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Isolation of an inhibitor of hepatic cholesterolgenesis from human milk.

Abstract：

:Two preparations active in reducing hepatic cholesterolgenesis in vitro were demonstrated in human milk. These appear to affect the cholesterol synthetic pathway at different loci. One inhibits the synthesis before the formation of mevalonic acid and has been isolated and subsequently identified as uric acid. The other inhibitor has yet to be identified. The apparent paradox of the active component being uric acid, of which high levels are known to cause gout, is discussed.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Ward PC,McCarthy RD,Kilara A

doi

10.1016/0021-9150(82)90184-8

subject

Has Abstract

pub_date

1982-02-01 00:00:00

pages

185-92

issue

2-3

eissn

0021-9150

issn

1879-1484

pii

0021-9150(82)90184-8

journal_volume

41

pub_type

杂志文章

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