Abstract：
BACKGROUND AND AIMS:Mac-2 binding protein (M2BP) was reported to be a useful biomarker for liver fibrosis and malignant tumors. We hypothesized that expression of M2BP might also change in the process of atherosclerosis. METHODS:This study included subjects who visited our hospital for a physical checkup. RESULTS:The M2BP levels in subjects with hypertension, dyslipidemia, or abnormal glucose metabolism were higher than those in subjects without such risk factors. Moreover, the M2BP levels were associated with severity of cardiovascular risk. Subdivision of M2BP levels into quartiles revealed that M2BP was significantly associated with reactive oxygen metabolites, central systolic blood pressure, and radial augmentation index (AI). Logistic regression analysis with the endpoint of high radial AI (above mean value) showed that high radial AI was independently associated with high M2BP. CONCLUSIONS:Although the spectrum was narrow as compared to that in cases of hepatic fibrosis, serum M2BP may reflect silent atherosclerosis in apparently healthy subjects.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Sugiura T,Dohi Y,Takase H,Yamashita S,Murai S,Tsuzuki Y,Ogawa S,Tanaka Y,Ohte Ndoi
10.1016/j.atherosclerosis.2016.06.027subject
Has Abstractpub_date
2016-08-01 00:00:00pages
192-196eissn
0021-9150issn
1879-1484pii
S0021-9150(16)30272-6journal_volume
251pub_type
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