Latvian registry of familial hypercholesterolemia: The first report of three-year results.

Abstract:

BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) was rarely diagnosed in Latvia before 2015, when the Latvian Registry of FH (LRFH) was established. Here, we report the first experience of the LRFH over three years (2015-2017). METHODS:The LRFH is an ongoing nationwide, dynamic, long-term prospective cohort. The diagnosis of FH was assessed using the Dutch Lipid Clinic Network (DLCN) criteria. Cascade screening of first-degree relatives using age- and sex-specific percentiles of low-density lipoprotein cholesterol (LDL-C) was performed in relatives of patients with definite and probable FH. RESULTS:Among the 416 individuals included in the LRFH, 181 patients were diagnosed with FH (140 index cases and 41 relatives) and 151 with possible FH (not analysed in this report). The mean age was 51.3 ± 14.1 years, 38.1% (n = 69) were men and 35.4% (n = 64) had a history of premature coronary heart disease. Only 54.1% (n = 98) of patients were on any lipid-lowering therapy before inclusion in the LRFH. The maximal statin dose was used by 23.2% (n = 42), and only 4.4% (n = 8) had their LDL-C levels below the goal. The initial mean total and LDL-C levels were 7.7 ± 2.2 and 5.5 ± 2.1 mmol/L, respectively. In a subgroup of patients (n = 49) with follow-up, LDL-C levels were reduced from 6.1 ± 2.1 to 3.6 ± 1.7 mmol/L (p < 0.001). CONCLUSIONS:An estimated 2.3% of FH patients in Latvia were diagnosed within three years. The vast majority of FH patients were under-recognized and poorly treated before their inclusion in the LRFH. Specialized care of FH patients within the frames of the registry substantially improved the management of this high-risk group.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Latkovskis G,Saripo V,Gilis D,Nesterovics G,Upena-Roze A,Erglis A

doi

10.1016/j.atherosclerosis.2018.06.011

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

347-354

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(18)30321-6

journal_volume

277

pub_type

杂志文章
  • Folate status is the major determinant of fasting total plasma homocysteine levels in maintenance dialysis patients.

    abstract::Limited data are available on the determinants of homocysteinemia or the association between plasma homocysteine (Hcy) levels and prevalent cardiovascular disease (CVD) in maintenance dialysis patients. We assessed etiology of renal failure, residual renal function and dialysis adequacy-related variables, and vitamin ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(96)05809-1

    authors: Bostom AG,Shemin D,Lapane KL,Nadeau MR,Sutherland P,Chan J,Rozen R,Yoburn D,Jacques PF,Selhub J,Rosenberg IH

    更新日期:1996-06-01 00:00:00

  • Internal elastic membrane in the internal mammary and left anterior descending coronary arteries and its relationship to intimal thickening.

    abstract::The internal mammary artery (IMA) is less prone to intimal thickening than coronary arteries and is routinely used in coronary bypass surgery. To resolve whether morphologic differences can explain why IMA develops less intimal thickening, morphometric measurement of the left anterior descending coronary artery (LAD) ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(90)90169-j

    authors: Svendsen E,Dregelid E,Eide GE

    更新日期:1990-08-01 00:00:00

  • Low density lipoprotein metabolism by cultured skin fibroblasts from atherosclerotic patients.

    abstract::The aim of this study was to determine whether an abnormality in low density lipoprotein (LDL) metabolism could be demonstrated in fibroblasts cultured from normolipidaemic subjects with atherosclerosis. Seventeen male subjects aged 30-55 years with normal plasma lipid concentrations were divided into 2 groups on the ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(82)90148-4

    authors: Behrman RG,Wynn V

    更新日期:1982-04-01 00:00:00

  • Dietary fiber and cholesterol metabolism in rats fed a high cholesterol diet.

    abstract::The effect of administering blackgram (Phaseolus mungo) fiber (isolated as neutral detergent residue) at the 30% dietary level has been studied with regard to lipid concentration in the tissues and that of biliary and fecal bile acids and sterols. Rats were fed a high fat-cholesterol diet and compared with those fed a...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(79)90196-5

    authors: Jayakumari N,Kurup PA

    更新日期:1979-05-01 00:00:00

  • Immune complexes containing modified lipoproteins are related to the progression of internal carotid intima-media thickness in patients with type 1 diabetes.

    abstract::Modified lipoproteins induce autoimmune responses including the synthesis of autoantibodies with pro-inflammatory characteristics. Circulating modified lipoprotein autoantibodies combine with circulating antigens and form immune complexes (IC). We now report the results of a study investigating the role of circulating...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2006.02.007

    authors: Lopes-Virella MF,McHenry MB,Lipsitz S,Yim E,Wilson PF,Lackland DT,Lyons T,Jenkins AJ,Virella G,DCCT\/EDIC Research Group.

    更新日期:2007-02-01 00:00:00

  • Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals.

    abstract:BACKGROUND:Risk factors of cardiovascular disease such as lipid aberrations, hypertension, abdominal adiposity and elevations in systemic inflammation, are prominent aetiologies in hyperlipidemia. Supplementation with n-3 PUFA is associated with a reduction in cardiovascular events through its hypotriglyceridemic, anti...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.atherosclerosis.2008.09.020

    authors: Micallef MA,Garg ML

    更新日期:2009-06-01 00:00:00

  • Resequencing the apolipoprotein A5 (APOA5) gene in patients with various forms of hypertriglyceridemia.

    abstract:OBJECTIVE:Genomewide association studies (GWAS), conventional association studies and the characterization of families with ApoA5 deficiency have shown that variation in the apolipoprotein A5 (APOA5) gene is associated with plasma triglyceride levels. The aim of this study was to determine the frequency of rare variant...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2011.09.030

    authors: Evans D,Aberle J,Beil FU

    更新日期:2011-12-01 00:00:00

  • Endothelium-dependent and -independent functions are impaired in patients with coronary heart disease.

    abstract::Endothelium plays a pivotal role in the development of atherosclerosis. Endothelial dysfunction participates in the course of acute coronary event. Using high-resolution ultrasound technique, endothelial dysfunction has been demonstrated in patients with atherosclerosis and risk factors for coronary disease, such as h...

    journal_title:Atherosclerosis

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0021-9150(99)00288-9

    authors: Zhang X,Zhao SP,Li XP,Gao M,Zhou QC

    更新日期:2000-03-01 00:00:00

  • Relation of plasma high-density lipoprotein cholesterol to lipoprotein-lipase activity in adipose tissue and skeletal muscle of man.

    abstract::Lipoprotein-lipase activity (LPL) was measured in biopsies of adipose tissue and skeletal muscle of normal human subjects, and the results were related to concentrations of cholesterol and triglycerides in plasma lipoproteins. Adipose-tissue LPL activity was significantly higher in females than in males, whereas no se...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(78)90178-8

    authors: Nikkilä EA,Taskinen MR,Kekki M

    更新日期:1978-04-01 00:00:00

  • A point mutation in ABC1 gene in a patient with severe premature coronary heart disease and mild clinical phenotype of Tangier disease.

    abstract::The proband is a 50 year-old woman born from a consanguineous marriage. She has been suffering from angina pectoris since the age of 38 and underwent coronary bypass surgery for three-vessel disease at 48. The presence of low plasma levels of total cholesterol and high density lipoprotein (HDL) cholesterol (2.4 and 0....

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(00)00587-6

    authors: Bertolini S,Pisciotta L,Seri M,Cusano R,Cantafora A,Calabresi L,Franceschini G,Ravazzolo R,Calandra S

    更新日期:2001-02-15 00:00:00

  • Environment-wide association study to identify novel factors associated with peripheral arterial disease: Evidence from the National Health and Nutrition Examination Survey (1999-2004).

    abstract:BACKGROUND AND AIMS:An environment-wide association study (EWAS) may be useful to comprehensively test and validate associations between environmental factors and peripheral arterial disease (PAD) in an unbiased manner. METHODS:Data from cross-sectional cohorts from the US National Health and Nutrition Examination Sur...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2018.01.006

    authors: Zhuang X,Ni A,Liao L,Guo Y,Dai W,Jiang Y,Zhou H,Hu X,Du Z,Wang X,Liao X

    更新日期:2018-02-01 00:00:00

  • Depression symptoms and the progression of carotid intima-media thickness: a 5-year follow-up study.

    abstract:OBJECTIVE:Only a few studies have investigated the changes in carotid intima-media thickness (IMT) over time, and uncertainties remain on the underlying mechanisms linking depression and subclinical atherosclerosis. We carried out a prospective cohort study to evaluate whether depression is associated with changes in c...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2014.01.012

    authors: Pizzi C,Costa GM,Santarella L,Flacco ME,Capasso L,Bert F,Manzoli L

    更新日期:2014-04-01 00:00:00

  • Arteriosclerosis in the African elephant: Part 2. Medial sclerosis.

    abstract:SUMMARY:A type of spontaneous arteriosclerosis, described as medial sclerosis and quite distinct from atherosclerosis, was found in the aortas, coronary arteries and aortic branch arteries of free-living elephants (Loxodonta africana) in Uganda and Kenya. The lesions took the form of calcified fibrotic plaques in the i...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(75)90093-3

    authors: McCullagh KG

    更新日期:1975-01-01 00:00:00

  • Inverse relationship between cardiorespiratory fitness and carotid atherosclerosis.

    abstract::The association between cardiorespiratory fitness (VO2max) and carotid atherosclerosis was analyzed in 163 men, aged 50 to 60 years. VO2max was assessed using breath-by-breath respiratory gas analyses during maximal exercise stress test. Atherosclerosis was evaluated quantitatively as intima-media thickness (IMT) of t...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(94)05416-g

    authors: Rauramaa R,Rankinen T,Tuomainen P,Väisänen S,Mercuri M

    更新日期:1995-01-20 00:00:00

  • Opposite effects on serum cholesteryl ester transfer protein levels between long-term treatments with pravastatin and probucol in patients with primary hypercholesterolemia and xanthoma.

    abstract::Long-term effects of pravastatin and probucol on serum cholesteryl ester transfer protein (CETP) and xanthoma/xanthelasma size were compared. Twenty-three patients with primary hypercholesterolemia and xanthoma/xanthelasma, including 11 patients with heterozygous familial hypercholesterolemia, were treated with pravas...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(99)00088-x

    authors: Inazu A,Koizumi J,Kajinami K,Kiyohar T,Chichibu K,Mabuchi H

    更新日期:1999-08-01 00:00:00

  • CETP expression enhances liver HDL-cholesteryl ester uptake but does not alter VLDL and biliary lipid secretion.

    abstract::The aim of this work was to study how CETP expression affects whole body cholesterol homeostasis. Thus, tissue uptake and plasma removal rates of labeled HDL-cholesteryl ester (CE), VLDL secretion rates, and biliary lipid secretion and fecal bile acid content were compared between human CETP transgenic (Tg) and non-tr...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2006.05.036

    authors: Harada LM,Amigo L,Cazita PM,Salerno AG,Rigotti AA,Quintão EC,Oliveira HC

    更新日期:2007-04-01 00:00:00

  • Regression of transplant coronary artery disease during chronic HELP therapy: a case study.

    abstract::This report concerns a heart transplant patient with hypercholesterolemia who showed rapid development of a severe transplant coronary artery disease. The patient received 10 mg pravastatine per day. Quantitative coronary angiography analyses of 4 serial angiograms clearly demonstrated that in the first 2.5 years foll...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(95)91034-o

    authors: Park JW,Vermeltfoort M,Braun P,May E,Merz M

    更新日期:1995-05-01 00:00:00

  • Cigarette smoke is an endothelial stressor and leads to cell cycle arrest.

    abstract::The molecular mechanisms underlying the atherogenic activity of cigarette smoke have yet to be fully elucidated. In the present study, genome-wide microarray analysis was performed on endothelial cells exposed to an aqueous cigarette smoke extract (CSE) for 3, 7, and 24 h, to obtain a better insight into how smoking m...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2008.02.022

    authors: Henderson B,Csordas A,Backovic A,Kind M,Bernhard D,Wick G

    更新日期:2008-12-01 00:00:00

  • The effect of acute exercise on high density lipoprotein-cholesterol and the subfractions in females.

    abstract::The effect of an acute exercise session on high density lipoprotein-cholesterol (HDL-C) and the subfractions HDL2-C and HDL3-C was determined for 9 healthy females (VO2max = 46.62 +/- 4.82 ml X kg-1 min-1). Each subject underwent a continuous 40-min run on a treadmill at a workload corresponding to 70% of VO2max. A ve...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(87)90120-1

    authors: Swank AM,Robertson RJ,Deitrich RW,Bates M

    更新日期:1987-02-01 00:00:00

  • Dietary fat and hormonal influences on lipoprotein fluidity and composition in premenopausal women.

    abstract::LDL and HDL became more fluid when health, free-living, premenopausal women were fed reduced fat diets with higher proportions of polyunsaturated fatty acids. Lipoproteins were isolated from plasma of 31 female subjects fed one of two sets of diets from typical U.S.A. foods with P/S ratios of 0.3 or 1.0. All subjects ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(91)90206-i

    authors: Berlin E,Judd JT,Nair PP,Jones DY,Taylor PR

    更新日期:1991-02-01 00:00:00

  • Stress-induced cardiovascular reactivity and atherogenesis in adolescents.

    abstract:OBJECTIVE:To examine the association between cardiovascular reactivity to a set of psychological stressors and carotid artery intima-media thickness, a marker of subclinical cardiovascular disease in healthy adolescents. METHODS:Participants were 25 boys and 23 girls age 14.2 ± 0.9 years who were measured for heart ra...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2010.12.030

    authors: Roemmich JN,Feda DM,Seelbinder AM,Lambiase MJ,Kala GK,Dorn J

    更新日期:2011-04-01 00:00:00

  • Lack of effect of probucol on atheroma formation in cholesterol-fed rabbits kept at comparable plasma cholesterol levels.

    abstract::Rabbits were fed cholesterol for 14 weeks to study the effect of probucol on atheroma formation. Three groups of animals were investigated: group CHOL was fed 1% cholesterol and served as control for group P + CHOL. fed 1% cholesterol and 1% probucol from the onset till the end of the experiment: group CHOL + P receiv...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(89)90171-8

    authors: Stein Y,Stein O,Delplanque B,Fesmire JD,Lee DM,Alaupovic P

    更新日期:1989-02-01 00:00:00

  • Is inflammation prior to renal transplantation predictive for cardiovascular and renal outcomes?

    abstract:OBJECTIVES:Markers of non-specific inflammation, such as C-reactive protein (CRP) or leukocyte count are increased in end-stage renal disease patients. Recent studies have shown positive associations between inflammatory markers and cardiovascular mortality in kidney transplant recipients, but these analyses had been l...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2010.01.004

    authors: Krüger B,Walberer A,Debler J,Böger CA,Farkas S,Reinhold SW,Obed A,Schlitt HJ,Fischereder M,Banas B,Krämer BK

    更新日期:2010-06-01 00:00:00

  • Effect of low-density lipoprotein receptor mutation on lipoproteins and cardiovascular disease risk: a parent-offspring study.

    abstract::Studies on the clinical consequences of different low-density lipoprotein (LDL) receptor genotypes in adult patients have yielded conflicting results. We hypothesized that children with familial hypercholesterolemia (FH) provide a better model to perform genotype-phenotype analyses than adults. We tested this hypothes...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2004.10.042

    authors: Koeijvoets KC,Wiegman A,Rodenburg J,Defesche JC,Kastelein JJ,Sijbrands EJ

    更新日期:2005-05-01 00:00:00

  • Catheter-based adenovirus-mediated anti-monocyte chemoattractant gene therapy attenuates in-stent neointima formation in cynomolgus monkeys.

    abstract::We have previously demonstrated great benefit from anti-monocyte chemoattractant protein-1 (MCP-1) gene therapy by "systemic" transfer of an N-terminal deletion mutant of human MCP-1 (called 7ND) gene into skeletal muscle for treatment of restenosis and atherosclerosis. However, recent evidence suggests that "local" g...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2006.10.029

    authors: Nakano K,Egashira K,Ohtani K,Zhao G,Funakoshi K,Ihara Y,Sunagawa K

    更新日期:2007-10-01 00:00:00

  • Regression of poloxamer 407-induced atherosclerotic lesions in C57BL/6 mice using atorvastatin.

    abstract::HMG-CoA reductase inhibitor drugs or 'statins' have been shown to effectively reduce plasma total cholesterol (CHOL), CHOL associated with low-density-lipoprotein (LDL), and triglycerides (TG). In addition, slight elevations in HDL-CHOL are also typically observed. Poloxamer 407 (P-407), a nonionic surfactant, effecti...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(99)00339-1

    authors: Johnston TP,Baker JC,Hall D,Jamal S,Palmer WK,Emeson EE

    更新日期:2000-04-01 00:00:00

  • Effects of lipids and lipoproteins on thrombosis and rheology.

    abstract::Atherosclerotic plaque rupture and erosions precipitate thrombus formation and may lead to an acute ischemic syndrome. Lipids and lipoproteins modulate the expression and/or function of thrombotic, fibrinolytic and rheologic factors, and thereby influence hemostasis and potential tissue damage resulting from vascular ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,评审

    doi:10.1016/s0021-9150(98)00144-0

    authors: Rosenson RS,Lowe GD

    更新日期:1998-10-01 00:00:00

  • Brain microangiopathy and macroangiopathy share common risk factors and biomarkers.

    abstract:AIMS:Besides carotid or cardiac embolism, stroke can occur via microangiopathy (small arterial disease [SAD]) and macroangiopathy (intracranial atherosclerotic stroke [ICAS]) of the intracranial vasculature. There have been efforts to identify risk factors specific to microangiopathy and macroangiopathy, including vasc...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2015.12.040

    authors: Bang OY,Chung JW,Ryoo S,Moon GJ,Kim GM,Chung CS,Lee KH

    更新日期:2016-03-01 00:00:00

  • Smoking is associated with lower amounts of arterial type I collagen and decorin.

    abstract:BACKGROUND:Smoking affects the arterial wall and increases the risk of cardiovascular disease. It also affects the extracellular matrix in skin, causing impaired wound healing. However, little is known about putative molecular changes in the arterial wall. Our aim was to investigate the possible correlation between ext...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2016.02.022

    authors: Faarvang AS,Rørdam Preil SA,Nielsen PS,Beck HC,Kristensen LP,Rasmussen LM

    更新日期:2016-04-01 00:00:00

  • Response of lipoprotein(a) levels to therapeutic life-style change in obese African-Americans.

    abstract::Lipoprotein(a) (Lp(a)) is regarded as an independent risk factor for Atherosclerotic cardiovascular disease. The objectives of this study were: to determine the effects of diet and exercise on Lp(a) and to evaluate the relation of Lp(a) with the lipid profile (total serum cholesterol (TC), triglycerides (TG), low dens...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2003.09.017

    authors: Randall OS,Feseha HB,Illoh K,Xu S,Ketete M,Kwagyan J,Tilghman C,Wrenn M

    更新日期:2004-01-01 00:00:00