Abstract:
:Enhanced and prolonged postprandial lipaemia is implicated in coronary and carotid artery disease. This study assessed the effects of atorvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, on postprandial plasma concentrations of triglyceride-rich lipoproteins (TRLs). Sixteen middle-aged men with combined hyperlipidaemia (baseline low density lipoprotein (LDL) cholesterol and plasma triglyceride concentrations (median (interquartile range) of 4.54 (4.17-5.26)) and 2.66 (2.04-3.20) mmol/l, respectively) and previous myocardial infarction were randomised to atorvastatin 40 mg or placebo once daily for 8 weeks in a double-blind, cross-over design. The apolipoprotein (apo) B-48 and B-100 contents were determined in subfractions of TRLs as a measure of chylomicron remnant and very low density lipoprotein (VLDL) particle concentrations (expressed as mg apo B-48 or apo B-100 per litre of plasma), in the fasting state and after intake of a mixed meal. Atorvastatin treatment reduced significantly the fasting plasma concentrations of VLDL cholesterol, LDL cholesterol and VLDL triglycerides (median% change) by 29, 44 and 27%, respectively, and increased high density lipoprotein (HDL) cholesterol by 19%, compared with baseline. The postprandial plasma concentrations of large (Svedberg flotation rate (Sf) 60-400) and small (Sf 20-60) VLDLs and chylomicron remnants were almost halved compared with baseline (mean 0-6 h plasma concentrations were reduced by 48% for Sf 60-400 apo B-100, by 46% for Sf 60-400 apo B-48, by 46% for Sf 20-60 apo B-100 and by 27% for Sf 20-60 apo B-48), and the postprandial triglyceridaemia was reduced by 23% during active treatment. In conclusion, atorvastatin 40 mg once daily causes profound reductions of postprandial plasma concentrations of all TRLs in combined hyperlipidaemic patients with premature coronary artery disease.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Boquist S,Karpe F,Danell-Toverud K,Hamsten Adoi
10.1016/s0021-9150(01)00689-xkeywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
163-70issue
1eissn
0021-9150issn
1879-1484pii
S0021-9150(01)00689-Xjournal_volume
162pub_type
临床试验,杂志文章,随机对照试验相关文献
ATHEROSCLEROSIS文献大全abstract::We previously identified a G>A single nucleotide polymorphism (SNP) between C57BL/6J (B6) and C3H/HeJ (C3H) mouse strains at position 2077 in the coding region of Vcam1 that leads to substitution of an amino acid from aspartic acid (D) to asparagine (N) in the protein product. In the present study, we investigated the...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2007.05.004
更新日期:2008-01-01 00:00:00
abstract::The elevated carbon monoxide level found in tobacco smokers has been suggested as one etiologic factor linking it with atherosclerosis. Unquestionably carbon monoxide does induce some arterial wall hypoxia, which has been established as an atherogenic factor, but without knowing the extent and location of this hypoxia...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(78)90148-x
更新日期:1978-05-01 00:00:00
abstract::Male adult New Zealand rabbits were fed a 2% cholesterol diet for 60 days followed by 10, 20, or 30 days of normal low cholesterol diet. Collagen synthesis was estimated by measuring aortic prolyl hydroxylase activity. Tissue cholesterol accumulation rates were estimated by dividing total tissue cholesterol by the num...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(80)90006-4
更新日期:1980-10-01 00:00:00
abstract::The effectiveness of a new, almost l-thyroxine free preparation of d-thyroxine (Dynothel) was tested in 15 patients with Type IIa and 4 patients with Type IIb hyperlipoproteinemia. Eleven patients with Type IIa and 3 with Type IIb were responsive to treatment and showed an average 26% decrease in plasma TC. This decre...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(76)90129-5
更新日期:1976-09-01 00:00:00
abstract::Cardiovascular event reduction in hypercholesterolemic subjects appropriately emphasizes the prominent role of statin therapy; however, niacin (nicotinic acid) is also an effective lipid-altering agent that prevents atherosclerosis and reduces cardiovascular events. Niacin has multifarious lipoprotein and anti-atherot...
journal_title:Atherosclerosis
pub_type: 杂志文章,评审
doi:10.1016/j.atherosclerosis.2003.07.003
更新日期:2003-11-01 00:00:00
abstract::Oxidative stress is associated with atherosclerosis. Familial combined hyperlipidemia (FCH) is considered as a human model of primary dyslipidemia and atherosclerosis frequently associated with insulin resistance (IR), but there are few data on its possible relation to oxidative stress. The objective of this study was...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2007.11.023
更新日期:2008-08-01 00:00:00
abstract::Known cytochrome P450-dependent oxygenase inhibitor ketoconazole (5-50 microM) blocked the murine macrophage-mediated modification of human low density lipoprotein (LDL) as measured by production of thiobarbituric acid-reactive substance, stimulation of [125I]LDL degradation in a fresh set of macrophages and LDL elect...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(94)05456-s
更新日期:1995-04-07 00:00:00
abstract:BACKGROUND:Previous studies have found polymorphisms of the HDL receptor, SR-BI, to be associated with plasma HDL-C in women, but not men, suggesting a modifying role of estrogen. We examined whether the association between SR-BI genotypes and HDL-C is modified by use of unopposed estrogen in community-dwelling postmen...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2004.12.013
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Osteoporosis and coronary heart disease (CHD) are very common conditions among elderly people, and both represent a public health concern due to their prognostic consequences. Osteoporosis and CHD share many risk factors and pathophysiological mechanisms, such as calcification pathways. Clinical evi...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2019.11.007
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Apolipoprotein E (apoE) has been implicated as conveying increased risk for coronary artery disease (CAD). Previous studies suggest a role of apoE as a modulator of immune response and inflammatory properties. We hypothesized that the presence of apo E4 is associated with an increased inflammatory burden in s...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.04.021
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Bisphenol A (BPA) levels have previously been associated with coronary heart disease (CHD). Since CHD is an atherosclerotic disease, we investigated if circulating levels of BPA and phthalate metabolites are related to atherosclerosis in a cross-sectional study. METHODS:In the population-based...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2011.05.001
更新日期:2011-09-01 00:00:00
abstract::Hepatic lipase (HL) not only plays an important role in plasma lipoprotein transport, but may also affect intracellular lipid metabolism. We hypothesize that HL expression is regulated as an integral part of intracellular lipid homeostasis. Addition of oleate (1 mM) to HepG2 cells increased HL secretion to 134+/-14% o...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2004.10.027
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:The present study aimed to verify the existence of a rebound inflammatory effect after statin withdrawal in the acute phase of myocardial infarction (MI). METHODS:In a prospective observational cohort, changes in C-reactive protein (CRP) between the first and the fifth day after MI were evaluated in 249 cons...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2009.04.008
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND AND AIMS:It remains unclear how trans fatty acid (TFA) at low-level intake affect lipid levels and the development of acute coronary syndrome (ACS). The study aimed to investigate how plasma TFA composition differs between male patients with ACS and healthy men. METHODS:Plasma fatty acid (FA) composition (a...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2019.02.025
更新日期:2019-05-01 00:00:00
abstract::Baroreceptor sensitivity was studied in twelve young normotensive subjects and forty hypertensive patients, separated into two groups according to their age, severity of hypertension and signs of severe atherosclerotic vascular disease. Under stabilized circulatory conditions, the changes of pulse rate in response to ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(76)90079-4
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Whether carotid atherosclerosis is associated with an increased risk for ischemic stroke in patients with atrial fibrillation (AF) on anticoagulant treatment is undefined. To explore this association, patients with AF on treatment with vitamin K antagonists were included in a multicenter, prospectiv...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究
doi:10.1016/j.atherosclerosis.2018.02.004
更新日期:2018-04-01 00:00:00
abstract::Methylamine can be converted by semicarbazide-sensitive amine oxidase (SSAO) to formaldehyde and hydrogen peroxide, which have been proven to be toxic towards cultured endothelial cells. We investigated whether or not these deaminated products from methylamine can exert potentially hazardous toxic effects in vivo. Lon...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(95)05701-3
更新日期:1996-02-01 00:00:00
abstract::The topography of atherosclerotic lesions in the human basilar arteries has been studied quantitatively by digitizing images of the excised vessels and producing contour probability maps. Fifteen basilar arteries were obtained at autopsy (age--61 +/- 2; males--6, females--9; black--6, white--9), fixed in formalin, ope...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(80)90029-5
更新日期:1980-01-01 00:00:00
abstract::Apolipoprotein E phenotypes and fasting lipid and other biochemical parameters were determined in 51 patients with recently diagnosed coronary heart disease (CHD) and 164 control subjects. The age of the participants was 62.5 +/- 6.6 (S.D.) and 63% were male. Forty-eight CHD cases and 51 control subjects were also stu...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(96)06062-5
更新日期:1997-04-01 00:00:00
abstract::Factor XIII is a transglutaminase that crosslinks fibrin in the last steps of the coagulation process. A few polymorphic sites have been identified in this gene, one of them being a point mutation (FXIII Val34Leu), leading to an amino acid change of valine to leucine. Recently, in British patients, FXIII 34Leu allele ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(98)00241-x
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Nonalcoholic fatty liver disease (NAFLD) may be associated with a wide spectrum of cardiac abnormalities, which share many metabolic risk factors. This study aimed to evaluate whether NAFLD is associated with left ventricular (LV) diastolic dysfunction independent of other classical risk factors. M...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2018.03.027
更新日期:2018-05-01 00:00:00
abstract::The hydrolysis of lipoprotein triglycerides is catalyzed by lipoprotein lipase (LPL), an enzyme found in many tissues. We have examined tissue LPL activity (LPLA) in rats with experimentally-induced hyperthyroidism. In younger, lighter rats, hyperthyroidism was accompanied by a decrease in LPL in adipose tissue wherea...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(77)90088-0
更新日期:1977-03-01 00:00:00
abstract:OBJECTIVE:Pravastatin has been reported to elevate circulating adiponectin levels in patients with various insulin resistant state, hypertension, coronary artery disease, and hypercholesterolemia. This study aimed to evaluate whether pravastatin increase serum total and high molecular weight adiponectin levels and impr...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.atherosclerosis.2013.01.045
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Atherosclerosis is a chronic inflammatory disease of medium and large vessels and is typically characterized by the predominant accumulation of low-density lipoprotein (LDL)-cholesterol inside macrophages that reside in the vessel walls. Previous studies clearly demonstrated an association specifica...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2016.10.038
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:Genomewide association studies (GWAS), conventional association studies and the characterization of families with ApoA5 deficiency have shown that variation in the apolipoprotein A5 (APOA5) gene is associated with plasma triglyceride levels. The aim of this study was to determine the frequency of rare variant...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2011.09.030
更新日期:2011-12-01 00:00:00
abstract::The negative correlation between percent flow-mediated dilation (FMD%) and baseline diameter (D(base)) has only recently been recognised as a fundamental ratio-scaling problem, which is not resolved by significance-testing of D(base) inequality between groups/conditions, nor by covariate-adjusting FMD% itself by D(bas...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.11.027
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Individuals with type 1 diabetes mellitus are at high risk of developing atherosclerotic cardiovascular disease, but the underlying mechanisms by which type 1 diabetes accelerates atherosclerosis remain unknown. Increased retention of low-density lipoprotein (LDL) in atherosclerosis-prone sites of t...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2017.05.019
更新日期:2017-08-01 00:00:00
abstract::Connective tissue growth factor (CTGF) is expressed in atherosclerotic plaques. It is generally recognized that CTGF contributes to atherosclerosis by stimulating vascular smooth muscle cell (VSMC) proliferation and extracellular matrix production during the development of atherosclerosis. Recent studies indicate that...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2006.06.025
更新日期:2007-05-01 00:00:00
abstract::The role of the immune system in modulating atherosclerosis has recently been the subject of intensive research. Several previous authors have put forward a paradigm of the autoimmune process occurring in the vicinity of the plaque. Two recent studies have shown that immunization of rabbits with homologous modified lo...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(98)00015-x
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Current approaches to cardiovascular (CV) risk assessment have limitations. Subclinical atherosclerosis (SCA) as determined by carotid ultrasound is an independent predictor of myocardial infarction and stroke and can refine CV risk assessment. OBJECTIVES:We aimed to determine the prevalence and predictors ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2007.06.020
更新日期:2008-03-01 00:00:00