), without clinical arterial disease, and 20 age- and sex-matched controls. Plasma fibrinogen was elevated in FH, associated with ...

journal_title：Atherosclerosis

authors： Jay RH,Rampling MW,Betteridge DJ

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Overt atherosclerotic cardiovascular disease (ASCVD) warrants aggressive lipid lowering. Imaging for ambiguous symptoms suggesting ischemia or for clarification of CV risk in asymptomatic individuals often uncovers previously unknown ASCVD. Guidelines do not provide clear recommendations for aggress...

journal_title：Atherosclerosis

authors： Mancini GBJ,Gupta M,Tsigoulis M,Cannon CP,Genest J,Ray KK,Santos RD,Watts GF,Raggi P

更新日期：2017-08-01 00:00:00

abstract：:Low-density lipoprotein cholesterol (LDL-C) and the small dense LDL (SdLDL) phenotype are both predictors for ischemic heart disease. We examined whether cholesterol of SdLDL (SdLDL-C) is more closely associated with carotid artery intima-media thickness (CA-IMT), a surrogate measure of atherosclerosis, than LDL-C and...

journal_title：Atherosclerosis

authors： Shoji T,Hatsuda S,Tsuchikura S,Shinohara K,Kimoto E,Koyama H,Emoto M,Nishizawa Y

更新日期：2009-02-01 00:00:00