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Effects of stimulation of nitric oxide synthesis on large artery stiffness in patients with peripheral arterial disease.

Abstract：

:The role of endothelium-derived nitric oxide (NO) in modulation of large artery stiffness in patients with peripheral arterial disease (PAD) is unexplored. The aim of this study was to evaluate, using pulse wave analysis (PWA), changes in aortic and systemic arterial stiffness following administration of nitroglycerin and beta(2)-agonist salbutamol in PAD patients (n = 24) and in healthy controls (n = 24). Changes in estimated aortic pulse wave velocity (T(r)) and in augmentation index (AIx), following administration of nitroglycerin and salbutamol, were assessed using PWA. Salbutamol-induced changes in T(r) and in AIx were significantly reduced in PAD patients (P < 0.001 and < 0.001, respectively), while nitroglycerin-produced changes were not different (P = 0.25 and 0.35, respectively). Changes in T(r) after salbutamol administration were independent of changes in mean arterial pressure (MAP) (R = -0.21, P = 0.16). This study shows that stimulation of NO synthesis fails to modify stiffness of the large arteries in PAD patients and changes in aortic stiffness are independent of changes in MAP. Our data support the utility of PWA as a non-invasive method for assessment of NO-mediated vascular changes.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Kals J,Kampus P,Kals M,Pulges A,Teesalu R,Zilmer M

doi

10.1016/j.atherosclerosis.2005.06.014

keywords:

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

368-74

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(05)00389-8

journal_volume

185

pub_type

杂志文章

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