Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr-/- mice.

abstract：:Several reports have shown that lipoprotein(a) is associated with ischemic diseases. Two characteristics might explain this association. Firstly, Lp(a) is an LDL-like lipoprotein which may be implicated in the atherosclerotic process and secondly, Lp(a) possesses an additional apolipoprotein(a) whose structure is clos...

journal_title：Atherosclerosis

authors： Delplanque B,Beaumont V,Lemort N,Beaumont JL

更新日期：1993-05-01 00:00:00

abstract：:Whether an association, causative or not, exists between the level of serum selenium and the risk of ischaemic heart disease (IHD) remains unsettled. We investigated the issue in a cohort of 3387 males aged 53-74 years (mean 63). Based on information about health status, life-style and socioeconomic factors given in a...

journal_title：Atherosclerosis

authors： Suadicani P,Hein HO,Gyntelberg F

更新日期：1992-09-01 00:00:00

abstract：AIMS:Apolipoprotein C-III (apoC-III) has been recognized as a useful marker of triglyceride-rich lipoproteins (TRLs) metabolism and proposed as an indicator of prognosis for coronary risk in healthy subjects. We studied cross-sectionally in a population having low cholesterol levels, but a high prevalence of the metabo...

journal_title：Atherosclerosis

authors： Onat A,Hergenç G,Sansoy V,Fobker M,Ceyhan K,Toprak S,Assmann G

更新日期：2003-05-01 00:00:00

abstract：:Proprotein convertase subtilisin kexin type 9 (PCSK9) is a circulating protein that impairs LDL clearance by promoting the LDL receptor (LDLR) degradation. PCSK9 has emerged as a new pharmacological target for hypercholesterolemia, and different PCSK9 inhibitors are now evaluated in clinical trials. Here, we propose a...

journal_title：Atherosclerosis

authors： Cariou B,Le May C,Costet P

更新日期：2011-06-01 00:00:00

abstract：:The search for markers to improve risk prediction for individuals at risk of developing serious cardiovascular events is ongoing. New markers of coronary artery disease progression have been identified in recent years, among which, circulating levels of pregnancy-associated plasma protein-A (PAPP-A) offer an interesti...

journal_title：Atherosclerosis

authors： Consuegra-Sanchez L,Fredericks S,Kaski JC

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease including atherosclerosis. We investigated the regulation of arginase...

journal_title：Atherosclerosis

authors： Thacher TN,Gambillara V,Riche F,Silacci P,Stergiopulos N,da Silva RF

更新日期：2010-05-01 00:00:00

abstract：INTRODUCTION:Although cardiovascular events are known to cluster in families it is unclear the extent to which atherosclerosis per se is genetically determined. The aim of this study was to assess the heritability of carotid intima media thickness (IMT) measurements, a surrogate marker of early atherosclerosis, using a...

journal_title：Atherosclerosis

authors： Swan L,Birnie DH,Inglis G,Connell JM,Hillis WS

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Moderate red wine has been shown to reduce cardiovascular disease (CVD) risk, however the effects on certain CVD risk factors are unclear. In this study we have investigated the effects of dealcoholised red wine (DRW) and full-complement red wine (RW) on several cardiovascular risk factors in mildly hypercho...

journal_title：Atherosclerosis

authors： Naissides M,Mamo JC,James AP,Pal S

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Anemia has been shown to be a risk factor for coronary artery disease and mortality. The involvement of body iron stores in the development of CAD remains controversial. So far, studies that examined hemoglobin and parameters of iron metabolism simultaneously do not exist. METHODS AND RESULTS:Hemoglobin and...

journal_title：Atherosclerosis

authors： Grammer TB,Kleber ME,Silbernagel G,Pilz S,Scharnagl H,Tomaschitz A,König W,März W

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Patients with hyperlipidemia who are unable to tolerate optimal statin therapy are at increased cardiovascular risk due to ongoing elevations in low-density lipoprotein cholesterol (LDL-C). The objective of CLEAR Tranquility (NCT03001076) was to evaluate the efficacy and safety of bempedoic acid whe...

journal_title：Atherosclerosis

authors： Ballantyne CM,Banach M,Mancini GBJ,Lepor NE,Hanselman JC,Zhao X,Leiter LA

更新日期：2018-10-01 00:00:00

abstract：:Despite numerous studies, the precise role of dietary n-6 polyunsaturated fatty acids in the pathogenesis of atherosclerosis remains controversial. It has been shown that feeding an n-6-enriched diet resulted in decreased atherosclerosis in African green monkeys and was associated with a reduction in LDL levels. Howev...

journal_title：Atherosclerosis

authors： George J,Mulkins M,Casey S,Schatzman R,Sigal E,Harats D

更新日期：2000-06-01 00:00:00

abstract：:Human aortic aneurysm is commonly characterized by the presence of advanced atherosclerosis associated with variable chronic adventitial inflammation. Histological examination of human aortic aneurysmal specimens revealed the presence of plasma cells and lymphoid aggregates in media and adventitia of the vessels. Immu...

journal_title：Atherosclerosis

authors： Yen HC,Lee FY,Chau LY

更新日期：1997-11-01 00:00:00

abstract：:Blood pressure elevation is frequently associated with elevated cholesterol, triglyceride or low density lipoprotein (LDL-C) or low high density lipoprotein (HDL-C). The relative importance of genetic and environmental factors in these associations is unclear. We examined the relative contribution of genetic and envir...

journal_title：Atherosclerosis

authors： Williams PD,Puddey IB,Martin NG,Beilin LJ

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVE:Our study aimed to evaluate the effects of psoriasis (Pso) on coronary microvascular function and whether there is a relationship between disease activity scores and coronary blood flow abnormalities. METHODS:56 young patients (pts) with Pso (42 M, aged 37±3 years) without clinical evidence of cardiovascular...

journal_title：Atherosclerosis

authors： Osto E,Piaserico S,Maddalozzo A,Forchetti G,Montisci R,Famoso G,Giovagnoni A,Peserico A,Iliceto S,Tona F

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH), which leads to premature cardiovascular events, still remains underrecognized and undertreated in most countries. Untreated FH individuals aged 20-39 years are at 100-fold higher risk of mortality from coronary heart disease compared to those of a general populati...

journal_title：Atherosclerosis

authors： Mickiewicz A,Chmara M,Futema M,Fijalkowski M,Chlebus K,Galaska R,Bandurski T,Pajkowski M,Zuk M,Wasag B,Limon J,Rynkiewicz A,Gruchala M

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Given the high risk of cardiovascular disease in South Asians and the importance of inflammation in coronary heart disease we tested the hypothesis that circulating C-reactive protein (CRP) and interleukin 6 (IL-6) would be higher in healthy British born infants of South Asian origin than in infants of Europe...

journal_title：Atherosclerosis

authors： Oldroyd JC,Heald A,Bansal N,Vyas A,Siddals K,Gibson M,Clayton P,Cruickshank JK

更新日期：2009-11-01 00:00:00

abstract：:Male and female rats kept on a long-term atherogenic regimen for periods up to 15 months developed marked atherosclerotic changes of cardiac valves in 100% of cases. The degree and the topography of valvular atherosclerotic plaques corresponded widely to that seen in human atherosclerotic valvular disease. The regular...

journal_title：Atherosclerosis

authors： Záhor Z,Czabanová V

更新日期：1977-05-01 00:00:00

abstract：OBJECTIVE:Recent studies have suggested that circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) is a useful marker for the identification of patients with coronary artery disease (CAD). However, the role of MDA-LDL in atherogenic mechanisms has not yet been fully determined. METHOD AND RESULTS:We i...

journal_title：Atherosclerosis

authors： Miyazaki T,Shimada K,Sato O,Kotani K,Kume A,Sumiyoshi K,Sato Y,Ohmura H,Watanabe Y,Mokuno H,Daida H

更新日期：2005-03-01 00:00:00

abstract：:The aim of this study is to assess the relationship of epicardial adipose tissue (EAT) and plaque vulnerability. We consecutively enrolled 82 patients with coronary artery disease (CAD). A symptom-related vessel was imaged by virtual histology intravascular ultrasound (VH-IVUS). In 60 out of 82 patients, all three ves...

journal_title：Atherosclerosis

authors： Park JS,Choi SY,Zheng M,Yang HM,Lim HS,Choi BJ,Yoon MH,Hwang GS,Tahk SJ,Shin JH

更新日期：2013-01-01 00:00:00

abstract：:The mechanism(s) by which doxazosin, an alpha 1 inhibitor, regulates plasma low density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) levels were investigated in 'normocholesterolemic' (average total cholesterol (TC) of 218 mg/dl) and 'hypercholesterolemic' (average TC of 350 mg/dl) cynomolgus monkeys. ...

journal_title：Atherosclerosis

authors： Stucchi AF,Vespa DB,Terpstra AH,Nicolosi RJ

更新日期：1993-11-01 00:00:00

abstract：:Collagenous components were extracted from bovine aorta by pepsin digestion. Differential salt precipitations separated the interstitial from the basement membrane (BM) collagens, and the latter were subsequently separated into three distinct types. Ion exchange chromatography, SDS-slab gel electrophoresis, cyanogen b...

journal_title：Atherosclerosis

authors： Leushner JR,Haust MD

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The risk of recurrence of myocardial infarction (MI) in HIV patients presenting with acute coronary syndrome (ACS) is well known, but there is limited evidence about potential differences in coronary plaques compared to non-HIV patients. METHODS:In this multicenter case-control study, HIV patients ...

journal_title：Atherosclerosis

authors： Peyracchia M,De Lio G,Montrucchio C,Omedè P,d'Ettore G,Calcagno A,Vullo V,Cerrato E,Pennacchi M,Sardella G,Manga P,GrossoMarra W,Vullo F,Fedele F,Biondi-Zoccai G,Moretti C,Vachiat A,Bonora S,Rinaldi M,Mancone M,D'

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Mitochondrial damage and augmented production of reactive oxygen species (ROS) may represent an intermediate step by which hypercholesterolemia exacerbates atherosclerotic lesion formation. METHODS:To test this hypothesis, in mice with severe but genetically reversible hypercholesterolemia (i.e. th...

journal_title：Atherosclerosis

authors： Vilne B,Skogsberg J,Foroughi Asl H,Talukdar HA,Kessler T,Björkegren JLM,Schunkert H

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Several risk prediction models for coronary heart disease (CHD) are available today, however, they only explain a modest proportion of the incidence. Circulating microRNAs (miRs) have recently been associated with processes in CHD development, and may therefore represent new potential risk markers. ...

journal_title：Atherosclerosis

authors： Velle-Forbord T,Eidlaug M,Debik J,Sæther JC,Follestad T,Nauman J,Gigante B,Røsjø H,Omland T,Langaas M,Bye A

更新日期：2019-10-01 00:00:00

abstract：:Administration of ursodeoxycholic acid (UDCA) has been shown to decrease serum total and low density lipoprotein (LDL) cholesterol in hypercholesterolemic patients with primary biliary cirrhosis. Results of previous studies prompted us to postulate that the cholesterol-lowering effect of UDCA may be due, at least in p...

journal_title：Atherosclerosis

authors： Ceryak S,Bouscarel B,Malavolti M,Robins SJ,Caslow KL,Fromm H

更新日期：2000-11-01 00:00:00

abstract：:Serum concentrations of lipoproteins, apolipoprotein A-I (Apo A-I), androgens, including biologically active free testosterone (free T), and sex hormone binding globulin (SHBG) and their associations were studied in 3 groups of men of different physical fitness and risk of CHD, consisting of male CHD patients, joggers...

journal_title：Atherosclerosis

authors： Hämäläinen E,Tikkanen H,Härkönen M,Näveri H,Adlercreutz H

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:Atherosclerotic plaques are heterogeneous with respect to inflammation, calcification, vascularity, oxygen, and temperature. We hypothesized that they also vary in pH and measured pH in living human carotid endarterectomized atherosclerotic plaques (CEA), Watanabe heritable hyperlipidemic (WHHL) rabbit aorta...

journal_title：Atherosclerosis

authors： Naghavi M,John R,Naguib S,Siadaty MS,Grasu R,Kurian KC,van Winkle WB,Soller B,Litovsky S,Madjid M,Willerson JT,Casscells W

更新日期：2002-09-01 00:00:00

abstract：:The purpose of this study was to compare the histologic variability of atheromas resected from patients with various risk factors for vascular disease. Twenty-seven plaques obtained using the Simpson atherectomy catheter were studied. The results of this light and electron microscopic study indicate that patients with...

journal_title：Atherosclerosis

authors： Barbano EF,Newman GE,McCann RL,Hackel DB,Stack RS,Palmos LE,Mikat EM

更新日期：1989-08-01 00:00:00

abstract：:Since VLDL and LDL are involved in atherogenesis, their response to dietary modification was studied in 15 normal male prisoners. A 3-month reference diet (P/S ratio 0.3, daily cholesterol intake 370 mg) was compared with a modified fat diet (P/S 1.0, 250 mg) given for further 3 months. The decrement in serum choleste...

journal_title：Atherosclerosis

authors： Weisweiler P,Drosner M,Janetschek P,Schwandt P

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Left-sided valvular calcification is associated with cardiovascular disease (CVD) morbidity and mortality. Resting heart rate (RHR) may influence valvular calcium progression through shear stress. Whether RHR, an established CVD risk factor, is associated with valvular calcium progression is unknown...

journal_title：Atherosclerosis

authors： Amoakwa K,Fashanu OE,Tibuakuu M,Zhao D,Guallar E,Whelton SP,O'Neal WT,Post WS,Budoff MJ,Michos ED

更新日期：2018-06-01 00:00:00